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Marja T. Nevalainen MD, PhD

Marja T. Nevalainen MD, PhD

Assistant Dean, Professor

Institution: Medical College of Wisconsin
Department: Pathology
Division: Administration

Member of the Cancer Center

View Curriculum Vitae

Publications

  • Targeting STAT5 or STAT5-Regulated Pathways Suppresses Leukemogenesis of Ph+ Acute Lymphoblastic Leukemia. (Minieri V, De Dominici M, Porazzi P, Mariani SA, Spinelli O, Rambaldi A, Peterson LF, Porcu P, Nevalainen MT, Calabretta B) Cancer Res 2018 Oct 15;78(20):5793-5807 PMID: 30154155 08/30/2018       1 Citations
  • Radio-pathomic Maps of Epithelium and Lumen Density Predict the Location of High-Grade Prostate Cancer. (McGarry SD, Hurrell SL, Iczkowski KA, Hall W, Kaczmarowski AL, Banerjee A, Keuter T, Jacobsohn K, Bukowy JD, Nevalainen MT, Hohenwalter MD, See WA, LaViolette PS) Int J Radiat Oncol Biol Phys 2018 Aug 01;101(5):1179-1187 PMID: 29908785 PMCID: PMC6190585 06/18/2018       1 Citations
  • STAT5A/B Blockade Sensitizes Prostate Cancer to Radiation through Inhibition of RAD51 and DNA Repair. (Maranto C, Udhane V, Hoang DT, Gu L, Alexeev V, Malas K, Cardenas K, Brody JR, Rodeck U, Bergom C, Iczkowski KA, Jacobsohn K, See W, Schmitt SM, Nevalainen MT) Clin Cancer Res 2018 Apr 15;24(8):1917-1931 PMID: 29483142 PMCID: PMC6036914 02/28/2018    
  • Optimized -value selection for the discrimination of prostate cancer grades, including the cribriform pattern, using diffusion weighted imaging. (Hurrell SL, McGarry SD, Kaczmarowski A, Iczkowski KA, Jacobsohn K, Hohenwalter MD, Hall WA, See WA, Banerjee A, Charles DK, Nevalainen MT, Mackinnon AC, LaViolette PS) J Med Imaging (Bellingham) 2018 01;5(1):011004 PMID: 29098169 PMCID: PMC5658575 11/04/2017    
  • Erratum: ETS Related Gene mediated Androgen Receptor Aggregation and Endoplasmic Reticulum Stress in Prostate Cancer Development. (Sreenath TL, Macalindong SS, Mikhalkevich N, Sharad S, Mohamed A, Young D, Borbiev T, Xavier C, Gupta R, Jamal M, Babcock K, Tan SH, Nevalainen MT, Dobi A, Petrovics G, Sesterhenn IA, Rosner IL, Bieberich CJ, Nelson P, Vasioukhin V, Srivastava S) Sci Rep 2017 Sep 06;7(1):10693 PMID: 28878398 PMCID: PMC5587674 09/08/2017    
  • ETS Related Gene mediated Androgen Receptor Aggregation and Endoplasmic Reticulum Stress in Prostate Cancer Development. (Sreenath TL, Macalindong SS, Mikhalkevich N, Sharad S, Mohamed A, Young D, Borbiev T, Xavier C, Gupta R, Jamal M, Babcock K, Tan SH, Nevalainen MT, Dobi A, Petrovics G, Sesterhenn IA, Rosner IL, Bieberich CJ, Nelson P, Vasioukhin V, Srivastava S) Sci Rep 2017 04 24;7(1):1109 PMID: 28439080 PMCID: PMC5430720 04/26/2017       6 Citations
  • miR-375 induces docetaxel resistance in prostate cancer by targeting SEC23A and YAP1. (Wang Y, Lieberman R, Pan J, Zhang Q, Du M, Zhang P, Nevalainen M, Kohli M, Shenoy NK, Meng H, You M, Wang L) Mol Cancer 2016 11 10;15(1):70 PMID: 27832783 PMCID: PMC5105253 11/12/2016       20 Citations
  • Androgen receptor-dependent and -independent mechanisms driving prostate cancer progression: Opportunities for therapeutic targeting from multiple angles. (Hoang DT, Iczkowski KA, Kilari D, See W, Nevalainen MT) Oncotarget 2017 Jan 10;8(2):3724-3745 PMID: 27741508 PMCID: PMC5356914 10/16/2016    
  • Exosome-mediated Transfer of αvβ3 Integrin from Tumorigenic to Nontumorigenic Cells Promotes a Migratory Phenotype. (Singh A, Fedele C, Lu H, Nevalainen MT, Keen JH, Languino LR) Mol Cancer Res 2016 11;14(11):1136-1146 PMID: 27439335 PMCID: PMC5107121 07/22/2016       23 Citations
  • Peptidylarginine Deiminase 3 (PAD3) Is Upregulated by Prolactin Stimulation of CID-9 Cells and Expressed in the Lactating Mouse Mammary Gland. (Li G, Hayward IN, Jenkins BR, Rothfuss HM, Young CH, Nevalainen MT, Muth A, Thompson PR, Navratil AM, Cherrington BD) PLoS One 2016;11(1):e0147503 PMID: 26799659 PMCID: PMC4723263 01/23/2016       5 Citations
  • Jak2-Stat5a/b Signaling Induces Epithelial-to-Mesenchymal Transition and Stem-Like Cell Properties in Prostate Cancer. (Talati PG, Gu L, Ellsworth EM, Girondo MA, Trerotola M, Hoang DT, Leiby B, Dagvadorj A, McCue PA, Lallas CD, Trabulsi EJ, Gomella L, Aplin AE, Languino L, Fatatis A, Rui H, Nevalainen MT) Am J Pathol 2015 Sep;185(9):2505-22 PMID: 26362718 PMCID: PMC4597281 09/13/2015       16 Citations
  • Structure-Based Screen Identifies a Potent Small Molecule Inhibitor of Stat5a/b with Therapeutic Potential for Prostate Cancer and Chronic Myeloid Leukemia. (Liao Z, Gu L, Vergalli J, Mariani SA, De Dominici M, Lokareddy RK, Dagvadorj A, Purushottamachar P, McCue PA, Trabulsi E, Lallas CD, Gupta S, Ellsworth E, Blackmon S, Ertel A, Fortina P, Leiby B, Xia G, Rui H, Hoang DT, Gomella LG, Cingolani G, Njar V, Pattabiraman N, Calabretta B, Nevalainen MT) Mol Cancer Ther 2015 Aug;14(8):1777-93 PMID: 26026053 PMCID: PMC4547362 05/31/2015       14 Citations
  • Inhibition of Stat5a/b Enhances Proteasomal Degradation of Androgen Receptor Liganded by Antiandrogens in Prostate Cancer. (Hoang DT, Gu L, Liao Z, Shen F, Talati PG, Koptyra M, Tan SH, Ellsworth E, Gupta S, Montie H, Dagvadorj A, Savolainen S, Leiby B, Mirtti T, Merry DE, Nevalainen MT) Mol Cancer Ther 2015 Mar;14(3):713-26 PMID: 25552366 PMCID: PMC4456253 01/02/2015       8 Citations
  • Pharmacologic suppression of JAK1/2 by JAK1/2 inhibitor AZD1480 potently inhibits IL-6-induced experimental prostate cancer metastases formation. (Gu L, Talati P, Vogiatzi P, Romero-Weaver AL, Abdulghani J, Liao Z, Leiby B, Hoang DT, Mirtti T, Alanen K, Zinda M, Huszar D, Nevalainen MT) Mol Cancer Ther 2014 May;13(5):1246-58 PMID: 24577942 PMCID: PMC4013199 03/01/2014       19 Citations
  • Pharmacologic inhibition of Jak2-Stat5 signaling By Jak2 inhibitor AZD1480 potently suppresses growth of both primary and castrate-resistant prostate cancer. (Gu L, Liao Z, Hoang DT, Dagvadorj A, Gupta S, Blackmon S, Ellsworth E, Talati P, Leiby B, Zinda M, Lallas CD, Trabulsi EJ, McCue P, Gomella L, Huszar D, Nevalainen MT) Clin Cancer Res 2013 Oct 15;19(20):5658-74 PMID: 23942095 PMCID: PMC6021137 08/15/2013       27 Citations
  • STAT5A/B gene locus undergoes amplification during human prostate cancer progression. (Haddad BR, Gu L, Mirtti T, Dagvadorj A, Vogiatzi P, Hoang DT, Bajaj R, Leiby B, Ellsworth E, Blackmon S, Ruiz C, Curtis M, Fortina P, Ertel A, Liu C, Rui H, Visakorpi T, Bubendorf L, Lallas CD, Trabulsi EJ, McCue P, Gomella L, Nevalainen MT) Am J Pathol 2013 Jun;182(6):2264-75 PMID: 23660011 PMCID: PMC3668029 05/11/2013       24 Citations
  • Ex vivo prostate cancer explant organ culture model system for targeted drug development in prostate cancer. (Gu L, Liao Z, McCue P, Trabulsi EJ, Nevalainen MT) J Clin Oncol 2013 Feb 20;31(6_suppl):110 PMID: 28136847 02/20/2013    
  • Nuclear Stat5a/b predicts early recurrence and prostate cancer-specific death in patients treated by radical prostatectomy. (Mirtti T, Leiby BE, Abdulghani J, Aaltonen E, Pavela M, Mamtani A, Alanen K, Egevad L, Granfors T, Josefsson A, Stattin P, Bergh A, Nevalainen MT) Hum Pathol 2013 Mar;44(3):310-9 PMID: 23026195 PMCID: PMC3548055 10/03/2012       21 Citations
  • Signal transducer and activator of transcription-5 mediates neuronal apoptosis induced by inhibition of Rac GTPase activity. (Stankiewicz TR, Loucks FA, Schroeder EK, Nevalainen MT, Tyler KL, Aktories K, Bouchard RJ, Linseman DA) J Biol Chem 2012 May 11;287(20):16835-48 PMID: 22378792 PMCID: PMC3351344 03/02/2012       13 Citations
  • Prolactin regulation of the prostate gland: a female player in a male game. (Goffin V, Hoang DT, Bogorad RL, Nevalainen MT) Nat Rev Urol 2011 Oct 04;8(11):597-607 PMID: 21971318 PMCID: PMC6035044 10/06/2011       42 Citations
  • Signal transducer and activator of transcription-3 and breast cancer prognosis. (Sato T, Neilson LM, Peck AR, Liu C, Tran TH, Witkiewicz A, Hyslop T, Nevalainen MT, Sauter G, Rui H) Am J Cancer Res 2011;1(3):347-55 PMID: 21776434 PMCID: PMC3138712 07/22/2011    
  • Signal transducer and activator of transcription 5a/b: biomarker and therapeutic target in prostate and breast cancer. (Koptyra M, Gupta S, Talati P, Nevalainen MT) Int J Biochem Cell Biol 2011 Oct;43(10):1417-21 PMID: 21704724 PMCID: PMC3163765 06/28/2011       22 Citations
  • Loss of nuclear localized and tyrosine phosphorylated Stat5 in breast cancer predicts poor clinical outcome and increased risk of antiestrogen therapy failure. (Peck AR, Witkiewicz AK, Liu C, Stringer GA, Klimowicz AC, Pequignot E, Freydin B, Tran TH, Yang N, Rosenberg AL, Hooke JA, Kovatich AJ, Nevalainen MT, Shriver CD, Hyslop T, Sauter G, Rimm DL, Magliocco AM, Rui H) J Clin Oncol 2011 Jun 20;29(18):2448-58 PMID: 21576635 PMCID: PMC3675698 05/18/2011       62 Citations
  • Targeting transcription factor Stat5a/b as a therapeutic strategy for prostate cancer. (Liao Z, Nevalainen MT) Am J Transl Res 2011 Feb;3(2):133-8 PMID: 21416055 PMCID: PMC3056559 03/19/2011    
  • Activating mutation (V617F) in the tyrosine kinase JAK2 is absent in locally-confined or castration-resistant prostate cancer. (Gu L, Zhu XH, Visakorpi T, Alanen K, Mirtti T, Edmonston TB, Nevalainen MT) Anal Cell Pathol (Amst) 2010;33(2):55-9 PMID: 20966544 PMCID: PMC4605774 10/23/2010       7 Citations
  • N-terminal truncation of Stat5a/b circumvents PIAS3-mediated transcriptional inhibition of Stat5 in prostate cancer cells. (Dagvadorj A, Tan SH, Liao Z, Xie J, Nurmi M, Alanen K, Rui H, Mirtti T, Nevalainen MT) Int J Biochem Cell Biol 2010 Dec;42(12):2037-46 PMID: 20854925 PMCID: PMC2982800 09/22/2010       12 Citations
  • Robust gene network analysis reveals alteration of the STAT5a network as a hallmark of prostate cancer. (Reddy A, Huang CC, Liu H, Delisi C, Nevalainen MT, Szalma S, Bhanot G) Genome Inform 2010;24:139-53 PMID: 22081596 PMCID: PMC6035043 07/01/2010       3 Citations
  • Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo. (Gu L, Vogiatzi P, Puhr M, Dagvadorj A, Lutz J, Ryder A, Addya S, Fortina P, Cooper C, Leiby B, Dasgupta A, Hyslop T, Bubendorf L, Alanen K, Mirtti T, Nevalainen MT) Endocr Relat Cancer 2010 Jun;17(2):481-93 PMID: 20233708 PMCID: PMC6260789 03/18/2010       82 Citations
  • Transcription factor Stat3 stimulates metastatic behavior of human prostate cancer cells in vivo, whereas Stat5b has a preferential role in the promotion of prostate cancer cell viability and tumor growth. (Gu L, Dagvadorj A, Lutz J, Leiby B, Bonuccelli G, Lisanti MP, Addya S, Fortina P, Dasgupta A, Hyslop T, Bubendorf L, Nevalainen MT) Am J Pathol 2010 Apr;176(4):1959-72 PMID: 20167868 PMCID: PMC2843484 02/20/2010       51 Citations
  • Transcription factor Stat5a/b as a therapeutic target protein for prostate cancer. (Liao Z, Lutz J, Nevalainen MT) Int J Biochem Cell Biol 2010 Feb;42(2):186-92 PMID: 19914392 PMCID: PMC2818495 11/17/2009       18 Citations
  • Androgen-regulated and highly tumorigenic human prostate cancer cell line established from a transplantable primary CWR22 tumor. (Dagvadorj A, Tan SH, Liao Z, Cavalli LR, Haddad BR, Nevalainen MT) Clin Cancer Res 2008 Oct 01;14(19):6062-72 PMID: 18829484 PMCID: PMC2570751 10/03/2008       20 Citations
  • Signal transducer and activator of transcription 5A/B in prostate and breast cancers. (Tan SH, Nevalainen MT) Endocr Relat Cancer 2008 Jun;15(2):367-90 PMID: 18508994 PMCID: PMC6036917 05/30/2008       83 Citations
  • Stat3 promotes metastatic progression of prostate cancer. (Abdulghani J, Gu L, Dagvadorj A, Lutz J, Leiby B, Bonuccelli G, Lisanti MP, Zellweger T, Alanen K, Mirtti T, Visakorpi T, Bubendorf L, Nevalainen MT) Am J Pathol 2008 Jun;172(6):1717-28 PMID: 18483213 PMCID: PMC2408430 05/17/2008       167 Citations
  • Transcription factor signal transducer and activator of transcription 5 promotes growth of human prostate cancer cells in vivo. (Dagvadorj A, Kirken RA, Leiby B, Karras J, Nevalainen MT) Clin Cancer Res 2008 Mar 01;14(5):1317-24 PMID: 18316550 03/05/2008       70 Citations
  • Transcription factor Stat5 synergizes with androgen receptor in prostate cancer cells. (Tan SH, Dagvadorj A, Shen F, Gu L, Liao Z, Abdulghani J, Zhang Y, Gelmann EP, Zellweger T, Culig Z, Visakorpi T, Bubendorf L, Kirken RA, Karras J, Nevalainen MT) Cancer Res 2008 Jan 01;68(1):236-48 PMID: 18172316 01/04/2008       75 Citations
  • Autocrine prolactin promotes prostate cancer cell growth via Janus kinase-2-signal transducer and activator of transcription-5a/b signaling pathway. (Dagvadorj A, Collins S, Jomain JB, Abdulghani J, Karras J, Zellweger T, Li H, Nurmi M, Alanen K, Mirtti T, Visakorpi T, Bubendorf L, Goffin V, Nevalainen MT) Endocrinology 2007 Jul;148(7):3089-101 PMID: 17412813 04/07/2007       88 Citations
  • The functional significance of nuclear receptor acetylation. (Popov VM, Wang C, Shirley LA, Rosenberg A, Li S, Nevalainen M, Fu M, Pestell RG) Steroids 2007 Feb;72(2):221-30 PMID: 17291555 PMCID: PMC2694494 02/13/2007       57 Citations
  • In vivo response-based identification of direct hormone target cell populations using high-density tissue arrays. (LeBaron MJ, Ahonen TJ, Nevalainen MT, Rui H) Endocrinology 2007 Mar;148(3):989-1008 PMID: 17138649 12/02/2006       27 Citations
  • Activation of signal transducer and activator of transcription-5 in prostate cancer predicts early recurrence. (Li H, Zhang Y, Glass A, Zellweger T, Gehan E, Bubendorf L, Gelmann EP, Nevalainen MT) Clin Cancer Res 2005 Aug 15;11(16):5863-8 PMID: 16115927 08/24/2005       82 Citations
  • Stat5 promotes homotypic adhesion and inhibits invasive characteristics of human breast cancer cells. (Sultan AS, Xie J, LeBaron MJ, Ealley EL, Nevalainen MT, Rui H) Oncogene 2005 Jan 27;24(5):746-60 PMID: 15592524 12/14/2004       132 Citations
  • Activation of signal transducer and activator of transcription 5 in human prostate cancer is associated with high histological grade. (Li H, Ahonen TJ, Alanen K, Xie J, LeBaron MJ, Pretlow TG, Ealley EL, Zhang Y, Nurmi M, Singh B, Martikainen PM, Nevalainen MT) Cancer Res 2004 Jul 15;64(14):4774-82 PMID: 15256446 07/17/2004       120 Citations
  • Signal transducer and activator of transcription-5 activation and breast cancer prognosis. (Nevalainen MT, Xie J, Torhorst J, Bubendorf L, Haas P, Kononen J, Sauter G, Rui H) J Clin Oncol 2004 Jun 01;22(11):2053-60 PMID: 15169792 06/01/2004       162 Citations
  • Inhibition of transcription factor Stat5 induces cell death of human prostate cancer cells. (Ahonen TJ, Xie J, LeBaron MJ, Zhu J, Nurmi M, Alanen K, Rui H, Nevalainen MT) J Biol Chem 2003 Jul 18;278(29):27287-92 PMID: 12719422 04/30/2003       95 Citations
  • Basal activation of transcription factor signal transducer and activator of transcription (Stat5) in nonpregnant mouse and human breast epithelium. (Nevalainen MT, Xie J, Bubendorf L, Wagner KU, Rui H) Mol Endocrinol 2002 May;16(5):1108-24 PMID: 11981045 05/01/2002       66 Citations
  • Role of tyrosine kinase Jak2 in prolactin-induced differentiation and growth of mammary epithelial cells. (Xie J, LeBaron MJ, Nevalainen MT, Rui H) J Biol Chem 2002 Apr 19;277(16):14020-30 PMID: 11821424 02/01/2002       35 Citations
  • PRL signal transduction in the epithelial compartment of rat prostate maintained as long-term organ cultures in vitro. (Ahonen TJ, Härkönen PL, Rui H, Nevalainen MT) Endocrinology 2002 Jan;143(1):228-38 PMID: 11751614 12/26/2001       46 Citations
  • Role of serine phosphorylation of Stat5a in prolactin-stimulated beta-casein gene expression. (Yamashita H, Nevalainen MT, Xu J, LeBaron MJ, Wagner KU, Erwin RA, Harmon JM, Hennighausen L, Kirken RA, Rui H) Mol Cell Endocrinol 2001 Oct 25;183(1-2):151-63 PMID: 11604235 10/18/2001       64 Citations
  • Increased expression of FGF-8 isoforms and FGF receptors in human premalignant prostatic intraepithelial neoplasia lesions and prostate cancer. (Valve EM, Nevalainen MT, Nurmi MJ, Laato MK, Martikainen PM, Härkönen PL) Lab Invest 2001 Jun;81(6):815-26 PMID: 11406643 06/15/2001       58 Citations
  • Increased expression of cyclooxygenase-2 and nitric oxide synthase-2 in human prostate cancer. (Uotila P, Valve E, Martikainen P, Nevalainen M, Nurmi M, Härkönen P) Urol Res 2001 Feb;29(1):23-8 PMID: 11310211 04/20/2001       127 Citations
  • Epithelial defect in prostates of Stat5a-null mice. (Nevalainen MT, Ahonen TJ, Yamashita H, Chandrashekar V, Bartke A, Grimley PM, Robinson GW, Hennighausen L, Rui H) Lab Invest 2000 Jul;80(7):993-1006 PMID: 10908145 07/25/2000       34 Citations
  • Prolactin is a survival factor for androgen-deprived rat dorsal and lateral prostate epithelium in organ culture. (Ahonen TJ, Härkönen PL, Laine J, Rui H, Martikainen PM, Nevalainen MT) Endocrinology 1999 Nov;140(11):5412-21 PMID: 10537173 10/28/1999       82 Citations
  • Group II phospholipase A2 in human male reproductive organs and genital tumors. (Kallajoki M, Alanen KA, Nevalainen M, Nevalainen TJ) Prostate 1998 Jun 01;35(4):263-72 PMID: 9609549 06/03/1998       43 Citations
  • Androgen-dependent expression of prolactin in rat prostate epithelium in vivo and in organ culture. (Nevalainen MT, Valve EM, Ahonen T, Yagi A, Paranko J, Härkönen PL) FASEB J 1997 Dec;11(14):1297-307 PMID: 9409549 12/31/1997       63 Citations
  • Prolactin and prolactin receptors are expressed and functioning in human prostate. (Nevalainen MT, Valve EM, Ingleton PM, Nurmi M, Martikainen PM, Harkonen PL) J Clin Invest 1997 Feb 15;99(4):618-27 PMID: 9045863 PMCID: PMC507843 02/15/1997       162 Citations
  • Expression and hormone regulation of prolactin receptors in rat dorsal and lateral prostate. (Nevalainen MT, Valve EM, Ingleton PM, Härkönen PL) Endocrinology 1996 Jul;137(7):3078-88 PMID: 8770934 07/01/1996       79 Citations
  • Hormone regulation of human prostate in organ culture. (Nevalainen MT, Härkönen PL, Valve EM, Ping W, Nurmi M, Martikainen PM) Cancer Res 1993 Nov 01;53(21):5199-207 PMID: 7693334 11/01/1993       56 Citations
  • Estrogen and prolactin regulation of rat dorsal and lateral prostate in organ culture. (Nevalainen MT, Valve EM, Mäkelä SI, Bläuer M, Tuohimaa PJ, Härkönen PL) Endocrinology 1991 Aug;129(2):612-22 PMID: 1830268 08/01/1991       74 Citations
    • Last update: 12/21/2018
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