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Mitchell H. Grayson MD

Mitchell H. Grayson MD

Associate Professor

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Allergy


I am willing to mentor a junior faculty member.


Research Experience

  • Allergy and Immunology
  • Asthma
  • Bronchiolitis, Viral
  • Dendritic Cells
  • Food Hypersensitivity
  • Immunoglobulin E
  • Models, Animal
  • Norovirus
  • Receptors, IgE
  • Clinical Expertise

  • Allergy and Immunology
  • Angioedema
  • Asthma
  • Drug Hypersensitivity
  • Food Hypersensitivity
  • Rhinitis, Allergic, Seasonal
  • Methodologies and Techniques

  • Adoptive Transfer
  • Bronchial Provocation Tests
  • Cell Separation
  • Flow Cytometry
  • Immunization, Passive
  • Polymerase Chain Reaction
  • Reverse Transcriptase Polymerase Chain Reaction
  • Publications

  • Year in review: basic science. (Grayson MH) Ann Allergy Asthma Immunol 2015 Mar;114(3):164-5 PMID: 25744897 03/07/2015
  • Structure-function analysis of CCL28 in the development of post-viral asthma. (Thomas MA, Buelow BJ, Nevins AM, Jones SE, Peterson FC, Gundry RL, Grayson MH, Volkman BF) J Biol Chem 2015 Feb 13;290(7):4528-36 PMID: 25556652 PMCID: PMC4326855 01/06/2015
  • A survivor: the eosinophil as a regulator in asthma. (Cheung DS, Grayson MH) J Allergy Clin Immunol 2015 Feb;135(2):461-2 PMID: 25533648 12/24/2014
  • Mice matter. (Kelly BT, Grayson MH) Ann Allergy Asthma Immunol 2014 Feb;112(2):87-9 PMID: 24468244 01/29/2014
  • CD49d-expressing neutrophils differentiate atopic from nonatopic individuals. (Sigua JA, Buelow B, Cheung DS, Buell E, Hunter D, Klancnik M, Grayson MH) J Allergy Clin Immunol 2014 Mar;133(3):901-4.e5 PMID: 24360325 12/24/2013
  • Rhinovirus specific IgE can be detected in human sera. (Tam JS, Jackson WT, Hunter D, Proud D, Grayson MH) J Allergy Clin Immunol 2013 Nov;132(5):1241-3 PMID: 23992751 09/03/2013
  • Evidence mounts that viruses drive atopic development. (Sigua JA, Grayson MH) J Allergy Clin Immunol 2013 May;131(5):1340-1 PMID: 23561800 04/09/2013
  • Dendritic cells, viruses, and the development of atopic disease. (Tam JS, Grayson MH) J Allergy (Cairo) 2012;2012:936870 PMID: 23118777 PMCID: PMC3478734 11/03/2012
  • Role of viruses in the development of atopic disease in pediatric patients. (Cheung DS, Grayson MH) Curr Allergy Asthma Rep 2012 Dec;12(6):613-20 PMID: 22911226 PMCID: PMC3504451 08/23/2012
  • Ghosts in the annals: boo! (Grayson MH, Marshall GD Jr) Ann Allergy Asthma Immunol 2012 Jul;109(1):1-2 PMID: 22727147 06/26/2012
  • Expression of high-affinity IgE receptor on human peripheral blood dendritic cells in children. (Vasudev M, Cheung DS, Pincsak H, Li SH, Yan K, Simpson P, Dasu T, Grayson MH) PLoS One 2012;7(2):e32556 PMID: 22384272 PMCID: PMC3285694 03/03/2012
  • Evaluation of vomiting and regurgitation in the infant. (Tam JS, Grayson MH) Ann Allergy Asthma Immunol 2012 Jan;108(1):3-6 PMID: 22192956 12/24/2011
  • Characterization of intestinal dendritic cells in murine norovirus infection. (Chen X, Leach D, Hunter DA, Sanfelippo D, Buell EJ, Zemple SJ, Grayson MH) Open Immunol J 2011;4:22-30 PMID: 22162983 PMCID: PMC3233262 12/14/2011
  • Granzyme B regulates antiviral CD8+ T cell responses. (Salti SM, Hammelev EM, Grewal JL, Reddy ST, Zemple SJ, Grossman WJ, Grayson MH, Verbsky JW) J Immunol 2011 Dec 15;187(12):6301-9 PMID: 22084442 PMCID: PMC3237805 11/16/2011
  • Can specific IgE discriminate between intrinsic and atopic asthma? (Camarda LE, Grayson MH) Am J Respir Crit Care Med 2011 Jul 15;184(2):152-3 PMID: 21765028 07/19/2011
  • Development of atopy by severe paramyxoviral infection in a mouse model. (Cheung DS, Ehlenbach SJ, Kitchens T, Riley DA, Grayson MH) Ann Allergy Asthma Immunol 2010 Dec;105(6):437-443.e1 PMID: 21130381 PMCID: PMC3059126 12/07/2010
  • Mechanisms of immunotherapy: a historical perspective. (Shakir EM, Cheung DS, Grayson MH) Ann Allergy Asthma Immunol 2010 Nov;105(5):340-7; quiz 348, 368 PMID: 21055659 11/09/2010
  • Cutting edge: CD49d+ neutrophils induce FcepsilonRI expression on lung dendritic cells in a mouse model of postviral asthma. (Cheung DS, Ehlenbach SJ, Kitchens RT, Riley DA, Thomas LL, Holtzman MJ, Grayson MH) J Immunol 2010 Nov 1;185(9):4983-7 PMID: 20876348 PMCID: PMC2959147 09/30/2010
  • The mannose-binding lectin gene in atopic dermatitis: lessons from genetics. (Shakir EM, Grayson MH) Ann Allergy Asthma Immunol 2010 Jul;105(1):1-2 PMID: 20642196 07/21/2010
  • Prenatal maternal stress and cord blood innate and adaptive cytokine responses in an inner-city cohort. (Wright RJ, Visness CM, Calatroni A, Grayson MH, Gold DR, Sandel MT, Lee-Parritz A, Wood RA, Kattan M, Bloomberg GR, Burger M, Togias A, Witter FR, Sperling RS, Sadovsky Y, Gern JE) Am J Respir Crit Care Med 2010 Jul 1;182(1):25-33 PMID: 20194818 PMCID: PMC2902757 03/03/2010
  • Cross-linking IgE augments human conventional dendritic cell production of CC chemokine ligand 28. (Khan SH, Grayson MH) J Allergy Clin Immunol 2010 Jan;125(1):265-7 PMID: 19962743 PMCID: PMC2813948 12/08/2009
  • The role of viruses in the development and exacerbation of atopic disease. (Kumar A, Grayson MH) Ann Allergy Asthma Immunol 2009 Sep;103(3):181-6; quiz 186-7, 219 PMID: 19788013 10/01/2009
  • Immune pathways for translating viral infection into chronic airway disease. (Holtzman MJ, Byers DE, Benoit LA, Battaile JT, You Y, Agapov E, Park C, Grayson MH, Kim EY, Patel AC) Adv Immunol 2009;102:245-76 PMID: 19477323 PMCID: PMC3010226 05/30/2009
  • The lymphotoxin LTalpha(1)beta(2) controls postnatal and adult spleen marginal sinus vascular structure and function. (Zindl CL, Kim TH, Zeng M, Archambault AS, Grayson MH, Choi K, Schreiber RD, Chaplin DD) Immunity 2009 Mar 20;30(3):408-20 PMID: 19303389 PMCID: PMC2874947 03/24/2009
  • Lower levels of plasmacytoid dendritic cells in peripheral blood are associated with a diagnosis of asthma 6 yr after severe respiratory syncytial virus bronchiolitis. (Silver E, Yin-DeClue H, Schechtman KB, Grayson MH, Bacharier LB, Castro M) Pediatr Allergy Immunol 2009 Aug;20(5):471-6 PMID: 19140903 PMCID: PMC3515331 01/15/2009
  • Basic science for the practicing clinician. (Grayson MH) Ann Allergy Asthma Immunol 2008 Sep;101(3):225 PMID: 18814443 09/26/2008
  • IL-12 p80-dependent macrophage recruitment primes the host for increased survival following a lethal respiratory viral infection. (Gunsten S, Mikols CL, Grayson MH, Schwendener RA, Agapov E, Tidwell RM, Cannon CL, Brody SL, Walter MJ) Immunology 2009 Apr;126(4):500-13 PMID: 18783467 PMCID: PMC2673362 09/12/2008
  • Respiratory virus and asthma: the role of immunoglobulin E. (Khan SH, Park SS, Sirajuddin IA, Grayson MH) Clin Ther 2008;30 Spec No:1017-24 PMID: 18640476 07/22/2008
  • Lung dendritic cells and IgE: the link between virus and atopy. (Park SS, Ehlenbach SJ, Grayson MH) Future Microbiol 2008 Jun;3(3):241-5 PMID: 18505388 05/29/2008
  • Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease. (Kim EY, Battaile JT, Patel AC, You Y, Agapov E, Grayson MH, Benoit LA, Byers DE, Alevy Y, Tucker J, Swanson S, Tidwell R, Tyner JW, Morton JD, Castro M, Polineni D, Patterson GA, Schwendener RA, Allard JD, Peltz G, Holtzman MJ) Nat Med 2008 Jun;14(6):633-40 PMID: 18488036 PMCID: PMC2575848 05/20/2008
  • Pulmonary defense mechanisms against pneumonia and sepsis. (Tsai KS, Grayson MH) Curr Opin Pulm Med 2008 May;14(3):260-5 PMID: 18427251 04/23/2008
  • Clinical research: protection of the "vulnerable"? (Park SS, Grayson MH) J Allergy Clin Immunol 2008 May;121(5):1103-7 PMID: 18313131 03/04/2008
  • Dipeptidyl peptidase I-dependent neutrophil recruitment modulates the inflammatory response to Sendai virus infection. (Akk AM, Simmons PM, Chan HW, Agapov E, Holtzman MJ, Grayson MH, Pham CT) J Immunol 2008 Mar 1;180(5):3535-42 PMID: 18292580 PMCID: PMC2597084 02/23/2008
  • Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia. (Grayson MH, Cheung D, Rohlfing MM, Kitchens R, Spiegel DE, Tucker J, Battaile JT, Alevy Y, Yan L, Agapov E, Kim EY, Holtzman MJ) J Exp Med 2007 Oct 29;204(11):2759-69 PMID: 17954569 PMCID: PMC2118483 10/24/2007
  • Emerging role of dendritic cells in respiratory viral infection. (Grayson MH, Holtzman MJ) J Mol Med (Berl) 2007 Oct;85(10):1057-68 PMID: 17891367 09/25/2007
  • Controls for lung dendritic cell maturation and migration during respiratory viral infection. (Grayson MH, Ramos MS, Rohlfing MM, Kitchens R, Wang HD, Gould A, Agapov E, Holtzman MJ) J Immunol 2007 Aug 1;179(3):1438-48 PMID: 17641009 07/21/2007
  • The role of antileukotriene drugs in management of rhinitis and rhinosinusitis. (Grayson MH, Korenblat PE) Curr Allergy Asthma Rep 2007 Jun;7(3):209-15 PMID: 17448333 04/24/2007
  • Treating asthma in the older patient: is there a place for leukotriene modifiers? (Grayson MH, Korenblat PE) Drugs Aging 2006;23(6):451-9 PMID: 16872230 07/29/2006
  • Chemokine complexity: the case for CCL5. (Grayson MH, Holtzman MJ) Am J Respir Cell Mol Biol 2006 Aug;35(2):143-6 PMID: 16847105 PMCID: PMC2643253 07/19/2006
  • Agonistic monoclonal antibody against CD40 receptor decreases lymphocyte apoptosis and improves survival in sepsis. (Schwulst SJ, Grayson MH, DiPasco PJ, Davis CG, Brahmbhatt TS, Ferguson TA, Hotchkiss RS) J Immunol 2006 Jul 1;177(1):557-65 PMID: 16785553 06/21/2006
  • Lung dendritic cells and the inflammatory response. (Grayson MH) Ann Allergy Asthma Immunol 2006 May;96(5):643-51; quiz 652-3, 678 PMID: 16729776 05/30/2006
  • Chemokine signaling regulates apoptosis as well as immune cell traffic in host defense. (Grayson MH, Holtzman MJ) Cell Cycle 2006 Feb;5(4):380-3 PMID: 16479157 02/16/2006
  • Occupational exposures as triggers of asthma. (Vigo PG, Grayson MH) Immunol Allergy Clin North Am 2005 Feb;25(1):191-205 PMID: 15579371 12/08/2004
  • "Hit-and-run" effects of paramyxoviruses as a basis for chronic respiratory disease. (Holtzman MJ, Shornick LP, Grayson MH, Kim EY, Tyner JW, Patel AC, Agapov E, Zhang Y) Pediatr Infect Dis J 2004 Nov;23(11 Suppl):S235-45 PMID: 15577579 12/04/2004
  • The emerging role of leukotriene modifiers in allergic rhinitis. (Grayson MH, Korenblat PE) Am J Respir Med 2003;2(6):441-50 PMID: 14719983 01/15/2004
  • Localization of T and B lymphocytes to the white pulp of the spleen is independent of L-, E-, and P-selectin. (Grayson MH, Chaplin DD) ScientificWorldJournal 2003 Jun 9;3:484-96 PMID: 12847299 07/09/2003
  • Sepsis induces apoptosis and profound depletion of splenic interdigitating and follicular dendritic cells. (Tinsley KW, Grayson MH, Swanson PE, Drewry AM, Chang KC, Karl IE, Hotchkiss RS) J Immunol 2003 Jul 15;171(2):909-14 PMID: 12847261 07/09/2003
  • Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis. (Hotchkiss RS, Chang KC, Grayson MH, Tinsley KW, Dunne BS, Davis CG, Osborne DF, Karl IE) Proc Natl Acad Sci U S A 2003 May 27;100(11):6724-9 PMID: 12736377 PMCID: PMC164514 05/09/2003
  • Intravital microscopy comparing T lymphocyte trafficking to the spleen and the mesenteric lymph node. (Grayson MH, Hotchkiss RS, Karl IE, Holtzman MJ, Chaplin DD) Am J Physiol Heart Circ Physiol 2003 Jun;284(6):H2213-26 PMID: 12586641 02/15/2003
  • Depletion of dendritic cells, but not macrophages, in patients with sepsis. (Hotchkiss RS, Tinsley KW, Swanson PE, Grayson MH, Osborne DF, Wagner TH, Cobb JP, Coopersmith C, Karl IE) J Immunol 2002 Mar 1;168(5):2493-500 PMID: 11859143 02/23/2002
  • Confocal fluorescent intravital microscopy of the murine spleen. (Grayson MH, Chaplin DD, Karl IE, Hotchkiss RS) J Immunol Methods 2001 Oct 1;256(1-2):55-63 PMID: 11516755 08/23/2001
  • The leukocyte integrin alpha D beta 2 binds VCAM-1: evidence for a binding interface between I domain and VCAM-1. (Van der Vieren M, Crowe DT, Hoekstra D, Vazeux R, Hoffman PA, Grayson MH, Bochner BS, Gallatin WM, Staunton DE) J Immunol 1999 Aug 15;163(4):1984-90 PMID: 10438935 08/10/1999
  • alphadbeta2 integrin is a ligand for vascular cell adhesion molecule-1. (Grayson MH, Van der Vieren M, Sterbinsky SA, Gallantin WM, Hoffman P, Staunton D, Bochner BS) Int Arch Allergy Immunol 1999 Feb-Apr;118(2-4):263-4 PMID: 10224405 05/04/1999
  • alphadbeta2 integrin is expressed on human eosinophils and functions as an alternative ligand for vascular cell adhesion molecule 1 (VCAM-1). (Grayson MH, Van der Vieren M, Sterbinsky SA, Michael Gallatin W, Hoffman PA, Staunton DE, Bochner BS) J Exp Med 1998 Dec 7;188(11):2187-91 PMID: 9841932 PMCID: PMC2212388 12/08/1998
  • New concepts in the pathogenesis and treatment of allergic asthma. (Grayson MH, Bochner BS) Mt Sinai J Med 1998 Sep;65(4):246-56 PMID: 9757744 10/03/1998
  • Last update: 08/17/2015