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Joseph C. Besharse PhD

Joseph C. Besharse PhD

Director, Professor

Institution: Medical College of Wisconsin
Department: Ophthalmology and Visual Sciences
Program: Research

Member of the Cancer Center
Member of the Neuroscience Research Center


I am willing to mentor a junior faculty member.
I am willing to collaborate on research projects.


Research Experience

  • Acetyltransferases
  • Amino Acid Sequence
  • Animals
  • Antibodies, Monoclonal
  • Arrestin
  • Arylamine N-Acetyltransferase
  • Autoradiography
  • Axoneme
  • Biological Clocks
  • Blotting, Western
  • CLOCK Proteins
  • Calcium
  • Cell Membrane
  • Cells, Cultured
  • Cilia
  • Circadian Rhythm
  • Culture Media
  • Culture Techniques
  • Cyclic AMP
  • Cytoskeletal Proteins
  • Cytoskeleton
  • Dark Adaptation
  • Darkness
  • Dopamine
  • Dopamine Antagonists
  • Dyneins
  • Epithelial Cells
  • Eye
  • Eye Proteins
  • Flagella
  • Freeze Fracturing
  • Gene Expression Regulation
  • Glutamates
  • Glycoconjugates
  • Golgi Apparatus
  • Green Fluorescent Proteins
  • Histocytochemistry
  • Immunochemistry
  • Immunohistochemistry
  • Immunoprecipitation
  • In Situ Hybridization
  • In Vitro Techniques
  • Intracellular Membranes
  • Kinesin
  • Light
  • Melatonin
  • Membrane Proteins
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Mutant Strains
  • Microscopy, Confocal
  • Microscopy, Electron
  • Microtubules
  • Mutation
  • Organ Culture Techniques
  • Phagocytosis
  • Phagosomes
  • Photic Stimulation
  • Photoperiod
  • Photoreceptor Cells
  • Photoreceptor Cells, Vertebrate
  • Pigment Epithelium of Eye
  • Pineal Gland
  • Quinpirole
  • RNA, Messenger
  • Retina
  • Retinal Cone Photoreceptor Cells
  • Retinal Degeneration
  • Retinal Pigment Epithelium
  • Retinal Rod Photoreceptor Cells
  • Rod Cell Outer Segment
  • Rod Opsins
  • Serotonin
  • Spiperone
  • Suprachiasmatic Nucleus
  • Transcription Factors
  • Tryptophan Hydroxylase
  • Tubulin
  • Tunicamycin
  • Urodela
  • Vertebrates
  • Xenopus
  • Xenopus laevis
  • Zebrafish
  • Zebrafish Proteins
  • Leadership Positions

  • Director of Interdisciplinary Graduate Program in Biomedical Sciences. 2010-2014
  • Chair, Department of Cell Biology, Neurobiology and Anatomy, 1997-2016
  • Publications

  • Sustained Anti-Vascular Endothelial Growth Factor Activity of Aflibercept (Eylea) After Storage in Polycarbonate Syringes Used for Intravitreal Injection: A Pathway to Safety and Efficiency. (Han DP, Skumatz C, Besharse JC, Kassem IS) J Ocul Pharmacol Ther 2019 Mar 27 PMID: 30916605 03/28/2019    
  • Kif17 phosphorylation regulates photoreceptor outer segment turnover. (Lewis TR, Kundinger SR, Link BA, Insinna C, Besharse JC) BMC Cell Biol 2018 11 20;19(1):25 PMID: 30458707 PMCID: PMC6245759 11/22/2018       1 Citations
  • Kif17 phosphorylation regulates its ciliary localization and photoreceptor outer segment turnover. (Lewis, TR Kundinger, SR Link, BA Besharse, JC) bioRxiv bioRxiv 351122; doi: https://doi.org/10.1101/351122 06/20/2018    
  • Cone myoid elongation involves unidirectional microtubule movement mediated by dynein-1. (Lewis TR, Zareba M, Link BA, Besharse JC) Mol Biol Cell 2018 01 15;29(2):180-190 PMID: 29142075 PMCID: PMC5909930 11/17/2017       1 Citations
  • Cos2/Kif7 and Osm-3/Kif17 regulate onset of outer segment development in zebrafish photoreceptors through distinct mechanisms. (Lewis TR, Kundinger SR, Pavlovich AL, Bostrom JR, Link BA, Besharse JC) Dev Biol 2017 05 15;425(2):176-190 PMID: 28341548 PMCID: PMC5558849 03/28/2017       8 Citations
  • Loss of Zebrafish Mfrp Causes Nanophthalmia, Hyperopia, and Accumulation of Subretinal Macrophages. (Collery RF, Volberding PJ, Bostrom JR, Link BA, Besharse JC) Invest Ophthalmol Vis Sci 2016 12 01;57(15):6805-6814 PMID: 28002843 PMCID: PMC5215506 12/22/2016       9 Citations
  • The Retina and Other Light-sensitive Ocular Clocks. (Besharse JC, McMahon DG) J Biol Rhythms 2016 06;31(3):223-43 PMID: 27095816 PMCID: PMC5479307 04/21/2016       13 Citations
  • Yap and Taz regulate retinal pigment epithelial cell fate. (Miesfeld JB, Gestri G, Clark BS, Flinn MA, Poole RJ, Bader JR, Besharse JC, Wilson SW, Link BA) Development 2015 Sep 01;142(17):3021-32 PMID: 26209646 PMCID: PMC4582179 07/26/2015       37 Citations
  • Subretinal infiltration of monocyte derived cells and complement misregulation in mice with AMD-like pathology. (Fogerty J, Besharse JC) Adv Exp Med Biol 2014;801:355-63 PMID: 24664718 PMCID: PMC4273561 03/26/2014       4 Citations
  • The kinesin superfamily protein KIF17: one protein with many functions. (Wong-Riley MT, Besharse JC) Biomol Concepts 2012 Jun 01;3(3):267-282 PMID: 23762210 PMCID: PMC3677786 06/14/2013    
  • Kinesin-2 family motors in the unusual photoreceptor cilium. (Malicki J, Besharse JC) Vision Res 2012 Dec 15;75:33-6 PMID: 23123805 PMCID: PMC3534980 11/06/2012       11 Citations
  • Analysis of KIF17 distal tip trafficking in zebrafish cone photoreceptors. (Bader JR, Kusik BW, Besharse JC) Vision Res 2012 Dec 15;75:37-43 PMID: 23099049 PMCID: PMC3556995 10/27/2012       10 Citations
  • The de-ubiquitinylating enzyme, USP2, is associated with the circadian clockwork and regulates its sensitivity to light. (Scoma HD, Humby M, Yadav G, Zhang Q, Fogerty J, Besharse JC) PLoS One 2011;6(9):e25382 PMID: 21966515 PMCID: PMC3179520 10/04/2011       29 Citations
  • 174delG mutation in mouse MFRP causes photoreceptor degeneration and RPE atrophy. (Fogerty J, Besharse JC) Invest Ophthalmol Vis Sci 2011 Sep 14;52(10):7256-66 PMID: 21810984 PMCID: PMC3207726 08/04/2011    
  • Analysis of a zebrafish dync1h1 mutant reveals multiple functions for cytoplasmic dynein 1 during retinal photoreceptor development. (Insinna C et al.) Neural Dev 2010;5:19 PMID: 20691075 08/10/2010    
  • Analysis of a zebrafish dync1h1 mutant reveals multiple functions for cytoplasmic dynein 1 during retinal photoreceptor development. (Insinna C, Baye LM, Amsterdam A, Besharse JC, Link BA) Neural Dev 2010 Apr 22;5:12 PMID: 20412557 PMCID: PMC2880287 04/24/2010       31 Citations
  • Different roles for KIF17 and kinesin II in photoreceptor development and maintenance. (Insinna C, Humby M, Sedmak T, Wolfrum U, Besharse JC) Dev Dyn 2009 Sep;238(9):2211-22 PMID: 19384852 PMCID: PMC2733920 04/23/2009       42 Citations
  • Photoreceptor IFT complexes containing chaperones, guanylyl cyclase 1 and rhodopsin. (Bhowmick R, Li M, Sun J, Baker SA, Insinna C, Besharse JC) Traffic 2009 Jun;10(6):648-63 PMID: 19302411 PMCID: PMC2827254 03/24/2009       40 Citations
  • Analysis of IFT kinesins in developing zebrafish cone photoreceptor sensory cilia. (Insinna C, Luby-Phelps K, Link BA, Besharse JC) Methods Cell Biol 2009;93:219-34 PMID: 20409820 01/01/2009       6 Citations
  • Intraflagellar transport and the sensory outer segment of vertebrate photoreceptors. (Insinna C, Besharse JC) Dev Dyn 2008 Aug;237(8):1982-92 PMID: 18489002 PMCID: PMC2692564 05/21/2008       118 Citations
  • The homodimeric kinesin, Kif17, is essential for vertebrate photoreceptor sensory outer segment development. (Insinna C, Pathak N, Perkins B, Drummond I, Besharse JC) Dev Biol 2008 Apr 01;316(1):160-70 PMID: 18304522 PMCID: PMC2362383 02/29/2008       100 Citations
  • Spatial distribution of intraflagellar transport proteins in vertebrate photoreceptors. (Luby-Phelps K, Fogerty J, Baker SA, Pazour GJ, Besharse JC) Vision Res 2008 Feb;48(3):413-23 PMID: 17931679 PMCID: PMC2276311 10/13/2007       23 Citations
  • Loss of Nocturnin, a circadian deadenylase, confers resistance to hepatic steatosis and diet-induced obesity. (Green CB, Douris N, Kojima S, Strayer CA, Fogerty J, Lourim D, Keller SR, Besharse JC) Proc Natl Acad Sci U S A 2007 Jun 05;104(23):9888-93 PMID: 17517647 PMCID: PMC1871564 05/23/2007       143 Citations
  • Immediate early response of the circadian polyA ribonuclease nocturnin to two extracellular stimuli. (Garbarino-Pico E, Niu S, Rollag MD, Strayer CA, Besharse JC, Green CB) RNA 2007 May;13(5):745-55 PMID: 17400819 PMCID: PMC1852813 04/03/2007       60 Citations
  • Regulation of photoreceptor Per1 and Per2 by light, dopamine and a circadian clock. (Besharse JC, Zhuang M, Freeman K, Fogerty J) Eur J Neurosci 2004 Jul;20(1):167-74 PMID: 15245489 07/13/2004       35 Citations
  • Quantification of the cytoplasmic spaces of living cells with EGFP reveals arrestin-EGFP to be in disequilibrium in dark adapted rod photoreceptors. (Peet JA, Bragin A, Calvert PD, Nikonov SS, Mani S, Zhao X, Besharse JC, Pierce EA, Knox BE, Pugh EN Jr) J Cell Sci 2004 Jun 15;117(Pt 14):3049-59 PMID: 15197244 06/16/2004       52 Citations
  • Photoreceptor intersegmental transport and retinal degeneration: a conserved pathway common to motile and sensory cilia. (Besharse JC, Baker SA, Luby-Phelps K, Pazour GJ) Adv Exp Med Biol 2003;533:157-64 PMID: 15180260 06/08/2004       37 Citations
  • Retinal circadian clocks and control of retinal physiology. (Green CB, Besharse JC) J Biol Rhythms 2004 Apr;19(2):91-102 PMID: 15038849 03/25/2004       109 Citations
  • IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia. (Baker SA, Freeman K, Luby-Phelps K, Pazour GJ, Besharse JC) J Biol Chem 2003 Sep 05;278(36):34211-8 PMID: 12821668 06/25/2003       97 Citations
  • Visualization of identified GFP-expressing cells by light and electron microscopy. (Luby-Phelps K, Ning G, Fogerty J, Besharse JC) J Histochem Cytochem 2003 Mar;51(3):271-4 PMID: 12588954 02/18/2003       52 Citations
  • Molecular structure of cytoplasmic dynein 2 and its distribution in neuronal and ciliated cells. (Mikami A, Tynan SH, Hama T, Luby-Phelps K, Saito T, Crandall JE, Besharse JC, Vallee RB) J Cell Sci 2002 Dec 15;115(Pt 24):4801-8 PMID: 12432068 11/15/2002       81 Citations
  • Introduction of Russell G. Foster, the 2001 recipient of the david g. Cogan award. (Besharse JC) Invest Ophthalmol Vis Sci 2002 May;43(5):1285 PMID: 11980835 05/01/2002    
  • The intraflagellar transport protein, IFT88, is essential for vertebrate photoreceptor assembly and maintenance. (Pazour GJ, Baker SA, Deane JA, Cole DG, Dickert BL, Rosenbaum JL, Witman GB, Besharse JC) J Cell Biol 2002 Apr 01;157(1):103-13 PMID: 11916979 PMCID: PMC2173265 03/28/2002       317 Citations
  • Implications of circadian gene expression in kidney, liver and the effects of fasting on pharmacogenomic studies. (Kita Y, Shiozawa M, Jin W, Majewski RR, Besharse JC, Greene AS, Jacob HJ) Pharmacogenetics 2002 Jan;12(1):55-65 PMID: 11773865 01/05/2002       122 Citations
  • Rhythmic expression of Nocturnin mRNA in multiple tissues of the mouse. (Wang Y, Osterbur DL, Megaw PL, Tosini G, Fukuhara C, Green CB, Besharse JC) BMC Dev Biol 2001;1:9 PMID: 11394964 PMCID: PMC32249 06/08/2001       78 Citations
  • Coupling an activated MAP kinase to circadian clock output. (Besharse JC) Neuron 2001 Jan;29(1):3-4 PMID: 11182074 02/22/2001       2 Citations
  • Differential regulation of two period genes in the Xenopus eye. (Zhuang M, Wang Y, Steenhard BM, Besharse JC) Brain Res Mol Brain Res 2000 Oct 20;82(1-2):52-64 PMID: 11042357 10/24/2000       49 Citations
  • Phase shifting the retinal circadian clock: xPer2 mRNA induction by light and dopamine. (Steenhard BM, Besharse JC) J Neurosci 2000 Dec 01;20(23):8572-7 PMID: 11102460 01/11/2000       52 Citations
  • Ontogeny of circadian and light regulation of melatonin release in Xenopus laevis embryos. (Green CB, Liang MY, Steenhard BM, Besharse JC) Brain Res Dev Brain Res 1999 Oct 20;117(1):109-16 PMID: 10536238 10/28/1999       23 Citations
  • Linkage of a nucleolin-related protein and casein kinase II with the detergent-stable photoreceptor cytoskeleton. (Hollander BA, Liang MY, Besharse JC) Cell Motil Cytoskeleton 1999;43(2):114-27 PMID: 10379836 06/24/1999       15 Citations
  • Immediate upstream sequence of arrestin directs rod-specific expression in Xenopus. (Mani SS, Besharse JC, Knox BE) J Biol Chem 1999 May 28;274(22):15590-7 PMID: 10336455 05/21/1999       30 Citations
  • Redefining rats, mice, and birds. AAA (American Association of Anatomists) Public Affairs Committee. (Besharse JC, Carlson BM, Jenkins DP, Lester DS, Olds JL, Satir P) Science 1999 Apr 02;284(5411):49-50 PMID: 10215528 04/24/1999    
  • Spectral sensitivity of melatonin synthesis suppression in Xenopus eyecups. (Cahill GM, Parsons SE, Besharse JC) Vis Neurosci 1998 May-Jun;15(3):499-502 PMID: 9685202 07/31/1998       4 Citations
  • Transgene expression in Xenopus rods. (Knox BE, Schlueter C, Sanger BM, Green CB, Besharse JC) FEBS Lett 1998 Feb 20;423(2):117-21 PMID: 9512341 03/25/1998       90 Citations
  • Evidence for kinesin-related proteins associated with the axoneme of retinal photoreceptors. (Muresan V, Bendala-Tufanisco E, Hollander BA, Besharse JC) Exp Eye Res 1997 Jun;64(6):895-903 PMID: 9301470 06/01/1997       29 Citations
  • Identification of vertebrate circadian clock-regulated genes by differential display. (Green CB, Besharse JC) Methods Mol Biol 1997;85:219-30 PMID: 9276327 01/01/1997       6 Citations
  • Identification of a novel vertebrate circadian clock-regulated gene encoding the protein nocturnin. (Green CB, Besharse JC) Proc Natl Acad Sci U S A 1996 Dec 10;93(25):14884-8 PMID: 8962150 PMCID: PMC26231 12/10/1996       109 Citations
  • Tryptophan hydroxylase mRNA levels are regulated by the circadian clock, temperature, and cAMP in chick pineal cells. (Green CB, Besharse JC, Zatz M) Brain Res 1996 Oct 28;738(1):1-7 PMID: 8949920 10/28/1996       25 Citations
  • The tau mutation shortens the period of rhythmic photoreceptor outer segment disk shedding in the hamster. (Grace MS, Wang LM, Pickard GE, Besharse JC, Menaker M) Brain Res 1996 Sep 30;735(1):93-100 PMID: 8905173 09/30/1996       29 Citations
  • Use of a high stringency differential display screen for identification of retinal mRNAs that are regulated by a circadian clock. (Green CB, Besharse JC) Brain Res Mol Brain Res 1996 Apr;37(1-2):157-65 PMID: 8738147 04/01/1996       51 Citations
  • Tryptophan hydroxylase is expressed by photoreceptors in Xenopus laevis retina. (Green CB, Cahill GM, Besharse JC) Vis Neurosci 1995 Jul-Aug;12(4):663-70 PMID: 8527368 07/01/1995       35 Citations
  • Immunocytochemical localization of opsin in rod photoreceptors during periods of rapid disc assembly. (Besharse JC, Wetzel MG) J Neurocytol 1995 May;24(5):371-88 PMID: 7544404 05/01/1995       23 Citations
  • Regulation of tryptophan hydroxylase expression by a retinal circadian oscillator in vitro. (Green CB, Cahill GM, Besharse JC) Brain Res 1995 Apr 24;677(2):283-90 PMID: 7552254 04/24/1995       45 Citations
  • Melatonin deacetylase activity in the pineal gland and brain of the lizards Anolis carolinensis and Sceloporus jarrovi. (Grace MS, Besharse JC) Neuroscience 1994 Sep;62(2):615-23 PMID: 7530349 09/01/1994       16 Citations
  • Tryptophan hydroxylase expression is regulated by a circadian clock in Xenopus laevis retina. (Green CB, Besharse JC) J Neurochem 1994 Jun;62(6):2420-8 PMID: 8189245 06/01/1994       65 Citations
  • Transport of phosphatidylcholine to Xenopus photoreceptor rod outer segments in the presence of tunicamycin. (Wetzel MG, Besharse JC) J Neurocytol 1994 Jun;23(6):333-42 PMID: 8089706 06/01/1994       4 Citations
  • Complex intermolecular interactions maintain a stable linkage between the photoreceptor connecting cilium axoneme and plasma membrane. (Muresan V, Besharse JC) Cell Motil Cytoskeleton 1994;28(3):213-30 PMID: 7954850 01/01/1994       9 Citations
  • D2-like dopamine receptors in amphibian retina: localization with fluorescent ligands. (Muresan Z, Besharse JC) J Comp Neurol 1993 May 08;331(2):149-60 PMID: 8509497 05/08/1993       58 Citations
  • Tunicamycin does not inhibit transport of phosphatidylinositol to Xenopus rod outer segments. (Wetzel MG, Bendala-Tufanisco E, Besharse JC) J Neurocytol 1993 May;22(5):397-412 PMID: 8315416 05/01/1993       9 Citations
  • Circadian clock functions localized in xenopus retinal photoreceptors. (Cahill GM, Besharse JC) Neuron 1993 Apr;10(4):573-7 PMID: 8476609 04/01/1993       258 Citations
  • Gamma-tubulin in differentiated cell types: localization in the vicinity of basal bodies in retinal photoreceptors and ciliated epithelia. (Muresan V, Joshi HC, Besharse JC) J Cell Sci 1993 Apr;104 ( Pt 4):1229-37 PMID: 7686172 04/01/1993       86 Citations
  • Solubilization and biochemical characterization of the melatonin deacetylase from Xenopus laevis retina. (Grace MS, Besharse JC) J Neurochem 1993 Mar;60(3):990-9 PMID: 8436983 03/01/1993       14 Citations
  • Reconstitution of the photoreceptor-pigment epithelium interface: L-glutamate stimulation of adhesive interactions and rod disc shedding after recombination of dissociated Xenopus laevis eyecups. (Defoe DM, Matsumoto B, Besharse JC) Exp Eye Res 1992 Jun;54(6):903-11 PMID: 1355741 06/01/1992       16 Citations
  • Light-sensitive melatonin synthesis by Xenopus photoreceptors after destruction of the inner retina. (Cahill GM, Besharse JC) Vis Neurosci 1992 May;8(5):487-90 PMID: 1586650 05/01/1992       107 Citations
  • Light-evoked contraction of red absorbing cones in the Xenopus retina is maximally sensitive to green light. (Besharse JC, Witkovsky P) Vis Neurosci 1992 Mar;8(3):243-9 PMID: 1547160 03/01/1992       17 Citations
  • Is dopamine a light-adaptive or a dark-adaptive modulator in retina? (Besharse JC, Iuvone PM) Neurochem Int 1992 Feb;20(2):193-9 PMID: 1304858 02/01/1992       57 Citations
  • The "ON"-bipolar agonist, L-2-amino-4-phosphonobutyrate, blocks light-evoked cone contraction in xenopus eye cups. (Besharse JC) Neurochem Res 1992 Jan;17(1):75-80 PMID: 1538827 01/01/1992       16 Citations
  • Rhythmic regulation of retinal melatonin: metabolic pathways, neurochemical mechanisms, and the ocular circadian clock. (Cahill GM, Grace MS, Besharse JC) Cell Mol Neurobiol 1991 Oct;11(5):529-60 PMID: 1742771 10/01/1991       149 Citations
  • Resetting the circadian clock in cultured Xenopus eyecups: regulation of retinal melatonin rhythms by light and D2 dopamine receptors. (Cahill GM, Besharse JC) J Neurosci 1991 Oct;11(10):2959-71 PMID: 1682423 10/01/1991       155 Citations
  • Melatonin deacetylation: retinal vertebrate class distribution and Xenopus laevis tissue distribution. (Grace MS, Cahill GM, Besharse JC) Brain Res 1991 Sep 13;559(1):56-63 PMID: 1782560 09/13/1991       70 Citations
  • Circadian regulation of melatonin in the retina of Xenopus laevis: limitation by serotonin availability. (Cahill GM, Besharse JC) J Neurochem 1990 Feb;54(2):716-9 PMID: 2299362 02/01/1990       84 Citations
  • Transmembrane assemblage of the photoreceptor connecting cilium and motile cilium transition zone contain a common immunologic epitope. (Horst CJ, Johnson LV, Besharse JC) Cell Motil Cytoskeleton 1990;17(4):329-44 PMID: 1706225 01/01/1990       50 Citations
  • Cytochalasin D inhibits L-glutamate-induced disc shedding without altering L-glutamate-induced increase in adhesiveness. (Defoe DM, Matsumoto B, Besharse JC) Exp Eye Res 1989 May;48(5):641-52 PMID: 2567678 05/01/1989       5 Citations
  • Retinal melatonin is metabolized within the eye of xenopus laevis. (Cahill GM, Besharse JC) Proc Natl Acad Sci U S A 1989 Feb;86(3):1098-102 PMID: 2492661 PMCID: PMC286629 02/01/1989       94 Citations
  • Excitatory amino acids and rod photoreceptor disc shedding: analysis using specific agonists. (Besharse JC, Spratt G) Exp Eye Res 1988 Oct;47(4):609-20 PMID: 3053226 10/01/1988       15 Citations
  • Effects of kynurenate and other excitatory amino acid antagonists as blockers of light- and kainate-induced retinal rod photoreceptor disc shedding. (Besharse JC, Spratt G, Reif-Lehrer L) J Comp Neurol 1988 Aug 08;274(2):295-303 PMID: 3264839 08/08/1988       9 Citations
  • Dopamine modifies the balance of rod and cone inputs to horizontal cells of the Xenopus retina. (Witkovsky P, Stone S, Besharse JC) Brain Res 1988 May 24;449(1-2):332-6 PMID: 3293703 05/24/1988       101 Citations
  • Circadian regulation of retinomotor movements: II. The role of GABA in the regulation of cone position. (Pierce ME, Besharse JC) J Comp Neurol 1988 Apr 08;270(2):279-87 PMID: 3379159 04/08/1988       30 Citations
  • Distribution of acetylated alpha-tubulin in retina and in vitro-assembled microtubules. (Sale WS, Besharse JC, Piperno G) Cell Motil Cytoskeleton 1988;9(3):243-53 PMID: 3259167 01/01/1988       67 Citations
  • Cytoskeletal-membrane interactions: a stable interaction between cell surface glycoconjugates and doublet microtubules of the photoreceptor connecting cilium. (Horst CJ, Forestner DM, Besharse JC) J Cell Biol 1987 Dec;105(6 Pt 2):2973-87 PMID: 3693403 PMCID: PMC2114726 12/01/1987       43 Citations
  • Membrane turnover in rod photoreceptors: ensheathment and phagocytosis of outer segment distal tips by pseudopodia of the retinal pigment epithelium. (Matsumoto B, Defoe DM, Besharse JC) Proc R Soc Lond B Biol Sci 1987 Apr 22;230(1260):339-54 PMID: 2438704 04/22/1987       35 Citations
  • Melatonin and rhythmic photoreceptor metabolism: melatonin-induced cone elongation is blocked at high light intensity. (Pierce ME, Besharse JC) Brain Res 1987 Mar 10;405(2):400-4 PMID: 3567617 03/10/1987       37 Citations
  • Tunicamycin-induced dysgenesis of retinal rod outer segment membranes. II. Quantitative freeze-fracture analysis. (Defoe DM, Besharse JC, Fliesler SJ) Invest Ophthalmol Vis Sci 1986 Nov;27(11):1595-601 PMID: 3771140 11/01/1986       10 Citations
  • Light-evoked and kainic-acid-induced disc shedding by rod photoreceptors: differential sensitivity to extracellular calcium. (Besharse JC, Spratt G, Forestner DM) J Comp Neurol 1986 Sep 08;251(2):185-97 PMID: 3491094 09/08/1986       16 Citations
  • Dopamine receptor-mediated inhibition of serotonin N-acetyltransferase activity in retina. (Iuvone PM, Besharse JC) Brain Res 1986 Mar 26;369(1-2):168-76 PMID: 3697740 03/26/1986       90 Citations
  • Biosynthesis and vectorial transport of opsin on vesicles in retinal rod photoreceptors. (Papermaster DS, Schneider BG, DeFoe D, Besharse JC) J Histochem Cytochem 1986 Jan;34(1):5-16 PMID: 2934469 01/01/1986       56 Citations
  • Cyclic AMP stimulates serotonin N-acetyltransferase activity in Xenopus retina in vitro. (Iuvone PM, Besharse JC) J Neurochem 1986 Jan;46(1):33-9 PMID: 2415681 01/01/1986       63 Citations
  • Involvement of calcium in the regulation of serotonin N-acetyltransferase in retina. (Iuvone PM, Besharse JC) J Neurochem 1986 Jan;46(1):82-8 PMID: 2415684 01/01/1986       40 Citations
  • Circadian regulation of retinomotor movements. I. Interaction of melatonin and dopamine in the control of cone length. (Pierce ME, Besharse JC) J Gen Physiol 1985 Nov;86(5):671-89 PMID: 2999294 PMCID: PMC2228813 11/01/1985       245 Citations
  • Vesicular transport of newly synthesized opsin from the Golgi apparatus toward the rod outer segment. Ultrastructural immunocytochemical and autoradiographic evidence in Xenopus retinas. (Papermaster DS, Schneider BG, Besharse JC) Invest Ophthalmol Vis Sci 1985 Oct;26(10):1386-404 PMID: 2931395 10/01/1985       132 Citations
  • Stimulation of photoreceptor disc shedding and pigment epithelial phagocytosis by glutamate, aspartate, and other amino acids. (Greenberger LM, Besharse JC) J Comp Neurol 1985 Sep 22;239(4):361-72 PMID: 2864363 09/22/1985       43 Citations
  • Light and temperature modulated staining of the rod outer segment distal tips with Lucifer yellow. (Matsumoto B, Besharse JC) Invest Ophthalmol Vis Sci 1985 May;26(5):628-35 PMID: 2581915 05/01/1985       35 Citations
  • Membrane assembly in retinal photoreceptors. III. Distinct membrane domains of the connecting cilium of developing rods. (Besharse JC, Forestner DM, Defoe DM) J Neurosci 1985 Apr;5(4):1035-48 PMID: 3156973 04/01/1985       71 Citations
  • Membrane assembly in retinal photoreceptors. II. Immunocytochemical analysis of freeze-fractured rod photoreceptor membranes using anti-opsin antibodies. (Defoe DM, Besharse JC) J Neurosci 1985 Apr;5(4):1023-34 PMID: 3156972 04/01/1985       23 Citations
  • Partial characterization of lectin binding sites of retinal photoreceptor outer segments and interphotoreceptor matrix. (Wood JG, Besharse JC, Napier-Marshall L) J Comp Neurol 1984 Sep 10;228(2):299-307 PMID: 6548230 09/10/1984       28 Citations
  • Regulation and possible role of serotonin N-acetyltransferase in the retina. (Besharse JC, Dunis DA, Iuvone PM) Fed Proc 1984 Sep;43(12):2704-8 PMID: 6468668 09/01/1984       26 Citations
  • Photoreceptor disc shedding in eye cups. Inhibition by deletion of extracellular divalent cations. (Greenberger LM, Besharse JC) Invest Ophthalmol Vis Sci 1983 Nov;24(11):1456-64 PMID: 6642925 11/01/1983       26 Citations
  • Circadian clock in Xenopus eye controlling retinal serotonin N-acetyltransferase. (Besharse JC, Iuvone PM) Nature 1983 Sep 8-14;305(5930):133-5 PMID: 6888555 09/08/1983       230 Citations
  • Regulation of indoleamine N-acetyltransferase activity in the retina: effects of light and dark, protein synthesis inhibitors and cyclic nucleotide analogs. (Iuvone PM, Besharse JC) Brain Res 1983 Aug 22;273(1):111-9 PMID: 6311344 08/22/1983       107 Citations
  • Rod photoreceptor disc shedding in eye cups: relationship to bicarbonate and amino acids. (Besharse JC, Dunis DA) Exp Eye Res 1983 Apr;36(4):567-79 PMID: 6852133 04/01/1983       43 Citations
  • Methoxyindoles and photoreceptor metabolism: activation of rod shedding. (Besharse JC, Dunis DA) Science 1983 Mar 18;219(4590):1341-3 PMID: 6828862 03/18/1983       130 Citations
  • Effects of cyclic adenosine 3',5'-monophosphate on photoreceptor disc shedding and retinomotor movement. Inhibition of rod shedding and stimulation of cone elongation. (Besharse JC, Dunis DA, Burnside B) J Gen Physiol 1982 May;79(5):775-90 PMID: 6284860 PMCID: PMC2215507 05/01/1982       56 Citations
  • Membrane assembly in retinal photoreceptors I. Freeze-fracture analysis of cytoplasmic vesicles in relationship to disc assembly. (Besharse JC, Pfenninger KH) J Cell Biol 1980 Nov;87(2 Pt 1):451-63 PMID: 7430251 PMCID: PMC2110759 11/01/1980       58 Citations
  • Turnover of mouse photoreceptor outer segments in constant light and darkness. (Besharse JC, Hollyfield JG) Invest Ophthalmol Vis Sci 1979 Oct;18(10):1019-24 PMID: 478775 10/01/1979       67 Citations
  • Purification and characterization of branched chain alpha-ketoacid dehydrogenase from bovine liver mitochondria. (Danner DJ, Lemmon SK, Besharse JC, Elsas LJ 2nd) J Biol Chem 1979 Jun 25;254(12):5522-6 PMID: 447664 06/25/1979       57 Citations
  • Turnover of rod photoreceptor outer segments. I. Membrane addition and loss in relationship to temperature. (Hollyfield JG, Besharse JC, Rayborn ME) J Cell Biol 1977 Nov;75(2 Pt 1):490-506 PMID: 318132 PMCID: PMC2109933 11/01/1977       51 Citations
  • Turnover of rod photoreceptor outer segments. II. Membrane addition and loss in relationship to light. (Besharse JC, Hollyfield JG, Rayborn ME) J Cell Biol 1977 Nov;75(2 Pt 1):507-27 PMID: 264121 PMCID: PMC2109927 11/01/1977       154 Citations
  • Photoreceptor outer segments: accelerated membrane renewal in rods after exposure to light. (Besharse JC, Hollyfield JG, Rayborn ME) Science 1977 Apr 29;196(4289):536-8 PMID: 300504 04/29/1977       61 Citations
  • Ultrastructural changes during degeneration of photoreceptors and pigment epithelium in the Ozark cave salamander. (Besharse JC, Hollyfield JG) J Ultrastruct Res 1977 Apr;59(1):31-43 PMID: 850299 04/01/1977       8 Citations
  • Visual pigment loss after light-induced shedding of rod outer segments. (Bridges CD, Hollyfield JG, Besharse JC, Rayborn ME) Exp Eye Res 1976 Dec;23(6):637-41 PMID: 1087246 12/01/1976       15 Citations
  • The effect of light on the quantity of phagosomes in the pigment epithelium. (Hollyfield JG, Besharse JC, Rayborn ME) Exp Eye Res 1976 Dec;23(6):623-35 PMID: 1087245 12/01/1976       43 Citations
  • Renewal of normal and degenerating photoreceptor outer segments in the Ozark cave salamander. (Besharse JC, Hollyfield JG) J Exp Zool 1976 Dec;198(3):287-302 PMID: 1003144 12/01/1976       13 Citations
  • Effects of continuous light and darkness on the eyes of the troglobitic salamander Typhlotriton spelaeus. (Besharse JC, Brandon RA) J Morphol 1976 Aug;149(4):527-46 PMID: 966284 08/01/1976       16 Citations
  • Postembryonic eye degeneration in the troglobitic salamander Typhlotriton spelaeus. (Besharse JC, Brandon RA) J Morphol 1974 Dec;144(4):381-405 PMID: 30322217 12/01/1974       16 Citations
  • Maturity and sexual dimorphism in the skull, mandible, and teeth of the beaked whale, Mesoplodon densirostris. (Besharse JC) J Mammal 1971 May;52(2):297-315 PMID: 5104081 05/01/1971       19 Citations
  • Last update: 04/09/2019
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