Medical College of Wisconsin
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Laura Ann Kresty PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Hematology and Oncology
Program: Hematology


Publications

  • MicroRNA alterations in Barrett's esophagus, esophageal adenocarcinoma, and esophageal adenocarcinoma cell lines following cranberry extract treatment: Insights for chemoprevention. (Kresty LA, Clarke J, Ezell K, Exum A, Howell AB, Guettouche T) J Carcinog 2011;10:34 PMID 22279419
  • Gankyrin, a biomarker for epithelial carcinogenesis, is overexpressed in human oral cancer. (Li J, Knobloch TJ, Kresty LA, Zhang Z, Lang JC, Schuller DE, Weghorst CM) Anticancer Res 2011 Sep;31(9):2683-92 PMID 21868508
  • Genetic polymorphisms of multiple DNA repair pathways impact age at diagnosis and TP53 mutations in breast cancer. (Smith TR, Liu-Mares W, Van Emburgh BO, Levine EA, Allen GO, Hill JW, Reis IM, Kresty LA, Pegram MD, Miller MS, Hu JJ) Carcinogenesis 2011 Sep;32(9):1354-60 PMID 21700777
  • Cranberry proanthocyanidins mediate growth arrest of lung cancer cells through modulation of gene expression and rapid induction of apoptosis. (Kresty LA, Howell AB, Baird M) Molecules 2011;16(3):2375-90 PMID 21399574
  • Intake of plant foods and associated nutrients in prostate cancer risk. (Lewis JE, Soler-Vilá H, Clark PE, Kresty LA, Allen GO, Hu JJ) Nutr Cancer 2009;61(2):216-24 PMID 19235037
  • Frequent alterations of p16INK4a and p14ARF in oral proliferative verrucous leukoplakia. (Kresty LA, Mallery SR, Knobloch TJ, Li J, Lloyd M, Casto BC, Weghorst CM) Cancer Epidemiol Biomarkers Prev 2008 Nov;17(11):3179-87 PMID 18990760
  • Effects of a topically applied bioadhesive berry gel on loss of heterozygosity indices in premalignant oral lesions. (Shumway BS, Kresty LA, Larsen PE, Zwick JC, Lu B, Fields HW, Mumper RJ, Stoner GD, Mallery SR) Clin Cancer Res 2008 Apr 15;14(8):2421-30 PMID 18413833
  • The effects of reactive species on the tumorigenic phenotype of human head and neck squamous cell carcinoma (HNSCC) cells. (Bradburn JE, Pei P, Kresty LA, Lang JC, Yates AJ, McCormick AP, Mallery SR) Anticancer Res 2007 Nov-Dec;27(6B):3819-27 PMID 18225538
  • Cranberry proanthocyanidins induce apoptosis and inhibit acid-induced proliferation of human esophageal adenocarcinoma cells. (Kresty LA, Howell AB, Baird M) J Agric Food Chem 2008 Feb 13;56(3):676-80 PMID 18211022
  • Effects of phenylethyl isothiocyanate on early molecular events in N-nitrosomethylbenzylamine-induced cytotoxicity in rat esophagus. (Reen RK, Dombkowski AA, Kresty LA, Cukovic D, Mele JM, Salagrama S, Nines R, Stoner GD) Cancer Res 2007 Jul 1;67(13):6484-92 PMID 17616710
  • In situ assessment of intraepithelial neoplasia in hamster trachea epithelium using angle-resolved low-coherence interferometry. (Chalut KJ, Kresty LA, Pyhtila JW, Nines R, Baird M, Steele VE, Wax A) Cancer Epidemiol Biomarkers Prev 2007 Feb;16(2):223-7 PMID 17301253
  • Transitioning from preclinical to clinical chemopreventive assessments of lyophilized black raspberries: interim results show berries modulate markers of oxidative stress in Barrett's esophagus patients. (Kresty LA, Frankel WL, Hammond CD, Baird ME, Mele JM, Stoner GD, Fromkes JJ) Nutr Cancer 2006;54(1):148-56 PMID 16800781
  • Protection against esophageal cancer in rodents with lyophilized berries: potential mechanisms. (Stoner GD, Chen T, Kresty LA, Aziz RM, Reinemann T, Nines R) Nutr Cancer 2006;54(1):33-46 PMID 16800771
  • Phase II study of celecoxib in metastatic differentiated thyroid carcinoma. (Mrozek E, Kloos RT, Ringel MD, Kresty L, Snider P, Arbogast D, Kies M, Munden R, Busaidy N, Klein MJ, Sherman SI, Shah MH) J Clin Endocrinol Metab 2006 Jun;91(6):2201-4 PMID 16522694
  • Expression of the serine protease DESC1 correlates directly with normal keratinocyte differentiation and inversely with head and neck squamous cell carcinoma progression. (Sedghizadeh PP, Mallery SR, Thompson SJ, Kresty L, Beck FM, Parkinson EK, Biancamano J, Lang JC) Head Neck 2006 May;28(5):432-40 PMID 16320362
  • Chemopreventive effects of a selective nitric oxide synthase inhibitor on carcinogen-induced rat esophageal tumorigenesis. (Chen T, Nines RG, Peschke SM, Kresty LA, Stoner GD) Cancer Res 2004 May 15;64(10):3714-7 PMID 15150132
  • Chemoprevention of oral cancer by black raspberries. (Casto BC, Kresty LA, Kraly CL, Pearl DK, Knobloch TJ, Schut HA, Stoner GD, Mallery SR, Weghorst CM) Anticancer Res 2002 Nov-Dec;22(6C):4005-15 PMID 12553025
  • Alterations of p16(INK4a) and p14(ARF) in patients with severe oral epithelial dysplasia. (Kresty LA, Mallery SR, Knobloch TJ, Song H, Lloyd M, Casto BC, Weghorst CM) Cancer Res 2002 Sep 15;62(18):5295-300 PMID 12234999
  • Effects of lyophilized black raspberries on azoxymethane-induced colon cancer and 8-hydroxy-2'-deoxyguanosine levels in the Fischer 344 rat. (Harris GK, Gupta A, Nines RG, Kresty LA, Habib SG, Frankel WL, LaPerle K, Gallaher DD, Schwartz SJ, Stoner GD) Nutr Cancer 2001;40(2):125-33 PMID 11962247
  • Incidence and effects of Ha-ras codon 12 G-->A transition mutations in preneoplastic lesions induced by N-nitrosomethylbenzylamine in the rat esophagus. (Liston BW, Gupta A, Nines R, Carlton PS, Kresty LA, Harris GK, Stoner GD) Mol Carcinog 2001 Sep;32(1):1-8 PMID 11568970
  • Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries. (Kresty LA, Morse MA, Morgan C, Carlton PS, Lu J, Gupta A, Blackwood M, Stoner GD) Cancer Res 2001 Aug 15;61(16):6112-9 PMID 11507061
  • Inhibition of N-nitrosomethylbenzylamine-induced tumorigenesis in the rat esophagus by dietary freeze-dried strawberries. (Carlton PS, Kresty LA, Siglin JC, Morse MA, Lu J, Morgan C, Stoner GD) Carcinogenesis 2001 Mar;22(3):441-6 PMID 11238184
  • Failure of dietary lyophilized strawberries to inhibit 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-and benzo[a]pyrene-induced lung tumorigenesis in strain A/J mice. (Carlton PS, Kresty LA, Stoner GD) Cancer Lett 2000 Oct 31;159(2):113-7 PMID 10996721
  • Sulindac sulfone induced regression of rectal polyps in patients with familial adenomatous polyposis. (Stoner GD, Budd GT, Ganapathi R, DeYoung B, Kresty LA, Nitert M, Fryer B, Church JM, Provencher K, Pamukcu R, Piazza G, Hawk E, Kelloff G, Elson P, van Stolk RU) Adv Exp Med Biol 1999;470:45-53 PMID 10709673
  • Isothiocyanates and freeze-dried strawberries as inhibitors of esophageal cancer. (Stoner GD, Kresty LA, Carlton PS, Siglin JC, Morse MA) Toxicol Sci 1999 Dec;52(2 Suppl):95-100 PMID 10630596
  • Inhibition of N'-nitrosonornicotine-induced esophageal tumorigenesis by 3-phenylpropyl isothiocyanate. (Stoner GD, Adams C, Kresty LA, Amin SG, Desai D, Hecht SS, Murphy SE, Morse MA) Carcinogenesis 1998 Dec;19(12):2139-43 PMID 9886569
  • Measurement and treatment of agitation following traumatic brain injury: II. A survey of the Brain Injury Special Interest Group of the American Academy of Physical Medicine and Rehabilitation. (Fugate LP, Spacek LA, Kresty LA, Levy CE, Johnson JC, Mysiw WJ) Arch Phys Med Rehabil 1997 Sep;78(9):924-8 PMID 9305262
  • Definition of agitation following traumatic brain injury: I. A survey of the Brain Injury Special Interest Group of the American Academy of Physical Medicine and Rehabilitation. (Fugate LP, Spacek LA, Kresty LA, Levy CE, Johnson JC, Mysiw WJ) Arch Phys Med Rehabil 1997 Sep;78(9):917-23 PMID 9305261
  • Effects of theaflavins on N-nitrosomethylbenzylamine-induced esophageal tumorigenesis. (Morse MA, Kresty LA, Steele VE, Kelloff GJ, Boone CW, Balentine DA, Harbowy ME, Stoner GD) Nutr Cancer 1997;29(1):7-12 PMID 9383778
  • Dysregulation of transforming growth factor-beta 1 expression in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis. (Wang Q, Sabourin C, Kresty L, Stoner G) Int J Oncol 1996 Sep;9(3):473-9 PMID 21541537
  • Metabolites of a tobacco-specific nitrosamine, 4-(methylnitrosamino)- 1-(3-pyridyl)-1-butanone (NNK), in the urine of smokeless tobacco users: relationship between urinary biomarkers and oral leukoplakia. (Kresty LA, Carmella SG, Borukhova A, Akerkar SA, Gopalakrishnan R, Harris RE, Stoner GD, Hecht SS) Cancer Epidemiol Biomarkers Prev 1996 Jul;5(7):521-5 PMID 8827356
  • The effects of dietary ellagic acid on rat hepatic and esophageal mucosal cytochromes P450 and phase II enzymes. (Ahn D, Putt D, Kresty L, Stoner GD, Fromm D, Hollenberg PF) Carcinogenesis 1996 Apr;17(4):821-8 PMID 8625497
  • Inhibition of metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by dietary benzaldehydes. (Morse MA, Kresty LA, Toburen AL) Cancer Lett 1995 Nov 6;97(2):255-61 PMID 7497471
  • Enhancement of esophageal carcinogenesis in male F344 rats by dietary phenylhexyl isothiocyanate. (Stoner GD, Siglin JC, Morse MA, Desai DH, Amin SG, Kresty LA, Toburen AL, Heffner EM, Francis DJ) Carcinogenesis 1995 Oct;16(10):2473-6 PMID 7586154
  • Failure of dietary oltipraz to inhibit benzo[a]pyrene-induced lung tumorigenesis in strain a mice. (Morse MA, Zu H, Kresty LA, Stoner GD) Cancer Lett 1995 May 4;91(1):133-8 PMID 7750088
  • Effect of alkyl chain length on inhibition of N-nitrosomethylbenzylamine-induced esophageal tumorigenesis and DNA methylation by isothiocyanates. (Wilkinson JT, Morse MA, Kresty LA, Stoner GD) Carcinogenesis 1995 May;16(5):1011-5 PMID 7767958
  • Dietary nitrogen and lipid utilization by growing pigs fed structured triacylglycerides synthesized from medium-chain triacylglycerides and menhaden oil. (Lepine AJ, Garleb KA, Reinhart GA, Kresty LA) J Anim Sci 1994 Apr;72(4):938-45 PMID 8014160
  • Grants and Awards

  • Inhibition of Reflux-Induced Esophageal Adenocarcinoma by Proanthocyanidins (#9207854 04/30/2013 - 01/31/2017) PI of Inhibition of Reflux-Induced Esophageal Adenocarcinoma by Proanthocyanidins (#2207854)
  • Cancer Center Chemoprevention Program (#9520180 11/01/2010 - 10/31/2016) PI of AHW Chemoprevention Program Recruitment of Laura Kresty, PhD (#5520251)
  • Cancer Cell Biology Research Program (#9520213 11/01/2011 - 10/31/2016) PI of Cancer Center Biology (CCB) Co-Recruitment of Laura Kresty (#5520296)