Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Mark T. McNally PhD

Mark T. McNally PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Microbiology and Immunology

Member of the Cancer Center

Research Experience

  • Alternative Splicing
  • Avian Leukosis Virus
  • Avian Sarcoma Viruses
  • Cleavage Stimulation Factor
  • Heterogeneous-Nuclear Ribonucleoprotein Group A-B
  • Heterogeneous-Nuclear Ribonucleoprotein Group F-H
  • Introns
  • Polyadenylation
  • RNA 3' Polyadenylation Signals
  • RNA Precursors
  • RNA Splice Sites
  • RNA Splicing
  • Ribonucleoproteins, Small Nuclear
  • Rous sarcoma virus
  • mRNA Cleavage and Polyadenylation Factors
  • Leadership Positions

  • Faculty Advisor, Research and Education Program, AHW
  • Chair, Course Evaluation Committee, Graduate School
  • Course Director, IAHI, M1 Medical School
  • Publications

  • Evidence that a threshold of serine/arginine-rich (SR) proteins recruits CFIm to promote rous sarcoma virus mRNA 3' end formation. (Hudson SW, McNally LM, McNally MT) Virology 2016 11;498:181-191 PMID: 27596537 PMCID: PMC5045808 09/07/2016    
  • A novel otoferlin splice-site mutation in siblings with auditory neuropathy spectrum disorder. (Runge CL, Erbe CB, McNally MT, Van Dusen C, Friedland DR, Kwitek AE, Kerschner JE) Audiol Neurootol 2013;18(6):374-82 PMID: 24135434 PMCID: PMC3877672 10/19/2013       5 Citations
  • Juxtaposition of two distant, serine-arginine-rich protein-binding elements is required for optimal polyadenylation in Rous sarcoma virus. (Hudson SW, McNally MT) J Virol 2011 Nov;85(21):11351-60 PMID: 21849435 PMCID: PMC3194969 08/19/2011       5 Citations
  • A glycine-rich domain of hnRNP H/F promotes nucleocytoplasmic shuttling and nuclear import through an interaction with transportin 1. (Van Dusen CM, Yee L, McNally LM, McNally MT) Mol Cell Biol 2010 May;30(10):2552-62 PMID: 20308327 PMCID: PMC2863714 03/24/2010       24 Citations
  • Articular cartilage vesicles contain RNA. (Mitton E, Gohr CM, McNally MT, Rosenthal AK) Biochem Biophys Res Commun 2009 Oct 23;388(3):533-8 PMID: 19679100 PMCID: PMC2754773 08/15/2009       12 Citations
  • RNA processing control in avian retroviruses. (McNally MT) Front Biosci 2008 May 01;13:3869-83 PMID: 18508481 PMCID: PMC2575692 05/30/2008       6 Citations
  • Characterization of Rous sarcoma virus polyadenylation site use in vitro. (Maciolek NL, McNally MT) Virology 2008 May 10;374(2):468-76 PMID: 18272196 PMCID: PMC2413101 02/15/2008       8 Citations
  • Serine/arginine-rich proteins contribute to negative regulator of splicing element-stimulated polyadenylation in rous sarcoma virus. (Maciolek NL, McNally MT) J Virol 2007 Oct;81(20):11208-17 PMID: 17670832 PMCID: PMC2045511 08/03/2007       23 Citations
  • Urea-nuclease treatment of concentrated retrovirions preserves viral RNA and removes polymerase chain reaction-amplifiable cellular RNA and DNA. (Sun HY, McNally MT, Jackson VE, Grossberg SE) J Virol Methods 2006 Nov;137(2):304-8 PMID: 16920200 PMCID: PMC2575689 08/22/2006       1 Citations
  • Analysis of RNA splicing defects in PITX2 mutants supports a gene dosage model of Axenfeld-Rieger syndrome. (Maciolek NL, Alward WL, Murray JC, Semina EV, McNally MT) BMC Med Genet 2006 Jul 11;7:59 PMID: 16834779 PMCID: PMC1553432 07/13/2006       18 Citations
  • The retrovirus RNA trafficking granule: from birth to maturity. (Cochrane AW, McNally MT, Mouland AJ) Retrovirology 2006 Mar 17;3:18 PMID: 16545126 PMCID: PMC1475878 03/21/2006       94 Citations
  • Heterogeneous nuclear ribonucleoprotein H is required for optimal U11 small nuclear ribonucleoprotein binding to a retroviral RNA-processing control element: implications for U12-dependent RNA splicing. (McNally LM, Yee L, McNally MT) J Biol Chem 2006 Feb 03;281(5):2478-88 PMID: 16308319 11/26/2005       16 Citations
  • Two regions promote U11 small nuclear ribonucleoprotein particle binding to a retroviral splicing inhibitor element (negative regulator of splicing). (McNally LM, Yee L, McNally MT) J Biol Chem 2004 Sep 10;279(37):38201-8 PMID: 15252020 07/15/2004       8 Citations
  • Position dependence of the Rous sarcoma virus negative regulator of splicing element reflects proximity to a 5' splice site. (Wang Y, McNally MT) Virology 2003 Sep 01;313(2):629-37 PMID: 12954228 09/05/2003    
  • mRNA decay: x (XRN1) marks the spot. (Long RM, McNally MT) Mol Cell 2003 May;11(5):1126-8 PMID: 12769838 05/29/2003       23 Citations
  • Efficient polyadenylation of Rous sarcoma virus RNA requires the negative regulator of splicing element. (Fogel BL, McNally LM, McNally MT) Nucleic Acids Res 2002 Feb 01;30(3):810-7 PMID: 11809895 PMCID: PMC100303 01/26/2002       24 Citations
  • A cellular protein, hnRNP H, binds to the negative regulator of splicing element from Rous sarcoma virus. (Fogel BL, McNally MT) J Biol Chem 2000 Oct 13;275(41):32371-8 PMID: 10934202 08/10/2000       43 Citations
  • Trace contamination following reuse of anion-exchange DNA purification resins. (Fogel BL, McNally MT) Biotechniques 2000 Feb;28(2):299-302 PMID: 10683741 02/23/2000       4 Citations
  • Rapid, economical filter alternative to chromosomal DNA centrifugation in the alkaline lysis plasmid protocol. (McNally MT) Biotechniques 1999 Jul;27(1):68-71 PMID: 10407667 07/17/1999    
  • U1 small nuclear ribonucleoprotein and splicing inhibition by the rous sarcoma virus negative regulator of splicing element. (McNally LM, McNally MT) J Virol 1999 Mar;73(3):2385-93 PMID: 9971822 PMCID: PMC104484 02/11/1999       41 Citations
  • Interaction between the negative regulator of splicing element and a 3' splice site: requirement for U1 small nuclear ribonucleoprotein and the 3' splice site branch point/pyrimidine tract. (Cook CR, McNally MT) J Virol 1999 Mar;73(3):2394-400 PMID: 9971823 PMCID: PMC104485 02/11/1999       24 Citations
  • An RNA splicing enhancer-like sequence is a component of a splicing inhibitor element from Rous sarcoma virus. (McNally LM, McNally MT) Mol Cell Biol 1998 Jun;18(6):3103-11 PMID: 9584151 PMCID: PMC108892 06/20/1998       39 Citations
  • SR protein and snRNP requirements for assembly of the Rous sarcoma virus negative regulator of splicing complex in vitro. (Cook CR, McNally MT) Virology 1998 Mar 01;242(1):211-20 PMID: 9501036 03/17/1998       25 Citations
  • Characterization of an RNP complex that assembles on the Rous sarcoma virus negative regulator of splicing element. (Cook CR, McNally MT) Nucleic Acids Res 1996 Dec 15;24(24):4962-8 PMID: 9016667 PMCID: PMC146344 12/15/1996       8 Citations
  • SR protein splicing factors interact with the Rous sarcoma virus negative regulator of splicing element. (McNally LM, McNally MT) J Virol 1996 Feb;70(2):1163-72 PMID: 8551577 PMCID: PMC189925 02/01/1996       54 Citations
  • Two strong 5' splice sites and competing, suboptimal 3' splice sites involved in alternative splicing of human immunodeficiency virus type 1 RNA. (O'Reilly MM, McNally MT, Beemon KL) Virology 1995 Nov 10;213(2):373-85 PMID: 7491762 11/10/1995    
  • Mutation of an RSV intronic element abolishes both U11/U12 snRNP binding and negative regulation of splicing. (Gontarek RR, McNally MT, Beemon K) Genes Dev 1993 Oct;7(10):1926-36 PMID: 8405999 10/01/1993       73 Citations
  • Induction of protective immunity in mice using a 62-kDa recombinant fragment of a Schistosoma mansoni surface antigen. (Soisson LM, Masterson CP, Tom TD, McNally MT, Lowell GH, Strand M) J Immunol 1992 Dec 01;149(11):3612-20 PMID: 1431131 12/01/1992       83 Citations
  • Intronic sequences and 3' splice sites control Rous sarcoma virus RNA splicing. (McNally MT, Beemon K) J Virol 1992 Jan;66(1):6-11 PMID: 1309264 PMCID: PMC238253 01/01/1992       67 Citations
  • Characterization of Rous sarcoma virus intronic sequences that negatively regulate splicing. (McNally MT, Gontarek RR, Beemon K) Virology 1991 Nov;185(1):99-108 PMID: 1656608 11/01/1991       60 Citations
  • Deoxyglucose-resistant mutants of Neurospora crassa: isolation, mapping, and biochemical characterization. (Allen KE, McNally MT, Lowendorf HS, Slayman CW, Free SJ) J Bacteriol 1989 Jan;171(1):53-8 PMID: 2521617 PMCID: PMC209552 01/01/1989       44 Citations
  • Isolation and characterization of a Neurospora glucose-repressible gene. (McNally MT, Free SJ) Curr Genet 1988 Dec;14(6):545-51 PMID: 2977301 12/01/1988       79 Citations
  • Neurospora glucamylase and a mutant affected in its regulation. (Sigmund RD, McNally MT, Lee DB, Free SJ) Biochem Genet 1985 Feb;23(1-2):89-103 PMID: 3922351 02/01/1985       15 Citations
  • Last update: 08/23/2018
    jenkins-FCD Prod-300 626508253d14e4184314fb9f66322a03a5906796