Medical College of Wisconsin
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John R. Schreiber MD

Sr Associate Dean, CEO MCP, President CP, Prof

Institution: Medical College of Wisconsin
Department: Medical College Physicians Administration
Division: MCP Operations
Program: Administration


  • Role of Toll like receptors in the antibody response to encapsulated bacteria. (Schreiber JR) Front Biosci (Elite Ed) 2012 Jun 01;4:2638-46 PMID: 22652666 06/02/2012       5 Citations
  • Carbohydrate moieties as vaccine candidates: targeting the sweet spot in the immune response. (Taylor CE, Cobb BA, Rittenhouse-Olson K, Paulson JC, Schreiber JR) Vaccine 2012 Jun 22;30(30):4409-13 PMID: 22575168 05/12/2012       4 Citations
  • IgG3 deficiency extends lifespan and attenuates progression of glomerulonephritis in MRL/lpr mice. (Greenspan NS, Lu MA, Shipley JW, Ding X, Li Q, Sultana D, Kollaros M, Schreiber JR, Fu P, Putterman C, Emancipator SN) Biol Direct 2012 Jan 16;7:3 PMID: 22248284 PMCID: PMC3293080 01/18/2012       19 Citations
  • Outer membrane protein complex of Meningococcus enhances the antipolysaccharide antibody response to pneumococcal polysaccharide-CRM₁₉₇ conjugate vaccine. (Lai Z, Schreiber JR) Clin Vaccine Immunol 2011 May;18(5):724-9 PMID: 21450979 PMCID: PMC3122513 04/01/2011       7 Citations
  • Antigen processing of glycoconjugate vaccines; the polysaccharide portion of the pneumococcal CRM(197) conjugate vaccine co-localizes with MHC II on the antigen processing cell surface. (Lai Z, Schreiber JR) Vaccine 2009 May 21;27(24):3137-44 PMID: 19446183 05/19/2009       26 Citations
  • Carbohydrate Moieties as Vaccine Candidates: meeting summary. (Lucas AH, Rittenhouse-Olson K, Kronenberg M, Apicella MA, Wang D, Schreiber JR, Taylor CE) Vaccine 2010 Jan 22;28(4):1121-31 PMID: 18579261 06/27/2008       14 Citations
  • Decreased expression of tumor necrosis factor family receptors involved in humoral immune responses in preterm neonates. (Kaur K, Chowdhury S, Greenspan NS, Schreiber JR) Blood 2007 Oct 15;110(8):2948-54 PMID: 17634409 07/20/2007       60 Citations
  • A human anti-Pseudomonas aeruginosa serotype O6ad immunoglobulin G1 expressed in transgenic tobacco is capable of recruiting immune system effector function in vitro. (McLean MD, Almquist KC, Niu Y, Kimmel R, Lai Z, Schreiber JR, Hall JC) Antimicrob Agents Chemother 2007 Sep;51(9):3322-8 PMID: 17606688 PMCID: PMC2043195 07/04/2007       19 Citations
  • Therapies and vaccines for emerging bacterial infections: learning from methicillin-resistant Staphylococcus aureus. (John CC, Schreiber JR) Pediatr Clin North Am 2006 Aug;53(4):699-713 PMID: 16873000 07/29/2006       13 Citations
  • Multi-valent human monoclonal antibody preparation against Pseudomonas aeruginosa derived from transgenic mice containing human immunoglobulin loci is protective against fatal pseudomonas sepsis caused by multiple serotypes. (Lai Z, Kimmel R, Petersen S, Thomas S, Pier G, Bezabeh B, Luo R, Schreiber JR) Vaccine 2005 May 09;23(25):3264-71 PMID: 15837231 04/20/2005       28 Citations
  • Clearance of Citrobacter rodentium requires B cells but not secretory immunoglobulin A (IgA) or IgM antibodies. (Maaser C, Housley MP, Iimura M, Smith JR, Vallance BA, Finlay BB, Schreiber JR, Varki NM, Kagnoff MF, Eckmann L) Infect Immun 2004 Jun;72(6):3315-24 PMID: 15155635 PMCID: PMC415672 05/25/2004       121 Citations
  • Haemophilus influenzae type b-outer membrane protein complex glycoconjugate vaccine induces cytokine production by engaging human toll-like receptor 2 (TLR2) and requires the presence of TLR2 for optimal immunogenicity. (Latz E, Franko J, Golenbock DT, Schreiber JR) J Immunol 2004 Feb 15;172(4):2431-8 PMID: 14764714 02/07/2004       98 Citations
  • T-cell hybridomas from HLA-transgenic mice as tools for analysis of human antigen processing. (Canaday DH, Gehring A, Leonard EG, Eilertson B, Schreiber JR, Harding CV, Boom WH) J Immunol Methods 2003 Oct 01;281(1-2):129-42 PMID: 14580887 10/29/2003       35 Citations
  • Genetic variation influences the B-cell response to immunization with a pneumococcal polysaccharide conjugate vaccine. (McCool TL, Schreiber JR, Greenspan NS) Infect Immun 2003 Sep;71(9):5402-6 PMID: 12933893 PMCID: PMC187339 08/23/2003       7 Citations
  • A family cluster of five cases of group A streptococcal pneumonia. (Roy S, Kaplan EL, Rodriguez B, Schreiber JR, Salata RA, Palavecino E, John CC) Pediatrics 2003 Jul;112(1 Pt 1):e61-5 PMID: 12837907 07/03/2003       20 Citations
  • Antigen processing of the heptavalent pneumococcal conjugate vaccine carrier protein CRM(197) differs depending on the serotype of the attached polysaccharide. (Leonard EG, Canaday DH, Harding CV, Schreiber JR) Infect Immun 2003 Jul;71(7):4186-9 PMID: 12819115 PMCID: PMC161992 06/24/2003       16 Citations
  • Significant variation in serotype-specific immunogenicity of the seven-valent Streptococcus pneumoniae capsular polysaccharide-CRM197 conjugate vaccine occurs despite vigorous T cell help induced by the carrier protein. (Kamboj KK, Kirchner HL, Kimmel R, Greenspan NS, Schreiber JR) J Infect Dis 2003 May 15;187(10):1629-38 PMID: 12721943 05/02/2003       48 Citations
  • The revolution in molecular biology leads to new understanding of the clinical expression of immunodeficiencies. (John CC, Schreiber JR) J Pediatr 2003 Feb;142(2):99-101 PMID: 12584526 02/14/2003    
  • Enhanced immunogenicity of pneumococcal surface adhesin A by genetic fusion to cytokines and evaluation of protective immunity in mice. (Gor DO, Ding X, Li Q, Schreiber JR, Dubinsky M, Greenspan NS) Infect Immun 2002 Oct;70(10):5589-95 PMID: 12228286 PMCID: PMC128336 09/14/2002       29 Citations
  • Gamma 3 gene-disrupted mice selectively deficient in the dominant IgG subclass made to bacterial polysaccharides. II. Increased susceptibility to fatal pneumococcal sepsis due to absence of anti-polysaccharide IgG3 is corrected by induction of anti-polysaccharide IgG1. (McLay J, Leonard E, Petersen S, Shapiro D, Greenspan NS, Schreiber JR) J Immunol 2002 Apr 01;168(7):3437-43 PMID: 11907102 03/22/2002       43 Citations
  • Immunization with Haemophilus influenzae type b-CRM(197) conjugate vaccine elicits a mixed Th1 and Th2 CD(4+) T cell cytokine response that correlates with the isotype of antipolysaccharide antibody. (Kamboj KK, King CL, Greenspan NS, Kirchner HL, Schreiber JR) J Infect Dis 2001 Oct 01;184(7):931-5 PMID: 11528593 08/31/2001       32 Citations
  • Human monoclonal antibodies against Pseudomonas aeruginosa lipopolysaccharide derived from transgenic mice containing megabase human immunoglobulin loci are opsonic and protective against fatal pseudomonas sepsis. (Hemachandra S, Kamboj K, Copfer J, Pier G, Green LL, Schreiber JR) Infect Immun 2001 Apr;69(4):2223-9 PMID: 11254577 PMCID: PMC98149 03/20/2001       37 Citations
  • Fluconazole prophylaxis in the very low birth weight infant: not ready for prime time. (Neely MN, Schreiber JR) Pediatrics 2001 Feb;107(2):404-5 PMID: 11158475 02/07/2001       17 Citations
  • CpG oligodeoxynucleotides act as adjuvants for pneumococcal polysaccharide-protein conjugate vaccines and enhance antipolysaccharide immunoglobulin G2a (IgG2a) and IgG3 antibodies. (Chu RS, McCool T, Greenspan NS, Schreiber JR, Harding CV) Infect Immun 2000 Mar;68(3):1450-6 PMID: 10678959 PMCID: PMC97300 02/26/2000       69 Citations
  • Severe La Crosse encephalitis with significant neurologic sequelae. (Balkhy HH, Schreiber JR) Pediatr Infect Dis J 2000 Jan;19(1):77-80 PMID: 10643856 01/22/2000       18 Citations
  • A polyclonal outbreak of predominantly VanB vancomycin-resistant enterococci in northeast Ohio. Northeast Ohio Vancomycin-Resistant Enterococcus Surveillance Program. (Donskey CJ, Schreiber JR, Jacobs MR, Shekar R, Salata RA, Gordon S, Whalen CC, Smith F, Rice LB) Clin Infect Dis 1999 Sep;29(3):573-9 PMID: 10530450 10/26/1999       65 Citations
  • B- and T-cell immune responses to pneumococcal conjugate vaccines: divergence between carrier- and polysaccharide-specific immunogenicity. (McCool TL, Harding CV, Greenspan NS, Schreiber JR) Infect Immun 1999 Sep;67(9):4862-9 PMID: 10456942 PMCID: PMC96820 08/24/1999       62 Citations
  • In vitro transport of active alpha(1)-antitrypsin to the apical surface of epithelia by targeting the polymeric immunoglobulin receptor. (Eckman EA, Mallender WD, Szegletes T, Silski CL, Schreiber JR, Davis PB, Ferkol TW) Am J Respir Cell Mol Biol 1999 Aug;21(2):246-52 PMID: 10423408 07/29/1999       12 Citations
  • Low yield of bacterial stool culture in children with nosocomial diarrhea. (Craven D, Brick D, Morrisey A, O'Riordan MA, Petran V, Schreiber JR) Pediatr Infect Dis J 1998 Nov;17(11):1040-4 PMID: 9849989 12/16/1998       9 Citations
  • Gamma 3 gene-disrupted mice selectively deficient in the dominant IgG subclass made to bacterial polysaccharides undergo normal isotype switching after immunization with polysaccharide-protein conjugate vaccines. (Shapiro DA, Threadgill DS, Copfer MJ, Corey DA, McCool TL, McCormick LL, Magnuson TR, Greenspan NS, Schreiber JR) J Immunol 1998 Oct 01;161(7):3393-9 PMID: 9759856 10/06/1998       6 Citations
  • Mitogenic synthetic polynucleotides suppress the antibody response to a bacterial polysaccharide. (Threadgill DS, McCormick LL, McCool TL, Greenspan NS, Schreiber JR) Vaccine 1998 Jan;16(1):76-82 PMID: 9607013 06/02/1998       11 Citations
  • Successful meropenem treatment of multiply resistant pneumococcal meningitis. (John CC, Aouad G, Berman B, Schreiber JR) Pediatr Infect Dis J 1997 Oct;16(10):1009-11 PMID: 9380459 11/05/1997       15 Citations
  • Bispecific antibodies overcome the opsonin-receptor mismatch of cystic fibrosis in vitro: restoration of neutrophil-mediated phagocytosis and killing of Pseudomonas aeruginosa. (McCormick LL, Karulin AY, Schreiber JR, Greenspan NS) J Immunol 1997 Apr 01;158(7):3474-82 PMID: 9120309 04/01/1997       8 Citations
  • Lemierre's syndrome in adolescent children--anaerobic sepsis with internal jugular vein thrombophlebitis following pharyngitis. (Alvarez A, Schreiber JR) Pediatrics 1995 Aug;96(2 Pt 1):354-9 PMID: 7630700 08/01/1995       88 Citations
  • Cross-sectional and longitudinal studies of naturally occurring antibodies to Pseudomonas aeruginosa in cystic fibrosis indicate absence of antibody-mediated protection and decline in opsonic quality after infection. (Tosi MF, Zakem-Cloud H, Demko CA, Schreiber JR, Stern RC, Konstan MW, Berger M) J Infect Dis 1995 Aug;172(2):453-61 PMID: 7622889 08/01/1995       21 Citations
  • Antibiotic-resistant pneumococci. (Schreiber JR, Jacobs MR) Pediatr Clin North Am 1995 Jun;42(3):519-37 PMID: 7761139 06/01/1995       60 Citations
  • Disseminated Histoplasma capsulatum in a patient with hyper IgM immunodeficiency. (Hostoffer RW, Berger M, Clark HT, Schreiber JR) Pediatrics 1994 Aug;94(2 Pt 1):234-6 PMID: 8036080 08/01/1994       24 Citations
  • Osteomyelitis due to Bacillus cereus in an adolescent: case report and review. (Schricker ME, Thompson GH, Schreiber JR) Clin Infect Dis 1994 Jun;18(6):863-7 PMID: 8086544 06/01/1994       14 Citations
  • Immunogenicity of tetanus toxoid conjugates of anti-idiotypes that mimic Pseudomonas aeruginosa surface polysaccharides. (Schreiber JR, Dahlhauser P) Infect Immun 1994 Jan;62(1):308-12 PMID: 8262644 PMCID: PMC186102 01/01/1994       6 Citations
  • Tissue-specific Fc gamma and complement receptor expression by alveolar macrophages determines relative importance of IgG and complement in promoting phagocytosis of Pseudomonas aeruginosa. (Berger M, Norvell TM, Tosi MF, Emancipator SN, Konstan MW, Schreiber JR) Pediatr Res 1994 Jan;35(1):68-77 PMID: 8134202 01/01/1994       30 Citations
  • Absence of antibiotic-resistant Streptococcus pneumoniae pharyngeal colonization in Cleveland children with sickle cell disease. (Schricker ME, Schreiber JR, Chiarucci K, Kerman J, Noe A, Jacobs MR, Berman B) Pediatr Infect Dis J 1993 Sep;12(9):775-7 PMID: 8414806 09/01/1993       13 Citations
  • Variable region-identical monoclonal antibodies of different IgG subclass directed to Pseudomonas aeruginosa lipopolysaccharide O-specific side chain function differently. (Schreiber JR, Cooper LJ, Diehn S, Dahlhauser PA, Tosi MF, Glass DD, Patawaran M, Greenspan NS) J Infect Dis 1993 Jan;167(1):221-6 PMID: 8418172 01/01/1993       40 Citations
  • Anti-idiotype vaccines for immunity to bacterial polysaccharides: induction of functional antibodies to polysaccharide antigens of Pseudomonas aeruginosa. (Schreiber JR) Springer Semin Immunopathol 1993;15(2-3):235-46 PMID: 7504840 01/01/1993       3 Citations
  • The spread of multiply resistant Streptococcus pneumoniae at a day care center in Ohio. (Reichler MR, Allphin AA, Breiman RF, Schreiber JR, Arnold JE, McDougal LK, Facklam RR, Boxerbaum B, May D, Walton RO) J Infect Dis 1992 Dec;166(6):1346-53 PMID: 1431252 12/01/1992       333 Citations
  • Intravenous immune globulin therapy for sepsis in premature neonates. (Schreiber JR, Berger M) J Pediatr 1992 Sep;121(3):401-4 PMID: 1517915 09/01/1992       5 Citations
  • Decline of Haemophilus disease in Cleveland. (Schreiber JR, Boxerbaum B, Morrissey AB) Pediatr Infect Dis J 1992 Sep;11(9):779-80 PMID: 1448329 09/01/1992       6 Citations
  • Induction of opsonic antibodies to Pseudomonas aeruginosa mucoid exopolysaccharide by an anti-idiotypic monoclonal antibody. (Schreiber JR, Pier GB, Grout M, Nixon K, Patawaran M) J Infect Dis 1991 Sep;164(3):507-14 PMID: 1831226 09/01/1991       17 Citations
  • The role of cytophilic IgG3 antibody in T cell-mediated resistance to infection with the extracellular bacterium, Pseudomonas aeruginosa. (Markham RB, Pier GB, Schreiber JR) J Immunol 1991 Jan 01;146(1):316-20 PMID: 1898604 01/01/1991       23 Citations
  • Anti-idiotype-induced, lipopolysaccharide-specific antibody response to Pseudomonas aeruginosa. II. Isotype and functional activity of the anti-idiotype-induced antibodies. (Schreiber JR, Nixon KL, Tosi MF, Pier GB, Patawaran MB) J Immunol 1991 Jan 01;146(1):188-93 PMID: 1898598 01/01/1991       35 Citations
  • Neonatal Haemophilus influenzae type b sepsis. (Abdul-Rauf A, Schreiber JR) Pediatr Infect Dis J 1990 Dec;9(12):918-21 PMID: 2277749 12/01/1990       4 Citations
  • Anti-idiotype-induced, lipopolysaccharide-specific antibody response to Pseudomonas aeruginosa. (Schreiber JR, Patawaran M, Tosi M, Lennon J, Pier GB) J Immunol 1990 Feb 01;144(3):1023-9 PMID: 2104908 02/01/1990       20 Citations
  • Postvaccination susceptibility to invasive Haemophilus influenzae type b disease in infant rats. (Sood SK, Schreiber JR, Siber GR, Daum RS) J Pediatr 1988 Nov;113(5):814-9 PMID: 3263486 11/01/1988       8 Citations
  • T cells recognizing polysaccharide-specific B cells function as contrasuppressor cells in the generation of T cell immunity to Pseudomonas aeruginosa. (Powderly WG, Schreiber JR, Pier GB, Markham RB) J Immunol 1988 Apr 15;140(8):2746-52 PMID: 3128607 04/15/1988       19 Citations
  • Effect of complement depletion on anticapsular-antibody-mediated immunity to experimental infection with Haemophilus influenzae type b. (Schreiber JR, Basker CJ, Siber GR) Infect Immun 1987 Nov;55(11):2830-3 PMID: 3499398 PMCID: PMC259984 11/01/1987       5 Citations
  • Functional characterization of human IgG, IgM, and IgA antibody directed to the capsule of Haemophilus influenzae type b. (Schreiber JR, Barrus V, Cates KL, Siber GR) J Infect Dis 1986 Jan;153(1):8-16 PMID: 3484506 01/01/1986       61 Citations
  • Decreased protective efficacy of reduced and alkylated human immune serum globulin in experimental infection with Haemophilus influenzae type b. (Schreiber JR, Barrus VA, Siber GR) Infect Immun 1985 Jan;47(1):142-8 PMID: 3871195 PMCID: PMC261489 01/01/1985       11 Citations
  • Candida antigen detection in two premature neonates with disseminated candidiasis. (Schreiber JR, Maynard E, Lew MA) Pediatrics 1984 Nov;74(5):838-41 PMID: 6436783 11/01/1984       12 Citations
  • Necrotizing enterocolitis and hemolysis associated with Clostridium perfringens. (Warren S, Schreiber JR, Epstein MF) Am J Dis Child 1984 Jul;138(7):686-8 PMID: 6328971 07/01/1984       21 Citations
  • Efficacy of human hyperimmune globulin in prevention of Haemophilus influenzae type b disease in infant rats. (Ambrosino D, Schreiber JR, Daum RS, Siber GR) Infect Immun 1983 Feb;39(2):709-14 PMID: 6601060 PMCID: PMC348007 02/01/1983       30 Citations
  • Frequency analysis of breath sounds by phonopneumography. (Schreiber JR, Anderson WF, Wegmann MJ, Waring WW) Med Instrum 1981 Sep-Oct;15(5):331-4 PMID: 7321928 09/01/1981       10 Citations
  • Last update: 06/20/2017
    jenkins-FCD Prod-256 97250b83e4554f37bec91ca291f44ff4aedcc508