Medical College of Wisconsin
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Michele A. Battle PhD

Michele A. Battle PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Cell Biology, Neurobiology and Anatomy
Program: Administration

Member of the Cancer Center
Member of the Neuroscience Research Center


Research Experience

  • Anatomy
  • Animals
  • Animals, Laboratory
  • Biology
  • Cells
  • Cellular Structures
  • Chimera
  • Developmental Biology
  • Digestive System
  • Digestive System Abnormalities
  • Digestive System Diseases
  • Embryology
  • Epithelial Cells
  • Epithelium
  • Eukaryotic Cells
  • Gastrointestinal Diseases
  • Gastrointestinal Tract
  • Genetics
  • Liver
  • Molecular Biology
  • Organisms, Genetically Modified
  • Organoids
  • Pancreas
  • Stem Cells
  • Tissues
  • Publications

  • GATA4 Is Sufficient to Establish Jejunal Versus Ileal Identity in the Small Intestine. (Thompson CA, Wojta K, Pulakanti K, Rao S, Dawson P, Battle MA) Cell Mol Gastroenterol Hepatol 2017 May;3(3):422-446 PMID: 28462382 PMCID: PMC5404030 05/04/2017
  • Efficient Precision Genome Editing in iPSCs via Genetic Co-targeting with Selection. (Mitzelfelt KA, McDermott-Roe C, Grzybowski MN, Marquez M, Kuo CT, Riedel M, Lai S, Choi MJ, Kolander KD, Helbling D, Dimmock DP, Battle MA, Jou CJ, Tristani-Firouzi M, Verbsky JW, Benjamin IJ, Geurts AM) Stem Cell Reports 2017 Mar 14;8(3):491-499 PMID: 28238794 PMCID: PMC5355643 02/28/2017
  • A Dynamic WNT/β-CATENIN Signaling Environment Leads to WNT-Independent and WNT-Dependent Proliferation of Embryonic Intestinal Progenitor Cells. (Chin AM, Tsai YH, Finkbeiner SR, Nagy MS, Walker EM, Ethen NJ, Williams BO, Battle MA, Spence JR) Stem Cell Reports 2016 Nov 08;7(5):826-839 PMID: 27720905 PMCID: PMC5106483 10/11/2016
  • GATA4 regulates epithelial cell proliferation to control intestinal growth and development in mice. (Kohlnhofer BM, Thompson CA, Walker EM, Battle MA) Cell Mol Gastroenterol Hepatol 2016 Mar;2(2):189-209 PMID: 27066525 PMCID: PMC4823006 04/12/2016
  • Transcriptional Regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4α (HNF4Α) Is Vital to Beta-cell Function. (Moore BD, Jin RU, Lo H, Jung M, Wang H, Battle MA, Wollheim CB, Urano F, Mills JC) J Biol Chem 2016 Mar 18;291(12):6146-57 PMID: 26792861 PMCID: PMC4813565 01/23/2016
  • Increased prefrontal cortex neurogranin enhances plasticity and extinction learning. (Zhong L, Brown J, Kramer A, Kaleka K, Petersen A, Krueger JN, Florence M, Muelbl MJ, Battle M, Murphy GG, Olsen CM, Gerges NZ) J Neurosci 2015 May 13;35(19):7503-8 PMID: 25972176 PMCID: PMC4429154 05/15/2015
  • Characterization of the developing small intestine in the absence of either GATA4 or GATA6. (Walker EM, Thompson CA, Kohlnhofer BM, Faber ML, Battle MA) BMC Res Notes 2014 Dec 11;7:902 PMID: 25495347 PMCID: PMC4307969 12/17/2014
  • GATA4 and GATA6 regulate intestinal epithelial cytodifferentiation during development. (Walker EM, Thompson CA, Battle MA) Dev Biol 2014 Aug 15;392(2):283-94 PMID: 24929016 PMCID: PMC4149467 06/15/2014
  • Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis. (Xuan S, Borok MJ, Decker KJ, Battle MA, Duncan SA, Hale MA, Macdonald RJ, Sussel L) J Clin Invest 2012 Oct;122(10):3516-28 PMID: 23006325 PMCID: PMC3461916 09/26/2012
  • E-cadherin is required for intestinal morphogenesis in the mouse. (Bondow BJ, Faber ML, Wojta KJ, Walker EM, Battle MA) Dev Biol 2012 Nov 01;371(1):1-12 PMID: 22766025 PMCID: PMC3455111 07/07/2012
  • Intestinal GATA4 deficiency protects from diet-induced hepatic steatosis. (Patankar JV, Obrowsky S, Doddapattar P, Hoefler G, Battle M, Levak-Frank S, Kratky D) J Hepatol 2012 Nov;57(5):1061-8 PMID: 22750465 PMCID: PMC3477492 07/04/2012
  • Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut. (Shulzhenko N, Morgun A, Hsiao W, Battle M, Yao M, Gavrilova O, Orandle M, Mayer L, Macpherson AJ, McCoy KD, Fraser-Liggett C, Matzinger P) Nat Med 2011 Nov 20;17(12):1585-93 PMID: 22101768 PMCID: PMC3902046 11/22/2011
  • HNF4A is essential for specification of hepatic progenitors from human pluripotent stem cells. (DeLaForest A, Nagaoka M, Si-Tayeb K, Noto FK, Konopka G, Battle MA, Duncan SA) Development 2011 Oct;138(19):4143-53 PMID: 21852396 PMCID: PMC3171218 08/20/2011
  • Loss of intestinal GATA4 prevents diet-induced obesity and promotes insulin sensitivity in mice. (Patankar JV, Chandak PG, Obrowsky S, Pfeifer T, Diwoky C, Uellen A, Sattler W, Stollberger R, Hoefler G, Heinemann A, Battle M, Duncan S, Kratky D, Levak-Frank S) Am J Physiol Endocrinol Metab 2011 Mar;300(3):E478-88 PMID: 21177287 PMCID: PMC3163292 12/24/2010
  • The Peroxisomal 3-keto-acyl-CoA thiolase B Gene Expression Is under the Dual Control of PPARα and HNF4α in the Liver. (Chamouton J, Hansmannel F, Bonzo JA, Clémencet MC, Chevillard G, Battle M, Martin P, Pineau T, Duncan S, Gonzalez FJ, Latruffe N, Mandard S, Nicolas-Francès V) PPAR Res 2010;2010:352957 PMID: 21437216 PMCID: PMC3061263 01/01/2010
  • Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells. (Si-Tayeb K, Noto FK, Nagaoka M, Li J, Battle MA, Duris C, North PE, Dalton S, Duncan SA) Hepatology 2010 Jan;51(1):297-305 PMID: 19998274 PMCID: PMC2946078 12/10/2009
  • Hepatocyte expression of serum response factor is essential for liver function, hepatocyte proliferation and survival, and postnatal body growth in mice. (Sun K, Battle MA, Misra RP, Duncan SA) Hepatology 2009 May;49(5):1645-54 PMID: 19205030 PMCID: PMC2810404 02/11/2009
  • GATA4 is essential for jejunal function in mice. (Battle MA, Bondow BJ, Iverson MA, Adams SJ, Jandacek RJ, Tso P, Duncan SA) Gastroenterology 2008 Nov;135(5):1676-1686.e1 PMID: 18812176 PMCID: PMC2844802 09/25/2008
  • Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H. (Luebke-Wheeler J, Zhang K, Battle M, Si-Tayeb K, Garrison W, Chhinder S, Li J, Kaufman RJ, Duncan SA) Hepatology 2008 Oct;48(4):1242-50 PMID: 18704925 PMCID: PMC2717709 08/16/2008
  • Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice. (Zhao R, Watt AJ, Battle MA, Li J, Bondow BJ, Duncan SA) Dev Biol 2008 May 15;317(2):614-9 PMID: 18400219 PMCID: PMC2423416 04/11/2008
  • Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver. (Battle MA, Konopka G, Parviz F, Gaggl AL, Yang C, Sladek FM, Duncan SA) Proc Natl Acad Sci U S A 2006 May 30;103(22):8419-24 PMID: 16714383 PMCID: PMC1482507 05/23/2006
  • Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon. (Garrison WD, Battle MA, Yang C, Kaestner KH, Sladek FM, Duncan SA) Gastroenterology 2006 Apr;130(4):1207-20 PMID: 16618389 PMCID: PMC3581272 04/19/2006
  • Transcriptional regulation of the human hepatic lipase (LIPC) gene promoter. (Rufibach LE, Duncan SA, Battle M, Deeb SS) J Lipid Res 2006 Jul;47(7):1463-77 PMID: 16603721 04/11/2006
  • GATA4 is essential for formation of the proepicardium and regulates cardiogenesis. (Watt AJ, Battle MA, Li J, Duncan SA) Proc Natl Acad Sci U S A 2004 Aug 24;101(34):12573-8 PMID: 15310850 PMCID: PMC515098 08/18/2004
  • ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways. (Battle MA, Maher VM, McCormick JJ) Biochemistry 2003 Jun 24;42(24):7270-82 PMID: 12809483 06/18/2003
  • Last update: 08/02/2017
    jenkins-FCD Prod-153 3ca6710ea990189ceb85f4312e7298b5922ce1a6