Medical College of Wisconsin
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Matthew J. Riese MD, PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Hematology and Oncology - Medicine
Program: Bone Marrow Transplant

Member of the Cancer Center


  • Long-term outcomes of a phase I study of agonist CD40 antibody and CTLA-4 blockade in patients with metastatic melanoma. (Bajor DL, Mick R, Riese MJ, Huang AC, Sullivan B, Richman LP, Torigian DA, George SM, Stelekati E, Chen F, Melenhorst JJ, Lacey SF, Xu X, Wherry EJ, Gangadhar TC, Amaravadi RK, Schuchter LM, Vonderheide RH) Oncoimmunology 2018;7(10):e1468956 PMID: 30288340 PMCID: PMC6169575 10/06/2018    
  • Frontline Science: PECAM-1 (CD31) expression in naïve and memory, but not acutely activated, CD8 T cells. (Newman DK, Fu G, McOlash L, Schauder D, Newman PJ, Cui W, Rao S, Johnson BD, Gershan JA, Riese MJ) J Leukoc Biol 2018 Nov;104(5):883-893 PMID: 30063264 PMCID: PMC6195461 08/01/2018       2 Citations
  • Diacylglycerol kinase ζ (DGKζ) and Casitas b-lineage proto-oncogene b-deficient mice have similar functional outcomes in T cells but DGKζ-deficient mice have increased T cell activation and tumor clearance. (Wesley EM, Xin G, McAllister D, Malarkannan S, Newman DK, Dwinell MB, Cui W, Johnson BD, Riese MJ) Immunohorizons 2018 Apr 01;2(4):107-118 PMID: 30027154 PMCID: PMC6048965 07/22/2018    
  • Dextran Enhances the Lentiviral Transduction Efficiency of Murine and Human Primary NK Cells. (Nanbakhsh A, Best B, Riese M, Rao S, Wang L, Medin J, Thakar MS, Malarkannan S) J Vis Exp 2018 01 15(131) PMID: 29364266 PMCID: PMC5908645 01/25/2018    
  • T Cells Deficient in Diacylglycerol Kinase ζ Are Resistant to PD-1 Inhibition and Help Create Persistent Host Immunity to Leukemia. (Jing W, Gershan JA, Holzhauer S, Weber J, Palen K, McOlash L, Pulakanti K, Wesley E, Rao S, Johnson BD, Riese MJ) Cancer Res 2017 10 15;77(20):5676-5686 PMID: 28916658 09/17/2017    
  • Immune Check Point Inhibition in Sarcomatoid Renal Cell Carcinoma: A New Treatment Paradigm. (Raychaudhuri R, Riese MJ, Bylow K, Burfeind J, Mackinnon AC, Tolat PP, Iczkowski KA, Kilari D) Clin Genitourin Cancer 2017 10;15(5):e897-e901 PMID: 28645484 06/25/2017       2 Citations
  • Adoptive cell therapy using PD-1 myeloma-reactive T cells eliminates established myeloma in mice. (Jing W, Gershan JA, Blitzer GC, Palen K, Weber J, McOlash L, Riese M, Johnson BD) J Immunother Cancer 2017;5:51 PMID: 28642819 PMCID: PMC5477110 06/24/2017       2 Citations
  • Academic Cancer Center Phase I Program Development. (Frankel AE, Flaherty KT, Weiner GJ, Chen R, Azad NS, Pishvaian MJ, Thompson JA, Taylor MH, Mahadevan D, Lockhart AC, Vaishampayan UN, Berlin JD, Smith DC, Sarantopoulos J, Riese M, Saleh MN, Ahn C, Frenkel EP) Oncologist 2017 04;22(4):369-374 PMID: 28314841 PMCID: PMC5388388 03/21/2017    
  • Diacylglycerol Kinases (DGKs): Novel Targets for Improving T Cell Activity in Cancer. (Riese MJ, Moon EK, Johnson BD, Albelda SM) Front Cell Dev Biol 2016;4:108 PMID: 27800476 PMCID: PMC5065962 11/02/2016    
  • Signaling in Effector Lymphocytes: Insights toward Safer Immunotherapy. (Rajasekaran K, Riese MJ, Rao S, Wang L, Thakar MS, Sentman CL, Malarkannan S) Front Immunol 2016;7:176 PMID: 27242783 PMCID: PMC4863891 06/01/2016    
  • The adhesion molecule PECAM-1 enhances the TGF-β-mediated inhibition of T cell function. (Newman DK, Fu G, Adams T, Cui W, Arumugam V, Bluemn T, Riese MJ) Sci Signal 2016 Mar 08;9(418):ra27 PMID: 26956486 PMCID: PMC5087802 03/10/2016       6 Citations
  • TCR signaling intensity controls CD8+ T cell responsiveness to TGF-β. (Arumugam V, Bluemn T, Wesley E, Schmidt AM, Kambayashi T, Malarkannan S, Riese MJ) J Leukoc Biol 2015 Nov;98(5):703-12 PMID: 26153417 PMCID: PMC4600064 07/15/2015       6 Citations
  • Regulatory T cells require TCR signaling for their suppressive function. (Schmidt AM, Lu W, Sindhava VJ, Huang Y, Burkhardt JK, Yang E, Riese MJ, Maltzman JS, Jordan MS, Kambayashi T) J Immunol 2015 May 01;194(9):4362-70 PMID: 25821220 PMCID: PMC4402269 03/31/2015       19 Citations
  • IQGAP1: insights into the function of a molecular puppeteer. (Abel AM, Schuldt KM, Rajasekaran K, Hwang D, Riese MJ, Rao S, Thakar MS, Malarkannan S) Mol Immunol 2015 Jun;65(2):336-49 PMID: 25733387 PMCID: PMC4480615 03/04/2015       17 Citations
  • Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice. (Min SH, Suzuki A, Stalker TJ, Zhao L, Wang Y, McKennan C, Riese MJ, Guzman JF, Zhang S, Lian L, Joshi R, Meng R, Seeholzer SH, Choi JK, Koretzky G, Marks MS, Abrams CS) Nat Commun 2014 Sep 02;5:4691 PMID: 25178411 PMCID: PMC4369914 09/03/2014       14 Citations
  • Overcoming intrinsic inhibitory pathways to augment the antineoplastic activity of adoptively transferred T cells: Re-tuning your CAR before hitting a rocky road. (Wang LC, Riese MJ, Moon EK, Albelda SM) Oncoimmunology 2013 Nov 01;2(11):e26492 PMID: 24490126 PMCID: PMC3897565 02/04/2014    
  • The ζ isoform of diacylglycerol kinase plays a predominant role in regulatory T cell development and TCR-mediated ras signaling. (Joshi RP, Schmidt AM, Das J, Pytel D, Riese MJ, Lester M, Diehl JA, Behrens EM, Kambayashi T, Koretzky GA) Sci Signal 2013 Nov 26;6(303):ra102 PMID: 24280043 PMCID: PMC4096120 11/28/2013       18 Citations
  • Enhanced effector responses in activated CD8+ T cells deficient in diacylglycerol kinases. (Riese MJ, Wang LC, Moon EK, Joshi RP, Ranganathan A, June CH, Koretzky GA, Albelda SM) Cancer Res 2013 Jun 15;73(12):3566-77 PMID: 23576561 PMCID: PMC3686869 04/12/2013       44 Citations
  • PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiation. (Bobrovnikova-Marjon E, Pytel D, Riese MJ, Vaites LP, Singh N, Koretzky GA, Witze ES, Diehl JA) Mol Cell Biol 2012 Jun;32(12):2268-78 PMID: 22493067 PMCID: PMC3372262 04/12/2012       48 Citations
  • Conditional deletion of SLP-76 in mature T cells abrogates peripheral immune responses. (Wu GF, Corbo E, Schmidt M, Smith-Garvin JE, Riese MJ, Jordan MS, Laufer TM, Brown EJ, Maltzman JS) Eur J Immunol 2011 Jul;41(7):2064-73 PMID: 21469089 PMCID: PMC3124603 04/07/2011       10 Citations
  • Decreased diacylglycerol metabolism enhances ERK activation and augments CD8+ T cell functional responses. (Riese MJ, Grewal J, Das J, Zou T, Patil V, Chakraborty AK, Koretzky GA) J Biol Chem 2011 Feb 18;286(7):5254-65 PMID: 21138839 PMCID: PMC3037638 12/09/2010       32 Citations
  • Chemotherapy for patients with poor prognosis germ cell tumors. (Riese MJ, Vaughn DJ) World J Urol 2009 Aug;27(4):471-6 PMID: 19330334 03/31/2009       2 Citations
  • Hematopoietic stem cell responsiveness to exogenous signals is limited by caspase-3. (Janzen V, Fleming HE, Riedt T, Karlsson G, Riese MJ, Lo Celso C, Reynolds G, Milne CD, Paige CJ, Karlsson S, Woo M, Scadden DT) Cell Stem Cell 2008 Jun 05;2(6):584-94 PMID: 18522851 PMCID: PMC2991117 06/05/2008       76 Citations
  • Molecular heterogeneity of a type III cytotoxin, Pseudomonas aeruginosa exoenzyme S. (Maresso AW, Riese MJ, Barbieri JT) Biochemistry 2003 Dec 09;42(48):14249-57 PMID: 14640693 12/04/2003       4 Citations
  • Intracellular localization modulates targeting of ExoS, a type III cytotoxin, to eukaryotic signalling proteins. (Pederson KJ, Krall R, Riese MJ, Barbieri JT) Mol Microbiol 2002 Dec;46(5):1381-90 PMID: 12453223 11/28/2002       39 Citations
  • Bacterial toxins that modify the actin cytoskeleton. (Barbieri JT, Riese MJ, Aktories K) Annu Rev Cell Dev Biol 2002;18:315-44 PMID: 12142277 07/27/2002       116 Citations
  • ADP-ribosylation and functional effects of Pseudomonas exoenzyme S on cellular RalA. (Fraylick JE, Riese MJ, Vincent TS, Barbieri JT, Olson JC) Biochemistry 2002 Jul 30;41(30):9680-7 PMID: 12135390 07/24/2002       29 Citations
  • Membrane localization contributes to the in vivo ADP-ribosylation of Ras by Pseudomonas aeruginosa ExoS. (Riese MJ, Barbieri JT) Infect Immun 2002 Apr;70(4):2230-2 PMID: 11895993 PMCID: PMC127869 03/16/2002       18 Citations
  • Auto-ADP-ribosylation of Pseudomonas aeruginosa ExoS. (Riese MJ, Goehring UM, Ehrmantraut ME, Moss J, Barbieri JT, Aktories K, Schmidt G) J Biol Chem 2002 Apr 05;277(14):12082-8 PMID: 11821389 02/01/2002       45 Citations
  • ADP ribosylation of Arg41 of Rap by ExoS inhibits the ability of Rap to interact with its guanine nucleotide exchange factor, C3G. (Riese MJ, Wittinghofer A, Barbieri JT) Biochemistry 2001 Mar 20;40(11):3289-94 PMID: 11258948 03/22/2001       31 Citations
  • A genetic screen for modifiers of Drosophila decapentaplegic signaling identifies mutations in punt, Mothers against dpp and the BMP-7 homologue, 60A. (Chen Y, Riese MJ, Killinger MA, Hoffmann FM) Development 1998 May;125(9):1759-68 PMID: 9521913 06/12/1998       42 Citations
  • Last update: 12/26/2018
    jenkins-FCD Prod-299 9ef562391eceb2b8f95265c767fbba1ce5a52fd6