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Jyoti N. Sengupta PhD

Jyoti N. Sengupta PhD


Institution: Medical College of Wisconsin
Department: Medicine
Division: Gastroenterology
Program: Research

Member of the Neuroscience Research Center


  • MicroRNA-mediated downregulation of potassium-chloride-cotransporter and vesicular γ-aminobutyric acid transporter expression in spinal cord contributes to neonatal cystitis-induced visceral pain in rats. (Zhang J, Yu J, Kannampalli P, Nie L, Meng H, Medda BK, Shaker R, Sengupta JN, Banerjee B) Pain 2017 Dec;158(12):2461-2474 PMID: 28885452 PMCID: PMC5680103 09/09/2017       8 Citations
  • Analgesic effect of ADX71441, a positive allosteric modulator (PAM) of GABA receptor in a rat model of bladder pain. (Kannampalli P, Poli SM, Boléa C, Sengupta JN) Neuropharmacology 2017 Nov;126:1-11 PMID: 28823612 08/22/2017       2 Citations
  • Percutaneous electrical nerve field stimulation modulates central pain pathways and attenuates post-inflammatory visceral and somatic hyperalgesia in rats. (Babygirija R, Sood M, Kannampalli P, Sengupta JN, Miranda A) Neuroscience 2017 07 25;356:11-21 PMID: 28526575 05/21/2017       5 Citations
  • Neonatal bladder inflammation induces long-term visceral pain and altered responses of spinal neurons in adult rats. (Kannampalli P, Babygirija R, Zhang J, Poe MM, Li G, Cook JM, Shaker R, Banerjee B, Sengupta JN) Neuroscience 2017 03 27;346:349-364 PMID: 28126369 PMCID: PMC5337157 01/28/2017       6 Citations
  • Prolonged esophageal acid exposures induce synaptic downscaling of cortical membrane AMPA receptor subunits in rats. (Banerjee B, Medda BK, Zhang J, Tuchscherer V, Babygirija R, Kannampalli P, Sengupta JN, Shaker R) Neurogastroenterol Motil 2016 Sep;28(9):1356-69 PMID: 27271201 PMCID: PMC5063079 06/09/2016    
  • Role of principal ionotropic and metabotropic receptors in visceral pain. (Kannampalli P, Sengupta JN) J Neurogastroenterol Motil 2015 Mar 30;21(2):147-58 PMID: 25843070 PMCID: PMC4398235 04/07/2015    
  • Probiotic Lactobacillus rhamnosus GG (LGG) and prebiotic prevent neonatal inflammation-induced visceral hypersensitivity in adult rats. (Kannampalli P, Pochiraju S, Chichlowski M, Berg BM, Rudolph C, Bruckert M, Miranda A, Sengupta JN) Neurogastroenterol Motil 2014 Dec;26(12):1694-704 PMID: 25298006 10/10/2014       17 Citations
  • NMDA receptor mediates chronic visceral pain induced by neonatal noxious somatic stimulation. (Miranda A, Mickle A, Bruckert M, Kannampalli P, Banerjee B, Sengupta JN) Eur J Pharmacol 2014 Dec 05;744:28-35 PMID: 25281204 PMCID: PMC4261000 10/05/2014       9 Citations
  • Analgesic effect of minocycline in rat model of inflammation-induced visceral pain. (Kannampalli P, Pochiraju S, Bruckert M, Shaker R, Banerjee B, Sengupta JN) Eur J Pharmacol 2014 Mar 15;727:87-98 PMID: 24485889 PMCID: PMC3984928 02/04/2014       13 Citations
  • Visceral analgesic effect of 5-HT(4) receptor agonist in rats involves the rostroventral medulla (RVM). (Sengupta JN, Mickle A, Kannampalli P, Spruell R, McRorie J, Shaker R, Miranda A) Neuropharmacology 2014 Apr;79:345-58 PMID: 24334068 PMCID: PMC4321751 12/18/2013       12 Citations
  • AMPA receptor subunits expression and phosphorylation in cingulate cortex in rats following esophageal acid exposure. (Banerjee B, Medda BK, Pochiraju S, Kannampalli P, Lang IM, Sengupta JN, Shaker R) Neurogastroenterol Motil 2013 Dec;25(12):973-e776 PMID: 24118589 PMCID: PMC4097166 10/15/2013       3 Citations
  • MicroRNA-mediated GABA Aα-1 receptor subunit down-regulation in adult spinal cord following neonatal cystitis-induced chronic visceral pain in rats. (Sengupta JN, Pochiraju S, Kannampalli P, Bruckert M, Addya S, Yadav P, Miranda A, Shaker R, Banerjee B) Pain 2013 Jan;154(1):59-70 PMID: 23273104 PMCID: PMC3535325 01/01/2013    
  • Pronociceptive effect of 5-HT(1A) receptor agonist on visceral pain involves spinal N-methyl-D-aspartate (NMDA) receptor. (Mickle A, Kannampalli P, Bruckert M, Miranda A, Banerjee B, Sengupta JN) Neuroscience 2012 Sep 06;219:243-54 PMID: 22626644 PMCID: PMC3402596 05/26/2012       7 Citations
  • Colonic butyrate- algesic or analgesic? (Kannampalli P, Shaker R, Sengupta JN) Neurogastroenterol Motil 2011 Nov;23(11):975-9 PMID: 21981302 PMCID: PMC3191935 10/11/2011       14 Citations
  • Neuronal plasticity in the cingulate cortex of rats following esophageal acid exposure in early life. (Banerjee B, Medda BK, Schmidt J, Lang IM, Sengupta JN, Shaker R) Gastroenterology 2011 Aug;141(2):544-52 PMID: 21616075 PMCID: PMC3152593 05/28/2011       7 Citations
  • Neonatal cystitis-induced colonic hypersensitivity in adult rats: a model of viscero-visceral convergence. (Miranda A, Mickle A, Schmidt J, Zhang Z, Shaker R, Banerjee B, Sengupta JN) Neurogastroenterol Motil 2011 Jul;23(7):683-e281 PMID: 21592255 PMCID: PMC3117950 05/20/2011       23 Citations
  • Antinociceptive effects of melatonin in a rat model of post-inflammatory visceral hyperalgesia: a centrally mediated process. (Mickle A, Sood M, Zhang Z, Shahmohammadi G, Sengupta JN, Miranda A) Pain 2010 Jun;149(3):555-64 PMID: 20413219 PMCID: PMC2884285 04/24/2010       31 Citations
  • Altered expression of P2X3 in vagal and spinal afferents following esophagitis in rats. (Banerjee B, Medda BK, Schmidt J, Zheng Y, Zhang Z, Shaker R, Sengupta JN) Histochem Cell Biol 2009 Dec;132(6):585-97 PMID: 19784665 PMCID: PMC4820021 09/29/2009       20 Citations
  • Visceral pain: the neurophysiological mechanism. (Sengupta JN) Handb Exp Pharmacol 2009(194):31-74 PMID: 19655104 PMCID: PMC3156094 08/06/2009       92 Citations
  • Altered mechanosensitive properties of vagal afferent fibers innervating the stomach following gastric surgery in rats. (Miranda A, Mickle A, Medda B, Zhang Z, Phillips RJ, Tipnis N, Powley TL, Shaker R, Sengupta JN) Neuroscience 2009 Sep 15;162(4):1299-306 PMID: 19477237 PMCID: PMC2741133 05/30/2009       11 Citations
  • Differential effects of transient receptor vanilloid one (TRPV1) antagonists in acid-induced excitation of esophageal vagal afferent fibers of rats. (Peles S, Medda BK, Zhang Z, Banerjee B, Lehmann A, Shaker R, Sengupta JN) Neuroscience 2009 Jun 30;161(2):515-25 PMID: 19324074 PMCID: PMC2703792 03/28/2009       26 Citations
  • Alterations in N-methyl-D-aspartate receptor subunits in primary sensory neurons following acid-induced esophagitis in cats. (Banerjee B, Medda BK, Zheng Y, Miller H, Miranda A, Sengupta JN, Shaker R) Am J Physiol Gastrointest Liver Physiol 2009 Jan;296(1):G66-77 PMID: 18974310 PMCID: PMC2636931 11/01/2008       15 Citations
  • The role of transient receptor potential vanilloid 1 in mechanical and chemical visceral hyperalgesia following experimental colitis. (Miranda A, Nordstrom E, Mannem A, Smith C, Banerjee B, Sengupta JN) Neuroscience 2007 Sep 21;148(4):1021-32 PMID: 17719181 PMCID: PMC2128774 08/28/2007       116 Citations
  • Neonatal gastric suctioning results in chronic visceral and somatic hyperalgesia: role of corticotropin releasing factor. (Smith C, Nordstrom E, Sengupta JN, Miranda A) Neurogastroenterol Motil 2007 Aug;19(8):692-9 PMID: 17640185 07/21/2007       32 Citations
  • Effect of reflux-induced inflammation on transient receptor potential vanilloid one (TRPV1) expression in primary sensory neurons innervating the oesophagus of rats. (Banerjee B, Medda BK, Lazarova Z, Bansal N, Shaker R, Sengupta JN) Neurogastroenterol Motil 2007 Aug;19(8):681-91 PMID: 17640184 07/21/2007       54 Citations
  • Effects of the 5-HT3 receptor antagonist, alosetron, in a rat model of somatic and visceral hyperalgesia. (Miranda A, Peles S, McLean PG, Sengupta JN) Pain 2006 Dec 15;126(1-3):54-63 PMID: 16844296 07/18/2006       33 Citations
  • Neonatal nociceptive somatic stimulation differentially modifies the activity of spinal neurons in rats and results in altered somatic and visceral sensation. (Miranda A, Peles S, Shaker R, Rudolph C, Sengupta JN) J Physiol 2006 May 01;572(Pt 3):775-87 PMID: 16513666 PMCID: PMC1779998 03/04/2006       19 Citations
  • Response properties of the brainstem neurons of the cat following intra-esophageal acid-pepsin infusion. (Medda BK, Sengupta JN, Lang IM, Shaker R) Neuroscience 2005;135(4):1285-94 PMID: 16165290 09/17/2005       30 Citations
  • Acute nociceptive somatic stimulus sensitizes neurones in the spinal cord to colonic distension in the rat. (Peles S, Miranda A, Shaker R, Sengupta JN) J Physiol 2004 Oct 01;560(Pt 1):291-302 PMID: 15284340 PMCID: PMC1665216 07/31/2004       35 Citations
  • Response properties of antral mechanosensitive afferent fibers and effects of ionotropic glutamate receptor antagonists. (Sengupta JN, Petersen J, Peles S, Shaker R) Neuroscience 2004;125(3):711-23 PMID: 15099685 04/22/2004       27 Citations
  • Altered visceral sensation in response to somatic pain in the rat. (Miranda A, Peles S, Rudolph C, Shaker R, Sengupta JN) Gastroenterology 2004 Apr;126(4):1082-9 PMID: 15057747 04/02/2004       63 Citations
  • Enhancement of antral contractions and vagal afferent signaling with synchronized electrical stimulation. (Peles S, Petersen J, Aviv R, Policker S, Abu-Hatoum O, Ben-Haim SA, Gutterman DD, Sengupta JN) Am J Physiol Gastrointest Liver Physiol 2003 Sep;285(3):G577-85 PMID: 12801883 06/13/2003       44 Citations
  • Effect of GABA(B) receptor agonist on distension-sensitive pelvic nerve afferent fibers innervating rat colon. (Sengupta JN, Medda BK, Shaker R) Am J Physiol Gastrointest Liver Physiol 2002 Dec;283(6):G1343-51 PMID: 12388205 10/22/2002       26 Citations
  • Models of gastric hyperalgesia in the rat. (Ozaki N, Bielefeldt K, Sengupta JN, Gebhart GF) Am J Physiol Gastrointest Liver Physiol 2002 Sep;283(3):G666-76 PMID: 12181181 08/16/2002       73 Citations
  • Biphasic modulation of spinal visceral nociceptive transmission from the rostroventral medial medulla in the rat. (Zhuo M, Sengupta JN, Gebhart GF) J Neurophysiol 2002 May;87(5):2225-36 PMID: 11976363 04/27/2002       68 Citations
  • Electrophysiological recording from neurons controlling sensory and motor functions of the esophagus. (Sengupta JN) Am J Med 2001 Dec 03;111 Suppl 8A:169S-173S PMID: 11749945 12/26/2001       12 Citations
  • Role of peripheral N-methyl-D-aspartate (NMDA) receptors in visceral nociception in rats. (McRoberts JA, Coutinho SV, Marvizón JC, Grady EF, Tognetto M, Sengupta JN, Ennes HS, Chaban VV, Amadesi S, Creminon C, Lanthorn T, Geppetti P, Bunnett NW, Mayer EA) Gastroenterology 2001 Jun;120(7):1737-48 PMID: 11375955 05/29/2001       161 Citations
  • Role of sensitized pelvic nerve afferents from the inflamed rat colon in the maintenance of visceral hyperalgesia. (Coutinho SV, Su X, Sengupta JN, Gebhart GF) Prog Brain Res 2000;129:375-87 PMID: 11098705 12/01/2000       24 Citations
  • Peripheral opioid modulation of visceral pain. (Gebhart GF, Su X, Joshi S, Ozaki N, Sengupta JN) Ann N Y Acad Sci 2000;909:41-50 PMID: 10911923 07/27/2000       28 Citations
  • Differential effects of mu-, delta-, and kappa-opioid receptor agonists on mechanosensitive gastric vagal afferent fibers in the rat. (Ozaki N, Sengupta JN, Gebhart GF) J Neurophysiol 2000 Apr;83(4):2209-16 PMID: 10758129 04/12/2000       51 Citations
  • An overview of esophageal sensory receptors. (Sengupta JN) Am J Med 2000 Mar 06;108 Suppl 4a:87S-89S PMID: 10718458 03/16/2000       52 Citations
  • Mechanosensitive properties of gastric vagal afferent fibers in the rat. (Ozaki N, Sengupta JN, Gebhart GF) J Neurophysiol 1999 Nov;82(5):2210-20 PMID: 10561400 11/24/1999       75 Citations
  • Effects of kappa opioids in the inflamed rat colon. (Sengupta JN, Snider A, Su X, Gebhart GF) Pain 1999 Feb;79(2-3):175-85 PMID: 10068163 03/06/1999       117 Citations
  • Attenuation of ischemia-induced activation of cardiac sympathetic afferents following brief myocardial ischemia in cats. (Abe T, Morgan D, Sengupta JN, Gebhart GF, Gutterman DD) J Auton Nerv Syst 1998 Jun 30;71(1):28-36 PMID: 9722192 08/29/1998       17 Citations
  • Responses of T2-4 spinal cord neurons to irritation of the lower airways in the rat. (Hummel T, Sengupta JN, Meller ST, Gebhart GF) Am J Physiol 1997 Sep;273(3 Pt 2):R1147-57 PMID: 9321898 10/10/1997       29 Citations
  • Effects of kappa opioid receptor-selective agonists on responses of pelvic nerve afferents to noxious colorectal distension. (Su X, Sengupta JN, Gebhart GF) J Neurophysiol 1997 Aug;78(2):1003-12 PMID: 9307130 08/01/1997       82 Citations
  • Effects of opioids on mechanosensitive pelvic nerve afferent fibers innervating the urinary bladder of the rat. (Su X, Sengupta JN, Gebhart GF) J Neurophysiol 1997 Mar;77(3):1566-80 PMID: 9084620 03/01/1997       79 Citations
  • Kappa, but not mu or delta, opioids attenuate responses to distention of afferent fibers innervating the rat colon. (Sengupta JN, Su X, Gebhart GF) Gastroenterology 1996 Oct;111(4):968-80 PMID: 8831591 10/01/1996       117 Citations
  • Differential c-fos expression in the nucleus of the solitary tract and spinal cord following noxious gastric distention in the rat. (Traub RJ, Sengupta JN, Gebhart GF) Neuroscience 1996 Oct;74(3):873-84 PMID: 8884783 10/01/1996       132 Citations
  • Mechanosensitive properties of pelvic nerve afferent fibers innervating the urinary bladder of the rat. (Sengupta JN, Gebhart GF) J Neurophysiol 1994 Nov;72(5):2420-30 PMID: 7884468 11/01/1994       184 Citations
  • Noxious distention of viscera results in differential c-Fos expression in second order sensory neurons receiving 'sympathetic' or 'parasympathetic' input. (Traub RJ, Lim F, Sengupta JN, Meller ST, Gebhart GF) Neurosci Lett 1994 Oct 10;180(1):71-5 PMID: 7877766 10/10/1994       32 Citations
  • Characterization of mechanosensitive pelvic nerve afferent fibers innervating the colon of the rat. (Sengupta JN, Gebhart GF) J Neurophysiol 1994 Jun;71(6):2046-60 PMID: 7931501 06/01/1994       189 Citations
  • Characterization of responses of T2-T4 spinal cord neurons to esophageal distension in the rat. (Euchner-Wamser I, Sengupta JN, Gebhart GF, Meller ST) J Neurophysiol 1993 Mar;69(3):868-83 PMID: 8385199 03/01/1993       51 Citations
  • Differential sensitivity to bradykinin of esophageal distension-sensitive mechanoreceptors in vagal and sympathetic afferents of the opossum. (Sengupta JN, Saha JK, Goyal RK) J Neurophysiol 1992 Oct;68(4):1053-67 PMID: 1432067 10/01/1992       58 Citations
  • Role of chloride ions in lower esophageal sphincter tone and relaxation. (Saha JK, Sengupta JN, Goyal RK) Am J Physiol 1992 Jul;263(1 Pt 1):G115-26 PMID: 1636707 07/01/1992       12 Citations
  • Effects of bradykinin and bradykinin analogs on the opossum lower esophageal sphincter: characterization of an inhibitory bradykinin receptor. (Saha JK, Sengupta JN, Goyal RK) J Pharmacol Exp Ther 1991 Oct;259(1):265-73 PMID: 1656023 10/01/1991       23 Citations
  • Stimulus-response function studies of esophageal mechanosensitive nociceptors in sympathetic afferents of opossum. (Sengupta JN, Saha JK, Goyal RK) J Neurophysiol 1990 Sep;64(3):796-812 PMID: 2230925 09/01/1990       127 Citations
  • Effect of ATP on smooth muscle of toad urinary bladder. (Saha JK, Sengupta JN, Koley BN, Koley J) Arch Int Pharmacodyn Ther 1990 Mar-Apr;304:93-104 PMID: 2122823 03/01/1990    
  • Effect of bradykinin on opossum esophageal longitudinal smooth muscle: evidence for novel bradykinin receptors. (Saha JK, Sengupta JN, Goyal RK) J Pharmacol Exp Ther 1990 Mar;252(3):1012-20 PMID: 2156987 03/01/1990       39 Citations
  • Characteristics of vagal esophageal tension-sensitive afferent fibers in the opossum. (Sengupta JN, Kauvar D, Goyal RK) J Neurophysiol 1989 May;61(5):1001-10 PMID: 2723726 05/01/1989       131 Citations
  • Interaction of enantiomers of hydroxy tolazoline with adrenoceptors. (Sengupta JN, Hamada A, Miller DD, Patil PN) Naunyn Schmiedebergs Arch Pharmacol 1987 Apr;335(4):391-6 PMID: 3600818 04/01/1987       7 Citations
  • Visceral receptors and their afferents in the caudal mesenteric nerve of the duck. (Koley J, Sen Gupta J, Pal P, Bhattacharyya S, Sarkar SP, Koley BN) Br Poult Sci 1982 Jul;23(4):315-24 PMID: 7127169 07/01/1982       2 Citations
  • Last update: 10/23/2017
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