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Ming You MD, PhD

Ming You MD, PhD

Associate Provost, Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Pharmacology

Member of the Cancer Center
Member of the Cardiovascular Center


Research Experience

  • Carcinoma, Non-Small-Cell Lung
  • Carcinoma, Small Cell
  • Chemoprevention
  • DNA Fingerprinting
  • Genes, Neoplasm
  • Molecular Biology
  • Tumor Suppressor Protein p53
  • Publications

  • Immunogenomic Landscape Contributes to Hyperprogressive Disease after Anti-PD-1 Immunotherapy for Cancer. (Xiong D, Wang Y, Singavi AK, Mackinnon AC, George B, You M) iScience 2018 Nov 30;9:258-277 PMID: 30439581 PMCID: PMC6234258 11/16/2018    
  • Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity. (Pan J, Lee Y, Cheng G, Zielonka J, Zhang Q, Bajzikova M, Xiong D, Tsaih SW, Hardy M, Flister M, Olsen CM, Wang Y, Vang O, Neuzil J, Myers CR, Kalyanaraman B, You M) iScience 2018 May 25;3:192-207 PMID: 30428319 PMCID: PMC6137433 11/15/2018    
  • Rare Variants in Known Susceptibility Loci and Their Contribution to Risk of Lung Cancer. (Liu Y, Lusk CM, Cho MH, Silverman EK, Qiao D, Zhang R, Scheurer ME, Kheradmand F, Wheeler DA, Tsavachidis S, Armstrong G, Zhu D, Wistuba II, Chow CB, Behrens C, Pikielny CW, Neslund-Dudas C, Pinney SM, Anderson M, Kupert E, Bailey-Wilson J, Gaba C, Mandal D, You M, de Andrade M, Yang P, Field JK, Liloglou T, Davies M, Lissowska J, Swiatkowska B, Zaridze D, Mukeriya A, Janout V, Holcatova I, Mates D, Milosavljevic S, Scelo G, Brennan P, McKay J, Liu G, Hung RJ, Christiani DC, Schwartz AG, Amos CI, Spitz MR) J Thorac Oncol 2018 Oct;13(10):1483-1495 PMID: 29981437 07/08/2018    
  • Genome-wide association study of familial lung cancer. (Byun J, Schwartz AG, Lusk C, Wenzlaff AS, de Andrade M, Mandal D, Gaba C, Yang P, You M, Kupert EY, Anderson MW, Han Y, Li Y, Qian D, Stilp A, Laurie C, Nelson S, Zheng W, Hung RJ, Gaborieau V, Mckay J, Brennan P, Caporaso NE, Landi MT, Wu X, McLaughlin JR, Brhane Y, Bossé Y, Pinney SM, Bailey-Wilson JE, Amos CI) Carcinogenesis 2018 Sep 21;39(9):1135-1140 PMID: 29924316 PMCID: PMC6148967 06/21/2018    
  • Airway brushing as a new experimental methodology to detect airway gene expression signatures in mouse lung squamous cell carcinoma. (Pan J, Xiong D, Zhang Q, Szabo E, Miller MS, Lubet RA, Wang Y, You M) Sci Rep 2018 Jun 11;8(1):8895 PMID: 29891994 PMCID: PMC5995924 06/13/2018    
  • Novel mutational landscapes and expression signatures of lung squamous cell carcinoma. (Xiong D, Pan J, Yin Y, Jiang H, Szabo E, Lubet RA, Wang Y, You M) Oncotarget 2018 Jan 26;9(7):7424-7441 PMID: 29484121 PMCID: PMC5800913 02/28/2018    
  • Immunoprevention of KRAS-driven lung adenocarcinoma by a multipeptide vaccine. (Pan J, Zhang Q, Sei S, Shoemaker RH, Lubet RA, Wang Y, You M) Oncotarget 2017 Oct 10;8(47):82689-82699 PMID: 29137294 PMCID: PMC5669920 11/16/2017    
  • Effect of weekly or daily dosing regimen of Gefitinib in mouse models of lung cancer. (Zhang Q, Li R, Chen X, Lee SB, Pan J, Xiong D, Hu J, Miller MS, Szabo E, Lubet RA, Wang Y, You M) Oncotarget 2017 Sep 22;8(42):72447-72456 PMID: 29069801 PMCID: PMC5641144 10/27/2017    
  • Parametric Linkage Analysis Identifies Five Novel Genome-Wide Significant Loci for Familial Lung Cancer. (Musolf AM, Simpson CL, de Andrade M, Mandal D, Gaba C, Yang P, Li Y, You M, Kupert EY, Anderson MW, Schwartz AG, Pinney SM, Amos CI, Bailey-Wilson JE) Hum Hered 2016;82(1-2):64-74 PMID: 28817824 08/18/2017    
  • Corrupting the DNA damage response: a critical role for Rad52 in tumor cell survival. (Lieberman R, You M) Aging (Albany NY) 2017 07 15;9(7):1647-1659 PMID: 28722656 PMCID: PMC5559167 07/20/2017       3 Citations
  • Pioglitazone-mediated reversal of elevated glucose metabolism in the airway epithelium of mouse lung adenocarcinomas. (Xiong D, Pan J, Zhang Q, Szabo E, Miller MS, Lubet RA, Wang Y, You M) JCI Insight 2017 Jul 06;2(13) PMID: 28679956 PMCID: PMC5499364 07/07/2017    
  • Rad52 deficiency decreases development of lung squamous cell carcinomas by enhancing immuno-surveillance. (Lieberman R, Pan J, Zhang Q, You M) Oncotarget 2017 May 23;8(21):34032-34044 PMID: 28415565 PMCID: PMC5470949 04/19/2017    
  • Familial Lung Cancer: A Brief History from the Earliest Work to the Most Recent Studies. (Musolf AM, Simpson CL, de Andrade M, Mandal D, Gaba C, Yang P, Li Y, You M, Kupert EY, Anderson MW, Schwartz AG, Pinney SM, Amos CI, Bailey-Wilson JE) Genes (Basel) 2017 Jan 17;8(1) PMID: 28106732 PMCID: PMC5295030 01/21/2017    
  • Bronchial airway gene expression signatures in mouse lung squamous cell carcinoma and their modulation by cancer chemopreventive agents. (Xiong D, Pan J, Zhang Q, Szabo E, Miller MS, Lubet RA, You M, Wang Y) Oncotarget 2017 Mar 21;8(12):18885-18900 PMID: 27935865 PMCID: PMC5386655 12/10/2016    
  • Honokiol Decreases Lung Cancer Metastasis through Inhibition of the STAT3 Signaling Pathway. (Pan J, Lee Y, Zhang Q, Xiong D, Wan TC, Wang Y, You M) Cancer Prev Res (Phila) 2017 Feb;10(2):133-141 PMID: 27849557 PMCID: PMC6005650 11/17/2016       9 Citations
  • miR-375 induces docetaxel resistance in prostate cancer by targeting SEC23A and YAP1. (Wang Y, Lieberman R, Pan J, Zhang Q, Du M, Zhang P, Nevalainen M, Kohli M, Shenoy NK, Meng H, You M, Wang L) Mol Cancer 2016 11 10;15(1):70 PMID: 27832783 PMCID: PMC5105253 11/12/2016       20 Citations
  • Brain metastasis in lung cancer: Building a molecular and systems-level understanding to improve outcomes. (Ebben JD, You M) Int J Biochem Cell Biol 2016 09;78:288-296 PMID: 27474492 PMCID: PMC6020150 07/31/2016       7 Citations
  • Honokiol targets mitochondria to halt cancer progression and metastasis. (Pan J, Lee Y, Wang Y, You M) Mol Nutr Food Res 2016 06;60(6):1383-95 PMID: 27276215 06/09/2016       16 Citations
  • Focused Analysis of Exome Sequencing Data for Rare Germline Mutations in Familial and Sporadic Lung Cancer. (Liu Y, Kheradmand F, Davis CF, Scheurer ME, Wheeler D, Tsavachidis S, Armstrong G, Simpson C, Mandal D, Kupert E, Anderson M, You M, Xiong D, Pikielny C, Schwartz AG, Bailey-Wilson J, Gaba C, De Andrade M, Yang P, Pinney SM, Genetic Epidemiology of Lung Cancer Consortium, Amos CI, Spitz MR) J Thorac Oncol 2016 Jan;11(1):52-61 PMID: 26762739 PMCID: PMC4714038 01/15/2016       8 Citations
  • Patterns and functional implications of rare germline variants across 12 cancer types. (Lu C, Xie M, Wendl MC, Wang J, McLellan MD, Leiserson MD, Huang KL, Wyczalkowski MA, Jayasinghe R, Banerjee T, Ning J, Tripathi P, Zhang Q, Niu B, Ye K, Schmidt HK, Fulton RS, McMichael JF, Batra P, Kandoth C, Bharadwaj M, Koboldt DC, Miller CA, Kanchi KL, Eldred JM, Larson DE, Welch JS, You M, Ozenberger BA, Govindan R, Walter MJ, Ellis MJ, Mardis ER, Graubert TA, Dipersio JF, Ley TJ, Wilson RK, Goodfellow PJ, Raphael BJ, Chen F, Johnson KJ, Parvin JD, Ding L) Nat Commun 2015 Dec 22;6:10086 PMID: 26689913 PMCID: PMC4703835 12/23/2015       66 Citations
  • Epidermal growth factor receptor derived peptide vaccination to prevent lung adenocarcinoma formation: An in vivo study in a murine model of EGFR mutant lung cancer. (Ebben JD, Lubet RA, Gad E, Disis ML, You M) Mol Carcinog 2016 Nov;55(11):1517-1525 PMID: 26346412 PMCID: PMC6019616 09/09/2015       7 Citations
  • PARK2 gene and familial lung cancer: what is the link? (Xiong D, Wang Y, You M) Future Oncol 2015;11(12):1707-10 PMID: 26075437 06/16/2015    
  • Inhibition of IGF1R signaling abrogates resistance to afatinib (BIBW2992) in EGFR T790M mutant lung cancer cells. (Lee Y, Wang Y, James M, Jeong JH, You M) Mol Carcinog 2016 May;55(5):991-1001 PMID: 26052929 PMCID: PMC6003619 06/09/2015       17 Citations
  • Functional characterization of RAD52 as a lung cancer susceptibility gene in the 12p13.33 locus. (Lieberman R, Xiong D, James M, Han Y, Amos CI, Wang L, You M) Mol Carcinog 2016 May;55(5):953-63 PMID: 26013599 PMCID: PMC4662629 05/28/2015       12 Citations
  • Enhanced antitumor activity of 3-bromopyruvate in combination with rapamycin in vivo and in vitro. (Zhang Q, Pan J, Lubet RA, Komas SM, Kalyanaraman B, Wang Y, You M) Cancer Prev Res (Phila) 2015 Apr;8(4):318-26 PMID: 25644152 PMCID: PMC6004825 02/04/2015       5 Citations
  • A recurrent mutation in PARK2 is associated with familial lung cancer. (Xiong D, Wang Y, Kupert E, Simpson C, Pinney SM, Gaba CR, Mandal D, Schwartz AG, Yang P, de Andrade M, Pikielny C, Byun J, Li Y, Stambolian D, Spitz MR, Liu Y, Amos CI, Bailey-Wilson JE, Anderson M, You M) Am J Hum Genet 2015 Feb 05;96(2):301-8 PMID: 25640678 PMCID: PMC4320264 02/03/2015       27 Citations
  • Honokiol inhibits lung tumorigenesis through inhibition of mitochondrial function. (Pan J, Zhang Q, Liu Q, Komas SM, Kalyanaraman B, Lubet RA, Wang Y, You M) Cancer Prev Res (Phila) 2014 Nov;7(11):1149-59 PMID: 25245764 PMCID: PMC6010030 09/24/2014       14 Citations
  • Targeting the insulin-like growth factor-1 receptor by picropodophyllin for lung cancer chemoprevention. (Zhang Q, Pan J, Lubet RA, Wang Y, You M) Mol Carcinog 2015 Jun;54 Suppl 1:E129-37 PMID: 25163779 08/29/2014       9 Citations
  • Clinical biomarkers of pulmonary carcinoid tumors in never smokers via profiling miRNA and target mRNA. (Deng B, Molina J, Aubry MC, Sun Z, Wang L, Eckloff BW, Vasmatzis G, You M, Wieben ED, Jen J, Wigle DA, Yang P) Cell Biosci 2014;4:35 PMID: 25105010 PMCID: PMC4124500 08/12/2014    
  • Conserved recurrent gene mutations correlate with pathway deregulation and clinical outcomes of lung adenocarcinoma in never-smokers. (Sun Z, Wang L, Eckloff BW, Deng B, Wang Y, Wampfler JA, Jang J, Wieben ED, Jen J, You M, Yang P) BMC Med Genomics 2014 Jun 04;7:32 PMID: 24894543 PMCID: PMC4060138 06/05/2014       24 Citations
  • Genome-wide association tests of inversions with application to psoriasis. (Ma J, Xiong M, You M, Lozano G, Amos CI) Hum Genet 2014 Aug;133(8):967-74 PMID: 24623382 PMCID: PMC4281304 03/14/2014       5 Citations
  • Whole-genome sequencing identifies genomic heterogeneity at a nucleotide and chromosomal level in bladder cancer. (Morrison CD, Liu P, Woloszynska-Read A, Zhang J, Luo W, Qin M, Bshara W, Conroy JM, Sabatini L, Vedell P, Xiong D, Liu S, Wang J, Shen H, Li Y, Omilian AR, Hill A, Head K, Guru K, Kunnev D, Leach R, Eng KH, Darlak C, Hoeflich C, Veeranki S, Glenn S, You M, Pruitt SC, Johnson CS, Trump DL) Proc Natl Acad Sci U S A 2014 Feb 11;111(6):E672-81 PMID: 24469795 PMCID: PMC3926024 01/29/2014       56 Citations
  • CRR9/CLPTM1L regulates cell survival signaling and is required for Ras transformation and lung tumorigenesis. (James MA, Vikis HG, Tate E, Rymaszewski AL, You M) Cancer Res 2014 Feb 15;74(4):1116-27 PMID: 24366883 PMCID: PMC6005686 12/25/2013       28 Citations
  • Transcriptomic analysis by RNA-seq reveals AP-1 pathway as key regulator that green tea may rely on to inhibit lung tumorigenesis. (Pan J, Zhang Q, Xiong D, Vedell P, Yan Y, Jiang H, Cui P, Ding F, Tichelaar JW, Wang Y, Lubet RA, You M) Mol Carcinog 2014 Jan;53(1):19-29 PMID: 24343902 12/18/2013    
  • EYA4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk. (Wilson IM, Vucic EA, Enfield KS, Thu KL, Zhang YA, Chari R, Lockwood WW, Radulovich N, Starczynowski DT, Banáth JP, Zhang M, Pusic A, Fuller M, Lonergan KM, Rowbotham D, Yee J, English JC, Buys TP, Selamat SA, Laird-Offringa IA, Liu P, Anderson M, You M, Tsao MS, Brown CJ, Bennewith KL, MacAulay CE, Karsan A, Gazdar AF, Lam S, Lam WL) Oncogene 2014 Sep 04;33(36):4464-73 PMID: 24096489 PMCID: PMC4527534 10/08/2013       14 Citations
  • Quantitative receptor-based imaging of tumor proliferation with the sigma-2 ligand [(18)F]ISO-1. (Shoghi KI, Xu J, Su Y, He J, Rowland D, Yan Y, Garbow JR, Tu Z, Jones LA, Higashikubo R, Wheeler KT, Lubet RA, Mach RH, You M) PLoS One 2013;8(9):e74188 PMID: 24073202 PMCID: PMC3779213 09/28/2013       28 Citations
  • Concordant effects of aromatase inhibitors on gene expression in ER+ Rat and human mammary cancers and modulation of the proteins coded by these genes. (Lu Y, You M, Ghazoui Z, Liu P, Vedell PT, Wen W, Bode AM, Grubbs CJ, Lubet RA) Cancer Prev Res (Phila) 2013 Nov;6(11):1151-61 PMID: 24067424 PMCID: PMC3874590 09/27/2013       6 Citations
  • Chemoprevention of lung squamous cell carcinoma by ginseng. (Pan J, Zhang Q, Li K, Liu Q, Wang Y, You M) Cancer Prev Res (Phila) 2013 Jun;6(6):530-9 PMID: 23550152 04/04/2013       8 Citations
  • Endothelial cell-specific chemotaxis receptor (ECSCR) enhances vascular endothelial growth factor (VEGF) receptor-2/kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR. (Kilari S, Remadevi I, Zhao B, Pan J, Miao R, Ramchandran R, North PE, You M, Rahimi N, Wilkinson GA) J Biol Chem 2013 Apr 12;288(15):10265-74 PMID: 23393131 PMCID: PMC3624410 02/09/2013       10 Citations
  • Effects on gene expression in rat liver after administration of RXR agonists: UAB30, 4-methyl-UAB30, and Targretin (Bexarotene). (Vedell PT, Lu Y, Grubbs CJ, Yin Y, Jiang H, Bland KI, Muccio DD, Cvetkovic D, You M, Lubet R) Mol Pharmacol 2013 Mar;83(3):698-708 PMID: 23292798 PMCID: PMC3583492 01/08/2013       18 Citations
  • Mouse models of lung squamous cell carcinomas. (You MS, Rouggly LC, You M, Wang Y) Cancer Metastasis Rev 2013 Jun;32(1-2):77-82 PMID: 23229817 12/12/2012       8 Citations
  • Lung cancer chemoprevention: difficulties, promise and potential agents? (Dragnev K, You M, Wang Y, Lubet R) Expert Opin Investig Drugs 2013 Jan;22(1):35-47 PMID: 23167766 11/22/2012       16 Citations
  • Genomic landscape of non-small cell lung cancer in smokers and never-smokers. (Govindan R, Ding L, Griffith M, Subramanian J, Dees ND, Kanchi KL, Maher CA, Fulton R, Fulton L, Wallis J, Chen K, Walker J, McDonald S, Bose R, Ornitz D, Xiong D, You M, Dooling DJ, Watson M, Mardis ER, Wilson RK) Cell 2012 Sep 14;150(6):1121-34 PMID: 22980976 PMCID: PMC3656590 09/18/2012       605 Citations
  • Strain-specific variation in murine natural killer gene complex contributes to differences in immunosurveillance for urethane-induced lung cancer. (Kreisel D, Gelman AE, Higashikubo R, Lin X, Vikis HG, White JM, Toth KA, Deshpande C, Carreno BM, You M, Taffner SM, Yokoyama WM, Bui JD, Schreiber RD, Krupnick AS) Cancer Res 2012 Sep 01;72(17):4311-7 PMID: 22751136 PMCID: PMC3432713 07/04/2012       15 Citations
  • WNT1-inducible signaling pathway protein 1 contributes to ventilator-induced lung injury. (Li HH, Li Q, Liu P, Liu Y, Li J, Wasserloos K, Chao W, You M, Oury TD, Chhinder S, Hackam DJ, Billiar TR, Leikauf GD, Pitt BR, Zhang LM) Am J Respir Cell Mol Biol 2012 Oct;47(4):528-35 PMID: 22700866 PMCID: PMC3488625 06/16/2012       20 Citations
  • Exome sequencing identifies MXRA5 as a novel cancer gene frequently mutated in non-small cell lung carcinoma from Chinese patients. (Xiong D, Li G, Li K, Xu Q, Pan Z, Ding F, Vedell P, Liu P, Cui P, Hua X, Jiang H, Yin Y, Zhu Z, Li X, Zhang B, Ma D, Wang Y, You M) Carcinogenesis 2012 Sep;33(9):1797-805 PMID: 22696596 PMCID: PMC3514907 06/15/2012       27 Citations
  • Functional characterization of CLPTM1L as a lung cancer risk candidate gene in the 5p15.33 locus. (James MA, Wen W, Wang Y, Byers LA, Heymach JV, Coombes KR, Girard L, Minna J, You M) PLoS One 2012;7(6):e36116 PMID: 22675468 PMCID: PMC3366984 06/08/2012       63 Citations
  • Identification of somatic mutations in non-small cell lung carcinomas using whole-exome sequencing. (Liu P, Morrison C, Wang L, Xiong D, Vedell P, Cui P, Hua X, Ding F, Lu Y, James M, Ebben JD, Xu H, Adjei AA, Head K, Andrae JW, Tschannen MR, Jacob H, Pan J, Zhang Q, Van den Bergh F, Xiao H, Lo KC, Patel J, Richmond T, Watt MA, Albert T, Selzer R, Anderson M, Wang J, Wang Y, Starnes S, Yang P, You M) Carcinogenesis 2012 Jul;33(7):1270-6 PMID: 22510280 PMCID: PMC3499051 04/19/2012       111 Citations
  • Beetroot red (betanin) inhibits vinyl carbamate- and benzo(a)pyrene-induced lung tumorigenesis through apoptosis. (Zhang Q, Pan J, Wang Y, Lubet R, You M) Mol Carcinog 2013 Sep;52(9):686-91 PMID: 22456940 03/30/2012       12 Citations
  • Aerosolized 3-bromopyruvate inhibits lung tumorigenesis without causing liver toxicity. (Zhang Q, Pan J, North PE, Yang S, Lubet RA, Wang Y, You M) Cancer Prev Res (Phila) 2012 May;5(5):717-25 PMID: 22401980 03/10/2012       24 Citations
  • MicroRNA profiling and prediction of recurrence/relapse-free survival in stage I lung cancer. (Lu Y, Govindan R, Wang L, Liu PY, Goodgame B, Wen W, Sezhiyan A, Pfeifer J, Li YF, Hua X, Wang Y, Yang P, You M) Carcinogenesis 2012 May;33(5):1046-54 PMID: 22331473 PMCID: PMC3334512 02/15/2012       98 Citations
  • Gene-expression signature predicts postoperative recurrence in stage I non-small cell lung cancer patients. (Lu Y, Wang L, Liu P, Yang P, You M) PLoS One 2012;7(1):e30880 PMID: 22292069 PMCID: PMC3264655 02/01/2012       22 Citations
  • Quantitative monitoring of mouse lung tumors by magnetic resonance imaging. (Krupnick AS, Tidwell VK, Engelbach JA, Alli VV, Nehorai A, You M, Vikis HG, Gelman AE, Kreisel D, Garbow JR) Nat Protoc 2012 Jan 05;7(1):128-42 PMID: 22222788 PMCID: PMC3870466 01/10/2012       17 Citations
  • Animal models of lung cancer characterization and use for chemoprevention research. (Wang Y, Rouggly L, You M, Lubet R) Prog Mol Biol Transl Sci 2012;105:211-26 PMID: 22137433 12/06/2011       14 Citations
  • Genome-wide association and fine mapping of genetic loci predisposing to colon carcinogenesis in mice. (Liu P, Lu Y, Liu H, Wen W, Jia D, Wang Y, You M) Mol Cancer Res 2012 Jan;10(1):66-74 PMID: 22127497 12/01/2011       17 Citations
  • Chemopreventive effect of a mixture of Chinese Herbs (antitumor B) on chemically induced oral carcinogenesis. (Wang Y, Yao R, Gao S, Wen W, Du Y, Szabo E, Hu M, Lubet RA, You M) Mol Carcinog 2013 Jan;52(1):49-56 PMID: 22086836 11/17/2011       10 Citations
  • Neutrophils are required for 3-methylcholanthrene-initiated, butylated hydroxytoluene-promoted lung carcinogenesis. (Vikis HG, Gelman AE, Franklin A, Stein L, Rymaszewski A, Zhu J, Liu P, Tichelaar JW, Krupnick AS, You M) Mol Carcinog 2012 Dec;51(12):993-1002 PMID: 22006501 PMCID: PMC3389580 10/19/2011       11 Citations
  • Modulation of gene expression and cell-cycle signaling pathways by the EGFR inhibitor gefitinib (Iressa) in rat urinary bladder cancer. (Lu Y, Liu P, Van den Bergh F, Zellmer V, James M, Wen W, Grubbs CJ, Lubet RA, You M) Cancer Prev Res (Phila) 2012 Feb;5(2):248-59 PMID: 21982874 10/11/2011       12 Citations
  • Principles for the post-GWAS functional characterization of cancer risk loci. (Freedman ML, Monteiro AN, Gayther SA, Coetzee GA, Risch A, Plass C, Casey G, De Biasi M, Carlson C, Duggan D, James M, Liu P, Tichelaar JW, Vikis HG, You M, Mills IG) Nat Genet 2011 Jun;43(6):513-8 PMID: 21614091 PMCID: PMC3325768 05/27/2011       250 Citations
  • Chemoprevention of lung carcinogenesis by the combination of aerosolized budesonide and oral pioglitazone in A/J mice. (Fu H, Zhang J, Pan J, Zhang Q, Lu Y, Wen W, Lubet RA, Szabo E, Chen R, Wang Y, Chen DR, You M) Mol Carcinog 2011 Dec;50(12):913-21 PMID: 21374736 PMCID: PMC6015734 03/05/2011       26 Citations
  • Efficacy of the EGFr inhibitor Iressa on development of chemically-induced urinary bladder cancers: dose dependency and modulation of biomarkers. (Lubet RA, Lu Y, Bode AM, You M, Verney ZM, Steele VE, Townsend R, Juliana MM, Grubbs CJ) Oncol Rep 2011 May;25(5):1389-97 PMID: 21369704 03/04/2011       7 Citations
  • Aerosolized bexarotene inhibits lung tumorigenesis without increasing plasma triglyceride and cholesterol levels in mice. (Zhang Q, Pan J, Zhang J, Liu P, Chen R, Chen DR, Lubet R, Wang Y, You M) Cancer Prev Res (Phila) 2011 Feb;4(2):270-6 PMID: 21163938 12/18/2010       15 Citations
  • Cross-species comparison of orthologous gene expression in human bladder cancer and carcinogen-induced rodent models. (Lu Y, Liu P, Wen W, Grubbs CJ, Townsend RR, Malone JP, Lubet RA, You M) Am J Transl Res 2010 Sep 20;3(1):8-27 PMID: 21139803 PMCID: PMC2981423 12/09/2010    
  • Dietary administration of berberine or Phellodendron amurense extract inhibits cell cycle progression and lung tumorigenesis. (James MA, Fu H, Liu Y, Chen DR, You M) Mol Carcinog 2011 Jan;50(1):1-7 PMID: 21061266 PMCID: PMC6004604 11/10/2010       33 Citations
  • Chemopreventive effects of pioglitazone on chemically induced lung carcinogenesis in mice. (Wang Y, James M, Wen W, Lu Y, Szabo E, Lubet RA, You M) Mol Cancer Ther 2010 Nov;9(11):3074-82 PMID: 21045137 11/04/2010       37 Citations
  • Ordered subset analysis identifies loci influencing lung cancer risk on chromosomes 6q and 12q. (Fang S, Pinney SM, Bailey-Wilson JE, de Andrade MA, Li Y, Kupert E, You M, Schwartz AG, Yang P, Anderson MW, Amos CI) Cancer Epidemiol Biomarkers Prev 2010 Dec;19(12):3157-66 PMID: 21030603 PMCID: PMC3249234 10/30/2010       6 Citations
  • A dominant-negative c-jun mutant inhibits lung carcinogenesis in mice. (Tichelaar JW, Yan Y, Tan Q, Wang Y, Estensen RD, Young MR, Colburn NH, Yin H, Goodin C, Anderson MW, You M) Cancer Prev Res (Phila) 2010 Sep;3(9):1148-56 PMID: 20716630 PMCID: PMC2933283 08/19/2010       8 Citations
  • Functional genomics of chlorine-induced acute lung injury in mice. (Leikauf GD, Pope-Varsalona H, Concel VJ, Liu P, Bein K, Brant KA, Dopico RA, Di YP, Jang AS, Dietsch M, Medvedovic M, Li Q, Vuga LJ, Kaminski N, You M, Prows DR) Proc Am Thorac Soc 2010 Jul;7(4):294-6 PMID: 20601635 PMCID: PMC3136967 07/06/2010       7 Citations
  • Strain-specific susceptibility for pulmonary metastasis of sarcoma 180 cells in inbred mice. (Vikis HG, Jackson EN, Krupnick AS, Franklin A, Gelman AE, Chen Q, Piwnica-Worms D, You M) Cancer Res 2010 Jun 15;70(12):4859-67 PMID: 20501835 PMCID: PMC4690845 05/27/2010       6 Citations
  • A second genetic variant on chromosome 15q24-25.1 associates with lung cancer. (Liu P, Yang P, Wu X, Vikis HG, Lu Y, Wang Y, Schwartz AG, Pinney SM, de Andrade M, Gazdar A, Gaba C, Mandal D, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Spitz M, Amos CI, Anderson MW, You M) Cancer Res 2010 Apr 15;70(8):3128-35 PMID: 20395203 PMCID: PMC3378320 04/17/2010       3 Citations
  • A susceptibility locus on chromosome 6q greatly increases lung cancer risk among light and never smokers. (Amos CI, Pinney SM, Li Y, Kupert E, Lee J, de Andrade MA, Yang P, Schwartz AG, Fain PR, Gazdar A, Minna J, Wiest JS, Zeng D, Rothschild H, Mandal D, You M, Coons T, Gaba C, Bailey-Wilson JE, Anderson MW) Cancer Res 2010 Mar 15;70(6):2359-67 PMID: 20215501 PMCID: PMC2855643 03/11/2010       31 Citations
  • Cumulative effect of multiple loci on genetic susceptibility to familial lung cancer. (Liu P, Vikis HG, Lu Y, Wang Y, Schwartz AG, Pinney SM, Yang P, de Andrade M, Gazdar A, Gaba C, Mandal D, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Amos CI, Anderson MW, You M) Cancer Epidemiol Biomarkers Prev 2010 Feb;19(2):517-24 PMID: 20142248 PMCID: PMC2846747 02/10/2010       24 Citations
  • Effect of dietary Polyphenon E and EGCG on lung tumorigenesis in A/J Mice. (Zhang Q, Fu H, Pan J, He J, Ryota S, Hara Y, Wang Y, Lubet RA, You M) Pharm Res 2010 Jun;27(6):1066-71 PMID: 20112129 PMCID: PMC6007862 01/30/2010       25 Citations
  • Preventive effects of bexarotene and budesonide in a genetically engineered mouse model of small cell lung cancer. (Wang Y, Wen W, Yi Y, Zhang Z, Lubet RA, You M) Cancer Prev Res (Phila) 2009 Dec;2(12):1059-64 PMID: 19934342 PMCID: PMC6001362 11/26/2009       22 Citations
  • Genetic variants cis-regulating Xrn2 expression contribute to the risk of spontaneous lung tumor. (Lu Y, Liu P, James M, Vikis HG, Liu H, Wen W, Franklin A, You M) Oncogene 2010 Feb 18;29(7):1041-9 PMID: 19915612 PMCID: PMC6019621 11/17/2009       13 Citations
  • Haplotype and cell proliferation analyses of candidate lung cancer susceptibility genes on chromosome 15q24-25.1. (Liu Y, Liu P, Wen W, James MA, Wang Y, Bailey-Wilson JE, Amos CI, Pinney SM, Yang P, de Andrade M, Petersen GM, Wiest JS, Fain PR, Schwartz AG, Gazdar A, Gaba C, Rothschild H, Mandal D, Kupert E, Lee J, Seminara D, Minna J, Anderson MW, You M) Cancer Res 2009 Oct 01;69(19):7844-50 PMID: 19789337 PMCID: PMC2846106 10/01/2009       34 Citations
  • Induced expression of drug metabolizing enzymes by preventive agents: role of the antioxidant response element. (Lubet RA, Yao R, Grubbs CJ, You M, Wang Y) Chem Biol Interact 2009 Nov 10;182(1):22-8 PMID: 19695238 PMCID: PMC3642098 08/22/2009       11 Citations
  • Identification of Las2, a major modifier gene affecting the Pas1 mouse lung tumor susceptibility locus. (Liu PY, Vikis H, James M, Lu Y, Wang DL, Liu HB, Wen WD, Wang Y, You M) Cancer Res 2009 Aug 01;69(15):6290-8 PMID: 19622765 07/23/2009       6 Citations
  • Chemoprevention of lung squamous cell carcinoma in mice by a mixture of Chinese herbs. (Wang Y, Zhang Z, Garbow JR, Rowland DJ, Lubet RA, Sit D, Law F, You M) Cancer Prev Res (Phila) 2009 Jul;2(7):634-40 PMID: 19584077 PMCID: PMC3890236 07/09/2009       28 Citations
  • Lung cancer inhibitory effect of epigallocatechin-3-gallate is dependent on its presence in a complex mixture (polyphenon E). (Fu H, He J, Mei F, Zhang Q, Hara Y, Ryota S, Lubet RA, Chen R, Chen DR, You M) Cancer Prev Res (Phila) 2009 Jun;2(6):531-7 PMID: 19470785 05/28/2009       30 Citations
  • Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5. (Wang JC, Cruchaga C, Saccone NL, Bertelsen S, Liu P, Budde JP, Duan W, Fox L, Grucza RA, Kern J, Mayo K, Reyes O, Rice J, Saccone SF, Spiegel N, Steinbach JH, Stitzel JA, Anderson MW, You M, Stevens VL, Bierut LJ, Goate AM, COGEND collaborators and GELCC collaborators) Hum Mol Genet 2009 Aug 15;18(16):3125-35 PMID: 19443489 PMCID: PMC2714722 05/16/2009       126 Citations
  • Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene. (You M, Wang D, Liu P, Vikis H, James M, Lu Y, Wang Y, Wang M, Chen Q, Jia D, Liu Y, Wen W, Yang P, Sun Z, Pinney SM, Zheng W, Shu XO, Long J, Gao YT, Xiang YB, Chow WH, Rothman N, Petersen GM, de Andrade M, Wu Y, Cunningham JM, Wiest JS, Fain PR, Schwartz AG, Girard L, Gazdar A, Gaba C, Rothschild H, Mandal D, Coons T, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Amos CI, Anderson MW) Clin Cancer Res 2009 Apr 15;15(8):2666-74 PMID: 19351763 PMCID: PMC2746091 04/09/2009       56 Citations
  • RGS17, an overexpressed gene in human lung and prostate cancer, induces tumor cell proliferation through the cyclic AMP-PKA-CREB pathway. (James MA, Lu Y, Liu Y, Vikis HG, You M) Cancer Res 2009 Mar 01;69(5):2108-16 PMID: 19244110 PMCID: PMC2746047 02/27/2009       51 Citations
  • Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. (Liu P, Vikis HG, Wang D, Lu Y, Wang Y, Schwartz AG, Pinney SM, Yang P, de Andrade M, Petersen GM, Wiest JS, Fain PR, Gazdar A, Gaba C, Rothschild H, Mandal D, Coons T, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Wu X, Spitz MR, Eisen T, Houlston RS, Amos CI, Anderson MW, You M) J Natl Cancer Inst 2008 Sep 17;100(18):1326-30 PMID: 18780872 PMCID: PMC2538550 09/11/2008       107 Citations
  • Effect of dietary green tea extract and aerosolized difluoromethylornithine during lung tumor progression in A/J strain mice. (Anderson MW, Goodin C, Zhang Y, Kim S, Estensen RD, Wiedmann TS, Sekar P, Buncher CR, Khoury JC, Garbow JR, You M, Tichelaar JW) Carcinogenesis 2008 Aug;29(8):1594-600 PMID: 18515278 PMCID: PMC2516483 06/03/2008       23 Citations
  • Quantitative monitoring of adenocarcinoma development in rodents by magnetic resonance imaging. (Garbow JR, Wang M, Wang Y, Lubet RA, You M) Clin Cancer Res 2008 Mar 01;14(5):1363-7 PMID: 18316556 03/05/2008       22 Citations
  • Enhanced susceptibility to chemical induction of ovarian tumors in mice with a germ line p53 mutation. (Wang Y, Zhang Z, Lu Y, Yao R, Jia D, Wen W, LaRegina M, Crist K, Lubet R, You M) Mol Cancer Res 2008 Jan;6(1):99-109 PMID: 18234966 02/01/2008       8 Citations
  • Common human cancer genes discovered by integrated gene-expression analysis. (Lu Y, Yi Y, Liu P, Wen W, James M, Wang D, You M) PLoS One 2007 Nov 07;2(11):e1149 PMID: 17989776 PMCID: PMC2065803 11/09/2007       56 Citations
  • Degradation of lung adenoma susceptibility 1, a major candidate mouse lung tumor modifier, is required for cell cycle progression. (Liu Y, Vikis HG, Yi Y, Futamura M, Wang Y, You M) Cancer Res 2007 Nov 01;67(21):10207-13 PMID: 17974961 11/03/2007       3 Citations
  • Enhanced lung tumor development in tobacco smoke-exposed p53 transgenic and Kras2 heterozygous deficient mice. (Yan Y, Tan Q, Wang Y, Wang D, Jin M, Gordon T, Lubet RA, You M) Inhal Toxicol 2007;19 Suppl 1:183-7 PMID: 17886066 10/04/2007       2 Citations
  • Large-scale in silico mapping of complex quantitative traits in inbred mice. (Liu P, Vikis H, Lu Y, Wang D, You M) PLoS One 2007 Jul 25;2(7):e651 PMID: 17653278 PMCID: PMC1920557 07/27/2007       31 Citations
  • Chemopreventive effect of aerosolized polyphenon E on lung tumorigenesis in A/J mice. (Yan Y, Cook J, McQuillan J, Zhang G, Hitzman CJ, Wang Y, Wiedmann TS, You M) Neoplasia 2007 May;9(5):401-5 PMID: 17534445 PMCID: PMC1877981 05/31/2007       37 Citations
  • EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity. (Vikis H, Sato M, James M, Wang D, Wang Y, Wang M, Jia D, Liu Y, Bailey-Wilson JE, Amos CI, Pinney SM, Petersen GM, de Andrade M, Yang P, Wiest JS, Fain PR, Schwartz AG, Gazdar A, Gaba C, Rothschild H, Mandal D, Kupert E, Seminara D, Viswanathan A, Govindan R, Minna J, Anderson MW, You M) Cancer Res 2007 May 15;67(10):4665-70 PMID: 17510392 PMCID: PMC3460269 05/19/2007       71 Citations
  • Gene expression profiling of chemically induced rat bladder tumors. (Yao R, Yi Y, Grubbs CJ, Lubet RA, You M) Neoplasia 2007 Mar;9(3):207-21 PMID: 17401461 PMCID: PMC1838579 04/03/2007       27 Citations
  • Fine mapping and candidate gene analyses of pulmonary adenoma resistance 1, a major genetic determinant of mouse lung adenoma resistance. (Wang M, Zhang Z, Zhang Z, Vikis H, Yan Y, Wang Y, You M) Cancer Res 2007 Mar 15;67(6):2508-16 PMID: 17363568 03/17/2007       5 Citations
  • Identification of a novel tumor suppressor gene p34 on human chromosome 6q25.1. (Wang M, Vikis HG, Wang Y, Jia D, Wang D, Bierut LJ, Bailey-Wilson JE, Amos CI, Pinney SM, Petersen GM, de Andrade M, Yang P, Wiest JS, Fain PR, Schwartz AG, Gazdar A, Minna J, Gaba C, Rothschild H, Mandal D, Kupert E, Seminara D, Liu Y, Viswanathan A, Govindan R, Anderson MW, You M) Cancer Res 2007 Jan 01;67(1):93-9 PMID: 17210687 PMCID: PMC3461257 01/11/2007       23 Citations
  • Effect of an epidermal growth factor receptor inhibitor in mouse models of lung cancer. (Yan Y, Lu Y, Wang M, Vikis H, Yao R, Wang Y, Lubet RA, You M) Mol Cancer Res 2006 Dec;4(12):971-81 PMID: 17189387 12/26/2006       27 Citations
  • TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. (Inoki K, Ouyang H, Zhu T, Lindvall C, Wang Y, Zhang X, Yang Q, Bennett C, Harada Y, Stankunas K, Wang CY, He X, MacDougald OA, You M, Williams BO, Guan KL) Cell 2006 Sep 08;126(5):955-68 PMID: 16959574 09/09/2006       773 Citations
  • Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice. (Liu P, Wang Y, Vikis H, Maciag A, Wang D, Lu Y, Liu Y, You M) Nat Genet 2006 Aug;38(8):888-95 PMID: 16862160 07/25/2006       65 Citations
  • p53 Transgenic mice are highly susceptible to 4-nitroquinoline-1-oxide-induced oral cancer. (Zhang Z, Wang Y, Yao R, Li J, Lubet RA, You M) Mol Cancer Res 2006 Jun;4(6):401-10 PMID: 16778087 06/17/2006       17 Citations
  • Organ-specific expression profiles of rat mammary gland, liver, and lung tissues treated with targretin, 9-cis retinoic acid, and 4-hydroxyphenylretinamide. (Wang Y, Yao R, Maciag A, Grubbs CJ, Lubet RA, You M) Mol Cancer Ther 2006 Apr;5(4):1060-72 PMID: 16648578 05/02/2006       20 Citations
  • Efficacy of polyphenon E, red ginseng, and rapamycin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice. (Yan Y, Wang Y, Tan Q, Hara Y, Yun TK, Lubet RA, You M) Neoplasia 2006 Jan;8(1):52-8 PMID: 16533426 PMCID: PMC1584290 03/15/2006       48 Citations
  • A gene expression signature that can predict green tea exposure and chemopreventive efficacy of lung cancer in mice. (Lu Y, Yao R, Yan Y, Wang Y, Hara Y, Lubet RA, You M) Cancer Res 2006 Feb 15;66(4):1956-63 PMID: 16488994 02/21/2006       32 Citations
  • Chemoprevention of lung cancer by tea. (Clark J, You M) Mol Nutr Food Res 2006 Feb;50(2):144-51 PMID: 16425282 01/21/2006       61 Citations
  • Efficacy of the farnesyltransferase inhibitor R115777 in a rat mammary tumor model: role of Ha-ras mutations and use of microarray analysis in identifying potential targets. (Yao R, Wang Y, Lu Y, Lemon WJ, End DW, Grubbs CJ, Lubet RA, You M) Carcinogenesis 2006 Jul;27(7):1420-31 PMID: 16403772 01/13/2006       7 Citations
  • Efficacy of deguelin and silibinin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice. (Yan Y, Wang Y, Tan Q, Lubet RA, You M) Neoplasia 2005 Dec;7(12):1053-7 PMID: 16354587 PMCID: PMC1501176 12/16/2005       39 Citations
  • Induction of invasive mouse skin carcinomas in transgenic mice with mutations in both H-ras and p53. (Zhang Z, Yao R, Li J, Wang Y, Boone CW, Lubet RA, You M) Mol Cancer Res 2005 Oct;3(10):563-74 PMID: 16254190 10/29/2005       13 Citations
  • Prevention of lung cancer progression by bexarotene in mouse models. (Wang Y, Zhang Z, Yao R, Jia D, Wang D, Lubet RA, You M) Oncogene 2006 Mar 02;25(9):1320-9 PMID: 16247446 10/26/2005       27 Citations
  • A mouse model for tumor progression of lung cancer in ras and p53 transgenic mice. (Wang Y, Zhang Z, Lubet RA, You M) Oncogene 2006 Feb 23;25(8):1277-80 PMID: 16247444 10/26/2005       15 Citations
  • Five loci, SLT1 to SLT5, controlling the susceptibility to spontaneously occurring lung cancer in mice. (Wang D, You M) Cancer Res 2005 Sep 15;65(18):8158-65 PMID: 16166290 09/17/2005       8 Citations
  • A moderate reduction of Bcl-x(L) expression protects against tumorigenesis; however, it also increases susceptibility to tissue injury. (Henderson CC, Zhang Z, Manson SR, Riehm JJ, Kataoka M, Flye MW, Garbow JR, You M, Weintraub SJ) Oncogene 2005 Oct 27;24(47):7120-4 PMID: 16007126 07/12/2005       4 Citations
  • Tobacco smoke-induced lung tumorigenesis in mutant A/J mice with alterations in K-ras, p53, or Ink4a/Arf. (Wang Y, Zhang Z, Lubet R, You M) Oncogene 2005 Apr 21;24(18):3042-9 PMID: 15846305 04/23/2005       30 Citations
  • Identification of genetic polymorphisms through comparative DNA sequence analysis on the K-ras gene: implications for lung tumor susceptibility. (Wang M, Wang Y, You M) Exp Lung Res 2005 Mar;31(2):165-77 PMID: 15824019 04/13/2005       3 Citations
  • K-ras mutations in lung tumors from p53 mutant mice exposed to cigarette smoke. (Yao R, Wang Y, D'Agostini F, Izzotti A, Lubet RA, You M, De Flora S) Exp Lung Res 2005 Mar;31(2):271-81 PMID: 15824025 04/13/2005       18 Citations
  • Characterization of two protein-binding sites in the second intron of the mouse K-ras gene. (Chen B, Wang Y, You M) Exp Lung Res 2005 Mar;31(2):179-92 PMID: 15824020 04/13/2005    
  • Induction and modulation of lung tumors: genomic and transcriptional alterations in cigarette smoke-exposed mice. (De Flora S, Izzotti A, D'Agostini F, Bennicelli C, You M, Lubet RA, Balansky RM) Exp Lung Res 2005 Jan-Feb;31(1):19-35 PMID: 15765917 03/16/2005       16 Citations
  • Mouse models incorporating alterations in the major tumor suppressor genes P53 and P16: their use in screening for potential carcinogens, developing further relevant mouse models, and screening for potential chemopreventive and chemotherapetutic agents. (Lubet R, Wang Y, Zhang Z, You M) Exp Lung Res 2005 Jan-Feb;31(1):117-33 PMID: 15765922 03/16/2005       11 Citations
  • Characterization of rat ovarian adenocarcinomas developed in response to direct instillation of 7,12-dimethylbenz[a]anthracene (DMBA) coated suture. (Crist KA, Zhang Z, You M, Gunning WT, Conran PB, Steele VE, Lubet RA) Carcinogenesis 2005 May;26(5):951-7 PMID: 15695234 02/08/2005       24 Citations
  • Pas1c1 is a candidate for the mouse pulmonary adenoma susceptibility 1 locus. (Wang M, Futamura M, Wang Y, You M) Oncogene 2005 Mar 10;24(11):1958-63 PMID: 15688036 02/03/2005       7 Citations
  • Tumor susceptibility of Rassf1a knockout mice. (Tommasi S, Dammann R, Zhang Z, Wang Y, Liu L, Tsark WM, Wilczynski SP, Li J, You M, Pfeifer GP) Cancer Res 2005 Jan 01;65(1):92-8 PMID: 15665283 01/25/2005       166 Citations
  • Gene expression in the lung of p53 mutant mice exposed to cigarette smoke. (Izzotti A, Cartiglia C, Longobardi M, Bagnasco M, Merello A, You M, Lubet RA, De Flora S) Cancer Res 2004 Dec 01;64(23):8566-72 PMID: 15574763 12/03/2004       36 Citations
  • Altered gene expression profile in mouse bladder cancers induced by hydroxybutyl(butyl)nitrosamine. (Yao R, Lemon WJ, Wang Y, Grubbs CJ, Lubet RA, You M) Neoplasia 2004 Sep-Oct;6(5):569-77 PMID: 15548366 PMCID: PMC1531661 11/19/2004       24 Citations
  • Budesonide exerts its chemopreventive efficacy during mouse lung tumorigenesis by modulating gene expressions. (Yao R, Wang Y, Lemon WJ, Lubet RA, You M) Oncogene 2004 Oct 07;23(46):7746-52 PMID: 15361829 09/14/2004       38 Citations
  • A major lung cancer susceptibility locus maps to chromosome 6q23-25. (Bailey-Wilson JE, Amos CI, Pinney SM, Petersen GM, de Andrade M, Wiest JS, Fain P, Schwartz AG, You M, Franklin W, Klein C, Gazdar A, Rothschild H, Mandal D, Coons T, Slusser J, Lee J, Gaba C, Kupert E, Perez A, Zhou X, Zeng D, Liu Q, Zhang Q, Seminara D, Minna J, Anderson MW) Am J Hum Genet 2004 Sep;75(3):460-74 PMID: 15272417 PMCID: PMC1182024 07/24/2004    
  • Chemoprevention of lung cancer in transgenic mice. (Lubet RA, Zhang Z, Wang Y, You M) Chest 2004 May;125(5 Suppl):144S-7S PMID: 15136469 05/12/2004       10 Citations
  • Detection of primary lung tumors in rodents by magnetic resonance imaging. (Garbow JR, Zhang Z, You M) Cancer Res 2004 Apr 15;64(8):2740-2 PMID: 15087388 04/17/2004       40 Citations
  • Pol iota is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia. (Wang M, Devereux TR, Vikis HG, McCulloch SD, Holliday W, Anna C, Wang Y, Bebenek K, Kunkel TA, Guan K, You M) Cancer Res 2004 Mar 15;64(6):1924-31 PMID: 15026325 03/18/2004       55 Citations
  • Cancer chemopreventive activity of a mixture of Chinese herbs (antitumor B) in mouse lung tumor models. (Zhang Z, Wang Y, Yao R, Li J, Yan Y, La Regina M, Lemon WL, Grubbs CJ, Lubet RA, You M) Oncogene 2004 May 06;23(21):3841-50 PMID: 15021904 03/17/2004       47 Citations
  • CpG methylation in the Fhit regulatory region: relation to Fhit expression in murine tumors. (Han SY, Iliopoulos D, Druck T, Guler G, Grubbs CJ, Pereira M, Zhang Z, You M, Lubet RA, Fong LY, Huebner K) Oncogene 2004 May 13;23(22):3990-8 PMID: 15007387 03/10/2004       23 Citations
  • A chemically induced model for squamous cell carcinoma of the lung in mice: histopathology and strain susceptibility. (Wang Y, Zhang Z, Yan Y, Lemon WJ, LaRegina M, Morrison C, Lubet R, You M) Cancer Res 2004 Mar 01;64(5):1647-54 PMID: 14996723 03/05/2004       83 Citations
  • Carcinogen-specific targeting of chromosome 12 for loss of heterozygosity in mouse lung adenocarcinomas: implications for chromosome instability and tumor progression. (Herzog CR, Bodon N, Pittman B, Maronpot RR, Massey TE, Anderson MW, You M, Devereux TR) Oncogene 2004 Apr 15;23(17):3033-9 PMID: 14755239 02/03/2004       16 Citations
  • Molecular profiling of mouse lung tumors: association with tumor progression, lung development, and human lung adenocarcinomas. (Bonner AE, Lemon WJ, Devereux TR, Lubet RA, You M) Oncogene 2004 Feb 05;23(5):1166-76 PMID: 14647414 12/03/2003       77 Citations
  • Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice. (Zhang Z, Futamura M, Vikis HG, Wang M, Li J, Wang Y, Guan KL, You M) Proc Natl Acad Sci U S A 2003 Oct 28;100(22):12642-7 PMID: 14583591 PMCID: PMC240671 10/30/2003       35 Citations
  • Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf. (Zhang Z, Wang Y, Lantry LE, Kastens E, Liu G, Hamilton AD, Sebti SM, Lubet RA, You M) Oncogene 2003 Sep 18;22(40):6257-65 PMID: 13679864 09/19/2003       32 Citations
  • Mice with alterations in both p53 and Ink4a/Arf display a striking increase in lung tumor multiplicity and progression: differential chemopreventive effect of budesonide in wild-type and mutant A/J mice. (Wang Y, Zhang Z, Kastens E, Lubet RA, You M) Cancer Res 2003 Aug 01;63(15):4389-95 PMID: 12907609 08/09/2003       59 Citations
  • Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice. (Fischer M, You M, Matsumoto M, Crabb DW) J Biol Chem 2003 Jul 25;278(30):27997-8004 PMID: 12791698 06/07/2003       179 Citations
  • Differential gene expression in chemically induced mouse lung adenomas. (Yao R, Wang Y, Lubet RA, You M) Neoplasia 2003 Jan-Feb;5(1):41-52 PMID: 12659669 PMCID: PMC1502122 03/28/2003       20 Citations
  • LOH of chromosome 12p correlates with Kras2 mutation in non-small cell lung cancer. (Li J, Zhang Z, Dai Z, Plass C, Morrison C, Wang Y, Wiest JS, Anderson MW, You M) Oncogene 2003 Feb 27;22(8):1243-6 PMID: 12606951 PMCID: PMC3438910 02/28/2003       43 Citations
  • Wildtype Kras2 can inhibit lung carcinogenesis in mice. (Zhang Z, Wang Y, Vikis HG, Johnson L, Liu G, Li J, Anderson MW, Sills RC, Hong HL, Devereux TR, Jacks T, Guan KL, You M) Nat Genet 2001 Sep;29(1):25-33 PMID: 11528387 08/31/2001       221 Citations
  • Chromosome 3p tumor-suppressor gene alterations in cervical carcinomas. (Herzog CR, Crist KA, Sabourin CL, Kelloff GJ, Boone CW, Stoner GD, You M) Mol Carcinog 2001 Mar;30(3):159-68 PMID: 11301476 04/13/2001       13 Citations
  • Chemopreventive efficacy of promising farnesyltransferase inhibitors. (Lantry LE, Zhang Z, Crist KA, Wang Y, Hara M, Zeeck A, Lubet RA, You M) Exp Lung Res 2000 Dec;26(8):773-90 PMID: 11195470 02/24/2001       21 Citations
  • Use of p53 transgenic mice in the development of cancer models for multiple purposes. (Lubet RA, Zhang Z, Wiseman RW, You M) Exp Lung Res 2000 Dec;26(8):581-93 PMID: 11195457 02/24/2001       30 Citations
  • Bcl-2 and Bax are differentially expressed in hyperplastic, premalignant, and malignant lesions of mammary carcinogenesis. (Shilkaitis A, Graves J, Mehta RR, Hu L, You M, Lubet R, Steele V, Kelloff G, Christov K) Cell Growth Differ 2000 Aug;11(8):437-45 PMID: 10965848 08/31/2000       15 Citations
  • A germ-line p53 mutation accelerates pulmonary tumorigenesis: p53-independent efficacy of chemopreventive agents green tea or dexamethasone/myo-inositol and chemotherapeutic agents taxol or adriamycin. (Zhang Z, Liu Q, Lantry LE, Wang Y, Kelloff GJ, Anderson MW, Wiseman RW, Lubet RA, You M) Cancer Res 2000 Feb 15;60(4):901-7 PMID: 10706103 03/08/2000       89 Citations
  • Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. (Lantry LE, Zhang Z, Yao R, Crist KA, Wang Y, Ohkanda J, Hamilton AD, Sebti SM, Lubet RA, You M) Carcinogenesis 2000 Jan;21(1):113-6 PMID: 10607742 12/23/1999       46 Citations
  • Measurement of oxygen and carbon dioxide partial pressures in synovial fluid after tonometry. (Geborek P, Lindoff B, Valind SO) Clin Physiol 1988 Aug;8(4):427-32 PMID: 3136967 08/01/1988       5 Citations
  • Electrophysiology and dye-coupling are sexually dimorphic characteristics of individual laryngeal muscle fibers in Xenopus laevis. (Tobias ML, Kelley DB) J Neurosci 1988 Jul;8(7):2422-9 PMID: 3249234 PMCID: PMC3493212 07/01/1988       24 Citations
  • Last update: 11/30/2018
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