Medical College of Wisconsin
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Kathryn M. Gauthier PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Pharmacology


Publications

  • Mice lacking macrophage 12/15-lipoxygenase are resistant to experimental hypertension. (Kriska T, Cepura C, Magier D, Siangjong L, Gauthier KM, Campbell WB) Am J Physiol Heart Circ Physiol 2012 Jun 1;302(11):H2428-38 PMID: 22467300 PMCID: PMC3378305
  • 11,12,20-Trihydroxy-eicosa-8(Z)-enoic acid: a selective inhibitor of 11,12-EET-induced relaxations of bovine coronary and rat mesenteric arteries. (Bukhari IA, Shah AJ, Gauthier KM, Walsh KA, Koduru SR, Imig JD, Falck JR, Campbell WB) Am J Physiol Heart Circ Physiol 2012 Apr 15;302(8):H1574-83 PMID: 22307677 PMCID: PMC3330801
  • Endothelial nitric oxide and 15-lipoxygenase-1 metabolites independently mediate relaxation of the rabbit aorta. (Aggarwal NT, Gauthier KM, Campbell WB) Vascul Pharmacol 2012 Jan-Feb;56(1-2):106-12 PMID: 22197897 PMCID: PMC3268834
  • Soluble epoxide hydrolase contamination of specific catalase preparations inhibits epoxyeicosatrienoic acid vasodilation of rat renal arterioles. (Gauthier KM, Olson L, Harder A, Isbell M, Imig JD, Gutterman DD, Falck JR, Campbell WB) Am J Physiol Renal Physiol 2011 Oct;301(4):F765-72 PMID: 21753077 PMCID: PMC3191800
  • Angiotensin II relaxations of bovine adrenal cortical arteries: role of angiotensin II metabolites and endothelial nitric oxide. (Gauthier KM, Zhang DX, Cui L, Nithipatikom K, Campbell WB) Hypertension 2008 Jul;52(1):150-5 PMID: 18490519 PMCID: PMC3202425
  • 15-Lipoxygenase metabolites contribute to age-related reduction in acetylcholine-induced hypotension in rabbits. (Aggarwal NT, Gauthier KM, Campbell WB) Am J Physiol Heart Circ Physiol 2008 Jul;295(1):H89-96 PMID: 18456739 PMCID: PMC2494760
  • Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart. (Gross GJ, Gauthier KM, Moore J, Falck JR, Hammock BD, Campbell WB, Nithipatikom K) Am J Physiol Heart Circ Physiol 2008 Jun;294(6):H2838-44 PMID: 18441205 PMCID: PMC2863006
  • 11(R),12(S),15(S)-trihydroxyeicosa-5(Z),8(Z),13(E)-trienoic acid: an endothelium-derived 15-lipoxygenase metabolite that relaxes rabbit aorta. (Gauthier KM, Chawengsub Y, Goldman DH, Conrow RE, Anjaiah S, Falck JR, Campbell WB) Am J Physiol Heart Circ Physiol 2008 Mar;294(3):H1467-72 PMID: 18203841
  • Identification of 15-hydroxy-11,12-epoxyeicosatrienoic acid as a vasoactive 15-lipoxygenase metabolite in rabbit aorta. (Chawengsub Y, Aggarwal NT, Nithipatikom K, Gauthier KM, Anjaiah S, Hammock BD, Falck JR, Campbell WB) Am J Physiol Heart Circ Physiol 2008 Mar;294(3):H1348-56 PMID: 18192225
  • Endothelial 15-lipoxygenase-1 overexpression increases acetylcholine-induced hypotension and vasorelaxation in rabbits. (Aggarwal NT, Chawengsub Y, Gauthier KM, Viita H, Yla-Herttuala S, Campbell WB) Hypertension 2008 Feb;51(2):246-51 PMID: 18180398
  • Roles of epoxyeicosatrienoic acids in vascular regulation and cardiac preconditioning. (Gauthier KM, Yang W, Gross GJ, Campbell WB) J Cardiovasc Pharmacol 2007 Dec;50(6):601-8 PMID: 18091575
  • Inhibition of 2-arachidonoylglycerol catabolism modulates vasoconstriction of rat middle cerebral artery by the thromboxane mimetic, U-46619. (Hillard CJ, Ho WS, Thompson J, Gauthier KM, Wheelock CE, Huang H, Hammock BD) Br J Pharmacol 2007 Nov;152(5):691-8 PMID: 17891162 PMCID: PMC2190024
  • Steroid-producing cells regulate arterial tone of adrenal cortical arteries. (Zhang DX, Gauthier KM, Falck JR, Siddam A, Campbell WB) Endocrinology 2007 Aug;148(8):3569-76 PMID: 17446179
  • ACh-induced relaxations of rabbit small mesenteric arteries: role of arachidonic acid metabolites and K+. (Zhang DX, Gauthier KM, Chawengsub Y, Campbell WB) Am J Physiol Heart Circ Physiol 2007 Jul;293(1):H152-9 PMID: 17337603
  • Metabolism of adrenic acid to vasodilatory 1alpha,1beta-dihomo-epoxyeicosatrienoic acids by bovine coronary arteries. (Yi XY, Gauthier KM, Cui L, Nithipatikom K, Falck JR, Campbell WB) Am J Physiol Heart Circ Physiol 2007 May;292(5):H2265-74 PMID: 17209008
  • Hypoxia-induced vascular smooth muscle relaxation: increased ATP-sensitive K+ efflux or decreased voltage-sensitive Ca2+ influx? (Gauthier KM) Am J Physiol Heart Circ Physiol 2006 Jul;291(1):H24-5 PMID: 16565315
  • Regulation of potassium channels in coronary smooth muscle by adenoviral expression of cytochrome P-450 epoxygenase. (Campbell WB, Holmes BB, Falck JR, Capdevila JH, Gauthier KM) Am J Physiol Heart Circ Physiol 2006 Jan;290(1):H64-71 PMID: 16143653
  • Novel mechanism of vasodilation in inflammatory bowel disease. (Hatoum OA, Gauthier KM, Binion DG, Miura H, Telford G, Otterson MF, Campbell WB, Gutterman DD) Arterioscler Thromb Vasc Biol 2005 Nov;25(11):2355-61 PMID: 16141408
  • Mechanisms of histamine-induced relaxation in bovine small adrenal cortical arteries. (Zhang DX, Gauthier KM, Campbell WB) Am J Physiol Endocrinol Metab 2005 Dec;289(6):E1058-63 PMID: 16076876
  • Angiotensin II dilates bovine adrenal cortical arterioles: role of endothelial nitric oxide. (Gauthier KM, Zhang DX, Edwards EM, Holmes B, Campbell WB) Endocrinology 2005 Aug;146(8):3319-24 PMID: 15890772
  • Stable 5,6-epoxyeicosatrienoic acid analog relaxes coronary arteries through potassium channel activation. (Yang W, Gauthier KM, Reddy LM, Sangras B, Sharma KK, Nithipatikom K, Falck JR, Campbell WB) Hypertension 2005 Apr;45(4):681-6 PMID: 15699458
  • 14,15-epoxyeicosatrienoic acid represents a transferable endothelium-dependent relaxing factor in bovine coronary arteries. (Gauthier KM, Edwards EM, Falck JR, Reddy DS, Campbell WB) Hypertension 2005 Apr;45(4):666-71 PMID: 15699460
  • U-46619 but not serotonin increases endocannabinoid content in middle cerebral artery: evidence for functional relevance. (Rademacher DJ, Patel S, Ho WS, Savoie AM, Rusch NJ, Gauthier KM, Hillard CJ) Am J Physiol Heart Circ Physiol 2005 Jun;288(6):H2694-701 PMID: 15695564
  • Endothelium-derived 2-arachidonylglycerol: an intermediate in vasodilatory eicosanoid release in bovine coronary arteries. (Gauthier KM, Baewer DV, Hittner S, Hillard CJ, Nithipatikom K, Reddy DS, Falck JR, Campbell WB) Am J Physiol Heart Circ Physiol 2005 Mar;288(3):H1344-51 PMID: 15528233
  • Cyclooxygenase- and lipoxygenase-dependent relaxation to arachidonic acid in rabbit small mesenteric arteries. (Zhang DX, Gauthier KM, Chawengsub Y, Holmes BB, Campbell WB) Am J Physiol Heart Circ Physiol 2005 Jan;288(1):H302-9 PMID: 15388505
  • Acetylcholine-induced relaxation and hyperpolarization in small bovine adrenal cortical arteries: role of cytochrome P450 metabolites. (Zhang DX, Gauthier KM, Campbell WB) Endocrinology 2004 Oct;145(10):4532-9 PMID: 15231705
  • 14,15-EET analogs: characterization of structural requirements for agonist and antagonist activity in bovine coronary arteries. (Gauthier KM, Falck JR, Reddy LM, Campbell WB) Pharmacol Res 2004 Jun;49(6):515-24 PMID: 15026029
  • Characterization of vasoconstrictor responses in small bovine adrenal cortical arteries in vitro. (Zhang DX, Gauthier KM, Campbell WB) Endocrinology 2004 Apr;145(4):1571-8 PMID: 14726440
  • Apamin-sensitive K+ currents mediate arachidonic acid-induced relaxations of rabbit aorta. (Gauthier KM, Spitzbarth N, Edwards EM, Campbell WB) Hypertension 2004 Feb;43(2):413-9 PMID: 14691199
  • 14,15-epoxyeicosa-5(Z)-enoic-mSI: a 14,15- and 5,6-EET antagonist in bovine coronary arteries. (Gauthier KM, Jagadeesh SG, Falck JR, Campbell WB) Hypertension 2003 Oct;42(4):555-61 PMID: 12953017
  • 11,12,15-Trihydroxyeicosatrienoic acid mediates ACh-induced relaxations in rabbit aorta. (Campbell WB, Spitzbarth N, Gauthier KM, Pfister SL) Am J Physiol Heart Circ Physiol 2003 Dec;285(6):H2648-56 PMID: 12907422
  • Freshly isolated bovine coronary endothelial cells do not express the BK Ca channel gene. (Gauthier KM, Liu C, Popovic A, Albarwani S, Rusch NJ) J Physiol 2002 Dec 15;545(Pt 3):829-36 PMID: 12482889 PMCID: PMC2290710
  • Comparison of vasodilatory properties of 14,15-EET analogs: structural requirements for dilation. (Falck JR, Krishna UM, Reddy YK, Kumar PS, Reddy KM, Hittner SB, Deeter C, Sharma KK, Gauthier KM, Campbell WB) Am J Physiol Heart Circ Physiol 2003 Jan;284(1):H337-49 PMID: 12388250
  • 14,15-Epoxyeicosa-5(Z)-enoic acid: a selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries. (Gauthier KM, Deeter C, Krishna UM, Reddy YK, Bondlela M, Falck JR, Campbell WB) Circ Res 2002 May 17;90(9):1028-36 PMID: 12016270
  • 14,15-Dihydroxyeicosatrienoic acid relaxes bovine coronary arteries by activation of K(Ca) channels. (Campbell WB, Deeter C, Gauthier KM, Ingraham RH, Falck JR, Li PL) Am J Physiol Heart Circ Physiol 2002 May;282(5):H1656-64 PMID: 11959628
  • What is new in endothelium-derived hyperpolarizing factors? (Campbell WB, Gauthier KM) Curr Opin Nephrol Hypertens 2002 Mar;11(2):177-83 PMID: 11856910
  • Rat Coronary Endothelial Cell Membrane Potential Responses During Hypertension. (Gauthier KM, Rusch NJ) Hypertension 2001 Jan;37(1):66-71 PMID: 11208758
  • Distinct endothelial impairment in coronary microvessels from hypertensive Dahl rats. (Gauthier-Rein KM, Rusch NJ) Hypertension 1998 Jan;31(1 Pt 2):328-34 PMID: 9453324
  • Hypoxia-induced hyperpolarization is not associated with vasodilation of bovine coronary resistance arteries. (Gauthier-Rein KM, Bizub DM, Lombard JH, Rusch NJ) Am J Physiol 1997 Mar;272(3 Pt 2):H1462-9 PMID: 9087625
  • Last update: 07/23/2012