Medical College of Wisconsin
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Liang Wang MD, PhD

Liang Wang MD, PhD

Professor

Institution: Medical College of Wisconsin
Department: Pathology
Division: Administration

Member of the Cancer Center
Member of the Cardiovascular Center


Research Experience

  • Biomarkers
  • Biomarkers, Tumor
  • Carcinoma, Non-Small-Cell Lung
  • Case-Control Studies
  • Colorectal Neoplasms
  • CpG Islands
  • DNA Copy Number Variations
  • DNA Methylation
  • Enhancer Elements, Genetic
  • Epigenesis, Genetic
  • Exosomes
  • Gene Expression Regulation, Neoplastic
  • Genetic Heterogeneity
  • Genetic Loci
  • Genetic Markers
  • Genetic Predisposition to Disease
  • Genetic Techniques
  • Genetic Variation
  • Genetics
  • Genetics, Population
  • Genome-Wide Association Study
  • Genomics
  • Genotype
  • Germ-Line Mutation
  • High-Throughput Nucleotide Sequencing
  • Lung Neoplasms
  • MicroRNAs
  • Mitochondria
  • Mutation
  • Nutrigenomics
  • Pancreatic Neoplasms
  • Penetrance
  • Physical Chromosome Mapping
  • Polymorphism, Genetic
  • Polymorphism, Single Nucleotide
  • Prostate
  • Prostatic Neoplasms
  • Quantitative Trait, Heritable
  • RNA
  • Regulatory Sequences, Nucleic Acid
  • Risk Factors
  • Sequence Analysis, DNA
  • genetics
  • Methodologies and Techniques

  • Biomarkers
  • Biomarkers, Tumor
  • Carcinoma, Non-Small-Cell Lung
  • Colorectal Neoplasms
  • CpG Islands
  • Cytogenetics
  • DNA Copy Number Variations
  • DNA Methylation
  • DNA Mutational Analysis
  • Databases, Nucleic Acid
  • Effect Modifier, Epidemiologic
  • Enhancer Elements, Genetic
  • Epidemiology
  • Epigenesis, Genetic
  • Exosomes
  • Gene Duplication
  • Gene Expression Regulation, Neoplastic
  • Genetic Association Studies
  • Genetic Heterogeneity
  • Genetic Linkage
  • Genetic Loci
  • Genetic Predisposition to Disease
  • Genetic Techniques
  • Genetic Testing
  • Genetic Variation
  • Genetics
  • Genetics, Population
  • Genome-Wide Association Study
  • Genotype
  • Germ-Line Mutation
  • High-Throughput Nucleotide Sequencing
  • Lung Neoplasms
  • MicroRNAs
  • Microarray Analysis
  • Mitochondria
  • Molecular Epidemiology
  • Molecular Sequence Data
  • Mutation
  • Mutation, Missense
  • Nutrigenomics
  • Penetrance
  • Physical Chromosome Mapping
  • Plasma
  • Polymorphism, Genetic
  • Polymorphism, Single Nucleotide
  • Promoter Regions, Genetic
  • Prostatic Neoplasms
  • Quantitative Trait, Heritable
  • RNA
  • RNA, Complementary
  • Regulatory Sequences, Nucleic Acid
  • Risk Assessment
  • Risk Factors
  • Sequence Analysis, DNA
  • Sequence Analysis, RNA
  • Systems Biology
  • genetics
  • Publications

  • Role of exosomal small RNA in prostate cancer metastasis. (Zhan F, Shen J, Wang R, Wang L, Dai Y, Zhang Y, Huang X) Cancer Manag Res 2018;10:4029-4038 PMID: 30319287 PMCID: PMC6167994 10/16/2018    
  • Synergistic Interaction of and Predisposes to Aggressive Prostate Cancer. (Sipeky C, Gao P, Zhang Q, Wang L, Ettala O, Talala KM, Tammela TLJ, Auvinen A, Wiklund F, Wei GH, Schleutker J) Clin Cancer Res 2018 Dec 15;24(24):6265-6276 PMID: 30181389 09/06/2018       1 Citations
  • Biology and Clinical Implications of the 19q13 Aggressive Prostate Cancer Susceptibility Locus. (Gao P, Xia JH, Sipeky C, Dong XM, Zhang Q, Yang Y, Zhang P, Cruz SP, Zhang K, Zhu J, Lee HM, Suleman S, Giannareas N, Liu S, PRACTICAL Consortium, Tammela TLJ, Auvinen A, Wang X, Huang Q, Wang L, Manninen A, Vaarala MH, Wang L, Schleutker J, Wei GH) Cell 2018 Jul 26;174(3):576-589.e18 PMID: 30033361 PMCID: PMC6091222 07/24/2018    
  • Cell-Free eccDNAs: A New Type of Nucleic Acid Component for Liquid Biopsy? (Zhu J, Chen S, Zhang F, Wang L) Mol Diagn Ther 2018 10;22(5):515-522 PMID: 29959693 07/01/2018    
  • Liquid biopsy approach in the management of prostate cancer. (Riaz IB, Wang L, Kohli M) Transl Res 2018 11;201:60-70 PMID: 29936077 06/25/2018    
  • Prognostic association of plasma cell-free DNA-based androgen receptor amplification and circulating tumor cells in pre-chemotherapy metastatic castration-resistant prostate cancer patients. (Kohli M, Li J, Du M, Hillman DW, Dehm SM, Tan W, Carlson R, Campion MB, Wang L, Wang L, Zhang H, Zhang P, Kilari D, Huang CC, Wang L) Prostate Cancer Prostatic Dis 2018 09;21(3):411-418 PMID: 29858592 PMCID: PMC6126974 06/03/2018       1 Citations
  • High-throughput screening of prostate cancer risk loci by single nucleotide polymorphisms sequencing. (Zhang P, Xia JH, Zhu J, Gao P, Tian YJ, Du M, Guo YC, Suleman S, Zhang Q, Kohli M, Tillmans LS, Thibodeau SN, French AJ, Cerhan JR, Wang LD, Wei GH, Wang L) Nat Commun 2018 05 22;9(1):2022 PMID: 29789573 PMCID: PMC5964124 05/24/2018       3 Citations
  • Genomic alterations of plasma cell-free DNAs in small cell lung cancer and their clinical relevance. (Du M, Thompson J, Fisher H, Zhang P, Huang CC, Wang L) Lung Cancer 2018 Jun;120:113-121 PMID: 29748005 05/12/2018    
  • Loss of ZG16 is associated with molecular and clinicopathological phenotypes of colorectal cancer. (Meng H, Li W, Boardman LA, Wang L) BMC Cancer 2018 04 16;18(1):433 PMID: 29661177 PMCID: PMC5902988 04/18/2018    
  • Network-directed cis-mediator analysis of normal prostate tissue expression profiles reveals downstream regulatory associations of prostate cancer susceptibility loci. (Larson NB, McDonnell SK, Fogarty Z, Larson MC, Cheville J, Riska S, Baheti S, Weber AM, Nair AA, Wang L, O'Brien D, Davila J, Schaid DJ, Thibodeau SN) Oncotarget 2017 Oct 17;8(49):85896-85908 PMID: 29156765 PMCID: PMC5689655 11/22/2017    
  • Plasma exosomal miRNAs-based prognosis in metastatic kidney cancer. (Du M, Giridhar KV, Tian Y, Tschannen MR, Zhu J, Huang CC, Kilari D, Kohli M, Wang L) Oncotarget 2017 Sep 08;8(38):63703-63714 PMID: 28969022 PMCID: PMC5609954 10/04/2017    
  • Molecular characterization of cell-free eccDNAs in human plasma. (Zhu J, Zhang F, Du M, Zhang P, Fu S, Wang L) Sci Rep 2017 Sep 08;7(1):10968 PMID: 28887493 PMCID: PMC5591271 09/10/2017    
  • Circulating exosomal miR-125a-3p as a novel biomarker for early-stage colon cancer. (Wang J, Yan F, Zhao Q, Zhan F, Wang R, Wang L, Zhang Y, Huang X) Sci Rep 2017 06 23;7(1):4150 PMID: 28646161 PMCID: PMC5482839 06/25/2017       16 Citations
  • Cell-free DNA copy number variations in plasma from colorectal cancer patients. (Li J, Dittmar RL, Xia S, Zhang H, Du M, Huang CC, Druliner BR, Boardman L, Wang L) Mol Oncol 2017 08;11(8):1099-1111 PMID: 28504856 PMCID: PMC5537711 05/16/2017       10 Citations
  • 3C-digital PCR for quantification of chromatin interactions. (Du M, Wang L) BMC Mol Biol 2016 12 06;17(1):23 PMID: 27923366 PMCID: PMC5139078 12/08/2016    
  • miR-375 induces docetaxel resistance in prostate cancer by targeting SEC23A and YAP1. (Wang Y, Lieberman R, Pan J, Zhang Q, Du M, Zhang P, Nevalainen M, Kohli M, Shenoy NK, Meng H, You M, Wang L) Mol Cancer 2016 11 10;15(1):70 PMID: 27832783 PMCID: PMC5105253 11/12/2016       20 Citations
  • Applications of Extracellular RNAs in Oncology. (Thompson JR, Zhu J, Kilari D, Wang L) Mol Diagn Ther 2017 02;21(1):1-11 PMID: 27688207 10/01/2016       1 Citations
  • GPC5, a novel epigenetically silenced tumor suppressor, inhibits tumor growth by suppressing Wnt/β-catenin signaling in lung adenocarcinoma. (Yuan S, Yu Z, Liu Q, Zhang M, Xiang Y, Wu N, Wu L, Hu Z, Xu B, Cai T, Ma X, Zhang Y, Liao C, Wang L, Yang P, Bai L, Li Y) Oncogene 2016 11 24;35(47):6120-6131 PMID: 27157618 05/10/2016       16 Citations
  • Copy number variations in urine cell free DNA as biomarkers in advanced prostate cancer. (Xia Y, Huang CC, Dittmar R, Du M, Wang Y, Liu H, Shenoy N, Wang L, Kohli M) Oncotarget 2016 Jun 14;7(24):35818-35831 PMID: 27127882 PMCID: PMC5094965 04/30/2016       15 Citations
  • Chromatin interactions and candidate genes at ten prostate cancer risk loci. (Du M, Tillmans L, Gao J, Gao P, Yuan T, Dittmar RL, Song W, Yang Y, Sahr N, Wang T, Wei GH, Thibodeau SN, Wang L) Sci Rep 2016 Mar 16;6:23202 PMID: 26979803 PMCID: PMC4793270 03/17/2016       9 Citations
  • Plasma extracellular RNA profiles in healthy and cancer patients. (Yuan T, Huang X, Woodcock M, Du M, Dittmar R, Wang Y, Tsai S, Kohli M, Boardman L, Patel T, Wang L) Sci Rep 2016 Jan 20;6:19413 PMID: 26786760 PMCID: PMC4726401 01/21/2016       46 Citations
  • Identification of candidate genes for prostate cancer-risk SNPs utilizing a normal prostate tissue eQTL data set. (Thibodeau SN, French AJ, McDonnell SK, Cheville J, Middha S, Tillmans L, Riska S, Baheti S, Larson MC, Fogarty Z, Zhang Y, Larson N, Nair A, O'Brien D, Wang L, Schaid DJ) Nat Commun 2015 Nov 27;6:8653 PMID: 26611117 PMCID: PMC4663677 11/28/2015       15 Citations
  • Meeting report: discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium. (Laurent LC, Abdel-Mageed AB, Adelson PD, Arango J, Balaj L, Breakefield X, Carlson E, Carter BS, Majem B, Chen CC, Cocucci E, Danielson K, Courtright A, Das S, Abd Elmageed ZY, Enderle D, Ezrin A, Ferrer M, Freedman J, Galas D, Gandhi R, Huentelman MJ, Van Keuren-Jensen K, Kalani Y, Kim Y, Krichevsky AM, Lai C, Lal-Nag M, Laurent CD, Leonardo T, Li F, Malenica I, Mondal D, Nejad P, Patel T, Raffai RL, Rubio R, Skog J, Spetzler R, Sun J, Tanriverdi K, Vickers K, Wang L, Wang Y, Wei Z, Weiner HL, Wong D, Yan IK, Yeri A, Gould S) J Extracell Vesicles 2015;4:26533 PMID: 26320937 PMCID: PMC4553263 09/01/2015    
  • Genomic variations in plasma cell free DNA differentiate early stage lung cancers from normal controls. (Xia S, Huang CC, Le M, Dittmar R, Du M, Yuan T, Guo Y, Wang Y, Wang X, Tsai S, Suster S, Mackinnon AC, Wang L) Lung Cancer 2015 Oct;90(1):78-84 PMID: 26233568 08/04/2015       16 Citations
  • Functional characterization of RAD52 as a lung cancer susceptibility gene in the 12p13.33 locus. (Lieberman R, Xiong D, James M, Han Y, Amos CI, Wang L, You M) Mol Carcinog 2016 May;55(5):953-63 PMID: 26013599 PMCID: PMC4662629 05/28/2015       12 Citations
  • Comprehensively evaluating cis-regulatory variation in the human prostate transcriptome by using gene-level allele-specific expression. (Larson NB, McDonnell S, French AJ, Fogarty Z, Cheville J, Middha S, Riska S, Baheti S, Nair AA, Wang L, Schaid DJ, Thibodeau SN) Am J Hum Genet 2015 Jun 04;96(6):869-82 PMID: 25983244 PMCID: PMC4457953 05/20/2015       17 Citations
  • Plasma genetic and genomic abnormalities predict treatment response and clinical outcome in advanced prostate cancer. (Xia S, Kohli M, Du M, Dittmar RL, Lee A, Nandy D, Yuan T, Guo Y, Wang Y, Tschannen MR, Worthey E, Jacob H, See W, Kilari D, Wang X, Hovey RL, Huang CC, Wang L) Oncotarget 2015 Jun 30;6(18):16411-21 PMID: 25915538 PMCID: PMC4599278 04/29/2015       21 Citations
  • DNA methylation and RNA expression profiles in lung adenocarcinomas of never-smokers. (Mansfield AS, Wang L, Cunningham JM, Jen J, Kolbert CP, Sun Z, Yang P) Cancer Genet 2015 May;208(5):253-60 PMID: 25650174 PMCID: PMC4465988 02/05/2015       5 Citations
  • Prognostic and predictive significance of thymidylate synthase protein expression in non-small cell lung cancer: a systematic review and meta-analysis. (Liu Q, Yu Z, Xiang Y, Wu N, Wu L, Xu B, Wang L, Yang P, Li Y, Bai L) Cancer Biomark 2015;15(1):65-78 PMID: 25524944 12/20/2014       11 Citations
  • Prostate cancer risk locus at 8q24 as a regulatory hub by physical interactions with multiple genomic loci across the genome. (Du M, Yuan T, Schilter KF, Dittmar RL, Mackinnon A, Huang X, Tschannen M, Worthey E, Jacob H, Xia S, Gao J, Tillmans L, Lu Y, Liu P, Thibodeau SN, Wang L) Hum Mol Genet 2015 Jan 01;24(1):154-66 PMID: 25149474 PMCID: PMC4262497 08/26/2014       23 Citations
  • Exosomal miR-1290 and miR-375 as prognostic markers in castration-resistant prostate cancer. (Huang X, Yuan T, Liang M, Du M, Xia S, Dittmar R, Wang D, See W, Costello BA, Quevedo F, Tan W, Nandy D, Bevan GH, Longenbach S, Sun Z, Lu Y, Wang T, Thibodeau SN, Boardman L, Kohli M, Wang L) Eur Urol 2015 Jan;67(1):33-41 PMID: 25129854 PMCID: PMC4252606 08/19/2014       173 Citations
  • Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations. (Wu C, Wang Z, Song X, Feng XS, Abnet CC, He J, Hu N, Zuo XB, Tan W, Zhan Q, Hu Z, He Z, Jia W, Zhou Y, Yu K, Shu XO, Yuan JM, Zheng W, Zhao XK, Gao SG, Yuan ZQ, Zhou FY, Fan ZM, Cui JL, Lin HL, Han XN, Li B, Chen X, Dawsey SM, Liao L, Lee MP, Ding T, Qiao YL, Liu Z, Liu Y, Yu D, Chang J, Wei L, Gao YT, Koh WP, Xiang YB, Tang ZZ, Fan JH, Han JJ, Zhou SL, Zhang P, Zhang DY, Yuan Y, Huang Y, Liu C, Zhai K, Qiao Y, Jin G, Guo C, Fu J, Miao X, Lu C, Yang H, Wang C, Wheeler WA, Gail M, Yeager M, Yuenger J, Guo ET, Li AL, Zhang W, Li XM, Sun LD, Ma BG, Li Y, Tang S, Peng XQ, Liu J, Hutchinson A, Jacobs K, Giffen C, Burdette L, Fraumeni JF Jr, Shen H, Ke Y, Zeng Y, Wu T, Kraft P, Chung CC, Tucker MA, Hou ZC, Liu YL, Hu YL, Liu Y, Wang L, Yuan G, Chen LS, Liu X, Ma T, Meng H, Sun L, Li XM, Li XM, Ku JW, Zhou YF, Yang LQ, Wang Z, Li Y, Qige Q, Yang WJ, Lei GY, Chen LQ, Li EM, Yuan L, Yue WB, Wang R, Wang LW, Fan XP, Zhu FH, Zhao WX, Mao YM, Zhang M, Xing GL, Li JL, Han M, Ren JL, Liu B, Ren SW, Kong QP, Li F, Sheyhidin I, Wei W, Zhang YR, Feng CW, Wang J, Yang YH, Hao HZ, Bao QD, Liu BC, Wu AQ, Xie D, Yang WC, Wang L, Zhao XH, Chen SQ, Hong JY, Zhang XJ, Freedman ND, Goldstein AM, Lin D, Taylor PR, Wang LD, Chanock SJ) Nat Genet 2014 Sep;46(9):1001-1006 PMID: 25129146 PMCID: PMC4212832 08/19/2014       63 Citations
  • Clinical biomarkers of pulmonary carcinoid tumors in never smokers via profiling miRNA and target mRNA. (Deng B, Molina J, Aubry MC, Sun Z, Wang L, Eckloff BW, Vasmatzis G, You M, Wieben ED, Jen J, Wigle DA, Yang P) Cell Biosci 2014;4:35 PMID: 25105010 PMCID: PMC4124500 08/12/2014    
  • eRNA: a graphic user interface-based tool optimized for large data analysis from high-throughput RNA sequencing. (Yuan T, Huang X, Dittmar RL, Du M, Kohli M, Boardman L, Thibodeau SN, Wang L) BMC Genomics 2014 Mar 05;15:176 PMID: 24593312 PMCID: PMC4029068 03/07/2014       10 Citations
  • Extracellular microRNAs in urologic malignancies: chances and challenges. (Huang X, Liang M, Dittmar R, Wang L) Int J Mol Sci 2013 Jul 16;14(7):14785-99 PMID: 23863690 PMCID: PMC3742273 07/19/2013    
  • Genome-wide association study of genetic predictors of overall survival for non-small cell lung cancer in never smokers. (Wu X, Wang L, Ye Y, Aakre JA, Pu X, Chang GC, Yang PC, Roth JA, Marks RS, Lippman SM, Chang JY, Lu C, Deschamps C, Su WC, Wang WC, Huang MS, Chang DW, Li Y, Pankratz VS, Minna JD, Hong WK, Hildebrandt MA, Hsiung CA, Yang P) Cancer Res 2013 Jul 01;73(13):4028-38 PMID: 23704207 PMCID: PMC3719971 05/25/2013       29 Citations
  • Characterization of human plasma-derived exosomal RNAs by deep sequencing. (Huang X, Yuan T, Tschannen M, Sun Z, Jacob H, Du M, Liang M, Dittmar RL, Liu Y, Liang M, Kohli M, Thibodeau SN, Boardman L, Wang L) BMC Genomics 2013 May 10;14:319 PMID: 23663360 PMCID: PMC3653748 05/15/2013       329 Citations
  • Network-based approach identified cell cycle genes as predictor of overall survival in lung adenocarcinoma patients. (Li Y, Tang H, Sun Z, Bungum AO, Edell ES, Lingle WL, Stoddard SM, Zhang M, Jen J, Yang P, Wang L) Lung Cancer 2013 Apr;80(1):91-8 PMID: 23357462 PMCID: PMC3595338 01/30/2013       17 Citations
  • Predictors of survival in never-smokers with non-small cell lung cancer: a large-scale, two-phase genetic study. (Pu X, Ye Y, Spitz MR, Wang L, Gu J, Lippman SM, Hildebrandt MA, Hong WK, Minna JD, Roth JA, Yang P, Wu X) Clin Cancer Res 2012 Nov 01;18(21):5983-91 PMID: 22977190 PMCID: PMC3640870 09/15/2012       7 Citations
  • Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma. (Agrawal N, Jiao Y, Bettegowda C, Hutfless SM, Wang Y, David S, Cheng Y, Twaddell WS, Latt NL, Shin EJ, Wang LD, Wang L, Yang W, Velculescu VE, Vogelstein B, Papadopoulos N, Kinzler KW, Meltzer SJ) Cancer Discov 2012 Oct;2(10):899-905 PMID: 22877736 PMCID: PMC3473124 08/11/2012       184 Citations
  • Variants in inflammation genes are implicated in risk of lung cancer in never smokers exposed to second-hand smoke. (Spitz MR, Gorlov IP, Amos CI, Dong Q, Chen W, Etzel CJ, Gorlova OY, Chang DW, Pu X, Zhang D, Wang L, Cunningham JM, Yang P, Wu X) Cancer Discov 2011 Oct;1(5):420-9 PMID: 22586632 PMCID: PMC3919666 05/16/2012       20 Citations
  • Identification of somatic mutations in non-small cell lung carcinomas using whole-exome sequencing. (Liu P, Morrison C, Wang L, Xiong D, Vedell P, Cui P, Hua X, Ding F, Lu Y, James M, Ebben JD, Xu H, Adjei AA, Head K, Andrae JW, Tschannen MR, Jacob H, Pan J, Zhang Q, Van den Bergh F, Xiao H, Lo KC, Patel J, Richmond T, Watt MA, Albert T, Selzer R, Anderson M, Wang J, Wang Y, Starnes S, Yang P, You M) Carcinogenesis 2012 Jul;33(7):1270-6 PMID: 22510280 PMCID: PMC3499051 04/19/2012       111 Citations
  • MicroRNA profiling and prediction of recurrence/relapse-free survival in stage I lung cancer. (Lu Y, Govindan R, Wang L, Liu PY, Goodgame B, Wen W, Sezhiyan A, Pfeifer J, Li YF, Hua X, Wang Y, Yang P, You M) Carcinogenesis 2012 May;33(5):1046-54 PMID: 22331473 PMCID: PMC3334512 02/15/2012       98 Citations
  • Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies. (Abnet CC, Wang Z, Song X, Hu N, Zhou FY, Freedman ND, Li XM, Yu K, Shu XO, Yuan JM, Zheng W, Dawsey SM, Liao LM, Lee MP, Ding T, Qiao YL, Gao YT, Koh WP, Xiang YB, Tang ZZ, Fan JH, Chung CC, Wang C, Wheeler W, Yeager M, Yuenger J, Hutchinson A, Jacobs KB, Giffen CA, Burdett L, Fraumeni JF Jr, Tucker MA, Chow WH, Zhao XK, Li JM, Li AL, Sun LD, Wei W, Li JL, Zhang P, Li HL, Cui WY, Wang WP, Liu ZC, Yang X, Fu WJ, Cui JL, Lin HL, Zhu WL, Liu M, Chen X, Chen J, Guo L, Han JJ, Zhou SL, Huang J, Wu Y, Yuan C, Huang J, Ji AF, Kul JW, Fan ZM, Wang JP, Zhang DY, Zhang LQ, Zhang W, Chen YF, Ren JL, Li XM, Dong JC, Xing GL, Guo ZG, Yang JX, Mao YM, Yuan Y, Guo ET, Zhang W, Hou ZC, Liu J, Li Y, Tang S, Chang J, Peng XQ, Han M, Yin WL, Liu YL, Hu YL, Liu Y, Yang LQ, Zhu FG, Yang XF, Feng XS, Wang Z, Li Y, Gao SG, Liu HL, Yuan L, Jin Y, Zhang YR, Sheyhidin I, Li F, Chen BP, Ren SW, Liu B, Li D, Zhang GF, Yue WB, Feng CW, Qige Q, Zhao JT, Yang WJ, Lei GY, Chen LQ, Li EM, Xu LY, Wu ZY, Bao ZQ, Chen JL, Li XC, Zhuang X, Zhou YF, Zuo XB, Dong ZM, Wang LW, Fan XP, Wang J, Zhou Q, Ma GS, Zhang QX, Liu H, Jian XY, Lian SY, Wang JS, Chang FB, Lu CD, Miao JJ, Chen ZG, Wang R, Guo M, Fan ZL, Tao P, Liu TJ, Wei JC, Kong QP, Fan L, Wang XZ, Gao FS, Wang TY, Xie D, Wang L, Chen SQ, Yang WC, Hong JY, Wang L, Qiu SL, Goldstein AM, Yuan ZQ, Chanock SJ, Zhang XJ, Taylor PR, Wang LD) Hum Mol Genet 2012 May 01;21(9):2132-41 PMID: 22323360 PMCID: PMC3315211 02/11/2012       38 Citations
  • Gene-expression signature predicts postoperative recurrence in stage I non-small cell lung cancer patients. (Lu Y, Wang L, Liu P, Yang P, You M) PLoS One 2012;7(1):e30880 PMID: 22292069 PMCID: PMC3264655 02/01/2012       22 Citations
  • miRNA expression in colon polyps provides evidence for a multihit model of colon cancer. (Oberg AL, French AJ, Sarver AL, Subramanian S, Morlan BW, Riska SM, Borralho PM, Cunningham JM, Boardman LA, Wang L, Smyrk TC, Asmann Y, Steer CJ, Thibodeau SN) PLoS One 2011;6(6):e20465 PMID: 21694772 PMCID: PMC3111419 06/23/2011       101 Citations
  • Leukocyte DNA methylation signature differentiates pancreatic cancer patients from healthy controls. (Pedersen KS, Bamlet WR, Oberg AL, de Andrade M, Matsumoto ME, Tang H, Thibodeau SN, Petersen GM, Wang L) PLoS One 2011 Mar 24;6(3):e18223 PMID: 21455317 PMCID: PMC3063802 04/02/2011       50 Citations
  • Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. (Wang LD, Zhou FY, Li XM, Sun LD, Song X, Jin Y, Li JM, Kong GQ, Qi H, Cui J, Zhang LQ, Yang JZ, Li JL, Li XC, Ren JL, Liu ZC, Gao WJ, Yuan L, Wei W, Zhang YR, Wang WP, Sheyhidin I, Li F, Chen BP, Ren SW, Liu B, Li D, Ku JW, Fan ZM, Zhou SL, Guo ZG, Zhao XK, Liu N, Ai YH, Shen FF, Cui WY, Song S, Guo T, Huang J, Yuan C, Huang J, Wu Y, Yue WB, Feng CW, Li HL, Wang Y, Tian JY, Lu Y, Yuan Y, Zhu WL, Liu M, Fu WJ, Yang X, Wang HJ, Han SL, Chen J, Han M, Wang HY, Zhang P, Li XM, Dong JC, Xing GL, Wang R, Guo M, Chang ZW, Liu HL, Guo L, Yuan ZQ, Liu H, Lu Q, Yang LQ, Zhu FG, Yang XF, Feng XS, Wang Z, Li Y, Gao SG, Qige Q, Bai LT, Yang WJ, Lei GY, Shen ZY, Chen LQ, Li EM, Xu LY, Wu ZY, Cao WK, Wang JP, Bao ZQ, Chen JL, Ding GC, Zhuang X, Zhou YF, Zheng HF, Zhang Z, Zuo XB, Dong ZM, Fan DM, He X, Wang J, Zhou Q, Zhang QX, Jiao XY, Lian SY, Ji AF, Lu XM, Wang JS, Chang FB, Lu CD, Chen ZG, Miao JJ, Fan ZL, Lin RB, Liu TJ, Wei JC, Kong QP, Lan Y, Fan YJ, Gao FS, Wang TY, Xie D, Chen SQ, Yang WC, Hong JY, Wang L, Qiu SL, Cai ZM, Zhang XJ) Nat Genet 2010 Sep;42(9):759-63 PMID: 20729853 08/24/2010       264 Citations
  • Methylation markers for small cell lung cancer in peripheral blood leukocyte DNA. (Wang L, Aakre JA, Jiang R, Marks RS, Wu Y, Chen J, Thibodeau SN, Pankratz VS, Yang P) J Thorac Oncol 2010 Jun;5(6):778-85 PMID: 20421821 PMCID: PMC3000124 04/28/2010       44 Citations
  • Genetic variants and risk of lung cancer in never smokers: a genome-wide association study. (Li Y, Sheu CC, Ye Y, de Andrade M, Wang L, Chang SC, Aubry MC, Aakre JA, Allen MS, Chen F, Cunningham JM, Deschamps C, Jiang R, Lin J, Marks RS, Pankratz VS, Su L, Li Y, Sun Z, Tang H, Vasmatzis G, Harris CC, Spitz MR, Jen J, Wang R, Zhang ZF, Christiani DC, Wu X, Yang P) Lancet Oncol 2010 Apr;11(4):321-30 PMID: 20304703 PMCID: PMC2945218 03/23/2010       149 Citations
  • Gene networks and microRNAs implicated in aggressive prostate cancer. (Wang L, Tang H, Thayanithy V, Subramanian S, Oberg AL, Cunningham JM, Cerhan JR, Steer CJ, Thibodeau SN) Cancer Res 2009 Dec 15;69(24):9490-7 PMID: 19996289 PMCID: PMC2795036 12/10/2009       100 Citations
  • Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states. (Sarver AL, French AJ, Borralho PM, Thayanithy V, Oberg AL, Silverstein KA, Morlan BW, Riska SM, Boardman LA, Cunningham JM, Subramanian S, Wang L, Smyrk TC, Rodrigues CM, Thibodeau SN, Steer CJ) BMC Cancer 2009 Nov 18;9:401 PMID: 19922656 PMCID: PMC2787532 11/20/2009       231 Citations
  • Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. (Eeles RA, Kote-Jarai Z, Al Olama AA, Giles GG, Guy M, Severi G, Muir K, Hopper JL, Henderson BE, Haiman CA, Schleutker J, Hamdy FC, Neal DE, Donovan JL, Stanford JL, Ostrander EA, Ingles SA, John EM, Thibodeau SN, Schaid D, Park JY, Spurdle A, Clements J, Dickinson JL, Maier C, Vogel W, Dörk T, Rebbeck TR, Cooney KA, Cannon-Albright L, Chappuis PO, Hutter P, Zeegers M, Kaneva R, Zhang HW, Lu YJ, Foulkes WD, English DR, Leongamornlert DA, Tymrakiewicz M, Morrison J, Ardern-Jones AT, Hall AL, O'Brien LT, Wilkinson RA, Saunders EJ, Page EC, Sawyer EJ, Edwards SM, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As N, Woodhouse CJ, Thompson A, Christmas T, Ogden C, Cooper CS, Southey MC, Lophatananon A, Liu JF, Kolonel LN, Le Marchand L, Wahlfors T, Tammela TL, Auvinen A, Lewis SJ, Cox A, FitzGerald LM, Koopmeiners JS, Karyadi DM, Kwon EM, Stern MC, Corral R, Joshi AD, Shahabi A, McDonnell SK, Sellers TA, Pow-Sang J, Chambers S, Aitken J, Gardiner RA, Batra J, Kedda MA, Lose F, Polanowski A, Patterson B, Serth J, Meyer A, Luedeke M, Stefflova K, Ray AM, Lange EM, Farnham J, Khan H, Slavov C, Mitkova A, Cao G, UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology, UK ProtecT Study Collaborators, PRACTICAL Consortium, Easton DF) Nat Genet 2009 Oct;41(10):1116-21 PMID: 19767753 PMCID: PMC2846760 09/22/2009       318 Citations
  • Evaluation of a new high-dimensional miRNA profiling platform. (Cunningham JM, Oberg AL, Borralho PM, Kren BT, French AJ, Wang L, Bot BM, Morlan BW, Silverstein KA, Staggs R, Zeng Y, Lamblin AF, Hilker CA, Fan JB, Steer CJ, Thibodeau SN) BMC Med Genomics 2009 Aug 27;2:57 PMID: 19712457 PMCID: PMC2744682 08/29/2009    
  • Genome-wide transcriptional profiling reveals microRNA-correlated genes and biological processes in human lymphoblastoid cell lines. (Wang L, Oberg AL, Asmann YW, Sicotte H, McDonnell SK, Riska SM, Liu W, Steer CJ, Subramanian S, Cunningham JM, Cerhan JR, Thibodeau SN) PLoS One 2009 Jun 11;4(6):e5878 PMID: 19517021 PMCID: PMC2691578 06/12/2009       60 Citations
  • Polymorphisms in mitochondrial genes and prostate cancer risk. (Wang L, McDonnell SK, Hebbring SJ, Cunningham JM, St Sauver J, Cerhan JR, Isaya G, Schaid DJ, Thibodeau SN) Cancer Epidemiol Biomarkers Prev 2008 Dec;17(12):3558-66 PMID: 19064571 PMCID: PMC2750891 12/10/2008       40 Citations
  • Mitochondrial genetic polymorphisms do not predict survival in patients with pancreatic cancer. (Halfdanarson TR, Wang L, Bamlet WR, de Andrade M, McWilliams RR, Cunningham JM, Petersen GM) Cancer Epidemiol Biomarkers Prev 2008 Sep;17(9):2512-3 PMID: 18768524 PMCID: PMC2674364 09/05/2008       12 Citations
  • BRAF V600E disrupts AZD6244-induced abrogation of negative feedback pathways between extracellular signal-regulated kinase and Raf proteins. (Friday BB, Yu C, Dy GK, Smith PD, Wang L, Thibodeau SN, Adjei AA) Cancer Res 2008 Aug 01;68(15):6145-53 PMID: 18676837 08/05/2008       109 Citations
  • The value of MUTYH testing in patients with early onset microsatellite stable colorectal cancer referred for hereditary nonpolyposis colon cancer syndrome testing. (Riegert-Johnson DL, Johnson RA, Rabe KG, Wang L, Thomas B, Baudhuin LM, Thibodeau SN, Boardman LA) Genet Test 2007;11(4):361-5 PMID: 18294051 02/26/2008       22 Citations
  • Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. (Gudmundsson J, Sulem P, Rafnar T, Bergthorsson JT, Manolescu A, Gudbjartsson D, Agnarsson BA, Sigurdsson A, Benediktsdottir KR, Blondal T, Jakobsdottir M, Stacey SN, Kostic J, Kristinsson KT, Birgisdottir B, Ghosh S, Magnusdottir DN, Thorlacius S, Thorleifsson G, Zheng SL, Sun J, Chang BL, Elmore JB, Breyer JP, McReynolds KM, Bradley KM, Yaspan BL, Wiklund F, Stattin P, Lindström S, Adami HO, McDonnell SK, Schaid DJ, Cunningham JM, Wang L, Cerhan JR, St Sauver JL, Isaacs SD, Wiley KE, Partin AW, Walsh PC, Polo S, Ruiz-Echarri M, Navarrete S, Fuertes F, Saez B, Godino J, Weijerman PC, Swinkels DW, Aben KK, Witjes JA, Suarez BK, Helfand BT, Frigge ML, Kristjansson K, Ober C, Jonsson E, Einarsson GV, Xu J, Gronberg H, Smith JR, Thibodeau SN, Isaacs WB, Catalona WJ, Mayordomo JI, Kiemeney LA, Barkardottir RB, Gulcher JR, Thorsteinsdottir U, Kong A, Stefansson K) Nat Genet 2008 Mar;40(3):281-3 PMID: 18264098 PMCID: PMC3598012 02/12/2008       286 Citations
  • Highly methylated genes in colorectal neoplasia: implications for screening. (Zou H, Harrington JJ, Shire AM, Rego RL, Wang L, Campbell ME, Oberg AL, Ahlquist DA) Cancer Epidemiol Biomarkers Prev 2007 Dec;16(12):2686-96 PMID: 18086775 12/19/2007       89 Citations
  • Fine mapping of familial prostate cancer families narrows the interval for a susceptibility locus on chromosome 22q12.3 to 1.36 Mb. (Johanneson B, McDonnell SK, Karyadi DM, Hebbring SJ, Wang L, Deutsch K, McIntosh L, Kwon EM, Suuriniemi M, Stanford JL, Schaid DJ, Ostrander EA, Thibodeau SN) Hum Genet 2008 Feb;123(1):65-75 PMID: 18066601 12/11/2007       7 Citations
  • Mitochondrial genetic polymorphisms and pancreatic cancer risk. (Wang L, Bamlet WR, de Andrade M, Boardman LA, Cunningham JM, Thibodeau SN, Petersen GM) Cancer Epidemiol Biomarkers Prev 2007 Jul;16(7):1455-9 PMID: 17627010 07/14/2007       64 Citations
  • Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer. (Cunningham JM, Hebbring SJ, McDonnell SK, Cicek MS, Christensen GB, Wang L, Jacobsen SJ, Cerhan JR, Blute ML, Schaid DJ, Thibodeau SN) Cancer Epidemiol Biomarkers Prev 2007 May;16(5):969-78 PMID: 17507624 05/18/2007       88 Citations
  • Higher frequency of diploidy in young-onset microsatellite-stable colorectal cancer. (Boardman LA, Johnson RA, Petersen GM, Oberg AL, Kabat BF, Slusser JP, Wang L, Morlan BW, French AJ, Smyrk TC, Lindor NM, Thibodeau SN) Clin Cancer Res 2007 Apr 15;13(8):2323-8 PMID: 17438090 04/18/2007       21 Citations
  • Two common chromosome 8q24 variants are associated with increased risk for prostate cancer. (Wang L, McDonnell SK, Slusser JP, Hebbring SJ, Cunningham JM, Jacobsen SJ, Cerhan JR, Blute ML, Schaid DJ, Thibodeau SN) Cancer Res 2007 Apr 01;67(7):2944-50 PMID: 17409399 04/06/2007       89 Citations
  • Truncating variants in p53AIP1 disrupting DNA damage-induced apoptosis are associated with prostate cancer risk. (Wang X, Wang F, Taniguchi K, Seelan RS, Wang L, Zarfas KE, McDonnell SK, Qian C, Pan K, Lu Y, Shridhar V, Couch FJ, Tindall DJ, Beebe-Dimmer JL, Cooney KA, Isaacs WB, Jacobsen SJ, Schaid DJ, Thibodeau SN, Liu W) Cancer Res 2006 Nov 01;66(21):10302-7 PMID: 17079449 11/03/2006       8 Citations
  • BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing. (Domingo E, Laiho P, Ollikainen M, Pinto M, Wang L, French AJ, Westra J, Frebourg T, Espín E, Armengol M, Hamelin R, Yamamoto H, Hofstra RM, Seruca R, Lindblom A, Peltomäki P, Thibodeau SN, Aaltonen LA, Schwartz S Jr) J Med Genet 2004 Sep;41(9):664-8 PMID: 15342696 PMCID: PMC1735885 09/03/2004       267 Citations
  • MYH mutations in patients with attenuated and classic polyposis and with young-onset colorectal cancer without polyps. (Wang L, Baudhuin LM, Boardman LA, Steenblock KJ, Petersen GM, Halling KC, French AJ, Johnson RA, Burgart LJ, Rabe K, Lindor NM, Thibodeau SN) Gastroenterology 2004 Jul;127(1):9-16 PMID: 15236166 07/06/2004       165 Citations
  • The APC E1317Q variant in adenomatous polyps and colorectal cancers. (Hahnloser D, Petersen GM, Rabe K, Snow K, Lindor NM, Boardman L, Koch B, Doescher D, Wang L, Steenblock K, Thibodeau SN) Cancer Epidemiol Biomarkers Prev 2003 Oct;12(10):1023-8 PMID: 14578138 10/28/2003       26 Citations
  • BRAF mutations in colon cancer are not likely attributable to defective DNA mismatch repair. (Wang L, Cunningham JM, Winters JL, Guenther JC, French AJ, Boardman LA, Burgart LJ, McDonnell SK, Schaid DJ, Thibodeau SN) Cancer Res 2003 Sep 01;63(17):5209-12 PMID: 14500346 09/23/2003       217 Citations
  • No association of germline alteration of MSR1 with prostate cancer risk. (Wang L, McDonnell SK, Cunningham JM, Hebbring S, Jacobsen SJ, Cerhan JR, Slager SL, Blute ML, Schaid DJ, Thibodeau SN) Nat Genet 2003 Oct;35(2):128-9 PMID: 12958598 09/06/2003       44 Citations
  • Candidate-gene association studies with pedigree data: controlling for environmental covariates. (Slager SL, Schaid DJ, Wang L, Thibodeau SN) Genet Epidemiol 2003 May;24(4):273-83 PMID: 12687644 04/11/2003       15 Citations
  • Mutations in CHEK2 associated with prostate cancer risk. (Dong X, Wang L, Taniguchi K, Wang X, Cunningham JM, McDonnell SK, Qian C, Marks AF, Slager SL, Peterson BJ, Smith DI, Cheville JC, Blute ML, Jacobsen SJ, Schaid DJ, Tindall DJ, Thibodeau SN, Liu W) Am J Hum Genet 2003 Feb;72(2):270-80 PMID: 12533788 PMCID: PMC379222 01/21/2003       182 Citations
  • Caution on pedigree haplotype inference with software that assumes linkage equilibrium. (Schaid DJ, McDonnell SK, Wang L, Cunningham JM, Thibodeau SN) Am J Hum Genet 2002 Oct;71(4):992-5 PMID: 12387273 PMCID: PMC378555 10/22/2002       87 Citations
  • Analysis of the RNASEL gene in familial and sporadic prostate cancer. (Wang L, McDonnell SK, Elkins DA, Slager SL, Christensen E, Marks AF, Cunningham JM, Peterson BJ, Jacobsen SJ, Cerhan JR, Blute ML, Schaid DJ, Thibodeau SN) Am J Hum Genet 2002 Jul;71(1):116-23 PMID: 12022038 PMCID: PMC384968 05/22/2002       86 Citations
  • Role of HPC2/ELAC2 in hereditary prostate cancer. (Wang L, McDonnell SK, Elkins DA, Slager SL, Christensen E, Marks AF, Cunningham JM, Peterson BJ, Jacobsen SJ, Cerhan JR, Blute ML, Schaid DJ, Thibodeau SN) Cancer Res 2001 Sep 01;61(17):6494-9 PMID: 11522646 08/28/2001       81 Citations
  • HMSH6 alterations in patients with microsatellite instability-low colorectal cancer. (Parc YR, Halling KC, Wang L, Christensen ER, Cunningham JM, French AJ, Burgart LJ, Price-Troska TL, Roche PC, Thibodeau SN) Cancer Res 2000 Apr 15;60(8):2225-31 PMID: 10786688 04/29/2000       78 Citations
  • Isolation of viable tumor cells following introduction of labelled antibody to an intracellular oncogene product using electroporation. (Berglund DL, Starkey JR) J Immunol Methods 1989 Dec 20;125(1-2):79-87 PMID: 2691578 12/20/1989       20 Citations
  • Last update: 11/05/2018
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