Medical College of Wisconsin
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John R. Lynch MD

Chief, Director, Associate Professor

Institution: Medical College of Wisconsin
Department: Neurology
Division: Neurointerventional
Program: NeuroInterventional

Member of the Neuroscience Research Center


  • Endovascular embolization of head and neck tumors. (Lazzaro MA, Badruddin A, Zaidat OO, Darkhabani Z, Pandya DJ, Lynch JR) Front Neurol 2011;2:64 PMID: 22022319 PMCID: PMC3195266 10/25/2011    
  • Multimodal endovascular therapy of traumatic and spontaneous carotid cavernous fistula using coils, n-BCA, Onyx and stent graft. (Zaidat OO, Lazzaro MA, Niu T, Hong SH, Fitzsimmons BF, Lynch JR, Sinson GP) J Neurointerv Surg 2011 Sep;3(3):255-62 PMID: 21990837 10/13/2011       26 Citations
  • Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease. (Dawson HN, Cantillana V, Jansen M, Wang H, Vitek MP, Wilcock DM, Lynch JR, Laskowitz DT) Neuroscience 2010 Aug 11;169(1):516-31 PMID: 20434528 PMCID: PMC2900546 05/04/2010       93 Citations
  • Long term clinical and angiographic outcomes with the Wingspan stent for treatment of symptomatic 50-99% intracranial atherosclerosis: single center experience in 51 cases. (Wolfe TJ, Fitzsimmons BF, Hussain SI, Lynch JR, Zaidat OO) J Neurointerv Surg 2009 Jul;1(1):40-3 PMID: 21994104 07/01/2009       11 Citations
  • Stent-assisted parent artery occlusion of giant cerebrovascular aneurysms to avoid mass effect. (Hussain SI, Lynch JR, Wolfe T, Fitzsimmons BF, Zaidat OO) J Neuroimaging 2009 Oct;19(4):370-4 PMID: 19453830 05/21/2009       2 Citations
  • Diagnostic cerebral angiography: the interventional neurology perspective. (Hussain SI, Wolfe TJ, Lynch JR, Fitzsimmons BF, Zaidat OO) J Neuroimaging 2010 Jul;20(3):251-4 PMID: 19226341 02/20/2009       4 Citations
  • Pediatric cerebral angiography: analysis of utilization and findings. (Wolfe TJ, Hussain SI, Lynch JR, Fitzsimmons BF, Zaidat OO) Pediatr Neurol 2009 Feb;40(2):98-101 PMID: 19135622 01/13/2009       27 Citations
  • Measurement of antiplatelet inhibition during neurointerventional procedures: the effect of antithrombotic duration and loading dose. (Pandya DJ, Fitzsimmons BF, Wolfe TJ, Hussain SI, Lynch JR, Ortega-Gutierrez S, Zaidat OO) J Neuroimaging 2010 Jan;20(1):64-9 PMID: 19018951 11/21/2008       21 Citations
  • Interventional acute ischemic stroke therapy with intracranial self-expanding stent. (Zaidat OO, Wolfe T, Hussain SI, Lynch JR, Gupta R, Delap J, Torbey MT, Fitzsimmons BF) Stroke 2008 Aug;39(8):2392-5 PMID: 18556584 06/17/2008       118 Citations
  • Takotsubo cardiomyopathy associated with seizures. (Lemke DM, Hussain SI, Wolfe TJ, Torbey MA, Lynch JR, Carlin A, Fitzsimmons BF, Zaidat OO) Neurocrit Care 2008;9(1):112-7 PMID: 18347760 03/19/2008       50 Citations
  • Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury. (Wang H, Lynch JR, Song P, Yang HJ, Yates RB, Mace B, Warner DS, Guyton JR, Laskowitz DT) Exp Neurol 2007 Jul;206(1):59-69 PMID: 17521631 05/25/2007       131 Citations
  • Apolipoprotein E modifies the CNS response to injury via a histamine-mediated pathway. (Mace BE, Wang H, Lynch JR, Moss J, Sullivan P, Colton H, Morgan K, Renauld JC, Laskowitz DT) Neurol Res 2007 Apr;29(3):243-50 PMID: 17509222 05/19/2007       8 Citations
  • Risk of cerebral vasopasm after subarachnoid hemorrhage reduced by statin therapy: A multivariate analysis of an institutional experience. (McGirt MJ, Blessing R, Alexander MJ, Nimjee SM, Woodworth GF, Friedman AH, Graffagnino C, Laskowitz DT, Lynch JR) J Neurosurg 2006 Nov;105(5):671-4 PMID: 17121126 11/24/2006       54 Citations
  • Levetiracetam is neuroprotective in murine models of closed head injury and subarachnoid hemorrhage. (Wang H, Gao J, Lassiter TF, McDonagh DL, Sheng H, Warner DS, Lynch JR, Laskowitz DT) Neurocrit Care 2006;5(1):71-8 PMID: 16960300 09/09/2006       75 Citations
  • Galbraith Award: simvastatin attenuates experimental cerebral vasospasm and ameliorates serum markers of neuronal and endothelial injury in patients after subarachnoid hemorrhage: a dose-response effect dependent on endothelial nitric oxide synthase. (McGirt MJ, Woodworth GF, Pradilla G, Legnani F, Warner D, Tamargo R, Clatterbuck R, Lynch JR, Laskowitz DT) Clin Neurosurg 2005;52:371-8 PMID: 16626096 04/22/2006       11 Citations
  • A novel apoE-derived therapeutic reduces vasospasm and improves outcome in a murine model of subarachnoid hemorrhage. (Gao J, Wang H, Sheng H, Lynch JR, Warner DS, Durham L, Vitek MP, Laskowitz DT) Neurocrit Care 2006;4(1):25-31 PMID: 16498192 02/25/2006       65 Citations
  • Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model. (Leinenweber SB, Sheng H, Lynch JR, Wang H, Batinić-Haberle I, Laskowitz DT, Crapo JD, Pearlstein RD, Warner DS) Eur J Pharmacol 2006 Feb 15;531(1-3):126-32 PMID: 16455070 02/04/2006       7 Citations
  • Panel of biomarkers predicts stroke. (Laskowitz DT, Blessing R, Floyd J, White WD, Lynch JR) Ann N Y Acad Sci 2005 Aug;1053:30 PMID: 16179504 09/24/2005       32 Citations
  • Toward solving the sedation-assessment conundrum: bi-spectral index monitoring and sedation interruption. (Olson DM, Graffagnino C, King K, Lynch JR) Crit Care Nurs Clin North Am 2005 Sep;17(3):257-67 PMID: 16115534 08/24/2005       9 Citations
  • Simvastatin reduces vasospasm after aneurysmal subarachnoid hemorrhage: results of a pilot randomized clinical trial. (Lynch JR, Wang H, McGirt MJ, Floyd J, Friedman AH, Coon AL, Blessing R, Alexander MJ, Graffagnino C, Warner DS, Laskowitz DT) Stroke 2005 Sep;36(9):2024-6 PMID: 16051891 07/30/2005       200 Citations
  • A novel therapeutic derived from apolipoprotein E reduces brain inflammation and improves outcome after closed head injury. (Lynch JR, Wang H, Mace B, Leinenweber S, Warner DS, Bennett ER, Vitek MP, McKenna S, Laskowitz DT) Exp Neurol 2005 Mar;192(1):109-16 PMID: 15698624 02/09/2005       92 Citations
  • Synthes Award for Resident Research in Spinal Cord & Spinal Column Injury: Statins for the treatment of neurological injury: a role beyond cholesterol lowering. (McGirt MJ, Woodworth GF, Lynch JR, Laskowitz DT) Clin Neurosurg 2004;51:320-8 PMID: 15571161 12/02/2004       2 Citations
  • Accurate patient history contributes to differentiating diabetes insipidus: a case study. (Olson DM, Meek LG, Lynch JR) J Neurosci Nurs 2004 Aug;36(4):228-30 PMID: 15366550 09/16/2004       3 Citations
  • Correlation of serum brain natriuretic peptide with hyponatremia and delayed ischemic neurological deficits after subarachnoid hemorrhage. (McGirt MJ, Blessing R, Nimjee SM, Friedman AH, Alexander MJ, Laskowitz DT, Lynch JR) Neurosurgery 2004 Jun;54(6):1369-73; discussion 1373-4 PMID: 15157293 05/26/2004       121 Citations
  • Effects of isoflurane versus fentanyl-nitrous oxide anesthesia on long-term outcome from severe forebrain ischemia in the rat. (Elsersy H, Sheng H, Lynch JR, Moldovan M, Pearlstein RD, Warner DS) Anesthesiology 2004 May;100(5):1160-6 PMID: 15114213 04/29/2004       79 Citations
  • Novel diagnostic test for acute stroke. (Lynch JR, Blessing R, White WD, Grocott HP, Newman MF, Laskowitz DT) Stroke 2004 Jan;35(1):57-63 PMID: 14671250 12/13/2003       173 Citations
  • APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response. (Lynch JR, Tang W, Wang H, Vitek MP, Bennett ER, Sullivan PM, Warner DS, Laskowitz DT) J Biol Chem 2003 Dec 05;278(49):48529-33 PMID: 14507923 09/26/2003       215 Citations
  • Leukocytosis as an independent risk factor for cerebral vasospasm following aneurysmal subarachnoid hemorrhage. (McGirt MJ, Mavropoulos JC, McGirt LY, Alexander MJ, Friedman AH, Laskowitz DT, Lynch JR) J Neurosurg 2003 Jun;98(6):1222-6 PMID: 12816268 06/21/2003       85 Citations
  • Protective effect of apolipoprotein E-mimetic peptides on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cell cultures. (Aono M, Bennett ER, Kim KS, Lynch JR, Myers J, Pearlstein RD, Warner DS, Laskowitz DT) Neuroscience 2003;116(2):437-45 PMID: 12559098 02/01/2003       55 Citations
  • Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage. (McGirt MJ, Lynch JR, Parra A, Sheng H, Pearlstein RD, Laskowitz DT, Pelligrino DA, Warner DS) Stroke 2002 Dec;33(12):2950-6 PMID: 12468796 12/07/2002       196 Citations
  • Serum von Willebrand factor, matrix metalloproteinase-9, and vascular endothelial growth factor levels predict the onset of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. (McGirt MJ, Lynch JR, Blessing R, Warner DS, Friedman AH, Laskowitz DT) Neurosurgery 2002 Nov;51(5):1128-34; discussion 1134-5 PMID: 12383357 10/18/2002       92 Citations
  • Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema. (Lynch JR, Pineda JA, Morgan D, Zhang L, Warner DS, Benveniste H, Laskowitz DT) Ann Neurol 2002 Jan;51(1):113-7 PMID: 11782990 01/10/2002       88 Citations
  • Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response. (Lynch JR, Morgan D, Mance J, Matthew WD, Laskowitz DT) J Neuroimmunol 2001 Mar 01;114(1-2):107-13 PMID: 11240021 03/10/2001       138 Citations
  • Survival and outcome after endotracheal intubation for acute stroke. (Bushnell CD, Phillips-Bute BG, Laskowitz DT, Lynch JR, Chilukuri V, Borel CO) Neurology 1999 Apr 22;52(7):1374-81 PMID: 10227620 05/05/1999       78 Citations
  • Surgical treatment of carpal tunnel syndrome in patients with peripheral neuropathy. (Morgenlander JC, Lynch JR, Sanders DB) Neurology 1997 Oct;49(4):1159-63 PMID: 9339710 10/27/1997       4 Citations
  • Last update: 11/13/2011
    jenkins-FCD Prod-300 626508253d14e4184314fb9f66322a03a5906796