Medical College of Wisconsin
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Matthew J. Riese MD, PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Hematology and Oncology - Medicine
Program: Bone Marrow Transplant

Member of the Cancer Center


Publications (43)

  • Single-cell transcriptome reveals the novel role of T-bet in suppressing the immature NK gene signature. (Yang C, Siebert JR, Burns R, Zheng Y, Mei A, Bonacci B, Wang D, Urrutia RA, Riese MJ, Rao S, Carlson KS, Thakar MS, Malarkannan S) Elife 2020 May 14;9 PMID: 32406817 PMCID: PMC7255804 SCOPUS ID: 2-s2.0-85085630468 05/15/2020    
  • Impact of Neoadjuvant Chemoradiation on Pathologic Response in Patients With Localized Pancreatic Cancer. (Wittmann D, Hall WA, Christians KK, Barnes CA, Jariwalla NR, Aldakkak M, Clarke CN, George B, Ritch PS, Riese M, Khan AH, Kulkarni N, Evans J, Erickson BA, Evans DB, Tsai S) Front Oncol 2020;10:460 PMID: 32351886 PMCID: PMC7175033 SCOPUS ID: 2-s2.0-85084010622 05/01/2020    
  • Salvage ipilimumab associated with a significant response in sarcomatoid renal cell carcinoma. (George G, Schmidt L, Tolat P, Riese M, Kilari D) J Immunother Cancer 2020 02;8(1) PMID: 32114501 PMCID: PMC7057424 SCOPUS ID: 2-s2.0-85080840435 03/03/2020    
  • Beyond the cell surface: Targeting intracellular negative regulators to enhance t cell anti-tumor activity (Sitaram P, Uyemura B, Malarkannan S, Riese MJ) International Journal of Molecular Sciences 1 December 2019;20(23) SCOPUS ID: 2-s2.0-85075296555 12/01/2019    
  • Beyond the Cell Surface: Targeting Intracellular Negative Regulators to Enhance T cell Anti-Tumor Activity. (Sitaram P, Uyemura B, Malarkannan S, Riese MJ) Int J Mol Sci 2019 Nov 20;20(23) PMID: 31756921 PMCID: PMC6929154 SCOPUS ID: 2-s2.0-85075296555 11/24/2019       1 Citation
  • Adenosine 2A Receptor Blockade as an Immunotherapy for Treatment-Refractory Renal Cell Cancer. (Fong L, Hotson A, Powderly JD, Sznol M, Heist RS, Choueiri TK, George S, Hughes BGM, Hellmann MD, Shepard DR, Rini BI, Kummar S, Weise AM, Riese MJ, Markman B, Emens LA, Mahadevan D, Luke JJ, Laport G, Brody JD, Hernandez-Aya L, Bonomi P, Goldman JW, Berim L, Renouf DJ, Goodwin RA, Munneke B, Ho PY, Hsieh J, McCaffery I, Kwei L, Willingham SB, Miller RA) Cancer Discov 2020 01;10(1):40-53 PMID: 31732494 PMCID: PMC6954326 SCOPUS ID: 2-s2.0-85077761754 11/17/2019       13 Citations
  • Mirc11 Disrupts Inflammatory but Not Cytotoxic Responses of NK Cells. (Nanbakhsh A, Srinivasamani A, Holzhauer S, Riese MJ, Zheng Y, Wang D, Burns R, Reimer MH, Rao S, Lemke A, Tsaih SW, Flister MJ, Lao S, Dahl R, Thakar MS, Malarkannan S) Cancer Immunol Res 2019 10;7(10):1647-1662 PMID: 31515257 SCOPUS ID: 2-s2.0-85072848720 09/14/2019       1 Citation
  • Diacylglycerol kinase ζ promotes allergic airway inflammation and airway hyperresponsiveness through distinct mechanisms. (Singh BK, Lu W, Schmidt Paustian AM, Ge MQ, Koziol-White CJ, Flayer CH, Killingbeck SS, Wang N, Dong X, Riese MJ, Deshpande DA, Panettieri RA Jr, Haczku A, Kambayashi T) Sci Signal 2019 09 03;12(597) PMID: 31481522 PMCID: PMC6996596 SCOPUS ID: 2-s2.0-85071736372 09/05/2019       1 Citation
  • Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome. (Yang C, Siebert JR, Burns R, Gerbec ZJ, Bonacci B, Rymaszewski A, Rau M, Riese MJ, Rao S, Carlson KS, Routes JM, Verbsky JW, Thakar MS, Malarkannan S) Nat Commun 2019 09 02;10(1):3931 PMID: 31477722 PMCID: PMC6718415 SCOPUS ID: 2-s2.0-85071610251 09/04/2019       8 Citations
  • STING agonist inflames the pancreatic cancer immune microenvironment and reduces tumor burden in mouse models. (Jing W, McAllister D, Vonderhaar EP, Palen K, Riese MJ, Gershan J, Johnson BD, Dwinell MB) J Immunother Cancer 2019 04 29;7(1):115 PMID: 31036082 PMCID: PMC6489306 SCOPUS ID: 2-s2.0-85065258266 05/01/2019       7 Citations
  • Diacylglycerol kinase ζ is a negative regulator of GPVI-mediated platelet activation. (Moroi AJ, Zwifelhofer NM, Riese MJ, Newman DK, Newman PJ) Blood Adv 2019 04 09;3(7):1154-1166 PMID: 30967391 PMCID: PMC6457232 SCOPUS ID: 2-s2.0-85068307036 04/11/2019       1 Citation
  • Long-term outcomes of a phase I study of agonist CD40 antibody and CTLA-4 blockade in patients with metastatic melanoma. (Bajor DL, Mick R, Riese MJ, Huang AC, Sullivan B, Richman LP, Torigian DA, George SM, Stelekati E, Chen F, Melenhorst JJ, Lacey SF, Xu X, Wherry EJ, Gangadhar TC, Amaravadi RK, Schuchter LM, Vonderheide RH) Oncoimmunology 2018;7(10):e1468956 PMID: 30288340 PMCID: PMC6169575 10/06/2018    
  • Frontline Science: PECAM-1 (CD31) expression in naïve and memory, but not acutely activated, CD8+ T cells. (Newman DK, Fu G, McOlash L, Schauder D, Newman PJ, Cui W, Rao S, Johnson BD, Gershan JA, Riese MJ) J Leukoc Biol 2018 11;104(5):883-893 PMID: 30063264 PMCID: PMC6195461 SCOPUS ID: 2-s2.0-85053248137 08/01/2018       5 Citations
  • Diacylglycerol kinase ζ (DGKζ) and Casitas b-lineage proto-oncogene b-deficient mice have similar functional outcomes in T cells but DGKζ-deficient mice have increased T cell activation and tumor clearance. (Wesley EM, Xin G, McAllister D, Malarkannan S, Newman DK, Dwinell MB, Cui W, Johnson BD, Riese MJ) Immunohorizons 2018 Apr 01;2(4):107-118 PMID: 30027154 PMCID: PMC6048965 07/22/2018    
  • Dextran Enhances the Lentiviral Transduction Efficiency of Murine and Human Primary NK Cells. (Nanbakhsh A, Best B, Riese M, Rao S, Wang L, Medin J, Thakar MS, Malarkannan S) J Vis Exp 2018 01 15(131) PMID: 29364266 PMCID: PMC5908645 SCOPUS ID: 2-s2.0-85041082468 01/25/2018       2 Citations
  • T Cells Deficient in Diacylglycerol Kinase ζ Are Resistant to PD-1 Inhibition and Help Create Persistent Host Immunity to Leukemia. (Jing W, Gershan JA, Holzhauer S, Weber J, Palen K, McOlash L, Pulakanti K, Wesley E, Rao S, Johnson BD, Riese MJ) Cancer Res 2017 10 15;77(20):5676-5686 PMID: 28916658 SCOPUS ID: 2-s2.0-85031429221 09/17/2017       7 Citations
  • T-Cell Immunity (Carty SA, Riese MJ, Koretzky GA) Hematology: Basic Principles and Practice 15 August 2017:221-239 SCOPUS ID: 2-s2.0-85055773660 08/15/2017    
  • Immune Check Point Inhibition in Sarcomatoid Renal Cell Carcinoma: A New Treatment Paradigm. (Raychaudhuri R, Riese MJ, Bylow K, Burfeind J, Mackinnon AC, Tolat PP, Iczkowski KA, Kilari D) Clin Genitourin Cancer 2017 10;15(5):e897-e901 PMID: 28645484 SCOPUS ID: 2-s2.0-85020921698 06/25/2017       8 Citations
  • Adoptive cell therapy using PD-1+ myeloma-reactive T cells eliminates established myeloma in mice. (Jing W, Gershan JA, Blitzer GC, Palen K, Weber J, McOlash L, Riese M, Johnson BD) J Immunother Cancer 2017;5:51 PMID: 28642819 PMCID: PMC5477110 SCOPUS ID: 2-s2.0-85021161579 06/24/2017       8 Citations
  • Academic Cancer Center Phase I Program Development. (Frankel AE, Flaherty KT, Weiner GJ, Chen R, Azad NS, Pishvaian MJ, Thompson JA, Taylor MH, Mahadevan D, Lockhart AC, Vaishampayan UN, Berlin JD, Smith DC, Sarantopoulos J, Riese M, Saleh MN, Ahn C, Frenkel EP) Oncologist 2017 04;22(4):369-374 PMID: 28314841 PMCID: PMC5388388 SCOPUS ID: 2-s2.0-85017435066 03/21/2017    
  • Diacylglycerol Kinases (DGKs): Novel Targets for Improving T Cell Activity in Cancer. (Riese MJ, Moon EK, Johnson BD, Albelda SM) Front Cell Dev Biol 2016;4:108 PMID: 27800476 PMCID: PMC5065962 11/02/2016    
  • Signaling in Effector Lymphocytes: Insights toward Safer Immunotherapy. (Rajasekaran K, Riese MJ, Rao S, Wang L, Thakar MS, Sentman CL, Malarkannan S) Front Immunol 2016;7:176 PMID: 27242783 PMCID: PMC4863891 06/01/2016    
  • The adhesion molecule PECAM-1 enhances the TGF-β-mediated inhibition of T cell function. (Newman DK, Fu G, Adams T, Cui W, Arumugam V, Bluemn T, Riese MJ) Sci Signal 2016 Mar 08;9(418):ra27 PMID: 26956486 PMCID: PMC5087802 SCOPUS ID: 2-s2.0-84960380725 03/10/2016       8 Citations
  • TCR signaling intensity controls CD8+ T cell responsiveness to TGF-β. (Arumugam V, Bluemn T, Wesley E, Schmidt AM, Kambayashi T, Malarkannan S, Riese MJ) J Leukoc Biol 2015 Nov;98(5):703-12 PMID: 26153417 PMCID: PMC4600064 SCOPUS ID: 2-s2.0-84946053957 07/15/2015       13 Citations
  • Regulatory T cells require TCR signaling for their suppressive function. (Schmidt AM, Lu W, Sindhava VJ, Huang Y, Burkhardt JK, Yang E, Riese MJ, Maltzman JS, Jordan MS, Kambayashi T) J Immunol 2015 May 01;194(9):4362-70 PMID: 25821220 PMCID: PMC4402269 SCOPUS ID: 2-s2.0-84928498802 03/31/2015       32 Citations
  • IQGAP1: insights into the function of a molecular puppeteer. (Abel AM, Schuldt KM, Rajasekaran K, Hwang D, Riese MJ, Rao S, Thakar MS, Malarkannan S) Mol Immunol 2015 Jun;65(2):336-49 PMID: 25733387 PMCID: PMC4480615 SCOPUS ID: 2-s2.0-84923604300 03/04/2015       26 Citations
  • Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice. (Min SH, Suzuki A, Stalker TJ, Zhao L, Wang Y, McKennan C, Riese MJ, Guzman JF, Zhang S, Lian L, Joshi R, Meng R, Seeholzer SH, Choi JK, Koretzky G, Marks MS, Abrams CS) Nat Commun 2014 Sep 02;5:4691 PMID: 25178411 PMCID: PMC4369914 SCOPUS ID: 2-s2.0-84907339485 09/03/2014       24 Citations
  • Overcoming intrinsic inhibitory pathways to augment the antineoplastic activity of adoptively transferred T cells: Re-tuning your CAR before hitting a rocky road. (Wang LC, Riese MJ, Moon EK, Albelda SM) Oncoimmunology 2013 Nov 01;2(11):e26492 PMID: 24490126 PMCID: PMC3897565 02/04/2014    
  • The ζ isoform of diacylglycerol kinase plays a predominant role in regulatory T cell development and TCR-mediated ras signaling. (Joshi RP, Schmidt AM, Das J, Pytel D, Riese MJ, Lester M, Diehl JA, Behrens EM, Kambayashi T, Koretzky GA) Sci Signal 2013 Nov 26;6(303):ra102 PMID: 24280043 PMCID: PMC4096120 SCOPUS ID: 2-s2.0-84889254459 11/28/2013       37 Citations
  • Enhanced effector responses in activated CD8+ T cells deficient in diacylglycerol kinases. (Riese MJ, Wang LC, Moon EK, Joshi RP, Ranganathan A, June CH, Koretzky GA, Albelda SM) Cancer Res 2013 Jun 15;73(12):3566-77 PMID: 23576561 PMCID: PMC3686869 SCOPUS ID: 2-s2.0-84879097325 04/12/2013       68 Citations
  • PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiation. (Bobrovnikova-Marjon E, Pytel D, Riese MJ, Vaites LP, Singh N, Koretzky GA, Witze ES, Diehl JA) Mol Cell Biol 2012 Jun;32(12):2268-78 PMID: 22493067 PMCID: PMC3372262 SCOPUS ID: 2-s2.0-84864003561 04/12/2012       58 Citations
  • Conditional deletion of SLP-76 in mature T cells abrogates peripheral immune responses. (Wu GF, Corbo E, Schmidt M, Smith-Garvin JE, Riese MJ, Jordan MS, Laufer TM, Brown EJ, Maltzman JS) Eur J Immunol 2011 Jul;41(7):2064-73 PMID: 21469089 PMCID: PMC3124603 SCOPUS ID: 2-s2.0-79959729423 04/07/2011       12 Citations
  • Decreased diacylglycerol metabolism enhances ERK activation and augments CD8+ T cell functional responses. (Riese MJ, Grewal J, Das J, Zou T, Patil V, Chakraborty AK, Koretzky GA) J Biol Chem 2011 Feb 18;286(7):5254-65 PMID: 21138839 PMCID: PMC3037638 SCOPUS ID: 2-s2.0-79953141058 12/09/2010       40 Citations
  • Chemotherapy for patients with poor prognosis germ cell tumors. (Riese MJ, Vaughn DJ) World J Urol 2009 Aug;27(4):471-6 PMID: 19330334 SCOPUS ID: 2-s2.0-68549088984 03/31/2009       2 Citations
  • Hematopoietic stem cell responsiveness to exogenous signals is limited by caspase-3. (Janzen V, Fleming HE, Riedt T, Karlsson G, Riese MJ, Lo Celso C, Reynolds G, Milne CD, Paige CJ, Karlsson S, Woo M, Scadden DT) Cell Stem Cell 2008 Jun 05;2(6):584-94 PMID: 18522851 PMCID: PMC2991117 SCOPUS ID: 2-s2.0-44349188910 06/05/2008       84 Citations
  • Molecular heterogeneity of a type III cytotoxin, Pseudomonas aeruginosa exoenzyme S. (Maresso AW, Riese MJ, Barbieri JT) Biochemistry 2003 Dec 09;42(48):14249-57 PMID: 14640693 SCOPUS ID: 2-s2.0-0344629874 12/04/2003       4 Citations
  • Intracellular localization modulates targeting of ExoS, a type III cytotoxin, to eukaryotic signalling proteins. (Pederson KJ, Krall R, Riese MJ, Barbieri JT) Mol Microbiol 2002 Dec;46(5):1381-90 PMID: 12453223 SCOPUS ID: 2-s2.0-0036887054 11/28/2002       39 Citations
  • Bacterial toxins that modify the actin cytoskeleton. (Barbieri JT, Riese MJ, Aktories K) Annu Rev Cell Dev Biol 2002;18:315-44 PMID: 12142277 SCOPUS ID: 2-s2.0-0036437349 07/27/2002       119 Citations
  • ADP-ribosylation and functional effects of Pseudomonas exoenzyme S on cellular RalA. (Fraylick JE, Riese MJ, Vincent TS, Barbieri JT, Olson JC) Biochemistry 2002 Jul 30;41(30):9680-7 PMID: 12135390 SCOPUS ID: 2-s2.0-0037199493 07/24/2002       29 Citations
  • Membrane localization contributes to the in vivo ADP-ribosylation of Ras by Pseudomonas aeruginosa ExoS. (Riese MJ, Barbieri JT) Infect Immun 2002 Apr;70(4):2230-2 PMID: 11895993 PMCID: PMC127869 SCOPUS ID: 2-s2.0-0036131313 03/16/2002       18 Citations
  • Auto-ADP-ribosylation of Pseudomonas aeruginosa ExoS. (Riese MJ, Goehring UM, Ehrmantraut ME, Moss J, Barbieri JT, Aktories K, Schmidt G) J Biol Chem 2002 Apr 05;277(14):12082-8 PMID: 11821389 SCOPUS ID: 2-s2.0-0037023740 02/01/2002       47 Citations
  • ADP ribosylation of Arg41 of Rap by ExoS inhibits the ability of Rap to interact with its guanine nucleotide exchange factor, C3G. (Riese MJ, Wittinghofer A, Barbieri JT) Biochemistry 2001 Mar 20;40(11):3289-94 PMID: 11258948 SCOPUS ID: 2-s2.0-0035916917 03/22/2001       31 Citations
  • A genetic screen for modifiers of Drosophila decapentaplegic signaling identifies mutations in punt, Mothers against dpp and the BMP-7 homologue, 60A. (Chen Y, Riese MJ, Killinger MA, Hoffmann FM) Development 1998 May;125(9):1759-68 PMID: 9521913 06/12/1998       44 Citations
  • Last update: 06/30/2020
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