Medical College of Wisconsin
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Mark T. McNally PhD

Mark T. McNally PhD profile photo picture

Associate Professor

Institution: Medical College of Wisconsin
Department: Microbiology and Immunology

Member of the Cancer Center

Research Experience

  • Alternative Splicing
  • Avian Leukosis Virus
  • Avian Sarcoma Viruses
  • Cleavage Stimulation Factor
  • Heterogeneous-Nuclear Ribonucleoprotein Group A-B
  • Heterogeneous-Nuclear Ribonucleoprotein Group F-H
  • Introns
  • Polyadenylation
  • RNA 3' Polyadenylation Signals
  • RNA Precursors
  • RNA Splice Sites
  • RNA Splicing
  • Ribonucleoproteins, Small Nuclear
  • Rous sarcoma virus
  • mRNA Cleavage and Polyadenylation Factors
  • Leadership Positions

  • Faculty Advisor, Research and Education Program, AHW
  • Chair, Course Evaluation Committee, Graduate School
  • Course Director, IAHI, M1 Medical School
  • Publications (36)

  • Splice switching an oncogenic ratio of SmgGDS isoforms as a strategy to diminish malignancy. (Brandt AC, McNally L, Lorimer EL, Unger B, Koehn OJ, Suazo KF, Rein L, Szabo A, Tsaih SW, Distefano MD, Flister MJ, Rigo F, McNally MT, Williams CL) Proc Natl Acad Sci U S A 2020 02 18;117(7):3627-3636 PMID: 32019878 PMCID: PMC7035473 SCOPUS ID: 2-s2.0-85079538992 02/06/2020       9 Citations
  • Evidence that a threshold of serine/arginine-rich (SR) proteins recruits CFIm to promote rous sarcoma virus mRNA 3' end formation. (Hudson SW, McNally LM, McNally MT) Virology 2016 11;498:181-191 PMID: 27596537 PMCID: PMC5045808 SCOPUS ID: 2-s2.0-84985990676 09/07/2016       2 Citations
  • A novel otoferlin splice-site mutation in siblings with auditory neuropathy spectrum disorder. (Runge CL, Erbe CB, McNally MT, Van Dusen C, Friedland DR, Kwitek AE, Kerschner JE) Audiol Neurootol 2013;18(6):374-82 PMID: 24135434 PMCID: PMC3877672 SCOPUS ID: 2-s2.0-84885522606 10/19/2013       13 Citations
  • Juxtaposition of two distant, serine-arginine-rich protein-binding elements is required for optimal polyadenylation in Rous sarcoma virus. (Hudson SW, McNally MT) J Virol 2011 Nov;85(21):11351-60 PMID: 21849435 PMCID: PMC3194969 SCOPUS ID: 2-s2.0-80055120941 08/19/2011       5 Citations
  • A glycine-rich domain of hnRNP H/F promotes nucleocytoplasmic shuttling and nuclear import through an interaction with transportin 1. (Van Dusen CM, Yee L, McNally LM, McNally MT) Mol Cell Biol 2010 May;30(10):2552-62 PMID: 20308327 PMCID: PMC2863714 SCOPUS ID: 2-s2.0-77951990307 03/24/2010       35 Citations
  • The waved with open eyelids (woe) locus is a hypomorphic mouse mutation in Adam17. (Hassemer EL, Le Gall SM, Liegel R, McNally M, Chang B, Zeiss CJ, Dubielzig RD, Horiuchi K, Kimura T, Okada Y, Blobel CP, Sidjanin DJ) Genetics 2010 May;185(1):245-55 PMID: 20194968 PMCID: PMC2870960 SCOPUS ID: 2-s2.0-77956635945 03/03/2010       34 Citations
  • Articular cartilage vesicles contain RNA. (Mitton E, Gohr CM, McNally MT, Rosenthal AK) Biochem Biophys Res Commun 2009 Oct 23;388(3):533-8 PMID: 19679100 PMCID: PMC2754773 SCOPUS ID: 2-s2.0-69549117350 08/15/2009       15 Citations
  • RNA processing control in avian retroviruses. (McNally MT) Front Biosci 2008 May 01;13:3869-83 PMID: 18508481 PMCID: PMC2575692 SCOPUS ID: 2-s2.0-42649114510 05/30/2008       7 Citations
  • Characterization of Rous sarcoma virus polyadenylation site use in vitro. (Maciolek NL, McNally MT) Virology 2008 May 10;374(2):468-76 PMID: 18272196 PMCID: PMC2413101 SCOPUS ID: 2-s2.0-42649140232 02/15/2008       11 Citations
  • Serine/arginine-rich proteins contribute to negative regulator of splicing element-stimulated polyadenylation in rous sarcoma virus. (Maciolek NL, McNally MT) J Virol 2007 Oct;81(20):11208-17 PMID: 17670832 PMCID: PMC2045511 SCOPUS ID: 2-s2.0-35148860145 08/03/2007       28 Citations
  • Urea-nuclease treatment of concentrated retrovirions preserves viral RNA and removes polymerase chain reaction-amplifiable cellular RNA and DNA. (Sun HY, McNally MT, Jackson VE, Grossberg SE) J Virol Methods 2006 Nov;137(2):304-8 PMID: 16920200 PMCID: PMC2575689 SCOPUS ID: 2-s2.0-33748714112 08/22/2006       1 Citation
  • Analysis of RNA splicing defects in PITX2 mutants supports a gene dosage model of Axenfeld-Rieger syndrome. (Maciolek NL, Alward WL, Murray JC, Semina EV, McNally MT) BMC Med Genet 2006 Jul 11;7:59 PMID: 16834779 PMCID: PMC1553432 SCOPUS ID: 2-s2.0-33748048489 07/13/2006       20 Citations
  • The retrovirus RNA trafficking granule: from birth to maturity. (Cochrane AW, McNally MT, Mouland AJ) Retrovirology 2006 Mar 17;3:18 PMID: 16545126 PMCID: PMC1475878 SCOPUS ID: 2-s2.0-33745103496 03/21/2006       97 Citations
  • Heterogeneous nuclear ribonucleoprotein H is required for optimal U11 small nuclear ribonucleoprotein binding to a retroviral RNA-processing control element: implications for U12-dependent RNA splicing. (McNally LM, Yee L, McNally MT) J Biol Chem 2006 Feb 03;281(5):2478-88 PMID: 16308319 SCOPUS ID: 2-s2.0-33646337943 11/26/2005       20 Citations
  • Two regions promote U11 small nuclear ribonucleoprotein particle binding to a retroviral splicing inhibitor element (negative regulator of splicing). (McNally LM, Yee L, McNally MT) J Biol Chem 2004 Sep 10;279(37):38201-8 PMID: 15252020 SCOPUS ID: 2-s2.0-4644293327 07/15/2004       9 Citations
  • Position dependence of the Rous sarcoma virus negative regulator of splicing element reflects proximity to a 5' splice site. (Wang Y, McNally MT) Virology 2003 Sep 01;313(2):629-37 PMID: 12954228 SCOPUS ID: 2-s2.0-0042386629 09/05/2003    
  • mRNA decay: x (XRN1) marks the spot. (Long RM, McNally MT) Mol Cell 2003 May;11(5):1126-8 PMID: 12769838 SCOPUS ID: 2-s2.0-0038730985 05/29/2003       24 Citations
  • Efficient polyadenylation of Rous sarcoma virus RNA requires the negative regulator of splicing element. (Fogel BL, McNally LM, McNally MT) Nucleic Acids Res 2002 Feb 01;30(3):810-7 PMID: 11809895 PMCID: PMC100303 SCOPUS ID: 2-s2.0-0036464505 01/26/2002       25 Citations
  • Erratum: A cellular protein, hnRNP H, binds to the negative regulator of splicing element from Rous sarcoma virus (The Journal of Biological Chemistry (2000) 275 (32371-32378)) (Fogel BL, McNally MT) Journal of Biological Chemistry 19 January 2001;276(3):2310 SCOPUS ID: 2-s2.0-0035910430 01/19/2001    
  • A cellular protein, hnRNP H, binds to the negative regulator of splicing element from Rous sarcoma virus. (Fogel BL, McNally MT) J Biol Chem 2000 Oct 13;275(41):32371-8 PMID: 10934202 SCOPUS ID: 2-s2.0-0034644743 08/10/2000       47 Citations
  • Trace contamination following reuse of anion-exchange DNA purification resins. (Fogel BL, McNally MT) Biotechniques 2000 Feb;28(2):299-302 PMID: 10683741 SCOPUS ID: 2-s2.0-0033973732 02/23/2000       4 Citations
  • Rapid, economical filter alternative to chromosomal DNA centrifugation in the alkaline lysis plasmid protocol. (McNally MT) Biotechniques 1999 Jul;27(1):68-71 PMID: 10407667 SCOPUS ID: 2-s2.0-0032986832 07/17/1999    
  • Interaction between the negative regulator of splicing element and a 3' splice site: requirement for U1 small nuclear ribonucleoprotein and the 3' splice site branch point/pyrimidine tract. (Cook CR, McNally MT) J Virol 1999 Mar;73(3):2394-400 PMID: 9971823 PMCID: PMC104485 SCOPUS ID: 2-s2.0-0032979419 02/11/1999       25 Citations
  • U1 small nuclear ribonucleoprotein and splicing inhibition by the rous sarcoma virus negative regulator of splicing element. (McNally LM, McNally MT) J Virol 1999 Mar;73(3):2385-93 PMID: 9971822 PMCID: PMC104484 SCOPUS ID: 2-s2.0-0032981016 02/11/1999       42 Citations
  • An RNA splicing enhancer-like sequence is a component of a splicing inhibitor element from Rous sarcoma virus. (McNally LM, McNally MT) Mol Cell Biol 1998 Jun;18(6):3103-11 PMID: 9584151 PMCID: PMC108892 SCOPUS ID: 2-s2.0-0031867840 06/20/1998       40 Citations
  • SR protein and snRNP requirements for assembly of the Rous sarcoma virus negative regulator of splicing complex in vitro. (Cook CR, McNally MT) Virology 1998 Mar 01;242(1):211-20 PMID: 9501036 SCOPUS ID: 2-s2.0-0032029767 03/17/1998       25 Citations
  • Characterization of an RNP complex that assembles on the Rous sarcoma virus negative regulator of splicing element. (Cook CR, McNally MT) Nucleic Acids Res 1996 Dec 15;24(24):4962-8 PMID: 9016667 PMCID: PMC146344 SCOPUS ID: 2-s2.0-0030459517 12/15/1996       8 Citations
  • SR protein splicing factors interact with the Rous sarcoma virus negative regulator of splicing element. (McNally LM, McNally MT) J Virol 1996 Feb;70(2):1163-72 PMID: 8551577 PMCID: PMC189925 SCOPUS ID: 2-s2.0-0030061154 02/01/1996       54 Citations
  • Two strong 5' splice sites and competing, suboptimal 3' splice sites involved in alternative splicing of human immunodeficiency virus type 1 RNA. (O'Reilly MM, McNally MT, Beemon KL) Virology 1995 Nov 10;213(2):373-85 PMID: 7491762 SCOPUS ID: 2-s2.0-0028807036 11/10/1995       100 Citations
  • Mutation of an RSV intronic element abolishes both U11/U12 snRNP binding and negative regulation of splicing. (Gontarek RR, McNally MT, Beemon K) Genes Dev 1993 Oct;7(10):1926-36 PMID: 8405999 SCOPUS ID: 2-s2.0-0027501973 10/01/1993       76 Citations
  • Induction of protective immunity in mice using a 62-kDa recombinant fragment of a Schistosoma mansoni surface antigen. (Soisson LM, Masterson CP, Tom TD, McNally MT, Lowell GH, Strand M) J Immunol 1992 Dec 01;149(11):3612-20 PMID: 1431131 SCOPUS ID: 2-s2.0-0026458038 12/01/1992       86 Citations
  • Intronic sequences and 3' splice sites control Rous sarcoma virus RNA splicing. (McNally MT, Beemon K) J Virol 1992 Jan;66(1):6-11 PMID: 1309264 PMCID: PMC238253 SCOPUS ID: 2-s2.0-0026500529 01/01/1992       69 Citations
  • Characterization of Rous sarcoma virus intronic sequences that negatively regulate splicing. (McNally MT, Gontarek RR, Beemon K) Virology 1991 Nov;185(1):99-108 PMID: 1656608 SCOPUS ID: 2-s2.0-0025953458 11/01/1991       63 Citations
  • Deoxyglucose-resistant mutants of Neurospora crassa: isolation, mapping, and biochemical characterization. (Allen KE, McNally MT, Lowendorf HS, Slayman CW, Free SJ) J Bacteriol 1989 Jan;171(1):53-8 PMID: 2521617 PMCID: PMC209552 SCOPUS ID: 2-s2.0-0024568866 01/01/1989       48 Citations
  • Isolation and characterization of a Neurospora glucose-repressible gene. (McNally MT, Free SJ) Curr Genet 1988 Dec;14(6):545-51 PMID: 2977301 SCOPUS ID: 2-s2.0-0024271454 12/01/1988       81 Citations
  • Neurospora glucamylase and a mutant affected in its regulation. (Sigmund RD, McNally MT, Lee DB, Free SJ) Biochem Genet 1985 Feb;23(1-2):89-103 PMID: 3922351 SCOPUS ID: 2-s2.0-0021914096 02/01/1985       15 Citations
  • Last update: 03/17/2020