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Michael J. Flister PhD

Michael J. Flister PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Physiology

Member of the Cancer Center
Member of the Cardiovascular Center
Member of the Genomic Sciences and Precision Medicine Center (GSPMC)


Research Experience

  • Antineoplastic Agents
  • Biomarkers, Tumor
  • Breast Neoplasms
  • Cancer-Associated Fibroblasts
  • Carcinoma
  • Cell Line, Tumor
  • Cell Proliferation
  • Cervical Intraepithelial Neoplasia
  • Endothelial Cells
  • Genes, Tumor Suppressor
  • Genetic Loci
  • Genetic Markers
  • Genetic Predisposition to Disease
  • Genetic Variation
  • Lymphatic Vessels
  • Mammary Tumor Virus, Mouse
  • Polymorphism, Single Nucleotide
  • Tumor Microenvironment
  • Methodologies and Techniques

  • Genetic Loci
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Mice
  • Molecular Sequence Data
  • Quantitative Trait Loci
  • Rats
  • Sequence Analysis, DNA
  • Sequence Analysis, RNA
  • Whole Exome Sequencing
  • Whole Genome Sequencing
  • Xenograft Model Antitumor Assays
  • Publications

  • Genetic variations in human papillomavirus and cervical cancer outcomes. (Rader JS, Tsaih SW, Fullin D, Murray MW, Iden M, Zimmermann MT, Flister MJ) Int J Cancer 2018 Dec 04 PMID: 30515767 12/06/2018    
  • IL13 Promotes in vivo Neonatal Cardiomyocyte Cell Cycle Activity and Heart Regeneration. (Wodsedalek DJ, Paddock SJ, Wan TC, Auchampach JA, Kenarsary A, Tsaih SW, Flister MJ, O'Meara CC) Am J Physiol Heart Circ Physiol 2018 Oct 19 PMID: 30339498 10/20/2018    
  • Erratum: Methods for detecting host genetic modifiers of tumor vascular function using dynamic near-infrared fluorescence imaging: errata. (Jagtap J, Sharma G, Parchur AK, Gogineni V, Bergom C, White S, Flister MJ, Joshi A) Biomed Opt Express 2018 Jun 01;9(6):2543 PMID: 30258671 PMCID: PMC6154194 09/28/2018    
  • Loss of Nuclear Localized Parathyroid Hormone-Related Protein in Primary Breast Cancer Predicts Poor Clinical Outcome and Correlates with Suppressed Stat5 Signaling. (Tran TH, Utama FE, Sato T, Peck AR, Langenheim JF, Udhane SS, Sun Y, Liu C, Girondo MA, Kovatich AJ, Hooke JA, Shriver CD, Hu H, Palazzo JP, Bibbo M, Auer PW, Flister MJ, Hyslop T, Mitchell EP, Chervoneva I, Rui H) Clin Cancer Res 2018 Dec 15;24(24):6355-6366 PMID: 30097435 08/12/2018    
  • Vascular Interventional Radiology-Guided Photothermal Therapy of Colorectal Cancer Liver Metastasis with Theranostic Gold Nanorods. (Parchur AK, Sharma G, Jagtap JM, Gogineni VR, LaViolette PS, Flister MJ, White SB, Joshi A) ACS Nano 2018 Jul 24;12(7):6597-6611 PMID: 29969226 07/04/2018    
  • Exploring drivers of gene expression in the Cancer Genome Atlas (Andrea Rau, Michael Flister, Hallgeir Rui, Paul L Auer) Bioinformatics Bioinformatics, bty551, https://doi.org/10.1093/bioinformatics/bty551 07/02/2018    
  • Genetic Modifiers of the Breast Tumor Microenvironment. (Flister MJ, Bergom C) Trends Cancer 2018 Jun;4(6):429-444 PMID: 29860987 PMCID: PMC5990047 06/05/2018    
  • mTORC1 and mTORC2 differentially promote natural killer cell development. (Yang C, Tsaih SW, Lemke A, Flister MJ, Thakar MS, Malarkannan S) Elife 2018 05 29;7 PMID: 29809146 PMCID: PMC5976438 05/29/2018       1 Citations
  • A High-Resolution Genetic Map for the Laboratory Rat. (Littrell J, Tsaih SW, Baud A, Rastas P, Solberg-Woods L, Flister MJ) G3 (Bethesda) 2018 07 02;8(7):2241-2248 PMID: 29760201 PMCID: PMC6027877 05/16/2018    
  • Methods for detecting host genetic modifiers of tumor vascular function using dynamic near-infrared fluorescence imaging. (Jagtap J, Sharma G, Parchur AK, Gogineni V, Bergom C, White S, Flister MJ, Joshi A) Biomed Opt Express 2018 Feb 01;9(2):543-556 PMID: 29552392 PMCID: PMC5854057 03/20/2018    
  • Characterization of Coding/Noncoding Variants for in Patients with CKD. (Prokop JW, Yeo NC, Ottmann C, Chhetri SB, Florus KL, Ross EJ, Sosonkina N, Link BA, Freedman BI, Coppola CJ, McDermott-Roe C, Leysen S, Milroy LG, Meijer FA, Geurts AM, Rauscher FJ 3rd, Ramaker R, Flister MJ, Jacob HJ, Mendenhall EM, Lazar J) J Am Soc Nephrol 2018 May;29(5):1525-1535 PMID: 29476007 PMCID: PMC5967772 02/25/2018    
  • Genetic Fine-Mapping and Identification of Candidate Genes and Variants for Adiposity Traits in Outbred Rats. (Keele GR, Prokop JW, He H, Holl K, Littrell J, Deal A, Francic S, Cui L, Gatti DM, Broman KW, Tschannen M, Tsaih SW, Zagloul M, Kim Y, Baur B, Fox J, Robinson M, Levy S, Flister MJ, Mott R, Valdar W, Solberg Woods LC) Obesity (Silver Spring) 2018 01;26(1):213-222 PMID: 29193816 PMCID: PMC5740008 12/02/2017       4 Citations
  • SmgGDS is a transient nucleolar protein that protects cells from nucleolar stress and promotes the cell cycle by regulating DREAM complex gene expression. (Gonyo P, Bergom C, Brandt AC, Tsaih SW, Sun Y, Bigley TM, Lorimer EL, Terhune SS, Rui H, Flister MJ, Long RM, Williams CL) Oncogene 2017 12 14;36(50):6873-6883 PMID: 28806394 PMCID: PMC5730474 08/15/2017       2 Citations
  • Host genetic modifiers of nonproductive angiogenesis inhibit breast cancer. (Flister MJ, Tsaih SW, Stoddard A, Plasterer C, Jagtap J, Parchur AK, Sharma G, Prisco AR, Lemke A, Murphy D, Al-Gizawiy M, Straza M, Ran S, Geurts AM, Dwinell MR, Greene AS, Bergom C, LaViolette PS, Joshi A) Breast Cancer Res Treat 2017 Aug;165(1):53-64 PMID: 28567545 06/02/2017       2 Citations
  • MicroRNA-135b Regulates Leucine Zipper Tumor Suppressor 1 in Cutaneous Squamous Cell Carcinoma. (Olasz EB, Seline LN, Schock AM, Duncan NE, Lopez A, Lazar J, Flister MJ, Lu Y, Liu P, Sokumbi O, Harwood CA, Proby CM, Neuburg M, Lazarova Z) PLoS One 2015;10(5):e0125412 PMID: 25938461 PMCID: PMC4418692 05/06/2015       14 Citations
  • 2015 Guidelines for Establishing Genetically Modified Rat Models for Cardiovascular Research. (Flister MJ, Prokop JW, Lazar J, Shimoyama M, Dwinell M, Geurts A, International Committee on Standardized Genetic Nomenclature for Mice, Rat Genome and Nomenclature Committee) J Cardiovasc Transl Res 2015 Jun;8(4):269-77 PMID: 25920443 PMCID: PMC4475456 04/30/2015       8 Citations
  • SH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis. (Flister MJ, Hoffman MJ, Lemke A, Prisco SZ, Rudemiller N, O'Meara CC, Tsaih SW, Moreno C, Geurts AM, Lazar J, Adhikari N, Hall JL, Jacob HJ) Circ Cardiovasc Genet 2015 Apr;8(2):294-304 PMID: 25628389 01/30/2015       6 Citations
  • Vascular dysfunction precedes hypertension associated with a blood pressure locus on rat chromosome 12. (Prisco SZ, Priestley JR, Weinberg BD, Prisco AR, Hoffman MJ, Jacob HJ, Flister MJ, Lombard JH, Lazar J) Am J Physiol Heart Circ Physiol 2014 Oct 15;307(8):H1103-10 PMID: 25320330 PMCID: PMC4200336 10/17/2014    
  • Shroom3 contributes to the maintenance of the glomerular filtration barrier integrity. (Yeo NC, O'Meara CC, Bonomo JA, Veth KN, Tomar R, Flister MJ, Drummond IA, Bowden DW, Freedman BI, Lazar J, Link BA, Jacob HJ) Genome Res 2015 Jan;25(1):57-65 PMID: 25273069 PMCID: PMC4317173 10/03/2014       20 Citations
  • CXM: a new tool for mapping breast cancer risk in the tumor microenvironment. (Flister MJ, Endres BT, Rudemiller N, Sarkis AB, Santarriaga S, Roy I, Lemke A, Geurts AM, Moreno C, Ran S, Tsaih SW, De Pons J, Carlson DF, Tan W, Fahrenkrug SC, Lazarova Z, Lazar J, North PE, LaViolette PS, Dwinell MB, Shull JD, Jacob HJ) Cancer Res 2014 Nov 15;74(22):6419-29 PMID: 25172839 PMCID: PMC4247541 08/31/2014       8 Citations
  • Mutation of Plekha7 attenuates salt-sensitive hypertension in the rat. (Endres BT, Priestley JR, Palygin O, Flister MJ, Hoffman MJ, Weinberg BD, Grzybowski M, Lombard JH, Staruschenko A, Moreno C, Jacob HJ, Geurts AM) Proc Natl Acad Sci U S A 2014 Sep 02;111(35):12817-22 PMID: 25136115 PMCID: PMC4156702 08/20/2014       24 Citations
  • Refined mapping of a hypertension susceptibility locus on rat chromosome 12. (Prisco SZ, Prokop JW, Sarkis AB, Yeo NC, Hoffman MJ, Hansen CC, Jacob HJ, Flister MJ, Lazar J) Hypertension 2014 Oct;64(4):883-90 PMID: 25001272 PMCID: PMC4162822 07/09/2014       2 Citations
  • Identifying multiple causative genes at a single GWAS locus. (Flister MJ, Tsaih SW, O'Meara CC, Endres B, Hoffman MJ, Geurts AM, Dwinell MR, Lazar J, Jacob HJ, Moreno C) Genome Res 2013 Dec;23(12):1996-2002 PMID: 24006081 PMCID: PMC3847770 09/06/2013       47 Citations
  • Female-specific hypertension loci on rat chromosome 13. (Hoffman MJ, Flister MJ, Nunez L, Xiao B, Greene AS, Jacob HJ, Moreno C) Hypertension 2013 Sep;62(3):557-63 PMID: 23817491 PMCID: PMC3870583 07/03/2013       11 Citations
  • Congenic mapping and sequence analysis of the Renin locus. (Flister MJ, Hoffman MJ, Reddy P, Jacob HJ, Moreno C) Hypertension 2013 Apr;61(4):850-6 PMID: 23460292 PMCID: PMC3770301 03/06/2013       7 Citations
  • Identification of hypertension susceptibility loci on rat chromosome 12. (Flister MJ, Prisco SZ, Sarkis AB, O'Meara CC, Hoffman M, Wendt-Andrae J, Moreno C, Lazar J, Jacob HJ) Hypertension 2012 Oct;60(4):942-8 PMID: 22868394 PMCID: PMC3873777 08/08/2012       14 Citations
  • New model of macrophage acquisition of the lymphatic endothelial phenotype. (Hall KL, Volk-Draper LD, Flister MJ, Ran S) PLoS One 2012;7(3):e31794 PMID: 22396739 PMCID: PMC3292559 03/08/2012    
  • Synergy of nab-paclitaxel and bevacizumab in eradicating large orthotopic breast tumors and preexisting metastases. (Volk LD, Flister MJ, Chihade D, Desai N, Trieu V, Ran S) Neoplasia 2011 Apr;13(4):327-38 PMID: 21472137 PMCID: PMC3071081 04/08/2011    
  • Characterization of Prox1 and VEGFR-3 expression and lymphatic phenotype in normal organs of mice lacking p50 subunit of NF-κB. (Flister MJ, Volk LD, Ran S) Microcirculation 2011 Feb;18(2):85-101 PMID: 21166921 PMCID: PMC3058545 12/21/2010       15 Citations
  • Lymphangiogenesis and lymphatic metastasis in breast cancer. (Ran S, Volk L, Hall K, Flister MJ) Pathophysiology 2010 Sep;17(4):229-51 PMID: 20036110 PMCID: PMC2891887 12/29/2009    
  • Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-kappaB and Prox1. (Flister MJ, Wilber A, Hall KL, Iwata C, Miyazono K, Nisato RE, Pepper MS, Zawieja DC, Ran S) Blood 2010 Jan 14;115(2):418-29 PMID: 19901262 PMCID: PMC2808162 11/11/2009       116 Citations
  • Nab-paclitaxel efficacy in the orthotopic model of human breast cancer is significantly enhanced by concurrent anti-vascular endothelial growth factor A therapy. (Volk LD, Flister MJ, Bivens CM, Stutzman A, Desai N, Trieu V, Ran S) Neoplasia 2008 Jun;10(6):613-23 PMID: 18516298 PMCID: PMC2386546 06/03/2008       57 Citations
  • Anti-VEGF-A therapy reduces lymphatic vessel density and expression of VEGFR-3 in an orthotopic breast tumor model. (Whitehurst B, Flister MJ, Bagaitkar J, Volk L, Bivens CM, Pickett B, Castro-Rivera E, Brekken RA, Gerard RD, Ran S) Int J Cancer 2007 Nov 15;121(10):2181-91 PMID: 17597103 06/29/2007       65 Citations
  • Last update: 01/15/2019
    jenkins-FCD Prod-300 626508253d14e4184314fb9f66322a03a5906796