Medical College of Wisconsin
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Ravi K. Singh PhD

Ravi K. Singh PhD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Pathology
Division: Administration
Program: Pediatrics

Member of the Cardiovascular Center


Publications (16)

  • SRSF2 Regulation of MDM2 Reveals Splicing as a Therapeutic Vulnerability of the p53 Pathway. (Comiskey DF Jr, Montes M, Khurshid S, Singh RK, Chandler DS) Mol Cancer Res 2020 02;18(2):194-203 PMID: 31662450 SCOPUS ID: 2-s2.0-85078893896 10/31/2019       6 Citations
  • Leukemic presentation of ALK-positive anaplastic large cell lymphoma with a novel partner, poly(A) binding protein cytoplasmic 1 (PABPC1), responding to single-agent crizotinib. (Graetz D, Crews KR, Azzato EM, Singh RK, Raimondi S, Mason J, Valentine M, Mullighan CG, Holland A, Inaba H, Leventaki V) Haematologica 2019 05;104(5):e218-e221 PMID: 30819904 PMCID: PMC6518893 SCOPUS ID: 2-s2.0-85065466454 03/02/2019       6 Citations
  • Rbfox-Splicing Factors Maintain Skeletal Muscle Mass by Regulating Calpain3 and Proteostasis. (Singh RK, Kolonin AM, Fiorotto ML, Cooper TA) Cell Rep 2018 07 03;24(1):197-208 PMID: 29972780 PMCID: PMC6070147 SCOPUS ID: 2-s2.0-85048989217 07/05/2018       25 Citations
  • Splicing factor SRSF1 negatively regulates alternative splicing of MDM2 under damage. (Comiskey DF Jr, Jacob AG, Singh RK, Tapia-Santos AS, Chandler DS) Nucleic Acids Res 2015 Apr 30;43(8):4202-18 PMID: 25845590 PMCID: PMC4417157 SCOPUS ID: 2-s2.0-84930221684 04/08/2015       24 Citations
  • Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levels. (Gennarino VA, Singh RK, White JJ, De Maio A, Han K, Kim JY, Jafar-Nejad P, di Ronza A, Kang H, Sayegh LS, Cooper TA, Orr HT, Sillitoe RV, Zoghbi HY) Cell 2015 Mar 12;160(6):1087-98 PMID: 25768905 PMCID: PMC4383046 SCOPUS ID: 2-s2.0-84924559965 03/15/2015       93 Citations
  • The RNA-binding protein Rbfox1 regulates splicing required for skeletal muscle structure and function. (Pedrotti S, Giudice J, Dagnino-Acosta A, Knoblauch M, Singh RK, Hanna A, Mo Q, Hicks J, Hamilton S, Cooper TA) Hum Mol Genet 2015 Apr 15;24(8):2360-74 PMID: 25575511 PMCID: PMC4380076 SCOPUS ID: 2-s2.0-84926480647 01/13/2015       41 Citations
  • Stress-induced alternative splice forms of MDM2 and MDMX modulate the p53-pathway in distinct ways. (Jacob AG, Singh RK, Comiskey DF Jr, Rouhier MF, Mohammad F, Bebee TW, Chandler DS) PLoS One 2014;9(8):e104444 PMID: 25105592 PMCID: PMC4126728 SCOPUS ID: 2-s2.0-84905652764 08/12/2014       16 Citations
  • Rbfox2-coordinated alternative splicing of Mef2d and Rock2 controls myoblast fusion during myogenesis. (Singh RK, Xia Z, Bland CS, Kalsotra A, Scavuzzo MA, Curk T, Ule J, Li W, Cooper TA) Mol Cell 2014 Aug 21;55(4):592-603 PMID: 25087874 PMCID: PMC4142074 SCOPUS ID: 2-s2.0-84906791713 08/05/2014       73 Citations
  • The splicing factor FUBP1 is required for the efficient splicing of oncogene MDM2 pre-mRNA. (Jacob AG, Singh RK, Mohammad F, Bebee TW, Chandler DS) J Biol Chem 2014 Jun 20;289(25):17350-64 PMID: 24798327 PMCID: PMC4067169 SCOPUS ID: 2-s2.0-84903471466 05/07/2014       26 Citations
  • The Mef2 transcription network is disrupted in myotonic dystrophy heart tissue, dramatically altering miRNA and mRNA expression. (Kalsotra A, Singh RK, Gurha P, Ward AJ, Creighton CJ, Cooper TA) Cell Rep 2014 Jan 30;6(2):336-45 PMID: 24412363 PMCID: PMC3927417 SCOPUS ID: 2-s2.0-84895907629 01/15/2014       69 Citations
  • Stress-induced isoforms of MDM2 and MDM4 correlate with high-grade disease and an altered splicing network in pediatric rhabdomyosarcoma. (Jacob AG, O'Brien D, Singh RK, Comiskey DF Jr, Littleton RM, Mohammad F, Gladman JT, Widmann MC, Jeyaraj SC, Bolinger C, Anderson JR, Barkauskas DA, Boris-Lawrie K, Chandler DS) Neoplasia 2013 Sep;15(9):1049-63 PMID: 24027430 PMCID: PMC3769884 SCOPUS ID: 2-s2.0-84884378820 09/13/2013       16 Citations
  • Pre-mRNA splicing in disease and therapeutics. (Singh RK, Cooper TA) Trends Mol Med 2012 Aug;18(8):472-82 PMID: 22819011 PMCID: PMC3411911 SCOPUS ID: 2-s2.0-84864390703 07/24/2012       300 Citations
  • Conserved sequences in the final intron of MDM2 are essential for the regulation of alternative splicing of MDM2 in response to stress. (Singh RK, Tapia-Santos A, Bebee TW, Chandler DS) Exp Cell Res 2009 Nov 15;315(19):3419-32 PMID: 19631207 SCOPUS ID: 2-s2.0-70350405712 07/28/2009       17 Citations
  • NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma. (Wang H, Garzon R, Sun H, Ladner KJ, Singh R, Dahlman J, Cheng A, Hall BM, Qualman SJ, Chandler DS, Croce CM, Guttridge DC) Cancer Cell 2008 Nov 04;14(5):369-81 PMID: 18977326 PMCID: PMC3829205 SCOPUS ID: 2-s2.0-54549119169 11/04/2008       502 Citations
  • Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4. (Chandler DS, Singh RK, Caldwell LC, Bitler JL, Lozano G) Cancer Res 2006 Oct 01;66(19):9502-8 PMID: 17018606 SCOPUS ID: 2-s2.0-33750378188 10/05/2006       80 Citations
  • Rotavirus nonstructural protein NSP4 induces heterotypic antibody responses during natural infection in children. (Ray P, Malik J, Singh RK, Bhatnagar S, Bahl R, Kumar R, Bhan MK) J Infect Dis 2003 Jun 01;187(11):1786-93 PMID: 12751037 SCOPUS ID: 2-s2.0-0037526576 05/17/2003       39 Citations
  • Last update: 02/03/2020