Medical College of Wisconsin
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Oleg Palygin PhD

Oleg Palygin PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Physiology

Member of the Cardiovascular Center
Member of the Neuroscience Research Center


  • Genetic mutation of Kcnj16 identifies Kir5.1-containing channels as key regulators of acute and chronic pH homeostasis. (Puissant MM, Muere C, Levchenko V, Manis AD, Martino P, Forster HV, Palygin O, Staruschenko A, Hodges MR) FASEB J 2019 Jan 03:fj201802257R PMID: 30605394 01/04/2019    
  • Characterization of purinergic receptor expression in ARPKD cystic epithelia. (Palygin O, Ilatovskaya DV, Levchenko V, Klemens CA, Dissanayake L, Williams AM, Pavlov TS, Staruschenko A) Purinergic Signal 2018 12;14(4):485-497 PMID: 30417216 PMCID: PMC6298916 11/13/2018    
  • Endothelin receptor A and p66Shc regulate spontaneous Ca oscillations in smooth muscle cells controlling renal arterial spontaneous motion. (Palygin O, Miller BS, Nishijima Y, Zhang DX, Staruschenko A, Sorokin A) FASEB J 2019 Feb;33(2):2636-2645 PMID: 30303741 PMCID: PMC6338658 10/12/2018    
  • Protective role of Trpc6 knockout in the progression of diabetic kidney disease. (Spires D, Ilatovskaya DV, Levchenko V, North PE, Geurts AM, Palygin O, Staruschenko A) Am J Physiol Renal Physiol 2018 Oct 01;315(4):F1091-F1097 PMID: 29923767 PMCID: PMC6230750 06/21/2018       2 Citations
  • Distal tubule basolateral potassium channels: cellular and molecular mechanisms of regulation. (Palygin O, Pochynyuk O, Staruschenko A) Curr Opin Nephrol Hypertens 2018 Sep;27(5):373-378 PMID: 29894319 PMCID: PMC6217967 06/13/2018    
  • A NOX4/TRPC6 Pathway in Podocyte Calcium Regulation and Renal Damage in Diabetic Kidney Disease. (Ilatovskaya DV, Blass G, Palygin O, Levchenko V, Pavlov TS, Grzybowski MN, Winsor K, Shuyskiy LS, Geurts AM, Cowley AW Jr, Birnbaumer L, Staruschenko A) J Am Soc Nephrol 2018 Jul;29(7):1917-1927 PMID: 29793963 PMCID: PMC6050934 05/26/2018    
  • Keratinocytes mediate innocuous and noxious touch via ATP-P2X4 signaling. (Moehring F, Cowie AM, Menzel AD, Weyer AD, Grzybowski M, Arzua T, Geurts AM, Palygin O, Stucky CL) Elife 2018 01 16;7 PMID: 29336303 PMCID: PMC5777822 01/18/2018       11 Citations
  • Nitric oxide production by glomerular podocytes. (Palygin O, Ilatovskaya DV, Levchenko V, Endres BT, Geurts AM, Staruschenko A) Nitric Oxide 2018 01 30;72:24-31 PMID: 29128399 PMCID: PMC5776695 11/13/2017    
  • Essential role of Kir5.1 channels in renal salt handling and blood pressure control. (Palygin O, Levchenko V, Ilatovskaya DV, Pavlov TS, Pochynyuk OM, Jacob HJ, Geurts AM, Hodges MR, Staruschenko A) JCI Insight 2017 Sep 21;2(18) PMID: 28931751 PMCID: PMC5621918 09/22/2017    
  • Acute In Vivo Analysis of ATP Release in Rat Kidneys in Response to Changes of Renal Perfusion Pressure. (Palygin O, Evans LC, Cowley AW Jr, Staruschenko A) J Am Heart Assoc 2017 Sep 12;6(9) PMID: 28899893 PMCID: PMC5634305 09/14/2017       4 Citations
  • Lack of Effects of Metformin and AICAR Chronic Infusion on the Development of Hypertension in Dahl Salt-Sensitive Rats. (Pavlov TS, Levchenko V, Ilatovskaya DV, Li H, Palygin O, Pastor-Soler NM, Hallows KR, Staruschenko A) Front Physiol 2017;8:227 PMID: 28473772 PMCID: PMC5397526 05/06/2017    
  • Intravital imaging of the kidney in a rat model of salt-sensitive hypertension. (Endres BT, Sandoval RM, Rhodes GJ, Campos-Bilderback SB, Kamocka MM, McDermott-Roe C, Staruschenko A, Molitoris BA, Geurts AM, Palygin O) Am J Physiol Renal Physiol 2017 Aug 01;313(2):F163-F173 PMID: 28404591 PMCID: PMC5582897 04/14/2017       4 Citations
  • The Role of Angiotensin II in Glomerular Volume Dynamics and Podocyte Calcium Handling. (Ilatovskaya DV, Palygin O, Levchenko V, Endres BT, Staruschenko A) Sci Rep 2017 03 22;7(1):299 PMID: 28331185 PMCID: PMC5428415 03/24/2017       11 Citations
  • Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac function. (McDermott-Roe C, Leleu M, Rowe GC, Palygin O, Bukowy JD, Kuo J, Rech M, Hermans-Beijnsberger S, Schaefer S, Adami E, Creemers EE, Heinig M, Schroen B, Arany Z, Petretto E, Geurts AM) PLoS One 2017;12(2):e0170458 PMID: 28158196 PMCID: PMC5291451 02/06/2017       2 Citations
  • Protease-activated receptors in kidney disease progression. (Palygin O, Ilatovskaya DV, Staruschenko A) Am J Physiol Renal Physiol 2016 12 01;311(6):F1140-F1144 PMID: 27733370 PMCID: PMC5210204 10/14/2016       5 Citations
  • Functional and therapeutic importance of purinergic signaling in polycystic kidney disease. (Ilatovskaya DV, Palygin O, Staruschenko A) Am J Physiol Renal Physiol 2016 12 01;311(6):F1135-F1139 PMID: 27654892 PMCID: PMC5210209 09/23/2016       5 Citations
  • ATP from synaptic terminals and astrocytes regulates NMDA receptors and synaptic plasticity through PSD-95 multi-protein complex. (Lalo U, Palygin O, Verkhratsky A, Grant SG, Pankratov Y) Sci Rep 2016 09 19;6:33609 PMID: 27640997 PMCID: PMC5027525 09/20/2016       14 Citations
  • p66Shc regulates renal vascular tone in hypertension-induced nephropathy. (Miller B, Palygin O, Rufanova VA, Chong A, Lazar J, Jacob HJ, Mattson D, Roman RJ, Williams JM, Cowley AW Jr, Geurts AM, Staruschenko A, Imig JD, Sorokin A) J Clin Invest 2016 07 01;126(7):2533-46 PMID: 27270176 PMCID: PMC4922697 06/09/2016       6 Citations
  • Role and mechanisms of regulation of the basolateral K 4.1/K 5.1K channels in the distal tubules. (Palygin O, Pochynyuk O, Staruschenko A) Acta Physiol (Oxf) 2017 01;219(1):260-273 PMID: 27129733 PMCID: PMC5086442 05/01/2016       5 Citations
  • Mechanosensory and ATP Release Deficits following Keratin14-Cre-Mediated TRPA1 Deletion Despite Absence of TRPA1 in Murine Keratinocytes. (Zappia KJ, Garrison SR, Palygin O, Weyer AD, Barabas ME, Lawlor MW, Staruschenko A, Stucky CL) PLoS One 2016;11(3):e0151602 PMID: 26978657 PMCID: PMC4792390 03/16/2016       10 Citations
  • Chronic central serotonin depletion attenuates ventilation and body temperature in young but not adult Tph2 knockout rats. (Kaplan K, Echert AE, Massat B, Puissant MM, Palygin O, Geurts AM, Hodges MR) J Appl Physiol (1985) 2016 05 01;120(9):1070-81 PMID: 26869713 PMCID: PMC4855209 02/13/2016       5 Citations
  • Two-photon imaging of endothelin-1-mediated intracellular Ca(2+) handling in smooth muscle cells of rat renal resistance arteries. (Palygin O, Miller B, Ilatovskaya DV, Sorokin A, Staruschenko A) Life Sci 2016 Aug 15;159:140-143 PMID: 26682937 PMCID: PMC4902792 12/20/2015       1 Citations
  • Podocyte injury in diabetic nephropathy: implications of angiotensin II-dependent activation of TRPC channels. (Ilatovskaya DV, Levchenko V, Lowing A, Shuyskiy LS, Palygin O, Staruschenko A) Sci Rep 2015 Dec 10;5:17637 PMID: 26656101 PMCID: PMC4674698 12/15/2015       27 Citations
  • Insulin and IGF-1 activate Kir4.1/5.1 channels in cortical collecting duct principal cells to control basolateral membrane voltage. (Zaika O, Palygin O, Tomilin V, Mamenko M, Staruschenko A, Pochynyuk O) Am J Physiol Renal Physiol 2016 Feb 15;310(4):F311-21 PMID: 26632606 PMCID: PMC4839479 12/04/2015       8 Citations
  • Use of Enzymatic Biosensors to Quantify Endogenous ATP or H2O2 in the Kidney. (Palygin O, Levchenko V, Evans LC, Blass G, Cowley AW Jr, Staruschenko A) J Vis Exp 2015 Oct 12(104) PMID: 26485400 PMCID: PMC4684070 10/21/2015       5 Citations
  • Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium. (Pavlov TS, Ilatovskaya DV, Palygin O, Levchenko V, Pochynyuk O, Staruschenko A) J Vis Exp 2015 Sep 01(103) PMID: 26381526 PMCID: PMC4581700 09/19/2015       5 Citations
  • Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli. (Ilatovskaya DV, Palygin O, Levchenko V, Staruschenko A) J Vis Exp 2015 Jun 27(100):e52850 PMID: 26167808 PMCID: PMC4544950 07/15/2015       8 Citations
  • Two-photon Imaging of Intracellular Ca2+ Handling and Nitric Oxide Production in Endothelial and Smooth Muscle Cells of an Isolated Rat Aorta. (Endres BT, Staruschenko A, Schulte M, Geurts AM, Palygin O) J Vis Exp 2015 Jun 10(100):e52734 PMID: 26132549 PMCID: PMC4545029 07/02/2015       1 Citations
  • Impaired epithelial Na+ channel activity contributes to cystogenesis and development of autosomal recessive polycystic kidney disease in PCK rats. (Pavlov TS, Levchenko V, Ilatovskaya DV, Palygin O, Staruschenko A) Pediatr Res 2015 Jan;77(1-1):64-9 PMID: 25279988 PMCID: PMC4268054 10/04/2014       8 Citations
  • Cannabinoid receptors contribute to astroglial Ca²⁺-signalling and control of synaptic plasticity in the neocortex. (Rasooli-Nejad S, Palygin O, Lalo U, Pankratov Y) Philos Trans R Soc Lond B Biol Sci 2014 Oct 19;369(1654):20140077 PMID: 25225106 PMCID: PMC4173298 09/17/2014       19 Citations
  • Mutation of Plekha7 attenuates salt-sensitive hypertension in the rat. (Endres BT, Priestley JR, Palygin O, Flister MJ, Hoffman MJ, Weinberg BD, Grzybowski M, Lombard JH, Staruschenko A, Moreno C, Jacob HJ, Geurts AM) Proc Natl Acad Sci U S A 2014 Sep 02;111(35):12817-22 PMID: 25136115 PMCID: PMC4156702 08/20/2014       24 Citations
  • The MK2/3 cascade regulates AMPAR trafficking and cognitive flexibility. (Eales KL, Palygin O, O'Loughlin T, Rasooli-Nejad S, Gaestel M, Müller J, Collins DR, Pankratov Y, Corrêa SA) Nat Commun 2014 Aug 19;5:4701 PMID: 25134715 PMCID: PMC4143933 08/20/2014       21 Citations
  • Angiotensin II has acute effects on TRPC6 channels in podocytes of freshly isolated glomeruli. (Ilatovskaya DV, Palygin O, Chubinskiy-Nadezhdin V, Negulyaev YA, Ma R, Birnbaumer L, Staruschenko A) Kidney Int 2014 Sep;86(3):506-14 PMID: 24646854 PMCID: PMC4149864 03/22/2014       35 Citations
  • Exocytosis of ATP from astrocytes modulates phasic and tonic inhibition in the neocortex. (Lalo U, Palygin O, Rasooli-Nejad S, Andrew J, Haydon PG, Pankratov Y) PLoS Biol 2014 Jan;12(1):e1001747 PMID: 24409095 PMCID: PMC3883644 01/11/2014       97 Citations
  • Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli. (Ilatovskaya DV, Palygin O, Levchenko V, Staruschenko A) Am J Physiol Cell Physiol 2013 Nov 15;305(10):C1050-9 PMID: 24048730 PMCID: PMC3840197 09/21/2013       20 Citations
  • Arp2/3 complex inhibitors adversely affect actin cytoskeleton remodeling in the cultured murine kidney collecting duct M-1 cells. (Ilatovskaya DV, Chubinskiy-Nadezhdin V, Pavlov TS, Shuyskiy LS, Tomilin V, Palygin O, Staruschenko A, Negulyaev YA) Cell Tissue Res 2013 Dec;354(3):783-92 PMID: 24036843 PMCID: PMC3850072 09/17/2013       5 Citations
  • Direct inhibition of basolateral Kir4.1/5.1 and Kir4.1 channels in the cortical collecting duct by dopamine. (Zaika OL, Mamenko M, Palygin O, Boukelmoune N, Staruschenko A, Pochynyuk O) Am J Physiol Renal Physiol 2013 Nov 01;305(9):F1277-87 PMID: 23986512 PMCID: PMC3840222 08/30/2013       22 Citations
  • miR-132/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity. (Remenyi J, van den Bosch MW, Palygin O, Mistry RB, McKenzie C, Macdonald A, Hutvagner G, Arthur JS, Frenguelli BG, Pankratov Y) PLoS One 2013;8(4):e62509 PMID: 23658634 PMCID: PMC3637221 05/10/2013       77 Citations
  • Epidermal growth factors in the kidney and relationship to hypertension. (Staruschenko A, Palygin O, Ilatovskaya DV, Pavlov TS) Am J Physiol Renal Physiol 2013 Jul 01;305(1):F12-20 PMID: 23637204 PMCID: PMC3725676 05/03/2013       17 Citations
  • Deficiency of renal cortical EGF increases ENaC activity and contributes to salt-sensitive hypertension. (Pavlov TS, Levchenko V, O'Connor PM, Ilatovskaya DV, Palygin O, Mori T, Mattson DL, Sorokin A, Lombard JH, Cowley AW Jr, Staruschenko A) J Am Soc Nephrol 2013 Jun;24(7):1053-62 PMID: 23599382 PMCID: PMC3699826 04/20/2013       35 Citations
  • Real-time electrochemical detection of ATP and H₂O₂ release in freshly isolated kidneys. (Palygin O, Levchenko V, Ilatovskaya DV, Pavlov TS, Ryan RP, Cowley AW Jr, Staruschenko A) Am J Physiol Renal Physiol 2013 Jul 01;305(1):F134-41 PMID: 23594827 PMCID: PMC3725679 04/19/2013       18 Citations
  • Detection of endogenous substances with enzymatic microelectrode biosensors in the kidney. (Palygin O, Staruschenko A) Am J Physiol Regul Integr Comp Physiol 2013 Jul 15;305(2):R89-91 PMID: 23594609 PMCID: PMC3726996 04/19/2013       2 Citations
  • MSK1 regulates homeostatic and experience-dependent synaptic plasticity. (Corrêa SA, Hunter CJ, Palygin O, Wauters SC, Martin KJ, McKenzie C, McKelvey K, Morris RG, Pankratov Y, Arthur JS, Frenguelli BG) J Neurosci 2012 Sep 19;32(38):13039-51 PMID: 22993422 09/21/2012       37 Citations
  • Modulation of ATP-induced LTP by cannabinoid receptors in rat hippocampus. (Ievglevskyi O, Palygin O, Kondratskaya E, Grebenyuk S, Krishtal O) Purinergic Signal 2012 Dec;8(4):705-13 PMID: 22453905 PMCID: PMC3486163 03/29/2012       6 Citations
  • Compartmentalization of the MAPK scaffold protein KSR1 modulates synaptic plasticity in hippocampal neurons. (Canal F, Palygin O, Pankratov Y, Corrêa SA, Müller J) FASEB J 2011 Jul;25(7):2362-72 PMID: 21471251 04/08/2011       15 Citations
  • Distinct pharmacological and functional properties of NMDA receptors in mouse cortical astrocytes. (Palygin O, Lalo U, Pankratov Y) Br J Pharmacol 2011 Aug;163(8):1755-66 PMID: 21449975 PMCID: PMC3166701 04/01/2011       58 Citations
  • Age-dependent remodelling of ionotropic signalling in cortical astroglia. (Lalo U, Palygin O, North RA, Verkhratsky A, Pankratov Y) Aging Cell 2011 Jun;10(3):392-402 PMID: 21272193 01/29/2011       40 Citations
  • Ionotropic NMDA and P2X1/5 receptors mediate synaptically induced Ca2+ signalling in cortical astrocytes. (Palygin O, Lalo U, Verkhratsky A, Pankratov Y) Cell Calcium 2010 Oct;48(4):225-31 PMID: 20926134 10/12/2010       84 Citations
  • Ca2+-dependent modulation of GABAA and NMDA receptors by extracellular ATP: implication for function of tripartite synapse. (Lalo U, Andrew J, Palygin O, Pankratov Y) Biochem Soc Trans 2009 Dec;37(Pt 6):1407-11 PMID: 19909286 11/17/2009       20 Citations
  • Regulation of caveolar cardiac sodium current by a single Gsalpha histidine residue. (Palygin OA, Pettus JM, Shibata EF) Am J Physiol Heart Circ Physiol 2008 Apr;294(4):H1693-9 PMID: 18281377 02/19/2008       35 Citations
  • Voltage-gated Nav channel targeting in the heart requires an ankyrin-G dependent cellular pathway. (Lowe JS, Palygin O, Bhasin N, Hund TJ, Boyden PA, Shibata E, Anderson ME, Mohler PJ) J Cell Biol 2008 Jan 14;180(1):173-86 PMID: 18180363 PMCID: PMC2213608 01/09/2008       123 Citations
  • Last update: 02/12/2019
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