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Michael James PhD

Michael James PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Surgery
Division: Administration
Program: General

Member of the Cancer Center


MCW Program / Core Facilities

  • Tumor Progression and Metastasis Program Member
  • Publications

  • CLPTM1L/CRR9 ectodomain interaction with GRP78 at the cell surface signals for survival and chemoresistance upon ER stress in pancreatic adenocarcinoma cells. (Clarke WR, Amundadottir L, James MA) Int J Cancer 2019 Mar 15;144(6):1367-1378 PMID: 30468251 11/24/2018    
  • Development of primary human pancreatic cancer organoids, matched stromal and immune cells and 3D tumor microenvironment models. (Tsai S, McOlash L, Palen K, Johnson B, Duris C, Yang Q, Dwinell MB, Hunt B, Evans DB, Gershan J, James MA) BMC Cancer 2018 03 27;18(1):335 PMID: 29587663 PMCID: PMC5870823 03/29/2018       3 Citations
  • Natural Products Discovered in a High-Throughput Screen Identified as Inhibitors of RGS17 and as Cytostatic and Cytotoxic Agents for Lung and Prostate Cancer Cell Lines. (Bodle CR, Mackie DI, Hayes MP, Schamp JH, Miller MR, Henry MD, Doorn JA, Houtman JCD, James MA, Roman DL) J Nat Prod 2017 07 28;80(7):1992-2000 PMID: 28621943 PMCID: PMC5567870 06/18/2017       3 Citations
  • Stromal Inflammation in Pancreatic Cancer: Mechanisms and Translational Applications (Boyle K, James MA, Tsai S, Evans DB, Dwinell MB.) Pancreatic Cancer. 2nd Ed. Springer-Verlag New York DOI: 10.1007/978-1-4939-6631-8_55-1 01/01/2017    
  • Novel Anti-CRR9/CLPTM1L Antibodies with Antitumorigenic Activity Inhibit Cell Surface Accumulation, PI3K Interaction, and Survival Signaling. (Puskás LG, Mán I, Szebeni G, Tiszlavicz L, Tsai S, James MA) Mol Cancer Ther 2016 05;15(5):985-97 PMID: 26939707 PMCID: PMC4873426 03/05/2016       5 Citations
  • Inhibition of IGF1R signaling abrogates resistance to afatinib (BIBW2992) in EGFR T790M mutant lung cancer cells. (Lee Y, Wang Y, James M, Jeong JH, You M) Mol Carcinog 2016 May;55(5):991-1001 PMID: 26052929 PMCID: PMC6003619 06/09/2015       17 Citations
  • Functional characterization of RAD52 as a lung cancer susceptibility gene in the 12p13.33 locus. (Lieberman R, Xiong D, James M, Han Y, Amos CI, Wang L, You M) Mol Carcinog 2016 May;55(5):953-63 PMID: 26013599 PMCID: PMC4662629 05/28/2015       12 Citations
  • A novel, soluble compound, C25, sensitizes to TRAIL-induced apoptosis through upregulation of DR5 expression. (James MA, Seibel WL, Kupert E, Hu XX, Potharla VY, Anderson MW) Anticancer Drugs 2015 Jun;26(5):518-30 PMID: 25646742 02/04/2015       1 Citations
  • CRR9/CLPTM1L regulates cell survival signaling and is required for Ras transformation and lung tumorigenesis. (James MA, Vikis HG, Tate E, Rymaszewski AL, You M) Cancer Res 2014 Feb 15;74(4):1116-27 PMID: 24366883 PMCID: PMC6005686 12/25/2013       29 Citations
  • Functional characterization of CLPTM1L as a lung cancer risk candidate gene in the 5p15.33 locus. (James MA, Wen W, Wang Y, Byers LA, Heymach JV, Coombes KR, Girard L, Minna J, You M) PLoS One 2012;7(6):e36116 PMID: 22675468 PMCID: PMC3366984 06/08/2012       63 Citations
  • Identification of somatic mutations in non-small cell lung carcinomas using whole-exome sequencing. (Liu P, Morrison C, Wang L, Xiong D, Vedell P, Cui P, Hua X, Ding F, Lu Y, James M, Ebben JD, Xu H, Adjei AA, Head K, Andrae JW, Tschannen MR, Jacob H, Pan J, Zhang Q, Van den Bergh F, Xiao H, Lo KC, Patel J, Richmond T, Watt MA, Albert T, Selzer R, Anderson M, Wang J, Wang Y, Starnes S, Yang P, You M) Carcinogenesis 2012 Jul;33(7):1270-6 PMID: 22510280 PMCID: PMC3499051 04/19/2012       112 Citations
  • Modulation of gene expression and cell-cycle signaling pathways by the EGFR inhibitor gefitinib (Iressa) in rat urinary bladder cancer. (Lu Y, Liu P, Van den Bergh F, Zellmer V, James M, Wen W, Grubbs CJ, Lubet RA, You M) Cancer Prev Res (Phila) 2012 Feb;5(2):248-59 PMID: 21982874 10/11/2011       12 Citations
  • Principles for the post-GWAS functional characterization of cancer risk loci. (Freedman ML, Monteiro AN, Gayther SA, Coetzee GA, Risch A, Plass C, Casey G, De Biasi M, Carlson C, Duggan D, James M, Liu P, Tichelaar JW, Vikis HG, You M, Mills IG) Nat Genet 2011 Jun;43(6):513-8 PMID: 21614091 PMCID: PMC3325768 05/27/2011       250 Citations
  • Dietary administration of berberine or Phellodendron amurense extract inhibits cell cycle progression and lung tumorigenesis. (James MA, Fu H, Liu Y, Chen DR, You M) Mol Carcinog 2011 Jan;50(1):1-7 PMID: 21061266 PMCID: PMC6004604 11/10/2010       33 Citations
  • Chemopreventive effects of pioglitazone on chemically induced lung carcinogenesis in mice. (Wang Y, James M, Wen W, Lu Y, Szabo E, Lubet RA, You M) Mol Cancer Ther 2010 Nov;9(11):3074-82 PMID: 21045137 11/04/2010       37 Citations
  • Genetic variants cis-regulating Xrn2 expression contribute to the risk of spontaneous lung tumor. (Lu Y, Liu P, James M, Vikis HG, Liu H, Wen W, Franklin A, You M) Oncogene 2010 Feb 18;29(7):1041-9 PMID: 19915612 PMCID: PMC6019621 11/17/2009       13 Citations
  • Haplotype and cell proliferation analyses of candidate lung cancer susceptibility genes on chromosome 15q24-25.1. (Liu Y, Liu P, Wen W, James MA, Wang Y, Bailey-Wilson JE, Amos CI, Pinney SM, Yang P, de Andrade M, Petersen GM, Wiest JS, Fain PR, Schwartz AG, Gazdar A, Gaba C, Rothschild H, Mandal D, Kupert E, Lee J, Seminara D, Minna J, Anderson MW, You M) Cancer Res 2009 Oct 01;69(19):7844-50 PMID: 19789337 PMCID: PMC2846106 10/01/2009       34 Citations
  • Identification of Las2, a major modifier gene affecting the Pas1 mouse lung tumor susceptibility locus. (Liu PY, Vikis H, James M, Lu Y, Wang DL, Liu HB, Wen WD, Wang Y, You M) Cancer Res 2009 Aug 01;69(15):6290-8 PMID: 19622765 07/23/2009       6 Citations
  • Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene. (You M, Wang D, Liu P, Vikis H, James M, Lu Y, Wang Y, Wang M, Chen Q, Jia D, Liu Y, Wen W, Yang P, Sun Z, Pinney SM, Zheng W, Shu XO, Long J, Gao YT, Xiang YB, Chow WH, Rothman N, Petersen GM, de Andrade M, Wu Y, Cunningham JM, Wiest JS, Fain PR, Schwartz AG, Girard L, Gazdar A, Gaba C, Rothschild H, Mandal D, Coons T, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Amos CI, Anderson MW) Clin Cancer Res 2009 Apr 15;15(8):2666-74 PMID: 19351763 PMCID: PMC2746091 04/09/2009       56 Citations
  • RGS17, an overexpressed gene in human lung and prostate cancer, induces tumor cell proliferation through the cyclic AMP-PKA-CREB pathway. (James MA, Lu Y, Liu Y, Vikis HG, You M) Cancer Res 2009 Mar 01;69(5):2108-16 PMID: 19244110 PMCID: PMC2746047 02/27/2009       54 Citations
  • Common human cancer genes discovered by integrated gene-expression analysis. (Lu Y, Yi Y, Liu P, Wen W, James M, Wang D, You M) PLoS One 2007 Nov 07;2(11):e1149 PMID: 17989776 PMCID: PMC2065803 11/09/2007       56 Citations
  • EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity. (Vikis H, Sato M, James M, Wang D, Wang Y, Wang M, Jia D, Liu Y, Bailey-Wilson JE, Amos CI, Pinney SM, Petersen GM, de Andrade M, Yang P, Wiest JS, Fain PR, Schwartz AG, Gazdar A, Gaba C, Rothschild H, Mandal D, Kupert E, Seminara D, Viswanathan A, Govindan R, Minna J, Anderson MW, You M) Cancer Res 2007 May 15;67(10):4665-70 PMID: 17510392 PMCID: PMC3460269 05/19/2007       71 Citations
  • IGFBP-3 regulates esophageal tumor growth through IGF-dependent and independent mechanisms. (Takaoka M, Kim SH, Okawa T, Michaylira CZ, Stairs DB, Johnstone CN, Andl CD, Rhoades B, Lee JJ, Klein-Szanto AJ, El-Deiry WS, Nakagawa H) Cancer Biol Ther 2007 Apr;6(4):534-40 PMID: 17457048 PMCID: PMC2993006 04/26/2007       20 Citations
  • HPV16-E6 associated hTERT promoter acetylation is E6AP dependent, increased in later passage cells and enhanced by loss of p300. (James MA, Lee JH, Klingelhutz AJ) Int J Cancer 2006 Oct 15;119(8):1878-85 PMID: 16708385 PMCID: PMC2223064 05/19/2006       52 Citations
  • Human papillomavirus type 16 E6 activates NF-kappaB, induces cIAP-2 expression, and protects against apoptosis in a PDZ binding motif-dependent manner. (James MA, Lee JH, Klingelhutz AJ) J Virol 2006 Jun;80(11):5301-7 PMID: 16699010 PMCID: PMC1472131 05/16/2006       96 Citations
  • Reduction of fecal shedding and egg contamination of Salmonella enteritidis by increasing the number of heterophil adaptations. (Kramer TT, Reinke CR, James M) Avian Dis 1998 Jul-Sep;42(3):585-8 PMID: 9777160 10/20/1998       7 Citations
  • Last update: 01/03/2019
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