Medical College of Wisconsin
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John M. Routes MD

John M. Routes MD

Chief, Professor

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Allergy

Member of the Cancer Center
Member of the Genomic Sciences and Precision Medicine Center (GSPMC)


Leadership Positions

  • Chair, NIH Study Section, Investigations on Primary Immunodeficiency Diseases
  • Section Head, Asthma, Allergy and Clinical Immunology
  • President, Clinical Immunology Society
  • Publications

  • Newborn Screening for Severe Combined Immunodeficiency. (Routes J, Verbsky J) Curr Allergy Asthma Rep 2018 May 10;18(6):34 PMID: 29749587 05/12/2018    
  • Antibiotic Use After Removal of Penicillin Allergy Label. (Vyles D, Chiu A, Routes J, Castells M, Phillips EJ, Kibicho J, Brousseau DC) Pediatrics 2018 May;141(5) PMID: 29678929 PMCID: PMC5914488 04/22/2018    
  • Human IL12RB1 expression is allele-biased and produces a novel IL12 response regulator. (Reeme AE, Claeys TA, Aggarwal P, Turner AJ, Routes JM, Broeckel U, Robinson RT) Genes Immun 2018 Mar 30 PMID: 29599514 PMCID: PMC6165718 03/31/2018    
  • Corrigendum: IRAK4 Deficiency in a Patient with Recurrent Pneumococcal Infections: Case Report and Review of the Literature. (Gobin KS, Hintermeyer M, Boisson B, Chrabieh M, Ghandil P, Puel A, Picard C, Casanova JL, Routes J, Verbsky J) Front Pediatr 2018;6:42 PMID: 29531937 PMCID: PMC5841209 03/14/2018    
  • Low Serum IgE Is a Sensitive and Specific Marker for Common Variable Immunodeficiency (CVID). (Lawrence MG, Palacios-Kibler TV, Workman LJ, Schuyler AJ, Steinke JW, Payne SC, McGowan EC, Patrie J, Fuleihan RL, Sullivan KE, Lugar PL, Hernandez CL, Beakes DE, Verbsky JW, Platts-Mills TAE, Cunningham-Rundles C, Routes JM, Borish L) J Clin Immunol 2018 Apr;38(3):225-233 PMID: 29453744 PMCID: PMC5934300 02/18/2018       5 Citations
  • Bronchiectasis. (Kelly BT, Knutsen AP, Routes JM) J Allergy Clin Immunol Pract 2018 Jan - Feb;6(1):315-316 PMID: 29310762 01/10/2018    
  • Abnormal T-Cell Receptor Excision Circle Newborn Screen: What Next? (Prince BT, Routes JM) J Allergy Clin Immunol Pract 2018 Jan - Feb;6(1):318-319 PMID: 29310763 01/10/2018    
  • A Practical Approach to Newborn Screening for Severe Combined Immunodeficiency Using the T Cell Receptor Excision Circle Assay. (Thakar MS, Hintermeyer MK, Gries MG, Routes JM, Verbsky JW) Front Immunol 2017;8:1470 PMID: 29167668 PMCID: PMC5682299 11/24/2017    
  • Autosomal Dominant Hyper-IgE Syndrome in the USIDNET Registry. (Gernez Y, Freeman AF, Holland SM, Garabedian E, Patel NC, Puck JM, Sullivan KE, Akhter J, Secord E, Chen K, Buckley R, Haddad E, Ochs HD, Fuleihan R, Routes J, Muskat M, Lugar P, Mancini J, Cunningham-Rundles C) J Allergy Clin Immunol Pract 2018 May - Jun;6(3):996-1001 PMID: 28939137 PMCID: PMC5858974 09/25/2017    
  • The Use of Salmonella Typhim Vaccine to Diagnose Antibody Deficiency. (Bausch-Jurken MT, Verbsky JW, Gonzaga KA, Elms NP, Hintermeyer MK, Gauld SB, Routes JM) J Clin Immunol 2017 Jul;37(5):427-433 PMID: 28589420 06/08/2017       3 Citations
  • IRAK4 Deficiency in a Patient with Recurrent Pneumococcal Infections: Case Report and Review of the Literature. (Gobin K, Hintermeyer M, Boisson B, Chrabieh M, Gandil P, Puel A, Picard C, Casanova JL, Routes J, Verbsky J) Front Pediatr 2017;5:83 PMID: 28503543 PMCID: PMC5408006 05/16/2017    
  • Immunodeficiency Presenting as an Undiagnosed Disease. (Routes JM, Verbsky JW) Pediatr Clin North Am 2017 Feb;64(1):27-37 PMID: 27894450 11/30/2016       1 Citations
  • Lack of Clinical Hypersensitivity to Penicillin Antibiotics in Common Variable Immunodeficiency. (Hartman H, Schneider K, Hintermeyer M, Bausch-Jurken M, Fuleihan R, Sullivan KE, Cunningham-Rundles C, Bonilla FA, USIDNET Consortium, Verbsky J, Routes J) J Clin Immunol 2017 01;37(1):22-24 PMID: 27873106 PMCID: PMC5392722 11/23/2016       2 Citations
  • Long-term outcomes of 176 patients with X-linked hyper-IgM syndrome treated with or without hematopoietic cell transplantation. (de la Morena MT, Leonard D, Torgerson TR, Cabral-Marques O, Slatter M, Aghamohammadi A, Chandra S, Murguia-Favela L, Bonilla FA, Kanariou M, Damrongwatanasuk R, Kuo CY, Dvorak CC, Meyts I, Chen K, Kobrynski L, Kapoor N, Richter D, DiGiovanni D, Dhalla F, Farmaki E, Speckmann C, Español T, Shcherbina A, Hanson IC, Litzman J, Routes JM, Wong M, Fuleihan R, Seneviratne SL, Small TN, Janda A, Bezrodnik L, Seger R, Raccio AG, Edgar JD, Chou J, Abbott JK, van Montfrans J, González-Granado LI, Bunin N, Kutukculer N, Gray P, Seminario G, Pasic S, Aquino V, Wysocki C, Abolhassani H, Dorsey M, Cunningham-Rundles C, Knutsen AP, Sleasman J, Costa Carvalho BT, Condino-Neto A, Grunebaum E, Chapel H, Ochs HD, Filipovich A, Cowan M, Gennery A, Cant A, Notarangelo LD, Roifman CM) J Allergy Clin Immunol 2017 Apr;139(4):1282-1292 PMID: 27697500 PMCID: PMC5374029 10/05/2016       28 Citations
  • Rubella persistence in epidermal keratinocytes and granuloma M2 macrophages in patients with primary immunodeficiencies. (Perelygina L, Plotkin S, Russo P, Hautala T, Bonilla F, Ochs HD, Joshi A, Routes J, Patel K, Wehr C, Icenogle J, Sullivan KE) J Allergy Clin Immunol 2016 11;138(5):1436-1439.e11 PMID: 27613149 PMCID: PMC5392721 09/11/2016       14 Citations
  • Reply. (Bonilla FA, Chapel H, Costa-Carvalho BT, Cunningham-Rundles C, de la Morena MT, Espinosa-Rosales FJ, Hammarström L, Nonoyama S, Quinti I, Routes JM, Tang ML, Warnatz K) J Allergy Clin Immunol Pract 2016 Sep-Oct;4(5):1019-20 PMID: 27587326 PMCID: PMC5886701 09/03/2016    
  • X-linked Hyper IgM Syndrome Presenting as Pulmonary Alveolar Proteinosis. (Gallagher J, Adams J, Hintermeyer M, Torgerson TR, Lopez-Guisa J, Ochs HD, Szabo S, Salib M, Verbsky J, Routes J) J Clin Immunol 2016 08;36(6):564-70 PMID: 27324886 06/22/2016       4 Citations
  • Newborn screening for SCID: lessons learned. (Buelow BJ, Verbsky JW, Routes JM) Expert Rev Hematol 2016 Jun;9(6):579-84 PMID: 27139719 05/04/2016       2 Citations
  • Health-Related Quality of Life and Health Resource Utilization in Patients with Primary Immunodeficiency Disease Prior to and Following 12 Months of Immunoglobulin G Treatment. (Routes J, Costa-Carvalho BT, Grimbacher B, Paris K, Ochs HD, Filipovich A, Hintermeyer M, de Melo KM, Workman S, Ito D, Ye X, Bonnet P, Li-McLeod J) J Clin Immunol 2016 07;36(5):450-61 PMID: 27091140 PMCID: PMC4896988 04/20/2016       4 Citations
  • Correction: Possible Role of Arginase-1 in Concomitant Tumor Immunity. (Korrer MJ, Zhang Y, Routes JM) PLoS One 2016;11(3):e0153122 PMID: 27031640 PMCID: PMC4816400 04/01/2016    
  • The introduction of RNA-DNA differences underlies interindividual variation in the human IL12RB1 mRNA repertoire. (Turner AJ, Aggarwal P, Miller HE, Waukau J, Routes JM, Broeckel U, Robinson RT) Proc Natl Acad Sci U S A 2015 Dec 15;112(50):15414-9 PMID: 26621740 PMCID: PMC4687591 12/02/2015       2 Citations
  • International Consensus Document (ICON): Common Variable Immunodeficiency Disorders. (Bonilla FA, Barlan I, Chapel H, Costa-Carvalho BT, Cunningham-Rundles C, de la Morena MT, Espinosa-Rosales FJ, Hammarström L, Nonoyama S, Quinti I, Routes JM, Tang ML, Warnatz K) J Allergy Clin Immunol Pract 2016 Jan-Feb;4(1):38-59 PMID: 26563668 PMCID: PMC4869529 11/14/2015       124 Citations
  • Practice parameter for the diagnosis and management of primary immunodeficiency. (Bonilla FA, Khan DA, Ballas ZK, Chinen J, Frank MM, Hsu JT, Keller M, Kobrynski LJ, Komarow HD, Mazer B, Nelson RP Jr, Orange JS, Routes JM, Shearer WT, Sorensen RU, Verbsky JW, Bernstein DI, Blessing-Moore J, Lang D, Nicklas RA, Oppenheimer J, Portnoy JM, Randolph CR, Schuller D, Spector SL, Tilles S, Wallace D, Joint Task Force on Practice Parameters, representing the American Academy of Allergy, Asthma & Immunology; the American College of Allergy, Asthma & Immunology; and the Joint Council of Allergy, Asthma & Immunology) J Allergy Clin Immunol 2015 Nov;136(5):1186-205.e1-78 PMID: 26371839 09/16/2015       108 Citations
  • Granulomatous and lymphocytic interstitial lung disease: a spectrum of pulmonary histopathologic lesions in common variable immunodeficiency--histologic and immunohistochemical analyses of 16 cases. (Rao N, Mackinnon AC, Routes JM) Hum Pathol 2015 Sep;46(9):1306-14 PMID: 26138782 PMCID: PMC4554947 07/04/2015       17 Citations
  • Adenovirus serotype 5 E1A expressing tumor cells elicit a tumor-specific CD8+ T cell response independent of NKG2D. (Korrer MJ, Routes JM) Results Immunol 2015;5:1-5 PMID: 25685658 PMCID: PMC4309920 02/17/2015    
  • Screening for and treatments of congenital immunodeficiency diseases. (Verbsky J, Routes J) Clin Perinatol 2014 Dec;41(4):1001-15 PMID: 25459787 12/03/2014       3 Citations
  • Granulomatous-lymphocytic interstitial lung disease in a patient with common variable immunodeficiency. (Lieberman P, Routes J) J Allergy Clin Immunol Pract 2014 Nov-Dec;2(6):824 PMID: 25439387 12/03/2014       2 Citations
  • Newborn screening for SCID: where are we now? (Buelow BJ, Routes JM, Verbsky JW) Expert Rev Clin Immunol 2014 Dec;10(12):1649-57 PMID: 25387596 11/13/2014       2 Citations
  • Gain of Function Mutations of PIK3CD as a Cause of Primary Sclerosing Cholangitis. (Hartman HN, Niemela J, Hintermeyer MK, Garofalo M, Stoddard J, Verbsky JW, Rosenzweig SD, Routes JM) J Clin Immunol 2015 Jan;35(1):11-4 PMID: 25352054 PMCID: PMC4769101 10/30/2014       23 Citations
  • Newborn screening for severe combined immunodeficiency in 11 screening programs in the United States. (Kwan A, Abraham RS, Currier R, Brower A, Andruszewski K, Abbott JK, Baker M, Ballow M, Bartoshesky LE, Bonilla FA, Brokopp C, Brooks E, Caggana M, Celestin J, Church JA, Comeau AM, Connelly JA, Cowan MJ, Cunningham-Rundles C, Dasu T, Dave N, De La Morena MT, Duffner U, Fong CT, Forbes L, Freedenberg D, Gelfand EW, Hale JE, Hanson IC, Hay BN, Hu D, Infante A, Johnson D, Kapoor N, Kay DM, Kohn DB, Lee R, Lehman H, Lin Z, Lorey F, Abdel-Mageed A, Manning A, McGhee S, Moore TB, Naides SJ, Notarangelo LD, Orange JS, Pai SY, Porteus M, Rodriguez R, Romberg N, Routes J, Ruehle M, Rubenstein A, Saavedra-Matiz CA, Scott G, Scott PM, Secord E, Seroogy C, Shearer WT, Siegel S, Silvers SK, Stiehm ER, Sugerman RW, Sullivan JL, Tanksley S, Tierce ML 4th, Verbsky J, Vogel B, Walker R, Walkovich K, Walter JE, Wasserman RL, Watson MS, Weinberg GA, Weiner LB, Wood H, Yates AB, Puck JM, Bonagura VR) JAMA 2014 Aug 20;312(7):729-38 PMID: 25138334 PMCID: PMC4492158 08/21/2014       208 Citations
  • Sarcoidosis and common variable immunodeficiency: similarities and differences. (Verbsky JW, Routes JM) Semin Respir Crit Care Med 2014 Jun;35(3):330-5 PMID: 25007085 07/10/2014       17 Citations
  • Characterization of Crohn disease in X-linked inhibitor of apoptosis-deficient male patients and female symptomatic carriers. (Aguilar C, Lenoir C, Lambert N, Bègue B, Brousse N, Canioni D, Berrebi D, Roy M, Gérart S, Chapel H, Schwerd T, Siproudhis L, Schäppi M, Al-Ahmari A, Mori M, Yamaide A, Galicier L, Neven B, Routes J, Uhlig HH, Koletzko S, Patel S, Kanegane H, Picard C, Fischer A, Bensussan NC, Ruemmele F, Hugot JP, Latour S) J Allergy Clin Immunol 2014 Nov;134(5):1131-41.e9 PMID: 24942515 06/20/2014       46 Citations
  • A172: Metaphyseal Chondrodysplasia, Ectodermal Dysplasia, Short Stature, Hypergammaglobulinemia, and Spontaneous Inflammation Without Infections in an Extended Family Due to Mutation in NFKB1A. (Oberle EJ, Verbsky JW, Routes J, Hintermeyer M, Worthey E, Dasu T, Bengtson C, Buzzell A) Arthritis Rheumatol 2014 Mar;66 Suppl 11:S224-5 PMID: 24677928 03/29/2014    
  • Possible role of arginase-1 in concomitant tumor immunity. (Korrer MJ, Zhang Y, Routes JM) PLoS One 2014;9(3):e91370 PMID: 24614600 PMCID: PMC3948845 03/13/2014       6 Citations
  • ICON: the early diagnosis of congenital immunodeficiencies. (Routes J, Abinun M, Al-Herz W, Bustamante J, Condino-Neto A, De La Morena MT, Etzioni A, Gambineri E, Haddad E, Kobrynski L, Le Deist F, Nonoyama S, Oliveira JB, Perez E, Picard C, Rezaei N, Sleasman J, Sullivan KE, Torgerson T) J Clin Immunol 2014 May;34(4):398-424 PMID: 24619621 03/13/2014       14 Citations
  • Recommendations for live viral and bacterial vaccines in immunodeficient patients and their close contacts. (Medical Advisory Committee of the Immune Deficiency Foundation, Shearer WT, Fleisher TA, Buckley RH, Ballas Z, Ballow M, Blaese RM, Bonilla FA, Conley ME, Cunningham-Rundles C, Filipovich AH, Fuleihan R, Gelfand EW, Hernandez-Trujillo V, Holland SM, Hong R, Lederman HM, Malech HL, Miles S, Notarangelo LD, Ochs HD, Orange JS, Puck JM, Routes JM, Stiehm ER, Sullivan K, Torgerson T, Winkelstein J) J Allergy Clin Immunol 2014 Apr;133(4):961-6 PMID: 24582311 PMCID: PMC4009347 03/04/2014       52 Citations
  • Primary Immune Deficiency Treatment Consortium (PIDTC) report. (Griffith LM, Cowan MJ, Notarangelo LD, Kohn DB, Puck JM, Pai SY, Ballard B, Bauer SC, Bleesing JJ, Boyle M, Brower A, Buckley RH, van der Burg M, Burroughs LM, Candotti F, Cant AJ, Chatila T, Cunningham-Rundles C, Dinauer MC, Dvorak CC, Filipovich AH, Fleisher TA, Bobby Gaspar H, Gungor T, Haddad E, Hovermale E, Huang F, Hurley A, Hurley M, Iyengar S, Kang EM, Logan BR, Long-Boyle JR, Malech HL, McGhee SA, Modell F, Modell V, Ochs HD, O'Reilly RJ, Parkman R, Rawlings DJ, Routes JM, Shearer WT, Small TN, Smith H, Sullivan KE, Szabolcs P, Thrasher A, Torgerson TR, Veys P, Weinberg K, Zuniga-Pflucker JC, workshop participants) J Allergy Clin Immunol 2014 Feb;133(2):335-47 PMID: 24139498 PMCID: PMC3960312 10/22/2013       35 Citations
  • Screening for severe combined immunodeficiency in neonates. (Kelly BT, Tam JS, Verbsky JW, Routes JM) Clin Epidemiol 2013;5:363-9 PMID: 24068875 PMCID: PMC3782515 09/27/2013    
  • Common variable immunodeficiency. (Tam JS, Routes JM) Am J Rhinol Allergy 2013 Jul-Aug;27(4):260-5 PMID: 23883805 PMCID: PMC3901442 07/26/2013       13 Citations
  • Inflammatory signals direct expression of human IL12RB1 into multiple distinct isoforms. (Ford NR, Miller HE, Reeme AE, Waukau J, Bengtson C, Routes JM, Robinson RT) J Immunol 2012 Nov 01;189(9):4684-94 PMID: 23024274 10/02/2012       9 Citations
  • Use of combination chemotherapy for treatment of granulomatous and lymphocytic interstitial lung disease (GLILD) in patients with common variable immunodeficiency (CVID). (Chase NM, Verbsky JW, Hintermeyer MK, Waukau JK, Tomita-Mitchell A, Casper JT, Singh S, Shahir KS, Tisol WB, Nugent ML, Rao RN, Mackinnon AC, Goodman LR, Simpson PM, Routes JM) J Clin Immunol 2013 Jan;33(1):30-9 PMID: 22930256 PMCID: PMC3557581 08/30/2012       80 Citations
  • Recombinant human hyaluronidase-facilitated subcutaneous infusion of human immunoglobulins for primary immunodeficiency. (Wasserman RL, Melamed I, Stein MR, Gupta S, Puck J, Engl W, Leibl H, McCoy B, Empson VG, Gelmont D, Schiff RI, IGSC, 10% with rHuPH20 Study Group) J Allergy Clin Immunol 2012 Oct;130(4):951-7.e11 PMID: 22846381 08/01/2012       65 Citations
  • The Wisconsin approach to newborn screening for severe combined immunodeficiency. (Verbsky J, Thakar M, Routes J) J Allergy Clin Immunol 2012 Mar;129(3):622-7 PMID: 22244594 01/17/2012       52 Citations
  • Newborn screening for SCID: three years of experience. (Chase NM, Verbsky JW, Routes JM) Ann N Y Acad Sci 2011 Nov;1238:99-105 PMID: 22129057 12/02/2011    
  • Newborn screening for severe combined immunodeficiency; the Wisconsin experience (2008-2011). (Verbsky JW, Baker MW, Grossman WJ, Hintermeyer M, Dasu T, Bonacci B, Reddy S, Margolis D, Casper J, Gries M, Desantes K, Hoffman GL, Brokopp CD, Seroogy CM, Routes JM) J Clin Immunol 2012 Feb;32(1):82-8 PMID: 22068910 11/10/2011       73 Citations
  • Screening newborns for primary T-cell immunodeficiencies: consensus and controversy. (Accetta Pedersen DJ, Verbsky J, Routes JM) Expert Rev Clin Immunol 2011 Nov;7(6):761-8 PMID: 22014017 10/22/2011       4 Citations
  • Expert commentary: practical issues in newborn screening for severe combined immune deficiency (SCID). (Puck JM, Routes J, Filipovich AH, Sullivan K) J Clin Immunol 2012 Feb;32(1):36-8 PMID: 22012274 PMCID: PMC4380147 10/21/2011       3 Citations
  • Cause of death in neonates with inconclusive or abnormal T-cell receptor excision circle assays on newborn screening. (Accetta DJ, Brokopp CD, Baker MW, Verbsky J, Routes JM) J Clin Immunol 2011 Dec;31(6):962-7 PMID: 21956495 10/01/2011       12 Citations
  • Global study of primary immunodeficiency diseases (PI)--diagnosis, treatment, and economic impact: an updated report from the Jeffrey Modell Foundation. (Modell V, Gee B, Lewis DB, Orange JS, Roifman CM, Routes JM, Sorensen RU, Notarangelo LD, Modell F) Immunol Res 2011 Oct;51(1):61-70 PMID: 21935653 09/22/2011       76 Citations
  • Making a definitive diagnosis: successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease. (Worthey EA, Mayer AN, Syverson GD, Helbling D, Bonacci BB, Decker B, Serpe JM, Dasu T, Tschannen MR, Veith RL, Basehore MJ, Broeckel U, Tomita-Mitchell A, Arca MJ, Casper JT, Margolis DA, Bick DP, Hessner MJ, Routes JM, Verbsky JW, Jacob HJ, Dimmock DP) Genet Med 2011 Mar;13(3):255-62 PMID: 21173700 12/22/2010       458 Citations
  • Human phagocyte defect caused by a Rac2 mutation detected by means of neonatal screening for T-cell lymphopenia. (Accetta D, Syverson G, Bonacci B, Reddy S, Bengtson C, Surfus J, Harbeck R, Huttenlocher A, Grossman W, Routes J, Verbsky J) J Allergy Clin Immunol 2011 Feb;127(2):535-538.e1-2 PMID: 21167572 12/21/2010       31 Citations
  • Newborn screening for T-cell deficiency. (Chase NM, Verbsky JW, Routes JM) Curr Opin Allergy Clin Immunol 2010 Dec;10(6):521-5 PMID: 20864885 09/25/2010       15 Citations
  • Multiplexed quantitative real-time PCR to detect 22q11.2 deletion in patients with congenital heart disease. (Tomita-Mitchell A, Mahnke DK, Larson JM, Ghanta S, Feng Y, Simpson PM, Broeckel U, Duffy K, Tweddell JS, Grossman WJ, Routes JM, Mitchell ME) Physiol Genomics 2010 Sep;42A(1):52-60 PMID: 20551144 PMCID: PMC2957771 06/17/2010       27 Citations
  • Implementing routine testing for severe combined immunodeficiency within Wisconsin's newborn screening program. (Baker MW, Laessig RH, Katcher ML, Routes JM, Grossman WJ, Verbsky J, Kurtycz DF, Brokopp CD) Public Health Rep 2010 May-Jun;125 Suppl 2:88-95 PMID: 20518449 PMCID: PMC2846807 06/04/2010       41 Citations
  • Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and management. (Griffith LM, Cowan MJ, Notarangelo LD, Puck JM, Buckley RH, Candotti F, Conley ME, Fleisher TA, Gaspar HB, Kohn DB, Ochs HD, O'Reilly RJ, Rizzo JD, Roifman CM, Small TN, Shearer WT, Workshop Participants) J Allergy Clin Immunol 2009 Dec;124(6):1152-60.e12 PMID: 20004776 PMCID: PMC2831471 12/17/2009       68 Citations
  • Statewide newborn screening for severe T-cell lymphopenia. (Routes JM, Grossman WJ, Verbsky J, Laessig RH, Hoffman GL, Brokopp CD, Baker MW) JAMA 2009 Dec 09;302(22):2465-70 PMID: 19996402 12/10/2009       115 Citations
  • Development of a routine newborn screening protocol for severe combined immunodeficiency. (Baker MW, Grossman WJ, Laessig RH, Hoffman GL, Brokopp CD, Kurtycz DF, Cogley MF, Litsheim TJ, Katcher ML, Routes JM) J Allergy Clin Immunol 2009 Sep;124(3):522-7 PMID: 19482345 06/02/2009       112 Citations
  • E1A oncogene enhancement of caspase-2-mediated mitochondrial injury sensitizes cells to macrophage nitric oxide-induced apoptosis. (Radke JR, Siddiqui ZK, Miura TA, Routes JM, Cook JL) J Immunol 2008 Jun 15;180(12):8272-9 PMID: 18523293 06/05/2008       6 Citations
  • Immunodeficiency overview. (Morimoto Y, Routes JM) Prim Care 2008 Mar;35(1):159-73, viii PMID: 18206723 01/22/2008       14 Citations
  • Measurement of natural-killer cell lytic activity of adenovirus-infected or adenovirus-transformed cells. (Routes JM) Methods Mol Med 2007;131:213-9 PMID: 17656785 07/28/2007       1 Citations
  • Pulmonary infection with Mycobacterium neoaurum identified by 16S ribosomal DNA sequence. (Morimoto Y, Chan ED, Heifets L, Routes JM) J Infect 2007 Apr;54(4):e227-31 PMID: 17306883 02/20/2007       13 Citations
  • The interaction of adenovirus E1A with p300 family members modulates cellular gene expression to reduce tumorigenicity. (Miura TA, Cook JL, Potter TA, Ryan S, Routes JM) J Cell Biochem 2007 Mar 01;100(4):929-40 PMID: 17063489 10/26/2006       4 Citations
  • Adenovirus serotype 5 E1A sensitizes tumor cells to NKG2D-dependent NK cell lysis and tumor rejection. (Routes JM, Ryan S, Morris K, Takaki R, Cerwenka A, Lanier LL) J Exp Med 2005 Dec 05;202(11):1477-82 PMID: 16314433 PMCID: PMC2213342 11/30/2005       56 Citations
  • Possible role of human herpesvirus 8 in the lymphoproliferative disorders in common variable immunodeficiency. (Wheat WH, Cool CD, Morimoto Y, Rai PR, Kirkpatrick CH, Lindenbaum BA, Bates CA, Ellison MC, Serls AE, Brown KK, Routes JM) J Exp Med 2005 Aug 15;202(4):479-84 PMID: 16103407 PMCID: PMC2212861 08/17/2005       115 Citations
  • Granulomatous disease in common variable immunodeficiency. (Morimoto Y, Routes JM) Curr Allergy Asthma Rep 2005 Sep;5(5):370-5 PMID: 16091208 08/11/2005       88 Citations
  • Practice parameter for the diagnosis and management of primary immunodeficiency. (Bonilla FA, Bernstein IL, Khan DA, Ballas ZK, Chinen J, Frank MM, Kobrynski LJ, Levinson AI, Mazer B, Nelson RP Jr, Orange JS, Routes JM, Shearer WT, Sorensen RU, American Academy of Allergy, Asthma and Immunology, American College of Allergy, Asthma and Immunology, Joint Council of Allergy, Asthma and Immunology) Ann Allergy Asthma Immunol 2005 May;94(5 Suppl 1):S1-63 PMID: 15945566 06/11/2005    
  • Uncommon conundrum in common variable immunodeficiency. (Cunningham-Rundles C, Routes JM, Hostoffer R, Sullivan KE) Clin Immunol 2005 Sep;116(3):208-10 PMID: 15905130 05/21/2005       2 Citations
  • Adenovirus E1A gene-induced tumor cell rejection through cellular sensitization to immune and nonimmune apoptotic injuries. (Cook JL, Routes JM) Front Biosci 2005 May 01;10:1396-414 PMID: 15769634 03/17/2005       8 Citations
  • Pre-event smallpox vaccination and postevent exposure and disease: a report of the Joint Task Force on Smallpox Vaccination for Allergists. (Ein D, Gruchalla R, Baker JR, Bellanti JA, Engler RA, Jones JF, Martin BL, Routes JM, Task Force on Smallpox Vaccination for Allergists) Ann Allergy Asthma Immunol 2005 Jan;94(1):4-7 PMID: 15702806 02/11/2005       3 Citations
  • Macrophages kill human papillomavirus type 16 E6-expressing tumor cells by tumor necrosis factor alpha- and nitric oxide-dependent mechanisms. (Routes JM, Morris K, Ellison MC, Ryan S) J Virol 2005 Jan;79(1):116-23 PMID: 15596807 PMCID: PMC538740 12/15/2004       20 Citations
  • Dose dependence and time course of the immunologic response to administration of standardized cat allergen extract. (Nanda A, O'connor M, Anand M, Dreskin SC, Zhang L, Hines B, Lane D, Wheat W, Routes JM, Sawyer R, Rosenwasser LJ, Nelson HS) J Allergy Clin Immunol 2004 Dec;114(6):1339-44 PMID: 15577832 12/04/2004       97 Citations
  • Granulomatous-lymphocytic lung disease shortens survival in common variable immunodeficiency. (Bates CA, Ellison MC, Lynch DA, Cool CD, Brown KK, Routes JM) J Allergy Clin Immunol 2004 Aug;114(2):415-21 PMID: 15316526 08/19/2004       175 Citations
  • Expression of an E1A/E7 chimeric protein sensitizes tumor cells to killing by activated macrophages but not NK cells. (Miura TA, Li H, Morris K, Ryan S, Hembre K, Cook JL, Routes JM) J Virol 2004 May;78(9):4646-54 PMID: 15078947 PMCID: PMC387719 04/14/2004       6 Citations
  • Expression of human herpesvirus 8 in primary pulmonary hypertension. (Cool CD, Rai PR, Yeager ME, Hernandez-Saavedra D, Serls AE, Bull TM, Geraci MW, Brown KK, Routes JM, Tuder RM, Voelkel NF) N Engl J Med 2003 Sep 18;349(12):1113-22 PMID: 13679525 09/19/2003       229 Citations
  • E1A oncogene-induced sensitization of human tumor cells to innate immune defenses and chemotherapy-induced apoptosis in vitro and in vivo. (Cook JL, Miura TA, Iklé DN, Lewis AM Jr, Routes JM) Cancer Res 2003 Jun 15;63(12):3435-43 PMID: 12810682 06/18/2003       15 Citations
  • Adenovirus E1A, not human papillomavirus E7, sensitizes tumor cells to lysis by macrophages through nitric oxide- and TNF-alpha-dependent mechanisms despite up-regulation of 70-kDa heat shock protein. (Miura TA, Morris K, Ryan S, Cook JL, Routes JM) J Immunol 2003 Apr 15;170(8):4119-26 PMID: 12682242 04/19/2003       17 Citations
  • Role of the innate immune response in determining the tumorigenicity of neoplastic cells. (Cook JL, Routes JM) Dev Biol (Basel) 2001;106:99-107; discussion 107-8, 143-60 PMID: 11761273 01/05/2002       1 Citations
  • MHC class I molecules on adenovirus E1A-expressing tumor cells inhibit NK cell killing but not NK cell-mediated tumor rejection. (Routes JM, Ryan JC, Ryan S, Nakamura M) Int Immunol 2001 Oct;13(10):1301-7 PMID: 11581175 10/03/2001       4 Citations
  • CREB (cAMP response element binding protein) and C/EBPalpha (CCAAT/enhancer binding protein) are required for the superstimulation of phosphoenolpyruvate carboxykinase gene transcription by adenoviral E1a and cAMP. (Routes JM, Colton LA, Ryan S, Klemm DJ) Biochem J 2000 Dec 01;352 Pt 2:335-42 PMID: 11085926 PMCID: PMC1221464 11/22/2000       10 Citations
  • Dissimilar immunogenicities of human papillomavirus E7 and adenovirus E1A proteins influence primary tumor development. (Routes JM, Ryan S, Li H, Steinke J, Cook JL) Virology 2000 Nov 10;277(1):48-57 PMID: 11062035 11/04/2000       15 Citations
  • Adenovirus E1A oncogene expression in tumor cells enhances killing by TNF-related apoptosis-inducing ligand (TRAIL). (Routes JM, Ryan S, Clase A, Miura T, Kuhl A, Potter TA, Cook JL) J Immunol 2000 Oct 15;165(8):4522-7 PMID: 11035092 10/18/2000       59 Citations
  • Lack of correlation between Chlamydia pneumoniae antibody titers and adult-onset asthma. (Routes JM, Nelson HS, Noda JA, Simon FT) J Allergy Clin Immunol 2000 Feb;105(2 Pt 1):391-2 PMID: 10669864 02/12/2000       20 Citations
  • E1A oncogene induction of cellular susceptibility to killing by cytolytic lymphocytes through target cell sensitization to apoptotic injury. (Cook JL, Routes BA, Walker TA, Colvin KL, Routes JM) Exp Cell Res 1999 Sep 15;251(2):414-23 PMID: 10471326 09/02/1999       18 Citations
  • Noninfectious immunologic disorders in adults. (Bensch G, Routes JM) Chest Surg Clin N Am 1999 Feb;9(1):113-24, ix PMID: 10079983 03/18/1999    
  • Hypersensitivity pneumonitis in a patient with hypogammaglobulinemia. (Schkade PA, Routes JM) J Allergy Clin Immunol 1996 Sep;98(3):710-2 PMID: 8828552 09/01/1996       11 Citations
  • Adenovirus E1A proteins regulate phosphoenolpyruvate carboxykinase gene transcription through multiple mechanisms. (Klemm DJ, Colton LA, Ryan S, Routes JM) J Biol Chem 1996 Apr 05;271(14):8082-8 PMID: 8626493 04/05/1996       10 Citations
  • Inhibition of IFN-stimulated gene expression and IFN induction of cytolytic resistance to natural killer cell lysis correlate with E1A-p300 binding. (Routes JM, Li H, Bayley ST, Ryan S, Klemm DJ) J Immunol 1996 Feb 01;156(3):1055-61 PMID: 8557979 02/01/1996       21 Citations
  • Oncogenicity of human papillomavirus- or adenovirus-transformed cells correlates with resistance to lysis by natural killer cells. (Routes JM, Ryan S) J Virol 1995 Dec;69(12):7639-47 PMID: 7494272 PMCID: PMC189704 12/01/1995       13 Citations
  • E1A gene expression induces susceptibility to killing by NK cells following immortalization but not adenovirus infection of human cells. (Routes JM, Cook JL) Virology 1995 Jul 10;210(2):421-8 PMID: 7618277 07/10/1995    
  • Oral desensitization to rifampin and ethambutol in mycobacterial disease. (Matz J, Borish LC, Routes JM, Rosenwasser LJ) Am J Respir Crit Care Med 1994 Mar;149(3 Pt 1):815-7 PMID: 8118654 03/01/1994       43 Citations
  • Endogenous expression of E1A in human cells enhances the effect of adenovirus E3 on class I major histocompatibility complex antigen expression. (Routes JM, Metz BA, Cook JL) J Virol 1993 Jun;67(6):3176-81 PMID: 8497046 PMCID: PMC237656 06/01/1993       12 Citations
  • Activities of superoxide dismutases and NADPH oxidase in neutrophils obtained from asthmatic and normal donors. (Joseph BZ, Routes JM, Borish L) Inflammation 1993 Jun;17(3):361-70 PMID: 8392494 06/01/1993       38 Citations
  • Adenovirus E1A inhibits IFN-induced resistance to cytolysis by natural killer cells. (Routes JM) J Immunol 1993 May 15;150(10):4315-22 PMID: 7683316 05/15/1993       16 Citations
  • Diffuse pulmonary infiltrates in hypogammaglobulinemia. (Matz J, Routes JM, Borish LC) Ann Allergy 1992 Dec;69(6):485-90 PMID: 1471779 12/01/1992       1 Citations
  • IFN increases class I MHC antigen expression on adenovirus-infected human cells without inducing resistance to natural killer cell killing. (Routes JM) J Immunol 1992 Oct 01;149(7):2372-7 PMID: 1382100 10/01/1992       22 Citations
  • Anti-adenovirus type 5 cytotoxic T lymphocytes: immunodominant epitopes are encoded by the E1A gene. (Routes JM, Bellgrau D, McGrory WJ, Bautista DS, Graham FL, Cook JL) J Virol 1991 Mar;65(3):1450-7 PMID: 1704928 PMCID: PMC239925 03/01/1991       26 Citations
  • Resistance of human cells to the adenovirus E3 effect on class I MHC antigen expression. Implications for antiviral immunity. (Routes JM, Cook JL) J Immunol 1990 Apr 01;144(7):2763-70 PMID: 2156934 04/01/1990       15 Citations
  • Adenovirus persistence in man. Defective E1A gene product targeting of infected cells for elimination by natural killer cells. (Routes JM, Cook JL) J Immunol 1989 Jun 01;142(11):4022-6 PMID: 2541204 06/01/1989       6 Citations
  • Corticosteroids in inflammatory bowel disease. A review. (Routes J, Claman HN) J Clin Gastroenterol 1987 Oct;9(5):529-35 PMID: 3316373 10/01/1987       4 Citations
  • Studies on nicotinic acetylcholine receptors in mammalian brain. Preliminary characterization of membrane-bound alpha-bungarotoxin receptors in rat cerebral cortex. (McQuarrie C, Salvaterra PM, De Blas A, Routes J, Mahler HR) J Biol Chem 1976 Oct 25;251(20):6335-9 PMID: 977573 10/25/1976       50 Citations
  • Last update: 11/16/2018
    jenkins-FCD Prod-299 9ef562391eceb2b8f95265c767fbba1ce5a52fd6