Medical College of Wisconsin
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Monica Thakar MD

Monica Thakar MD

Associate Professor

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Hematology/Oncology
Program: Oncology

Member of the Cancer Center

Clinical Expertise

  • Fanconi Anemia
  • Hematopoietic Stem Cell Transplantation
  • Immunotherapy, Adoptive
  • Publications

  • Signaling in Effector Lymphocytes: Insights toward Safer Immunotherapy. (Rajasekaran K, Riese MJ, Rao S, Wang L, Thakar MS, Sentman CL, Malarkannan S) Front Immunol 2016;7:176 PMID: 27242783 PMCID: PMC4863891 06/01/2016
  • The Fyn-ADAP Axis: Cytotoxicity Versus Cytokine Production in Killer Cells. (Gerbec ZJ, Thakar MS, Malarkannan S) Front Immunol 2015;6:472 PMID: 26441977 PMCID: PMC4584950 10/07/2015
  • IQGAP1: insights into the function of a molecular puppeteer. (Abel AM, Schuldt KM, Rajasekaran K, Hwang D, Riese MJ, Rao S, Thakar MS, Malarkannan S) Mol Immunol 2015 Jun;65(2):336-49 PMID: 25733387 PMCID: PMC4480615 03/04/2015
  • Treosulfan-based conditioning and hematopoietic cell transplantation for nonmalignant diseases: a prospective multicenter trial. (Burroughs LM, Nemecek ER, Torgerson TR, Storer BE, Talano JA, Domm J, Giller RH, Shimamura A, Delaney C, Skoda-Smith S, Thakar MS, Baker KS, Rawlings DJ, Englund JA, Flowers ME, Deeg HJ, Storb R, Woolfrey AE) Biol Blood Marrow Transplant 2014 Dec;20(12):1996-2003 PMID: 25196857 PMCID: PMC4324724 09/10/2014
  • Corrigendum: Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells. (Rajasekaran K, Kumar P, Schuldt KM, Peterson EJ, Vanhaesebroeck B, Dixit V, Thakar MS, Malarkannan S) Nat Immunol 2014 Jan 21;15(2):205 PMID: 24448581 01/23/2014
  • Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells. (Rajasekaran K, Kumar P, Schuldt KM, Peterson EJ, Vanhaesebroeck B, Dixit V, Thakar MS, Malarkannan S) Nat Immunol 2013 Nov;14(11):1127-36 PMID: 24036998 PMCID: PMC3855032 09/17/2013
  • Allogeneic hematopoietic cell transplantation for fanconi anemia in patients with pretransplantation cytogenetic abnormalities, myelodysplastic syndrome, or acute leukemia. (Ayas M, Saber W, Davies SM, Harris RE, Hale GA, Socie G, LeRademacher J, Thakar M, Deeg HJ, Al-Seraihy A, Battiwalla M, Camitta BM, Olsson R, Bajwa RS, Bonfim CM, Pasquini R, Macmillan ML, George B, Copelan EA, Wirk B, Al Jefri A, Fasth AL, Guinan EC, Horn BN, Lewis VA, Slavin S, Stepensky P, Bierings M, Gale RP) J Clin Oncol 2013 May 1;31(13):1669-76 PMID: 23547077 PMCID: PMC3635221 04/03/2013
  • Clinical relevance of natural killer cells following hematopoietic stem cell transplantation. (Palmer JM, Rajasekaran K, Thakar MS, Malarkannan S) J Cancer 2013;4(1):25-35 PMID: 23386902 PMCID: PMC3564244 02/07/2013
  • IL-22: An Evolutionary Missing-Link Authenticating the Role of the Immune System in Tissue Regeneration. (Kumar P, Rajasekaran K, Palmer JM, Thakar MS, Malarkannan S) J Cancer 2013;4(1):57-65 PMID: 23386905 PMCID: PMC3564247 02/07/2013
  • Cyclophosphamide-based in vivo T-cell depletion for HLA-haploidentical transplantation in Fanconi anemia. (Thakar MS, Bonfim C, Sandmaier BM, O'Donnell P, Ribeiro L, Gooley T, Deeg HJ, Flowers ME, Pasquini R, Storb R, Woolfrey AE, Kiem HP) Pediatr Hematol Oncol 2012 Sep;29(6):568-78 PMID: 22839094 PMCID: PMC3622043 07/31/2012
  • IL-22 from conventional NK cells is epithelial regenerative and inflammation protective during influenza infection. (Kumar P, Thakar MS, Ouyang W, Malarkannan S) Mucosal Immunol 2013 Jan;6(1):69-82 PMID: 22739232 PMCID: PMC3835350 06/29/2012
  • IQGAP1: a regulator of intracellular spacetime relativity. (Malarkannan S, Awasthi A, Rajasekaran K, Kumar P, Schuldt KM, Bartoszek A, Manoharan N, Goldner NK, Umhoefer CM, Thakar MS) J Immunol 2012 Mar 1;188(5):2057-63 PMID: 22345702 PMCID: PMC3286039 02/22/2012
  • High-throughput detection method for influenza virus. (Kumar P, Bartoszek AE, Moran TM, Gorski J, Bhattacharyya S, Navidad JF, Thakar MS, Malarkannan S) J Vis Exp 2012 Feb 04(60) PMID: 22331038 PMCID: PMC3369630 02/15/2012
  • The Wisconsin approach to newborn screening for severe combined immunodeficiency. (Verbsky J, Thakar M, Routes J) J Allergy Clin Immunol 2012 Mar;129(3):622-7 PMID: 22244594 01/17/2012
  • Immunomodulatory effects induced by cytotoxic T lymphocyte antigen 4 immunoglobulin with donor peripheral blood mononuclear cell infusion in canine major histocompatibility complex-haplo-identical non-myeloablative hematopoietic cell transplantation. (Chen Y, Fukuda T, Thakar MS, Kornblit BT, Storer BE, Santos EB, Storb R, Sandmaier BM) Cytotherapy 2011 Nov;13(10):1269-80 PMID: 21846291 PMCID: PMC3195840 08/19/2011
  • Transforming growth factor-beta-activated kinase 1 regulates natural killer cell-mediated cytotoxicity and cytokine production. (Rajasekaran K, Chu H, Kumar P, Xiao Y, Tinguely M, Samarakoon A, Kim TW, Li X, Thakar MS, Zhang J, Malarkannan S) J Biol Chem 2011 Sep 9;286(36):31213-24 PMID: 21771792 PMCID: PMC3173069 07/21/2011
  • Evaluation of posttransplant methotrexate to facilitate engraftment in the canine major histocompatibility complex-haploidentical nonmyeloablative transplant model. (Thakar MS, Santos EB, Gooley TA, Sale G, Storb R, Kiem HP, Sandmaier BM) Transplantation 2010 Jul 15;90(1):14-22 PMID: 20626083 PMCID: PMC2921965 07/14/2010
  • Treatment of Fanconi anemia patients using fludarabine and low-dose TBI, followed by unrelated donor hematopoietic cell transplantation. (Thakar MS, Kurre P, Storb R, Kletzel M, Frangoul H, Pulsipher MA, Leisenring W, Flowers ME, Sandmaier BM, Woolfrey A, Kiem HP) Bone Marrow Transplant 2011 Apr;46(4):539-44 PMID: 20581880 PMCID: PMC2976796 06/29/2010
  • Plerixafor-moblized stem cells alone are capable of inducing early engraftment across the MHC-haploidentical canine barrier. (Thakar MS, Santos EB, Fricker S, Bridger G, Storb R, Sandmaier BM) Blood 2010 Jan 28;115(4):916-7 PMID: 20110438 PMCID: PMC2815512 01/30/2010
  • ASH evidence-based guidelines: is there a role for second allogeneic transplant after relapse? (Thakar MS, Forman SJ) Hematology Am Soc Hematol Educ Program 2009:414-8 PMID: 20008227 12/17/2009
  • Reagents for astatination of biomolecules. 4. Comparison of maleimido-closo-decaborate(2-) and meta-[(211)At]astatobenzoate conjugates for labeling anti-CD45 antibodies with [(211)At]astatine. (Wilbur DS, Thakar MS, Hamlin DK, Santos EB, Chyan MK, Nakamae H, Pagel JM, Press OW, Sandmaier BM) Bioconjug Chem 2009 Oct 21;20(10):1983-91 PMID: 19731929 PMCID: PMC2888658 09/08/2009
  • Transmission and expansion of HOXB4-induced leukemia in two immunosuppressed dogs: implications for a new canine leukemia model. (Thakar MS, Zhang XB, Beard BC, Sale GE, Santos EB, Peterson L, Kiem HP, Sandmaier BM) Exp Hematol 2009 Oct;37(10):1157-66 PMID: 19616601 PMCID: PMC2748853 07/21/2009
  • Biodistributions, myelosuppression, and toxicities in mice treated with an anti-CD45 antibody labeled with the alpha-emitting radionuclides bismuth-213 or astatine-211. (Nakamae H, Wilbur DS, Hamlin DK, Thakar MS, Santos EB, Fisher DR, Kenoyer AL, Pagel JM, Press OW, Storb R, Sandmaier BM) Cancer Res 2009 Mar 15;69(6):2408-15 PMID: 19244101 PMCID: PMC2657815 02/27/2009
  • Last update: 10/27/2016
    jenkins-FCD Prod-29 84643b21e512b06ca32a9eea21e90ce5435f61b4