Medical College of Wisconsin
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Li-Shu Wang PhD

Li-Shu Wang PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Hematology and Oncology - Medicine
Program: Hematology

Member of the Cancer Center


Publications

  • An immunological perspective for preventing cancer with berries. (Pan P, Huang YW, Oshima K, Yearsley M, Zhang J, Yu J, Arnold M, Wang LS) J Berry Res 2018;8(3):163-175 PMID: 30159104 PMCID: PMC6110394 08/31/2018    
  • A Synthetic Disaccharide Derivative of Diphyllin, TAARD, Activates Human Natural Killer Cells to Secrete Interferon-Gamma Toll-Like Receptor-Mediated NF-κB and STAT3 Signaling Pathways. (Yi L, Chen L, Guo X, Lu T, Wang H, Ji X, Zhang J, Ren Y, Pan P, Kinghorn AD, Huang X, Wang LS, Fan Z, Caligiuri MA, Yu J) Front Immunol 2018;9:1509 PMID: 30072983 PMCID: PMC6058043 08/04/2018    
  • Inhibition of the development of N-nitrosomethylbenzylamine-induced esophageal tumors in rats by strawberries and aspirin, alone and in combination. (Pan P, Peiffer DS, Huang YW, Oshima K, Stoner GD, Wang LS) J Berry Res 2018;8(2):137-146 PMID: 29977412 PMCID: PMC6029707 07/07/2018    
  • miR-137 is a tumor suppressor in endometrial cancer and is repressed by DNA hypermethylation. (Zhang W, Chen JH, Shan T, Aguilera-Barrantes I, Wang LS, Huang TH, Rader JS, Sheng X, Huang YW) Lab Invest 2018 Nov;98(11):1397-1407 PMID: 29955087 PMCID: PMC6214735 06/30/2018       1 Citations
  • The natural product chitosan enhances the anti-tumor activity of natural killer cells by activating dendritic cells. (Li X, Dong W, Nalin AP, Wang Y, Pan P, Xu B, Zhang Y, Tun S, Zhang J, Wang LS, He X, Caligiuri MA, Yu J) Oncoimmunology 2018;7(6):e1431085 PMID: 29872557 PMCID: PMC5980345 06/07/2018    
  • Loss of FFAR2 promotes colon cancer by epigenetic dysregulation of inflammation suppressors. (Pan P, Oshima K, Huang YW, Agle KA, Drobyski WR, Chen X, Zhang J, Yearsley MM, Yu J, Wang LS) Int J Cancer 2018 08 15;143(4):886-896 PMID: 29524208 PMCID: PMC6041131 03/11/2018       2 Citations
  • Colon Cancer: What We Eat. (Pan P, Yu J, Wang LS) Surg Oncol Clin N Am 2018 04;27(2):243-267 PMID: 29496088 PMCID: PMC5836483 03/03/2018    
  • Berries and other natural products in the pancreatic cancer chemoprevention in human clinical trials. (Pan P, Skaer C, Yu J, Zhao H, Ren H, Oshima K, Wang LS) J Berry Res 2017;7(3):147-161 PMID: 29367867 PMCID: PMC5777607 01/26/2018    
  • Could Aspirin and Diets High in Fiber Act Synergistically to Reduce the Risk of Colon Cancer in Humans? (Pan P, Huang YW, Oshima K, Yearsley M, Zhang J, Yu J, Arnold M, Wang LS) Int J Mol Sci 2018 Jan 06;19(1) PMID: 29316620 PMCID: PMC5796115 01/11/2018       3 Citations
  • Black Raspberries Enhance Natural Killer Cell Infiltration into the Colon and Suppress the Progression of Colorectal Cancer. (Pan P, Kang S, Wang Y, Liu K, Oshima K, Huang YW, Zhang J, Yearsley M, Yu J, Wang LS) Front Immunol 2017;8:997 PMID: 28861089 PMCID: PMC5561013 09/02/2017    
  • Black Raspberries and Their Anthocyanin and Fiber Fractions Alter the Composition and Diversity of Gut Microbiota in F-344 Rats. (Pan P, Lam V, Salzman N, Huang YW, Yu J, Zhang J, Wang LS) Nutr Cancer 2017 Aug-Sep;69(6):943-951 PMID: 28718724 PMCID: PMC6139254 07/19/2017       11 Citations
  • Systemic Metabolite Changes in Wild-type C57BL/6 Mice Fed Black Raspberries. (Pan P, Skaer CW, Wang HT, Kreiser MA, Stirdivant SM, Oshima K, Huang YW, Young MR, Wang LS) Nutr Cancer 2017 Feb-Mar;69(2):299-306 PMID: 28094560 PMCID: PMC5644389 01/18/2017       10 Citations
  • Loss of free fatty acid receptor 2 enhances colonic adenoma development and reduces the chemopreventive effects of black raspberries in ApcMin/+ mice. (Pan P, W Skaer C, Wang HT, Oshima K, Huang YW, Yu J, Zhang J, M Yearsley M, A Agle K, R Drobyski W, Chen X, Wang LS) Carcinogenesis 2017 01;38(1):86-93 PMID: 27866157 PMCID: PMC5219051 11/21/2016       16 Citations
  • Black raspberries demethylate Sfrp4, a WNT pathway antagonist, in rat esophageal squamous cell papilloma. (Huang YW, Gu F, Dombkowski A, Wang LS, Stoner GD) Mol Carcinog 2016 Nov;55(11):1867-1875 PMID: 27696538 10/04/2016       5 Citations
  • Urolithin A suppresses the proliferation of endometrial cancer cells by mediating estrogen receptor-α-dependent gene expression. (Zhang W, Chen JH, Aguilera-Barrantes I, Shiau CW, Sheng X, Wang LS, Stoner GD, Huang YW) Mol Nutr Food Res 2016 11;60(11):2387-2395 PMID: 27342949 PMCID: PMC5144574 06/28/2016       9 Citations
  • Dietary Consumption of Black Raspberries or Their Anthocyanin Constituents Alters Innate Immune Cell Trafficking in Esophageal Cancer. (Peiffer DS, Wang LS, Zimmerman NP, Ransom BW, Carmella SG, Kuo CT, Chen JH, Oshima K, Huang YW, Hecht SS, Stoner GD) Cancer Immunol Res 2016 Jan;4(1):72-82 PMID: 26603620 11/26/2015       15 Citations
  • Black raspberries suppress colonic adenoma development in ApcMin/+ mice: relation to metabolite profiles. (Pan P, Skaer CW, Wang HT, Stirdivant SM, Young MR, Oshima K, Stoner GD, Lechner JF, Huang YW, Wang LS) Carcinogenesis 2015 Oct;36(10):1245-53 PMID: 26246425 PMCID: PMC4598815 08/08/2015       15 Citations
  • A phase Ib study of the effects of black raspberries on rectal polyps in patients with familial adenomatous polyposis. (Wang LS, Burke CA, Hasson H, Kuo CT, Molmenti CL, Seguin C, Liu P, Huang TH, Frankel WL, Stoner GD) Cancer Prev Res (Phila) 2014 Jul;7(7):666-74 PMID: 24764585 04/26/2014       38 Citations
  • Chemoprevention of esophageal cancer with black raspberries, their component anthocyanins, and a major anthocyanin metabolite, protocatechuic acid. (Peiffer DS, Zimmerman NP, Wang LS, Ransom BW, Carmella SG, Kuo CT, Siddiqui J, Chen JH, Oshima K, Huang YW, Hecht SS, Stoner GD) Cancer Prev Res (Phila) 2014 Jun;7(6):574-84 PMID: 24667581 PMCID: PMC6108893 03/29/2014       39 Citations
  • Black raspberries protectively regulate methylation of Wnt pathway genes in precancerous colon tissue. (Wang LS, Kuo CT, Huang TH, Yearsley M, Oshima K, Stoner GD, Yu J, Lechner JF, Huang YW) Cancer Prev Res (Phila) 2013 Dec;6(12):1317-27 PMID: 24129635 PMCID: PMC3902171 10/17/2013       20 Citations
  • Dietary black raspberries modulate DNA methylation in dextran sodium sulfate (DSS)-induced ulcerative colitis. (Wang LS, Kuo CT, Stoner K, Yearsley M, Oshima K, Yu J, Huang TH, Rosenberg D, Peiffer D, Stoner G, Huang YW) Carcinogenesis 2013 Dec;34(12):2842-50 PMID: 24067901 PMCID: PMC3845896 09/27/2013       21 Citations
  • Black raspberry-derived anthocyanins demethylate tumor suppressor genes through the inhibition of DNMT1 and DNMT3B in colon cancer cells. (Wang LS, Kuo CT, Cho SJ, Seguin C, Siddiqui J, Stoner K, Weng YI, Huang TH, Tichelaar J, Yearsley M, Stoner GD, Huang YW) Nutr Cancer 2013;65(1):118-25 PMID: 23368921 PMCID: PMC3570951 02/02/2013       61 Citations
  • Plasma cytokines as potential response indicators to dietary freeze-dried black raspberries in colorectal cancer patients. (Mentor-Marcel RA, Bobe G, Sardo C, Wang LS, Kuo CT, Stoner G, Colburn NH) Nutr Cancer 2012 Aug;64(6):820-5 PMID: 22823889 PMCID: PMC3427773 07/25/2012       20 Citations
  • Chemoprevention of esophageal squamous cell carcinoma with berries. (Stoner GD, Wang LS) Top Curr Chem 2013;329:1-20 PMID: 22752584 07/04/2012       21 Citations
  • Hedgehog signaling activation in the development of squamous cell carcinoma and adenocarcinoma of esophagus. (Yang L, Wang LS, Chen XL, Gatalica Z, Qiu S, Liu Z, Stoner G, Zhang H, Weiss H, Xie J) Int J Biochem Mol Biol 2012;3(1):46-57 PMID: 22509480 PMCID: PMC3325770 04/18/2012    
  • Gene-Diet Interactions on Colorectal Cancer Risk. (Wang LS, Kuo CT, Huang YW, Stoner GD, Lechner JF) Curr Nutr Rep 2012;1:132-141 PMID: 24392268 PMCID: PMC3873016 01/01/2012    
  • Mechanistic basis for the chemopreventive effects of black raspberries at a late stage of rat esophageal carcinogenesis. (Wang LS, Dombkowski AA, Seguin C, Rocha C, Cukovic D, Mukundan A, Henry C, Stoner GD) Mol Carcinog 2011 Apr;50(4):291-300 PMID: 21465577 04/06/2011       24 Citations
  • Modulation of genetic and epigenetic biomarkers of colorectal cancer in humans by black raspberries: a phase I pilot study. (Wang LS, Arnold M, Huang YW, Sardo C, Seguin C, Martin E, Huang TH, Riedl K, Schwartz S, Frankel W, Pearl D, Xu Y, Winston J 3rd, Yang GY, Stoner G) Clin Cancer Res 2011 Feb 01;17(3):598-610 PMID: 21123457 PMCID: PMC3076314 12/03/2010       86 Citations
  • Anti-inflammatory effects of freeze-dried black raspberry powder in ulcerative colitis. (Montrose DC, Horelik NA, Madigan JP, Stoner GD, Wang LS, Bruno RS, Park HJ, Giardina C, Rosenberg DW) Carcinogenesis 2011 Mar;32(3):343-50 PMID: 21098643 PMCID: PMC3047236 11/26/2010       74 Citations
  • An overview of epigenetics and chemoprevention. (Huang YW, Kuo CT, Stoner K, Huang TH, Wang LS) FEBS Lett 2011 Jul 07;585(13):2129-36 PMID: 21056563 PMCID: PMC3071863 11/09/2010       40 Citations
  • Black raspberries inhibit intestinal tumorigenesis in apc1638+/- and Muc2-/- mouse models of colorectal cancer. (Bi X, Fang W, Wang LS, Stoner GD, Yang W) Cancer Prev Res (Phila) 2010 Nov;3(11):1443-50 PMID: 21045162 PMCID: PMC3019096 11/04/2010       36 Citations
  • Function and regulatory mechanisms of the candidate tumor suppressor receptor protein tyrosine phosphatase gamma (PTPRG) in breast cancer cells. (Shu ST, Sugimoto Y, Liu S, Chang HL, Ye W, Wang LS, Huang YW, Yan P, Lin YC) Anticancer Res 2010 Jun;30(6):1937-46 PMID: 20651337 07/24/2010       17 Citations
  • Induction of apoptosis by (-)-gossypol-enriched cottonseed oil in human breast cancer cells. (Ye W, Chang HL, Wang LS, Huang YW, Shu S, Sugimoto Y, Dowd MK, Wan PJ, Lin YC) Int J Mol Med 2010 Jul;26(1):113-9 PMID: 20514430 06/02/2010       12 Citations
  • Drinking water with red beetroot food color antagonizes esophageal carcinogenesis in N-nitrosomethylbenzylamine-treated rats. (Lechner JF, Wang LS, Rocha CM, Larue B, Henry C, McIntyre CM, Riedl KM, Schwartz SJ, Stoner GD) J Med Food 2010 Jun;13(3):733-9 PMID: 20438319 PMCID: PMC3133561 05/05/2010       33 Citations
  • Multiple berry types prevent N-nitrosomethylbenzylamine-induced esophageal cancer in rats. (Stoner GD, Wang LS, Seguin C, Rocha C, Stoner K, Chiu S, Kinghorn AD) Pharm Res 2010 Jun;27(6):1138-45 PMID: 20232121 PMCID: PMC3016717 03/17/2010       79 Citations
  • Profiling DNA methylomes from microarray to genome-scale sequencing. (Huang YW, Huang TH, Wang LS) Technol Cancer Res Treat 2010 Apr;9(2):139-47 PMID: 20218736 PMCID: PMC3011833 03/12/2010       38 Citations
  • Black raspberry components inhibit proliferation, induce apoptosis, and modulate gene expression in rat esophageal epithelial cells. (Zikri NN, Riedl KM, Wang LS, Lechner J, Schwartz SJ, Stoner GD) Nutr Cancer 2009;61(6):816-26 PMID: 20155622 PMCID: PMC3015087 02/16/2010       52 Citations
  • Berry ellagitannins may not be sufficient for prevention of tumors in the rodent esophagus. (Wang LS, Hecht S, Carmella S, Seguin C, Rocha C, Yu N, Stoner K, Chiu S, Stoner G) J Agric Food Chem 2010 Apr 14;58(7):3992-5 PMID: 20121200 PMCID: PMC3070955 02/04/2010       19 Citations
  • Keratinocyte growth factor (KGF) regulates estrogen receptor-alpha (ER-alpha) expression and cell apoptosis via phosphatidylinositol 3-kinase (PI3K)/Akt pathway in human breast cancer cells. (Chang HL, Sugimoto Y, Liu S, Wang LS, Huang YW, Ye W, Lin YC) Anticancer Res 2009 Aug;29(8):3195-205 PMID: 19661335 08/08/2009       13 Citations
  • (-)-Gossypol reduces invasiveness in metastatic prostate cancer cells. (Huang YW, Wang LS, Dowd MK, Wan PJ, Lin YC) Anticancer Res 2009 Jun;29(6):2179-88 PMID: 19528479 06/17/2009       18 Citations
  • Anthocyanins in black raspberries prevent esophageal tumors in rats. (Wang LS, Hecht SS, Carmella SG, Yu N, Larue B, Henry C, McIntyre C, Rocha C, Lechner JF, Stoner GD) Cancer Prev Res (Phila) 2009 Jan;2(1):84-93 PMID: 19139022 PMCID: PMC3079338 01/14/2009       113 Citations
  • Effects of a black raspberry diet on gene expression in the rat esophagus. (Lechner JF, Reen RK, Dombkowski AA, Cukovic D, Salagrama S, Wang LS, Stoner GD) Nutr Cancer 2008;60 Suppl 1:61-9 PMID: 19003582 11/15/2008       20 Citations
  • Carcinogen-altered genes in rat esophagus positively modulated to normal levels of expression by both black raspberries and phenylethyl isothiocyanate. (Stoner GD, Dombkowski AA, Reen RK, Cukovic D, Salagrama S, Wang LS, Lechner JF) Cancer Res 2008 Aug 01;68(15):6460-7 PMID: 18676871 PMCID: PMC3015106 08/05/2008       42 Citations
  • Conjugated linoleic acid induces apoptosis through estrogen receptor alpha in human breast tissue. (Wang LS, Huang YW, Liu S, Yan P, Lin YC) BMC Cancer 2008 Jul 24;8:208 PMID: 18652667 PMCID: PMC2517598 07/26/2008       29 Citations
  • Anthocyanins and their role in cancer prevention. (Wang LS, Stoner GD) Cancer Lett 2008 Oct 08;269(2):281-90 PMID: 18571839 PMCID: PMC2582525 06/24/2008       522 Citations
  • Laboratory and clinical studies of cancer chemoprevention by antioxidants in berries. (Stoner GD, Wang LS, Casto BC) Carcinogenesis 2008 Sep;29(9):1665-74 PMID: 18544560 PMCID: PMC3246882 06/12/2008       129 Citations
  • Cancer prevention with freeze-dried berries and berry components. (Stoner GD, Wang LS, Zikri N, Chen T, Hecht SS, Huang C, Sardo C, Lechner JF) Semin Cancer Biol 2007 Oct;17(5):403-10 PMID: 17574861 PMCID: PMC2196225 06/19/2007       121 Citations
  • Chemoprevention of esophageal squamous cell carcinoma. (Stoner GD, Wang LS, Chen T) Toxicol Appl Pharmacol 2007 Nov 01;224(3):337-49 PMID: 17475300 PMCID: PMC2128258 05/04/2007       62 Citations
  • Primary cultured human breast epithelial cells up-regulate protein disulfide isomerase in response to zeranol. (Updike MS, Sawdy JC, Wang LS, Liu S, Huang YW, Ye W, Farrar WB, Lin YC, Wick M) Anticancer Res 2007 Jan-Feb;27(1A):407-10 PMID: 17352260 03/14/2007       15 Citations
  • Modulation of multidrug resistance gene expression in human breast cancer cells by (-)-gossypol-enriched cottonseed oil. (Ye W, Chang HL, Wang LS, Huang YW, Shu S, Dowd MK, Wan PJ, Sugimoto Y, Lin YC) Anticancer Res 2007 Jan-Feb;27(1A):107-16 PMID: 17352222 03/14/2007       26 Citations
  • Effects of serum on (-)-gossypol-suppressed growth in human prostate cancer cells. (Huang YW, Wang LS, Chang HL, Ye W, Sugimoto Y, Dowd MK, Wan PJ, Lin YC) Anticancer Res 2006 Sep-Oct;26(5A):3613-20 PMID: 17094491 11/11/2006       20 Citations
  • Effect of keratinocyte growth factor on cell viability in primary cultured human prostate cancer stromal cells. (Huang YW, Wang LS, Chang HL, Ye W, Shu S, Sugimoto Y, Lin YC) J Steroid Biochem Mol Biol 2006 Jul;100(1-3):24-33 PMID: 16854582 07/21/2006       16 Citations
  • Keratinocyte growth factor (KGF) induces tamoxifen (Tam) resistance in human breast cancer MCF-7 cells. (Chang HL, Sugimoto Y, Liu S, Ye W, Wang LS, Huang YW, Lin YC) Anticancer Res 2006 May-Jun;26(3A):1773-84 PMID: 16827106 07/11/2006       18 Citations
  • Molecular mechanisms of (-)-gossypol-induced apoptosis in human prostate cancer cells. (Huang YW, Wang LS, Chang HL, Ye W, Dowd MK, Wan PJ, Lin YC) Anticancer Res 2006 May-Jun;26(3A):1925-33 PMID: 16827126 07/11/2006       44 Citations
  • Conjugated linoleic acid (CLA) modulates prostaglandin E2 (PGE2) signaling in canine mammary cells. (Wang LS, Huang YW, Liu S, Chang HL, Ye W, Shu S, Sugimoto Y, Funk JA, Smeaks DD, Hill LN, Lin YC) Anticancer Res 2006 Mar-Apr;26(2A):889-98 PMID: 16619484 04/20/2006       17 Citations
  • Conjugated linoleic acid (CLA) up-regulates the estrogen-regulated cancer suppressor gene, protein tyrosine phosphatase gamma (PTPgama), in human breast cells. (Wang LS, Huang YW, Sugimoto Y, Liu S, Chang HL, Ye W, Shu S, Lin YC) Anticancer Res 2006 Jan-Feb;26(1A):27-34 PMID: 16475675 02/16/2006       17 Citations
  • Effects of human breast stromal cells on conjugated linoleic acid (CLA) modulated vascular endothelial growth factor-A (VEGF-A) expression in MCF-7 cells. (Wang LS, Huang YW, Sugimoto Y, Liu S, Chang HL, Ye W, Shu S, Lin YC) Anticancer Res 2005 Nov-Dec;25(6B):4061-8 PMID: 16312046 11/30/2005       13 Citations
  • Decreased MCF-7 breast cancer cell proliferation by serum from a selected line of beef cattle. (Updike MS, Davis ME, Wang LS, Huang YW, Wick M, Lin YC) Anticancer Res 2005 Mar-Apr;25(2A):871-4 PMID: 15868921 05/05/2005       1 Citations
  • Last update: 12/07/2018
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