Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Li-Shu Wang PhD

Li-Shu Wang PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Hematology and Oncology
Program: Hematology


Publications

  • Black raspberries protectively regulate methylation of Wnt pathway genes in precancerous colon tissue. (Wang LS, Kuo CT, Huang TH, Yearsley M, Oshima K, Stoner GD, Yu J, Lechner JF, Huang YW) Cancer Prev Res (Phila) 2013 Dec;6(12):1317-27 PMID 24129635
  • Dietary black raspberries modulate DNA methylation in dextran sodium sulfate (DSS)-induced ulcerative colitis. (Wang LS, Kuo CT, Stoner K, Yearsley M, Oshima K, Yu J, Huang TH, Rosenberg D, Peiffer D, Stoner G, Huang YW) Carcinogenesis 2013 Dec;34(12):2842-50 PMID 24067901
  • Black raspberry-derived anthocyanins demethylate tumor suppressor genes through the inhibition of DNMT1 and DNMT3B in colon cancer cells. (Wang LS, Kuo CT, Cho SJ, Seguin C, Siddiqui J, Stoner K, Weng YI, Huang TH, Tichelaar J, Yearsley M, Stoner GD, Huang YW) Nutr Cancer 2013;65(1):118-25 PMID 23368921
  • Plasma cytokines as potential response indicators to dietary freeze-dried black raspberries in colorectal cancer patients. (Mentor-Marcel RA, Bobe G, Sardo C, Wang LS, Kuo CT, Stoner G, Colburn NH) Nutr Cancer 2012 Aug;64(6):820-5 PMID 22823889
  • Chemoprevention of esophageal squamous cell carcinoma with berries. (Stoner GD, Wang LS) Top Curr Chem 2013;329:1-20 PMID 22752584
  • Hedgehog signaling activation in the development of squamous cell carcinoma and adenocarcinoma of esophagus. (Yang L, Wang LS, Chen XL, Gatalica Z, Qiu S, Liu Z, Stoner G, Zhang H, Weiss H, Xie J) Int J Biochem Mol Biol 2012;3(1):46-57 PMID 22509480
  • Gene-Diet Interactions on Colorectal Cancer Risk. (Wang LS, Kuo CT, Huang YW, Stoner GD, Lechner JF) Curr Nutr Rep 2012;1:132-141 PMID 24392268
  • Mechanistic basis for the chemopreventive effects of black raspberries at a late stage of rat esophageal carcinogenesis. (Wang LS, Dombkowski AA, Seguin C, Rocha C, Cukovic D, Mukundan A, Henry C, Stoner GD) Mol Carcinog 2011 Apr;50(4):291-300 PMID 21465577
  • Modulation of genetic and epigenetic biomarkers of colorectal cancer in humans by black raspberries: a phase I pilot study. (Wang LS, Arnold M, Huang YW, Sardo C, Seguin C, Martin E, Huang TH, Riedl K, Schwartz S, Frankel W, Pearl D, Xu Y, Winston J 3rd, Yang GY, Stoner G) Clin Cancer Res 2011 Feb 1;17(3):598-610 PMID 21123457
  • Anti-inflammatory effects of freeze-dried black raspberry powder in ulcerative colitis. (Montrose DC, Horelik NA, Madigan JP, Stoner GD, Wang LS, Bruno RS, Park HJ, Giardina C, Rosenberg DW) Carcinogenesis 2011 Mar;32(3):343-50 PMID 21098643
  • An overview of epigenetics and chemoprevention. (Huang YW, Kuo CT, Stoner K, Huang TH, Wang LS) FEBS Lett 2011 Jul 7;585(13):2129-36 PMID 21056563
  • Black raspberries inhibit intestinal tumorigenesis in apc1638+/- and Muc2-/- mouse models of colorectal cancer. (Bi X, Fang W, Wang LS, Stoner GD, Yang W) Cancer Prev Res (Phila) 2010 Nov;3(11):1443-50 PMID 21045162
  • Function and regulatory mechanisms of the candidate tumor suppressor receptor protein tyrosine phosphatase gamma (PTPRG) in breast cancer cells. (Shu ST, Sugimoto Y, Liu S, Chang HL, Ye W, Wang LS, Huang YW, Yan P, Lin YC) Anticancer Res 2010 Jun;30(6):1937-46 PMID 20651337
  • Induction of apoptosis by (-)-gossypol-enriched cottonseed oil in human breast cancer cells. (Ye W, Chang HL, Wang LS, Huang YW, Shu S, Sugimoto Y, Dowd MK, Wan PJ, Lin YC) Int J Mol Med 2010 Jul;26(1):113-9 PMID 20514430
  • Drinking water with red beetroot food color antagonizes esophageal carcinogenesis in N-nitrosomethylbenzylamine-treated rats. (Lechner JF, Wang LS, Rocha CM, Larue B, Henry C, McIntyre CM, Riedl KM, Schwartz SJ, Stoner GD) J Med Food 2010 Jun;13(3):733-9 PMID 20438319
  • Multiple berry types prevent N-nitrosomethylbenzylamine-induced esophageal cancer in rats. (Stoner GD, Wang LS, Seguin C, Rocha C, Stoner K, Chiu S, Kinghorn AD) Pharm Res 2010 Jun;27(6):1138-45 PMID 20232121
  • Profiling DNA methylomes from microarray to genome-scale sequencing. (Huang YW, Huang TH, Wang LS) Technol Cancer Res Treat 2010 Apr;9(2):139-47 PMID 20218736
  • Black raspberry components inhibit proliferation, induce apoptosis, and modulate gene expression in rat esophageal epithelial cells. (Zikri NN, Riedl KM, Wang LS, Lechner J, Schwartz SJ, Stoner GD) Nutr Cancer 2009;61(6):816-26 PMID 20155622
  • Berry ellagitannins may not be sufficient for prevention of tumors in the rodent esophagus. (Wang LS, Hecht S, Carmella S, Seguin C, Rocha C, Yu N, Stoner K, Chiu S, Stoner G) J Agric Food Chem 2010 Apr 14;58(7):3992-5 PMID 20121200
  • Keratinocyte growth factor (KGF) regulates estrogen receptor-alpha (ER-alpha) expression and cell apoptosis via phosphatidylinositol 3-kinase (PI3K)/Akt pathway in human breast cancer cells. (Chang HL, Sugimoto Y, Liu S, Wang LS, Huang YW, Ye W, Lin YC) Anticancer Res 2009 Aug;29(8):3195-205 PMID 19661335
  • (-)-Gossypol reduces invasiveness in metastatic prostate cancer cells. (Huang YW, Wang LS, Dowd MK, Wan PJ, Lin YC) Anticancer Res 2009 Jun;29(6):2179-88 PMID 19528479
  • Anthocyanins in black raspberries prevent esophageal tumors in rats. (Wang LS, Hecht SS, Carmella SG, Yu N, Larue B, Henry C, McIntyre C, Rocha C, Lechner JF, Stoner GD) Cancer Prev Res (Phila) 2009 Jan;2(1):84-93 PMID 19139022
  • Effects of a black raspberry diet on gene expression in the rat esophagus. (Lechner JF, Reen RK, Dombkowski AA, Cukovic D, Salagrama S, Wang LS, Stoner GD) Nutr Cancer 2008;60 Suppl 1:61-9 PMID 19003582
  • Carcinogen-altered genes in rat esophagus positively modulated to normal levels of expression by both black raspberries and phenylethyl isothiocyanate. (Stoner GD, Dombkowski AA, Reen RK, Cukovic D, Salagrama S, Wang LS, Lechner JF) Cancer Res 2008 Aug 1;68(15):6460-7 PMID 18676871
  • Conjugated linoleic acid induces apoptosis through estrogen receptor alpha in human breast tissue. (Wang LS, Huang YW, Liu S, Yan P, Lin YC) BMC Cancer 2008;8:208 PMID 18652667
  • Anthocyanins and their role in cancer prevention. (Wang LS, Stoner GD) Cancer Lett 2008 Oct 8;269(2):281-90 PMID 18571839
  • Laboratory and clinical studies of cancer chemoprevention by antioxidants in berries. (Stoner GD, Wang LS, Casto BC) Carcinogenesis 2008 Sep;29(9):1665-74 PMID 18544560
  • Cancer prevention with freeze-dried berries and berry components. (Stoner GD, Wang LS, Zikri N, Chen T, Hecht SS, Huang C, Sardo C, Lechner JF) Semin Cancer Biol 2007 Oct;17(5):403-10 PMID 17574861
  • Chemoprevention of esophageal squamous cell carcinoma. (Stoner GD, Wang LS, Chen T) Toxicol Appl Pharmacol 2007 Nov 1;224(3):337-49 PMID 17475300
  • Modulation of multidrug resistance gene expression in human breast cancer cells by (-)-gossypol-enriched cottonseed oil. (Ye W, Chang HL, Wang LS, Huang YW, Shu S, Dowd MK, Wan PJ, Sugimoto Y, Lin YC) Anticancer Res 2007 Jan-Feb;27(1A):107-16 PMID 17352222
  • Primary cultured human breast epithelial cells up-regulate protein disulfide isomerase in response to zeranol. (Updike MS, Sawdy JC, Wang LS, Liu S, Huang YW, Ye W, Farrar WB, Lin YC, Wick M) Anticancer Res 2007 Jan-Feb;27(1A):407-10 PMID 17352260
  • Effects of serum on (-)-gossypol-suppressed growth in human prostate cancer cells. (Huang YW, Wang LS, Chang HL, Ye W, Sugimoto Y, Dowd MK, Wan PJ, Lin YC) Anticancer Res 2006 Sep-Oct;26(5A):3613-20 PMID 17094491
  • Effect of keratinocyte growth factor on cell viability in primary cultured human prostate cancer stromal cells. (Huang YW, Wang LS, Chang HL, Ye W, Shu S, Sugimoto Y, Lin YC) J Steroid Biochem Mol Biol 2006 Jul;100(1-3):24-33 PMID 16854582
  • Keratinocyte growth factor (KGF) induces tamoxifen (Tam) resistance in human breast cancer MCF-7 cells. (Chang HL, Sugimoto Y, Liu S, Ye W, Wang LS, Huang YW, Lin YC) Anticancer Res 2006 May-Jun;26(3A):1773-84 PMID 16827106
  • Molecular mechanisms of (-)-gossypol-induced apoptosis in human prostate cancer cells. (Huang YW, Wang LS, Chang HL, Ye W, Dowd MK, Wan PJ, Lin YC) Anticancer Res 2006 May-Jun;26(3A):1925-33 PMID 16827126
  • Conjugated linoleic acid (CLA) modulates prostaglandin E2 (PGE2) signaling in canine mammary cells. (Wang LS, Huang YW, Liu S, Chang HL, Ye W, Shu S, Sugimoto Y, Funk JA, Smeaks DD, Hill LN, Lin YC) Anticancer Res 2006 Mar-Apr;26(2A):889-98 PMID 16619484
  • Conjugated linoleic acid (CLA) up-regulates the estrogen-regulated cancer suppressor gene, protein tyrosine phosphatase gamma (PTPgama), in human breast cells. (Wang LS, Huang YW, Sugimoto Y, Liu S, Chang HL, Ye W, Shu S, Lin YC) Anticancer Res 2006 Jan-Feb;26(1A):27-34 PMID 16475675
  • Effects of human breast stromal cells on conjugated linoleic acid (CLA) modulated vascular endothelial growth factor-A (VEGF-A) expression in MCF-7 cells. (Wang LS, Huang YW, Sugimoto Y, Liu S, Chang HL, Ye W, Shu S, Lin YC) Anticancer Res 2005 Nov-Dec;25(6B):4061-8 PMID 16312046
  • Decreased MCF-7 breast cancer cell proliferation by serum from a selected line of beef cattle. (Updike MS, Davis ME, Wang LS, Huang YW, Wick M, Lin YC) Anticancer Res 2005 Mar-Apr;25(2A):871-4 PMID 15868921
  • Grants and Awards

  • Prevention of Ulcerative Colitis, a Colorectal Cancer Precursor, by Berries (#9208153 07/01/2013 - 06/30/2017) Sponsor: American Cancer Society National
  • Mechanisms of Tumor Suppressor Gene Reactivation in Colon Cancer by Berries (#9207105 07/01/2011 - 01/31/2015) Sponsor: NIH Cancer Institute
  • Cancer Center Chemoprevention Program (#9520180 11/01/2010 - 10/31/2016) PI of AHW Chemoprevention Program Recruitment of Li-Shu Wang (#5520192)