Medical College of Wisconsin
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Pui Kei Wu PhD

Pui Kei Wu PhD

Instructor

Institution: Medical College of Wisconsin
Department: Biochemistry

Member of the Cancer Center


I am willing to collaborate on research projects.


Research Experience

  • Apoptosis
  • Cell Cycle
  • Cell Cycle Checkpoints
  • Cell Differentiation
  • Cell Survival
  • Cell Transformation, Neoplastic
  • Drug Resistance, Neoplasm
  • HSP70 Heat-Shock Proteins
  • MAP Kinase Signaling System
  • Melanoma
  • Mice
  • Mitochondria
  • Mutation
  • Protein Kinase Inhibitors
  • Proto-Oncogene Proteins B-raf
  • Clinical Expertise

  • Animals
  • Apoptosis
  • Cell Differentiation
  • Cell Line, Tumor
  • Cell Transformation, Neoplastic
  • Drug Resistance, Neoplasm
  • MAP Kinase Signaling System
  • Melanoma
  • Mice
  • Mutation
  • Proto-Oncogene Proteins B-raf
  • Xenograft Model Antitumor Assays
  • raf Kinases
  • Methodologies and Techniques

  • Animals
  • Apoptosis
  • Cell Cycle
  • Cell Cycle Checkpoints
  • Cell Differentiation
  • Cell Line, Tumor
  • Cell Proliferation
  • Cell Survival
  • Cell Transformation, Neoplastic
  • Drug Resistance, Neoplasm
  • Gene Expression Regulation
  • Gene Expression Regulation, Neoplastic
  • Mice
  • Mitochondria
  • Mutation
  • Phosphorylation
  • Plasmids
  • Xenograft Model Antitumor Assays
  • Publications

  • A cellular threshold for active ERK1/2 levels determines Raf/MEK/ERK-mediated growth arrest versus death responses. (Hong SK, Wu PK, Park JI) Cell Signal 2018 Jan;42:11-20 PMID: 28986121 PMCID: PMC5732048 10/08/2017    
  • Steady-State Levels of Phosphorylated Mitogen-Activated Protein Kinase Kinase 1/2 Determined by Mortalin/HSPA9 and Protein Phosphatase 1 Alpha in and Tumor Cells. (Wu PK, Hong SK, Park JI) Mol Cell Biol 2017 Sep 15;37(18) PMID: 28674184 PMCID: PMC5574043 07/05/2017       1 Citations
  • Vandetanib and cabozantinib potentiate mitochondria-targeted agents to suppress medullary thyroid carcinoma cells. (Starenki D, Hong SK, Wu PK, Park JI) Cancer Biol Ther 2017 Jul 03;18(7):473-483 PMID: 28475408 PMCID: PMC5639831 05/06/2017       2 Citations
  • Suppression of B-Raf melanoma cell survival by targeting mitochondria using triphenyl-phosphonium-conjugated nitroxide or ubiquinone. (Hong SK, Starenki D, Wu PK, Park JI) Cancer Biol Ther 2017 02;18(2):106-114 PMID: 27786591 PMCID: PMC5362989 10/28/2016       4 Citations
  • MEK1/2 Inhibitors: Molecular Activity and Resistance Mechanisms. (Wu PK, Park JI) Semin Oncol 2015 Dec;42(6):849-62 PMID: 26615130 PMCID: PMC4663016 11/29/2015       14 Citations
  • ERK1/2 can feedback-regulate cellular MEK1/2 levels. (Hong SK, Wu PK, Karkhanis M, Park JI) Cell Signal 2015 Oct;27(10):1939-48 PMID: 26163823 PMCID: PMC4540659 07/15/2015       4 Citations
  • Active ERK2 is sufficient to mediate growth arrest and differentiation signaling. (Wu PK, Hong SK, Yoon SH, Park JI) FEBS J 2015 Mar;282(6):1017-30 PMID: 25639353 PMCID: PMC4368470 02/03/2015       6 Citations
  • Raf/MEK/ERK can regulate cellular levels of LC3B and SQSTM1/p62 at expression levels. (Kim JH, Hong SK, Wu PK, Richards AL, Jackson WT, Park JI) Exp Cell Res 2014 Oct 01;327(2):340-52 PMID: 25128814 PMCID: PMC4164593 08/17/2014       35 Citations
  • A mortalin/HSPA9-mediated switch in tumor-suppressive signaling of Raf/MEK/extracellular signal-regulated kinase. (Wu PK, Hong SK, Veeranki S, Karkhanis M, Starenki D, Plaza JA, Park JI) Mol Cell Biol 2013 Oct;33(20):4051-67 PMID: 23959801 PMCID: PMC3811686 08/21/2013       30 Citations
  • The Predicted Proteomic Network Associated with the Antiarthritic Action of Qingfu Guanjieshu in Collagen-II-Induced Arthritis in Rats. (Wang TY, Zhou H, Wong YF, Wu PK, Hsiao WL, Leung EL, Liu L) Evid Based Complement Alternat Med 2013;2013:582493 PMID: 23781264 PMCID: PMC3678439 06/20/2013    
  • Chemical and DNA authentication of taste variants of Gynostemma pentaphyllum herbal tea. (Wu PK, Tai WC, Choi RC, Tsim KW, Zhou H, Liu X, Jiang ZH, Hsiao WL) Food Chem 2011 Sep 01;128(1):70-80 PMID: 25214331 09/01/2011    
  • Oleanolic acid isolated from Oldenlandia diffusa exhibits a unique growth inhibitory effect against ras-transformed fibroblasts. (Wu PK, Chi Shing Tai W, Liang ZT, Zhao ZZ, Hsiao WL) Life Sci 2009 Jul 17;85(3-4):113-21 PMID: 19433096 05/13/2009       27 Citations
  • The angiosuppressive effects of 20(R)- ginsenoside Rg3. (Yue PY, Wong DY, Wu PK, Leung PY, Mak NK, Yeung HW, Liu L, Cai Z, Jiang ZH, Fan TP, Wong RN) Biochem Pharmacol 2006 Aug 14;72(4):437-45 PMID: 16793023 06/24/2006       155 Citations
  • Involvement of protein kinase C and E2F-5 in euxanthone-induced neurite differentiation of neuroblastoma. (Ha WY, Wu PK, Kok TW, Leung KW, Mak NK, Yue PY, Ngai SM, Tsai SN, Wong RN) Int J Biochem Cell Biol 2006;38(8):1393-401 PMID: 16546434 03/21/2006       15 Citations
  • Last update: 02/06/2019
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