Medical College of Wisconsin
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Mark T. McNally PhD

Mark T. McNally PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Microbiology and Molecular Genetics


Research Experience

  • Alternative Splicing
  • Avian Sarcoma Viruses
  • Avian leukosis virus
  • Cleavage Stimulation Factor
  • Heterogeneous-Nuclear Ribonucleoprotein Group A-B
  • Heterogeneous-Nuclear Ribonucleoprotein Group F-H
  • Introns
  • Polyadenylation
  • RNA 3' Polyadenylation Signals
  • RNA Precursors
  • RNA Splice Sites
  • RNA Splicing
  • Ribonucleoproteins, Small Nuclear
  • Rous sarcoma virus
  • mRNA Cleavage and Polyadenylation Factors
  • Leadership Positions

  • Chair, M1/2 Subcommittee of the CEC (ended 2013)
  • Chair, IDP Mentoring and Welfare Committee
  • Chair, Program Evaluation Committee of the Graduate School
  • Faculty Advisor, Research and Education Program, AHW
  • Publications

  • A novel otoferlin splice-site mutation in siblings with auditory neuropathy spectrum disorder. (Runge CL, Erbe CB, McNally MT, Van Dusen C, Friedland DR, Kwitek AE, Kerschner JE) Audiol Neurootol 2013;18(6):374-82 PMID 24135434
  • Juxtaposition of two distant, serine-arginine-rich protein-binding elements is required for optimal polyadenylation in Rous sarcoma virus. (Hudson SW, McNally MT) J Virol 2011 Nov;85(21):11351-60 PMID 21849435
  • A glycine-rich domain of hnRNP H/F promotes nucleocytoplasmic shuttling and nuclear import through an interaction with transportin 1. (Van Dusen CM, Yee L, McNally LM, McNally MT) Mol Cell Biol 2010 May;30(10):2552-62 PMID 20308327
  • Articular cartilage vesicles contain RNA. (Mitton E, Gohr CM, McNally MT, Rosenthal AK) Biochem Biophys Res Commun 2009 Oct 23;388(3):533-8 PMID 19679100
  • RNA processing control in avian retroviruses. (McNally MT) Front Biosci 2008;13:3869-83 PMID 18508481
  • Characterization of Rous sarcoma virus polyadenylation site use in vitro. (Maciolek NL, McNally MT) Virology 2008 May 10;374(2):468-76 PMID 18272196
  • Serine/arginine-rich proteins contribute to negative regulator of splicing element-stimulated polyadenylation in rous sarcoma virus. (Maciolek NL, McNally MT) J Virol 2007 Oct;81(20):11208-17 PMID 17670832
  • Urea-nuclease treatment of concentrated retrovirions preserves viral RNA and removes polymerase chain reaction-amplifiable cellular RNA and DNA. (Sun HY, McNally MT, Jackson VE, Grossberg SE) J Virol Methods 2006 Nov;137(2):304-8 PMID 16920200
  • Analysis of RNA splicing defects in PITX2 mutants supports a gene dosage model of Axenfeld-Rieger syndrome. (Maciolek NL, Alward WL, Murray JC, Semina EV, McNally MT) BMC Med Genet 2006;7:59 PMID 16834779
  • The retrovirus RNA trafficking granule: from birth to maturity. (Cochrane AW, McNally MT, Mouland AJ) Retrovirology 2006;3:18 PMID 16545126
  • Heterogeneous nuclear ribonucleoprotein H is required for optimal U11 small nuclear ribonucleoprotein binding to a retroviral RNA-processing control element: implications for U12-dependent RNA splicing. (McNally LM, Yee L, McNally MT) J Biol Chem 2006 Feb 3;281(5):2478-88 PMID 16308319
  • Two regions promote U11 small nuclear ribonucleoprotein particle binding to a retroviral splicing inhibitor element (negative regulator of splicing). (McNally LM, Yee L, McNally MT) J Biol Chem 2004 Sep 10;279(37):38201-8 PMID 15252020
  • Position dependence of the Rous sarcoma virus negative regulator of splicing element reflects proximity to a 5' splice site. (Wang Y, McNally MT) Virology 2003 Sep 1;313(2):629-37 PMID 12954228
  • mRNA decay: x (XRN1) marks the spot. (Long RM, McNally MT) Mol Cell 2003 May;11(5):1126-8 PMID 12769838
  • Efficient polyadenylation of Rous sarcoma virus RNA requires the negative regulator of splicing element. (Fogel BL, McNally LM, McNally MT) Nucleic Acids Res 2002 Feb 1;30(3):810-7 PMID 11809895
  • A cellular protein, hnRNP H, binds to the negative regulator of splicing element from Rous sarcoma virus. (Fogel BL, McNally MT) J Biol Chem 2000 Oct 13;275(41):32371-8 PMID 10934202
  • Trace contamination following reuse of anion-exchange DNA purification resins. (Fogel BL, McNally MT) Biotechniques 2000 Feb;28(2):299-302 PMID 10683741
  • Rapid, economical filter alternative to chromosomal DNA centrifugation in the alkaline lysis plasmid protocol. (McNally MT) Biotechniques 1999 Jul;27(1):68-71 PMID 10407667
  • Interaction between the negative regulator of splicing element and a 3' splice site: requirement for U1 small nuclear ribonucleoprotein and the 3' splice site branch point/pyrimidine tract. (Cook CR, McNally MT) J Virol 1999 Mar;73(3):2394-400 PMID 9971823
  • U1 small nuclear ribonucleoprotein and splicing inhibition by the rous sarcoma virus negative regulator of splicing element. (McNally LM, McNally MT) J Virol 1999 Mar;73(3):2385-93 PMID 9971822
  • An RNA splicing enhancer-like sequence is a component of a splicing inhibitor element from Rous sarcoma virus. (McNally LM, McNally MT) Mol Cell Biol 1998 Jun;18(6):3103-11 PMID 9584151
  • SR protein and snRNP requirements for assembly of the Rous sarcoma virus negative regulator of splicing complex in vitro. (Cook CR, McNally MT) Virology 1998 Mar 1;242(1):211-20 PMID 9501036
  • Characterization of an RNP complex that assembles on the Rous sarcoma virus negative regulator of splicing element. (Cook CR, McNally MT) Nucleic Acids Res 1996 Dec 15;24(24):4962-8 PMID 9016667
  • SR protein splicing factors interact with the Rous sarcoma virus negative regulator of splicing element. (McNally LM, McNally MT) J Virol 1996 Feb;70(2):1163-72 PMID 8551577
  • Two strong 5' splice sites and competing, suboptimal 3' splice sites involved in alternative splicing of human immunodeficiency virus type 1 RNA. (O'Reilly MM, McNally MT, Beemon KL) Virology 1995 Nov 10;213(2):373-85 PMID 7491762
  • Mutation of an RSV intronic element abolishes both U11/U12 snRNP binding and negative regulation of splicing. (Gontarek RR, McNally MT, Beemon K) Genes Dev 1993 Oct;7(10):1926-36 PMID 8405999
  • Induction of protective immunity in mice using a 62-kDa recombinant fragment of a Schistosoma mansoni surface antigen. (Soisson LM, Masterson CP, Tom TD, McNally MT, Lowell GH, Strand M) J Immunol 1992 Dec 1;149(11):3612-20 PMID 1431131
  • Intronic sequences and 3' splice sites control Rous sarcoma virus RNA splicing. (McNally MT, Beemon K) J Virol 1992 Jan;66(1):6-11 PMID 1309264
  • Characterization of Rous sarcoma virus intronic sequences that negatively regulate splicing. (McNally MT, Gontarek RR, Beemon K) Virology 1991 Nov;185(1):99-108 PMID 1656608
  • Deoxyglucose-resistant mutants of Neurospora crassa: isolation, mapping, and biochemical characterization. (Allen KE, McNally MT, Lowendorf HS, Slayman CW, Free SJ) J Bacteriol 1989 Jan;171(1):53-8 PMID 2521617
  • Isolation and characterization of a Neurospora glucose-repressible gene. (McNally MT, Free SJ) Curr Genet 1988 Dec;14(6):545-51 PMID 2977301
  • Neurospora glucamylase and a mutant affected in its regulation. (Sigmund RD, McNally MT, Lee DB, Free SJ) Biochem Genet 1985 Feb;23(1-2):89-103 PMID 3922351
  • Grants and Awards

  • KDF-13 - Antisense Oligo Modulation of SmgGDS in Breast Cancer (#9306422 03/01/2014 - 02/28/2015) Sponsor: Cancer Center
  • RNA Splicing Control in Rous Sarcoma Virus (#9206951 07/01/2011 - 06/30/2014) Sponsor: NIH Cancer Institute