Medical College of Wisconsin
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Matthew J. Riese MD, PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Hematology and Oncology - Medicine
Program: Hematology

Member of the Cancer Center


  • Immune Check Point Inhibition in Sarcomatoid Renal Cell Carcinoma: A New Treatment Paradigm. (Raychaudhuri R, Riese MJ, Bylow K, Burfeind J, Mackinnon AC, Tolat PP, Iczkowski KA, Kilari D) Clin Genitourin Cancer 2017 May 25 PMID: 28645484 06/25/2017
  • Adoptive cell therapy using PD-1(+) myeloma-reactive T cells eliminates established myeloma in mice. (Jing W, Gershan JA, Blitzer GC, Palen K, Weber J, McOlash L, Riese M, Johnson BD) J Immunother Cancer 2017;5:51 PMID: 28642819 PMCID: PMC5477110 06/24/2017
  • Academic Cancer Center Phase I Program Development. (Frankel AE, Flaherty KT, Weiner GJ, Chen R, Azad NS, Pishvaian MJ, Thompson JA, Taylor MH, Mahadevan D, Lockhart AC, Vaishampayan UN, Berlin JD, Smith DC, Sarantopoulos J, Riese M, Saleh MN, Ahn C, Frenkel EP) Oncologist 2017 Apr;22(4):369-374 PMID: 28314841 PMCID: PMC5388388 03/21/2017
  • Diacylglycerol Kinases (DGKs): Novel Targets for Improving T Cell Activity in Cancer. (Riese MJ, Moon EK, Johnson BD, Albelda SM) Front Cell Dev Biol 2016;4:108 PMID: 27800476 PMCID: PMC5065962 11/02/2016
  • Signaling in Effector Lymphocytes: Insights toward Safer Immunotherapy. (Rajasekaran K, Riese MJ, Rao S, Wang L, Thakar MS, Sentman CL, Malarkannan S) Front Immunol 2016;7:176 PMID: 27242783 PMCID: PMC4863891 06/01/2016
  • The adhesion molecule PECAM-1 enhances the TGF-β-mediated inhibition of T cell function. (Newman DK, Fu G, Adams T, Cui W, Arumugam V, Bluemn T, Riese MJ) Sci Signal 2016 Mar 08;9(418):ra27 PMID: 26956486 PMCID: PMC5087802 03/10/2016
  • TCR signaling intensity controls CD8+ T cell responsiveness to TGF-β. (Arumugam V, Bluemn T, Wesley E, Schmidt AM, Kambayashi T, Malarkannan S, Riese MJ) J Leukoc Biol 2015 Nov;98(5):703-12 PMID: 26153417 PMCID: PMC4600064 07/15/2015
  • Regulatory T cells require TCR signaling for their suppressive function. (Schmidt AM, Lu W, Sindhava VJ, Huang Y, Burkhardt JK, Yang E, Riese MJ, Maltzman JS, Jordan MS, Kambayashi T) J Immunol 2015 May 01;194(9):4362-70 PMID: 25821220 PMCID: PMC4402269 03/31/2015
  • IQGAP1: insights into the function of a molecular puppeteer. (Abel AM, Schuldt KM, Rajasekaran K, Hwang D, Riese MJ, Rao S, Thakar MS, Malarkannan S) Mol Immunol 2015 Jun;65(2):336-49 PMID: 25733387 PMCID: PMC4480615 03/04/2015
  • Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice. (Min SH, Suzuki A, Stalker TJ, Zhao L, Wang Y, McKennan C, Riese MJ, Guzman JF, Zhang S, Lian L, Joshi R, Meng R, Seeholzer SH, Choi JK, Koretzky G, Marks MS, Abrams CS) Nat Commun 2014 Sep 02;5:4691 PMID: 25178411 PMCID: PMC4369914 09/03/2014
  • Overcoming intrinsic inhibitory pathways to augment the antineoplastic activity of adoptively transferred T cells: Re-tuning your CAR before hitting a rocky road. (Wang LC, Riese MJ, Moon EK, Albelda SM) Oncoimmunology 2013 Nov 01;2(11):e26492 PMID: 24490126 PMCID: PMC3897565 02/04/2014
  • The ζ isoform of diacylglycerol kinase plays a predominant role in regulatory T cell development and TCR-mediated ras signaling. (Joshi RP, Schmidt AM, Das J, Pytel D, Riese MJ, Lester M, Diehl JA, Behrens EM, Kambayashi T, Koretzky GA) Sci Signal 2013 Nov 26;6(303):ra102 PMID: 24280043 PMCID: PMC4096120 11/28/2013
  • Enhanced effector responses in activated CD8+ T cells deficient in diacylglycerol kinases. (Riese MJ, Wang LC, Moon EK, Joshi RP, Ranganathan A, June CH, Koretzky GA, Albelda SM) Cancer Res 2013 Jun 15;73(12):3566-77 PMID: 23576561 PMCID: PMC3686869 04/12/2013
  • PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiation. (Bobrovnikova-Marjon E, Pytel D, Riese MJ, Vaites LP, Singh N, Koretzky GA, Witze ES, Diehl JA) Mol Cell Biol 2012 Jun;32(12):2268-78 PMID: 22493067 PMCID: PMC3372262 04/12/2012
  • Conditional deletion of SLP-76 in mature T cells abrogates peripheral immune responses. (Wu GF, Corbo E, Schmidt M, Smith-Garvin JE, Riese MJ, Jordan MS, Laufer TM, Brown EJ, Maltzman JS) Eur J Immunol 2011 Jul;41(7):2064-73 PMID: 21469089 PMCID: PMC3124603 04/07/2011
  • Decreased diacylglycerol metabolism enhances ERK activation and augments CD8+ T cell functional responses. (Riese MJ, Grewal J, Das J, Zou T, Patil V, Chakraborty AK, Koretzky GA) J Biol Chem 2011 Feb 18;286(7):5254-65 PMID: 21138839 PMCID: PMC3037638 12/09/2010
  • Chemotherapy for patients with poor prognosis germ cell tumors. (Riese MJ, Vaughn DJ) World J Urol 2009 Aug;27(4):471-6 PMID: 19330334 03/31/2009
  • Hematopoietic stem cell responsiveness to exogenous signals is limited by caspase-3. (Janzen V, Fleming HE, Riedt T, Karlsson G, Riese MJ, Lo Celso C, Reynolds G, Milne CD, Paige CJ, Karlsson S, Woo M, Scadden DT) Cell Stem Cell 2008 Jun 05;2(6):584-94 PMID: 18522851 PMCID: PMC2991117 06/05/2008
  • Molecular heterogeneity of a type III cytotoxin, Pseudomonas aeruginosa exoenzyme S. (Maresso AW, Riese MJ, Barbieri JT) Biochemistry 2003 Dec 09;42(48):14249-57 PMID: 14640693 12/04/2003
  • Intracellular localization modulates targeting of ExoS, a type III cytotoxin, to eukaryotic signalling proteins. (Pederson KJ, Krall R, Riese MJ, Barbieri JT) Mol Microbiol 2002 Dec;46(5):1381-90 PMID: 12453223 11/28/2002
  • Bacterial toxins that modify the actin cytoskeleton. (Barbieri JT, Riese MJ, Aktories K) Annu Rev Cell Dev Biol 2002;18:315-44 PMID: 12142277 07/27/2002
  • ADP-ribosylation and functional effects of Pseudomonas exoenzyme S on cellular RalA. (Fraylick JE, Riese MJ, Vincent TS, Barbieri JT, Olson JC) Biochemistry 2002 Jul 30;41(30):9680-7 PMID: 12135390 07/24/2002
  • Membrane localization contributes to the in vivo ADP-ribosylation of Ras by Pseudomonas aeruginosa ExoS. (Riese MJ, Barbieri JT) Infect Immun 2002 Apr;70(4):2230-2 PMID: 11895993 PMCID: PMC127869 03/16/2002
  • Auto-ADP-ribosylation of Pseudomonas aeruginosa ExoS. (Riese MJ, Goehring UM, Ehrmantraut ME, Moss J, Barbieri JT, Aktories K, Schmidt G) J Biol Chem 2002 Apr 05;277(14):12082-8 PMID: 11821389 02/01/2002
  • ADP ribosylation of Arg41 of Rap by ExoS inhibits the ability of Rap to interact with its guanine nucleotide exchange factor, C3G. (Riese MJ, Wittinghofer A, Barbieri JT) Biochemistry 2001 Mar 20;40(11):3289-94 PMID: 11258948 03/22/2001
  • A genetic screen for modifiers of Drosophila decapentaplegic signaling identifies mutations in punt, Mothers against dpp and the BMP-7 homologue, 60A. (Chen Y, Riese MJ, Killinger MA, Hoffmann FM) Development 1998 May;125(9):1759-68 PMID: 9521913 06/12/1998
  • Last update: 08/25/2017
    jenkins-FCD Prod-130 96200611f8481f0aa4f84230b11dd74d063847a3