Medical College of Wisconsin
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Li-Shu Wang PhD

Li-Shu Wang PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Hematology and Oncology
Program: Hematology

Member of the Cancer Center


Publications

  • A phase Ib study of the effects of black raspberries on rectal polyps in patients with familial adenomatous polyposis. (Wang LS, Burke CA, Hasson H, Kuo CT, Molmenti CL, Seguin C, Liu P, Huang TH, Frankel WL, Stoner GD) Cancer Prev Res (Phila) 2014 Jul;7(7):666-74 PMID: 24764585 04/26/2014
  • Chemoprevention of esophageal cancer with black raspberries, their component anthocyanins, and a major anthocyanin metabolite, protocatechuic acid. (Peiffer DS, Zimmerman NP, Wang LS, Ransom BW, Carmella SG, Kuo CT, Siddiqui J, Chen JH, Oshima K, Huang YW, Hecht SS, Stoner GD) Cancer Prev Res (Phila) 2014 Jun;7(6):574-84 PMID: 24667581 03/29/2014
  • Black raspberries protectively regulate methylation of Wnt pathway genes in precancerous colon tissue. (Wang LS, Kuo CT, Huang TH, Yearsley M, Oshima K, Stoner GD, Yu J, Lechner JF, Huang YW) Cancer Prev Res (Phila) 2013 Dec;6(12):1317-27 PMID: 24129635 PMCID: PMC3902171 10/17/2013
  • Dietary black raspberries modulate DNA methylation in dextran sodium sulfate (DSS)-induced ulcerative colitis. (Wang LS, Kuo CT, Stoner K, Yearsley M, Oshima K, Yu J, Huang TH, Rosenberg D, Peiffer D, Stoner G, Huang YW) Carcinogenesis 2013 Dec;34(12):2842-50 PMID: 24067901 PMCID: PMC3845896 09/27/2013
  • Black raspberry-derived anthocyanins demethylate tumor suppressor genes through the inhibition of DNMT1 and DNMT3B in colon cancer cells. (Wang LS, Kuo CT, Cho SJ, Seguin C, Siddiqui J, Stoner K, Weng YI, Huang TH, Tichelaar J, Yearsley M, Stoner GD, Huang YW) Nutr Cancer 2013;65(1):118-25 PMID: 23368921 PMCID: PMC3570951 02/02/2013
  • Plasma cytokines as potential response indicators to dietary freeze-dried black raspberries in colorectal cancer patients. (Mentor-Marcel RA, Bobe G, Sardo C, Wang LS, Kuo CT, Stoner G, Colburn NH) Nutr Cancer 2012 Aug;64(6):820-5 PMID: 22823889 PMCID: PMC3427773 07/25/2012
  • Chemoprevention of esophageal squamous cell carcinoma with berries. (Stoner GD, Wang LS) Top Curr Chem 2013;329:1-20 PMID: 22752584 07/04/2012
  • Hedgehog signaling activation in the development of squamous cell carcinoma and adenocarcinoma of esophagus. (Yang L, Wang LS, Chen XL, Gatalica Z, Qiu S, Liu Z, Stoner G, Zhang H, Weiss H, Xie J) Int J Biochem Mol Biol 2012;3(1):46-57 PMID: 22509480 PMCID: PMC3325770 04/18/2012
  • Gene-Diet Interactions on Colorectal Cancer Risk. (Wang LS, Kuo CT, Huang YW, Stoner GD, Lechner JF) Curr Nutr Rep 2012;1:132-141 PMID: 24392268 PMCID: PMC3873016 01/01/2012
  • Mechanistic basis for the chemopreventive effects of black raspberries at a late stage of rat esophageal carcinogenesis. (Wang LS, Dombkowski AA, Seguin C, Rocha C, Cukovic D, Mukundan A, Henry C, Stoner GD) Mol Carcinog 2011 Apr;50(4):291-300 PMID: 21465577 04/06/2011
  • Modulation of genetic and epigenetic biomarkers of colorectal cancer in humans by black raspberries: a phase I pilot study. (Wang LS, Arnold M, Huang YW, Sardo C, Seguin C, Martin E, Huang TH, Riedl K, Schwartz S, Frankel W, Pearl D, Xu Y, Winston J 3rd, Yang GY, Stoner G) Clin Cancer Res 2011 Feb 1;17(3):598-610 PMID: 21123457 PMCID: PMC3076314 12/03/2010
  • Anti-inflammatory effects of freeze-dried black raspberry powder in ulcerative colitis. (Montrose DC, Horelik NA, Madigan JP, Stoner GD, Wang LS, Bruno RS, Park HJ, Giardina C, Rosenberg DW) Carcinogenesis 2011 Mar;32(3):343-50 PMID: 21098643 PMCID: PMC3047236 11/26/2010
  • An overview of epigenetics and chemoprevention. (Huang YW, Kuo CT, Stoner K, Huang TH, Wang LS) FEBS Lett 2011 Jul 7;585(13):2129-36 PMID: 21056563 PMCID: PMC3071863 11/09/2010
  • Black raspberries inhibit intestinal tumorigenesis in apc1638+/- and Muc2-/- mouse models of colorectal cancer. (Bi X, Fang W, Wang LS, Stoner GD, Yang W) Cancer Prev Res (Phila) 2010 Nov;3(11):1443-50 PMID: 21045162 PMCID: PMC3019096 11/04/2010
  • Function and regulatory mechanisms of the candidate tumor suppressor receptor protein tyrosine phosphatase gamma (PTPRG) in breast cancer cells. (Shu ST, Sugimoto Y, Liu S, Chang HL, Ye W, Wang LS, Huang YW, Yan P, Lin YC) Anticancer Res 2010 Jun;30(6):1937-46 PMID: 20651337 07/24/2010
  • Induction of apoptosis by (-)-gossypol-enriched cottonseed oil in human breast cancer cells. (Ye W, Chang HL, Wang LS, Huang YW, Shu S, Sugimoto Y, Dowd MK, Wan PJ, Lin YC) Int J Mol Med 2010 Jul;26(1):113-9 PMID: 20514430 06/02/2010
  • Drinking water with red beetroot food color antagonizes esophageal carcinogenesis in N-nitrosomethylbenzylamine-treated rats. (Lechner JF, Wang LS, Rocha CM, Larue B, Henry C, McIntyre CM, Riedl KM, Schwartz SJ, Stoner GD) J Med Food 2010 Jun;13(3):733-9 PMID: 20438319 PMCID: PMC3133561 05/05/2010
  • Multiple berry types prevent N-nitrosomethylbenzylamine-induced esophageal cancer in rats. (Stoner GD, Wang LS, Seguin C, Rocha C, Stoner K, Chiu S, Kinghorn AD) Pharm Res 2010 Jun;27(6):1138-45 PMID: 20232121 PMCID: PMC3016717 03/17/2010
  • Profiling DNA methylomes from microarray to genome-scale sequencing. (Huang YW, Huang TH, Wang LS) Technol Cancer Res Treat 2010 Apr;9(2):139-47 PMID: 20218736 PMCID: PMC3011833 03/12/2010
  • Black raspberry components inhibit proliferation, induce apoptosis, and modulate gene expression in rat esophageal epithelial cells. (Zikri NN, Riedl KM, Wang LS, Lechner J, Schwartz SJ, Stoner GD) Nutr Cancer 2009;61(6):816-26 PMID: 20155622 PMCID: PMC3015087 02/16/2010
  • Berry ellagitannins may not be sufficient for prevention of tumors in the rodent esophagus. (Wang LS, Hecht S, Carmella S, Seguin C, Rocha C, Yu N, Stoner K, Chiu S, Stoner G) J Agric Food Chem 2010 Apr 14;58(7):3992-5 PMID: 20121200 PMCID: PMC3070955 02/04/2010
  • Keratinocyte growth factor (KGF) regulates estrogen receptor-alpha (ER-alpha) expression and cell apoptosis via phosphatidylinositol 3-kinase (PI3K)/Akt pathway in human breast cancer cells. (Chang HL, Sugimoto Y, Liu S, Wang LS, Huang YW, Ye W, Lin YC) Anticancer Res 2009 Aug;29(8):3195-205 PMID: 19661335 08/08/2009
  • (-)-Gossypol reduces invasiveness in metastatic prostate cancer cells. (Huang YW, Wang LS, Dowd MK, Wan PJ, Lin YC) Anticancer Res 2009 Jun;29(6):2179-88 PMID: 19528479 06/17/2009
  • Anthocyanins in black raspberries prevent esophageal tumors in rats. (Wang LS, Hecht SS, Carmella SG, Yu N, Larue B, Henry C, McIntyre C, Rocha C, Lechner JF, Stoner GD) Cancer Prev Res (Phila) 2009 Jan;2(1):84-93 PMID: 19139022 PMCID: PMC3079338 01/14/2009
  • Effects of a black raspberry diet on gene expression in the rat esophagus. (Lechner JF, Reen RK, Dombkowski AA, Cukovic D, Salagrama S, Wang LS, Stoner GD) Nutr Cancer 2008;60 Suppl 1:61-9 PMID: 19003582 11/15/2008
  • Carcinogen-altered genes in rat esophagus positively modulated to normal levels of expression by both black raspberries and phenylethyl isothiocyanate. (Stoner GD, Dombkowski AA, Reen RK, Cukovic D, Salagrama S, Wang LS, Lechner JF) Cancer Res 2008 Aug 1;68(15):6460-7 PMID: 18676871 PMCID: PMC3015106 08/05/2008
  • Conjugated linoleic acid induces apoptosis through estrogen receptor alpha in human breast tissue. (Wang LS, Huang YW, Liu S, Yan P, Lin YC) BMC Cancer 2008;8:208 PMID: 18652667 PMCID: PMC2517598 07/26/2008
  • Anthocyanins and their role in cancer prevention. (Wang LS, Stoner GD) Cancer Lett 2008 Oct 8;269(2):281-90 PMID: 18571839 PMCID: PMC2582525 06/24/2008
  • Laboratory and clinical studies of cancer chemoprevention by antioxidants in berries. (Stoner GD, Wang LS, Casto BC) Carcinogenesis 2008 Sep;29(9):1665-74 PMID: 18544560 PMCID: PMC3246882 06/12/2008
  • Cancer prevention with freeze-dried berries and berry components. (Stoner GD, Wang LS, Zikri N, Chen T, Hecht SS, Huang C, Sardo C, Lechner JF) Semin Cancer Biol 2007 Oct;17(5):403-10 PMID: 17574861 PMCID: PMC2196225 06/19/2007
  • Chemoprevention of esophageal squamous cell carcinoma. (Stoner GD, Wang LS, Chen T) Toxicol Appl Pharmacol 2007 Nov 1;224(3):337-49 PMID: 17475300 PMCID: PMC2128258 05/04/2007
  • Primary cultured human breast epithelial cells up-regulate protein disulfide isomerase in response to zeranol. (Updike MS, Sawdy JC, Wang LS, Liu S, Huang YW, Ye W, Farrar WB, Lin YC, Wick M) Anticancer Res 2007 Jan-Feb;27(1A):407-10 PMID: 17352260 03/14/2007
  • Modulation of multidrug resistance gene expression in human breast cancer cells by (-)-gossypol-enriched cottonseed oil. (Ye W, Chang HL, Wang LS, Huang YW, Shu S, Dowd MK, Wan PJ, Sugimoto Y, Lin YC) Anticancer Res 2007 Jan-Feb;27(1A):107-16 PMID: 17352222 03/14/2007
  • Effects of serum on (-)-gossypol-suppressed growth in human prostate cancer cells. (Huang YW, Wang LS, Chang HL, Ye W, Sugimoto Y, Dowd MK, Wan PJ, Lin YC) Anticancer Res 2006 Sep-Oct;26(5A):3613-20 PMID: 17094491 11/11/2006
  • Effect of keratinocyte growth factor on cell viability in primary cultured human prostate cancer stromal cells. (Huang YW, Wang LS, Chang HL, Ye W, Shu S, Sugimoto Y, Lin YC) J Steroid Biochem Mol Biol 2006 Jul;100(1-3):24-33 PMID: 16854582 07/21/2006
  • Keratinocyte growth factor (KGF) induces tamoxifen (Tam) resistance in human breast cancer MCF-7 cells. (Chang HL, Sugimoto Y, Liu S, Ye W, Wang LS, Huang YW, Lin YC) Anticancer Res 2006 May-Jun;26(3A):1773-84 PMID: 16827106 07/11/2006
  • Molecular mechanisms of (-)-gossypol-induced apoptosis in human prostate cancer cells. (Huang YW, Wang LS, Chang HL, Ye W, Dowd MK, Wan PJ, Lin YC) Anticancer Res 2006 May-Jun;26(3A):1925-33 PMID: 16827126 07/11/2006
  • Conjugated linoleic acid (CLA) modulates prostaglandin E2 (PGE2) signaling in canine mammary cells. (Wang LS, Huang YW, Liu S, Chang HL, Ye W, Shu S, Sugimoto Y, Funk JA, Smeaks DD, Hill LN, Lin YC) Anticancer Res 2006 Mar-Apr;26(2A):889-98 PMID: 16619484 04/20/2006
  • Conjugated linoleic acid (CLA) up-regulates the estrogen-regulated cancer suppressor gene, protein tyrosine phosphatase gamma (PTPgama), in human breast cells. (Wang LS, Huang YW, Sugimoto Y, Liu S, Chang HL, Ye W, Shu S, Lin YC) Anticancer Res 2006 Jan-Feb;26(1A):27-34 PMID: 16475675 02/16/2006
  • Effects of human breast stromal cells on conjugated linoleic acid (CLA) modulated vascular endothelial growth factor-A (VEGF-A) expression in MCF-7 cells. (Wang LS, Huang YW, Sugimoto Y, Liu S, Chang HL, Ye W, Shu S, Lin YC) Anticancer Res 2005 Nov-Dec;25(6B):4061-8 PMID: 16312046 11/30/2005
  • Decreased MCF-7 breast cancer cell proliferation by serum from a selected line of beef cattle. (Updike MS, Davis ME, Wang LS, Huang YW, Wick M, Lin YC) Anticancer Res 2005 Mar-Apr;25(2A):871-4 PMID: 15868921 05/05/2005
  • Last update: 07/27/2015