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Robert H. Lane MD

Robert H. Lane MD

Associate Dean, Chair, Center Associate Dir, Prof

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Administration
Program: Chairman

Member of the Cardiovascular Center
Member of the Genomic Sciences and Precision Medicine Center (GSPMC)


Publications (104)

  • Adverse maternal environment leads to cardiac fibrosis in adult male mice. (Spearman AD, Ke X, Fu Q, Lane RH, Majnik A) Birth Defects Res 2018 12 01;110(20):1551-1555 PMID: 30576090 SCOPUS ID: 2-s2.0-85058916836 12/24/2018    
  • Persistent pulmonary hypertension alters the epigenetic characteristics of endothelial nitric oxide synthase gene in pulmonary artery endothelial cells in a fetal lamb model. (Ke X, Johnson H, Jing X, Michalkiewicz T, Huang YW, Lane RH, Konduri GG) Physiol Genomics 2018 10 01;50(10):828-836 PMID: 30004838 PMCID: PMC6230868 SCOPUS ID: 2-s2.0-85055279790 07/14/2018    
  • DUSP5 functions as a feedback regulator of TNFα-induced ERK1/2 dephosphorylation and inflammatory gene expression in adipocytes. (Habibian JS, Jefic M, Bagchi RA, Lane RH, McKnight RA, McKinsey TA, Morrison RF, Ferguson BS) Sci Rep 2017 10 10;7(1):12879 PMID: 29018280 PMCID: PMC5635013 SCOPUS ID: 2-s2.0-85030997754 10/12/2017       1 Citation
  • Protective effect of maternal uteroplacental insufficiency on oxygen-induced retinopathy in offspring: removing bias of premature birth. (Becker S, Wang H, Yu B, Brown R, Han X, Lane RH, Hartnett ME) Sci Rep 2017 02 14;7:42301 PMID: 28195189 PMCID: PMC5307308 SCOPUS ID: 2-s2.0-85012912670 02/15/2017       5 Citations
  • Intrauterine growth restriction combined with a maternal high-fat diet increases hepatic cholesterol and low-density lipoprotein receptor activity in rats. (Zinkhan EK, Zalla JM, Carpenter JR, Yu B, Yu X, Chan G, Joss-Moore L, Lane RH) Physiol Rep 2016 Jul;4(13) PMID: 27401460 PMCID: PMC4945843 SCOPUS ID: 2-s2.0-84978818572 07/13/2016       5 Citations
  • The relationship between early-life environment, the epigenome and the microbiota. (Majnik AV, Lane RH) Epigenomics 2015 Oct;7(7):1173-84 PMID: 26585860 SCOPUS ID: 2-s2.0-84949797048 11/21/2015       13 Citations
  • Intrauterine growth restriction perturbs nucleosome depletion at a growth hormone-responsive element in the mouse IGF-1 gene. (McKnight RA, Yost CC, Yu X, Wiedmeier JE, Callaway CW, Brown AS, Lane RH, Fung CM) Physiol Genomics 2015 Dec;47(12):634-43 PMID: 26487705 SCOPUS ID: 2-s2.0-84951292479 10/22/2015       2 Citations
  • Programmed regulation of rat offspring adipogenic transcription factor (PPARγ) by maternal nutrition. (Desai M, Jellyman JK, Han G, Lane RH, Ross MG) J Dev Orig Health Dis 2015 Dec;6(6):530-8 PMID: 26286138 PMCID: PMC4630004 SCOPUS ID: 2-s2.0-84945448991 08/20/2015       9 Citations
  • In utero nicotine exposure epigenetically alters fetal chromatin structure and differentially regulates transcription of the glucocorticoid receptor in a rat model. (Suter MA, Abramovici AR, Griffin E, Branch DW, Lane RH, Mastrobattista J, Rehan VK, Aagaard K) Birth Defects Res A Clin Mol Teratol 2015 Jul;103(7):583-8 PMID: 26172404 PMCID: PMC4821574 SCOPUS ID: 2-s2.0-84937562451 07/15/2015       13 Citations
  • IUGR increases chromatin-remodeling factor Brg1 expression and binding to GR exon 1.7 promoter in newborn male rat hippocampus. (Ke X, McKnight RA, Gracey Maniar LE, Sun Y, Callaway CW, Majnik A, Lane RH, Cohen SS) Am J Physiol Regul Integr Comp Physiol 2015 Jul 15;309(2):R119-27 PMID: 25972460 SCOPUS ID: 2-s2.0-84937440345 05/15/2015       2 Citations
  • IUGR prevents IGF-1 upregulation in juvenile male mice by perturbing postnatal IGF-1 chromatin remodeling. (Fung CM, Yang Y, Fu Q, Brown AS, Yu B, Callaway CW, Li J, Lane RH, McKnight RA) Pediatr Res 2015 Jul;78(1):14-23 PMID: 25826117 SCOPUS ID: 2-s2.0-84931846529 04/01/2015       5 Citations
  • Resistance strength training exercise in children with spinal muscular atrophy. (Lewelt A, Krosschell KJ, Stoddard GJ, Weng C, Xue M, Marcus RL, Gappmaier E, Viollet L, Johnson BA, White AT, Viazzo-Trussell D, Lopes P, Lane RH, Carey JC, Swoboda KJ) Muscle Nerve 2015 Oct;52(4):559-67 PMID: 25597614 PMCID: PMC4506899 SCOPUS ID: 2-s2.0-84935010763 01/20/2015       21 Citations
  • Epigenetic contributions to the developmental origins of adult lung disease. (Joss-Moore LA, Lane RH, Albertine KH) Biochem Cell Biol 2015 Apr;93(2):119-27 PMID: 25493710 PMCID: PMC5683896 SCOPUS ID: 2-s2.0-84964304821 12/11/2014       8 Citations
  • Intrauterine growth restriction disrupts developmental epigenetics around distal growth hormone response elements on the rat hepatic IGF-1 gene. (Fu Q, McKnight RA, Callaway CW, Yu X, Lane RH, Majnik AV) FASEB J 2015 Apr;29(4):1176-84 PMID: 25466885 SCOPUS ID: 2-s2.0-84931304700 12/04/2014       17 Citations
  • Preface. Current controversies in perinatology. (Lane RH, Kliegman RM) Clin Perinatol 2014 Dec;41(4):xix-xx PMID: 25459789 SCOPUS ID: 2-s2.0-84911001439 12/03/2014    
  • Fetal programming, epigenetics, and adult onset disease. (Lane RH) Clin Perinatol 2014 Dec;41(4):815-31 PMID: 25459776 SCOPUS ID: 2-s2.0-84910138439 12/03/2014       33 Citations
  • Essential nutrient supplementation prevents heritable metabolic disease in multigenerational intrauterine growth-restricted rats. (Goodspeed D, Seferovic MD, Holland W, Mcknight RA, Summers SA, Branch DW, Lane RH, Aagaard KM) FASEB J 2015 Mar;29(3):807-19 PMID: 25395450 PMCID: PMC4422359 SCOPUS ID: 2-s2.0-84933038710 11/15/2014       19 Citations
  • Epigenetics: an accessible mechanism through which to track and respond to an obesogenic environment. (Majnik A, Gunn V, Fu Q, Lane RH) Expert Rev Endocrinol Metab 2014 Nov;9(6):605-614 PMID: 30736198 11/01/2014    
  • Combination of intrauterine growth restriction and a high-fat diet impairs cholesterol elimination in rats. (Zinkhan EK, Chin JR, Zalla JM, Yu B, Numpang B, Yu X, Jiang C, Callaway CW, McKnight RA, Joss-Moore L, Lane RH) Pediatr Res 2014 Nov;76(5):432-40 PMID: 25119340 SCOPUS ID: 2-s2.0-84908600019 08/15/2014       12 Citations
  • Maternal tobacco smoke increased visceral adiposity and serum corticosterone levels in adult male rat offspring. (Zinkhan EK, Lang BY, Yu B, Wang Y, Jiang C, Fitzhugh M, Dahl M, Campbell MS, Fung C, Malleske D, Albertine KH, Joss-Moore L, Lane RH) Pediatr Res 2014 Jul;76(1):17-23 PMID: 24727947 SCOPUS ID: 2-s2.0-84902653279 04/15/2014       7 Citations
  • Maternal obesity and high-fat diet program offspring metabolic syndrome. (Desai M, Jellyman JK, Han G, Beall M, Lane RH, Ross MG) Am J Obstet Gynecol 2014 Sep;211(3):237.e1-237.e13 PMID: 24631702 PMCID: PMC4149836 SCOPUS ID: 2-s2.0-85058205849 03/19/2014       88 Citations
  • Epigenetics: where environment, society and genetics meet. (Majnik AV, Lane RH) Epigenomics 2014 Feb;6(1):1-4 PMID: 24579939 SCOPUS ID: 2-s2.0-84895484643 03/04/2014       5 Citations
  • High-frequency nasal ventilation for 21 d maintains gas exchange with lower respiratory pressures and promotes alveolarization in preterm lambs. (Null DM, Alvord J, Leavitt W, Wint A, Dahl MJ, Presson AP, Lane RH, DiGeronimo RJ, Yoder BA, Albertine KH) Pediatr Res 2014 Apr;75(4):507-16 PMID: 24378898 PMCID: PMC3961520 SCOPUS ID: 2-s2.0-84896487016 01/01/2014       32 Citations
  • Dysregulation of Npas2 leads to altered metabolic pathways in a murine knockout model. (O'Neil D, Mendez-Figueroa H, Mistretta TA, Su C, Lane RH, Aagaard KM) Mol Genet Metab 2013 Nov;110(3):378-87 PMID: 24067359 PMCID: PMC3874417 09/27/2013       10 Citations
  • Erythropoietin improved cognitive function and decreased hippocampal caspase activity in rat pups after traumatic brain injury. (Schober ME, Requena DF, Block B, Davis LJ, Rodesch C, Casper TC, Juul SE, Kesner RP, Lane RH) J Neurotrauma 2014 Feb 15;31(4):358-69 PMID: 23972011 PMCID: PMC3922399 08/27/2013       23 Citations
  • Effects of oxygen on the development and severity of retinopathy of prematurity. (Hartnett ME, Lane RH) J AAPOS 2013 Jun;17(3):229-34 PMID: 23791404 PMCID: PMC3740273 SCOPUS ID: 2-s2.0-84879223858 06/26/2013       36 Citations
  • Epigenetic mechanisms in fetal origins of health and disease. (Osborne-Majnik A, Fu Q, Lane RH) Clin Obstet Gynecol 2013 Sep;56(3):622-32 PMID: 23787712 PMCID: PMC3757540 SCOPUS ID: 2-s2.0-84882452083 06/22/2013       13 Citations
  • Tactile and Kinesthetic Stimulation (TKS) intervention improves outcomes in weanling rat bone in a neonatal stress model. (Haley S, Gulliver K, Baldassarre R, Miller S, Lane RH, Moyer-Mileur LJ) J Musculoskelet Neuronal Interact 2013 Jun;13(2):157-65 PMID: 23728102 06/04/2013    
  • Molecular determinants of lung development. (Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS) Ann Am Thorac Soc 2013 Apr;10(2):S12-6 PMID: 23607856 PMCID: PMC3955361 04/24/2013       39 Citations
  • Maternal docosahexaenoic acid increases adiponectin and normalizes IUGR-induced changes in rat adipose deposition. (Bagley HN, Wang Y, Campbell MS, Yu X, Lane RH, Joss-Moore LA) J Obes 2013;2013:312153 PMID: 23533720 PMCID: PMC3606778 03/28/2013       16 Citations
  • Intrauterine growth restriction transiently delays alveolar formation and disrupts retinoic acid receptor expression in the lung of female rat pups. (Joss-Moore L, Carroll T, Yang Y, Fitzhugh M, Metcalfe D, Oman J, Hale M, Dong L, Wang ZM, Yu X, Callaway CW, O'Brien E, McKnight RA, Lane RH, Albertine KH) Pediatr Res 2013 May;73(5):612-620 PMID: 23419538 PMCID: PMC4021738 02/20/2013       14 Citations
  • Mechanical-tactile stimulation (MTS) intervention in a neonatal stress model alters adult adipose tissue deposition and prevents hyperinsulinemia in male rats. (Haley S, Neff K, Gulliver K, Gough G, Slater H, Lane RH, Moyer-Mileur LJ) Early Hum Dev 2013 Jun;89(6):387-92 PMID: 23290636 01/08/2013       10 Citations
  • Epigenetics and the developmental origins of disease: the key to unlocking the door of personalized medicine. (Joss-Moore LA, Lane RH) Epigenomics 2012 Oct;4(5):471-3 PMID: 23130826 11/08/2012       9 Citations
  • Maternal high-fat diet modulates the fetal thyroid axis and thyroid gene expression in a nonhuman primate model. (Suter MA, Sangi-Haghpeykar H, Showalter L, Shope C, Hu M, Brown K, Williams S, Harris RA, Grove KL, Lane RH, Aagaard KM) Mol Endocrinol 2012 Dec;26(12):2071-80 PMID: 23015752 PMCID: PMC3517714 09/28/2012       29 Citations
  • A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates. (Suter MA, Chen A, Burdine MS, Choudhury M, Harris RA, Lane RH, Friedman JE, Grove KL, Tackett AJ, Aagaard KM) FASEB J 2012 Dec;26(12):5106-14 PMID: 22982377 PMCID: PMC3509051 09/18/2012       82 Citations
  • Intrauterine growth restriction decreases endochondral ossification and bone strength in female rats. (Chen H, Miller S, Lane RH, Moyer-Mileur LJ) Am J Perinatol 2013 Apr;30(4):261-6 PMID: 22875655 08/10/2012       4 Citations
  • Peroxisome proliferator-activated receptor gamma modulation and lipogenic response in adipocytes of small-for-gestational age offspring. (Yee JK, Lee WN, Ross MG, Lane RH, Han G, Vega J, Desai M) Nutr Metab (Lond) 2012 Jun 22;9(1):62 PMID: 22726273 PMCID: PMC3495639 06/26/2012    
  • Predicting later-life outcomes of early-life exposures. (Boekelheide K, Blumberg B, Chapin RE, Cote I, Graziano JH, Janesick A, Lane R, Lillycrop K, Myatt L, States JC, Thayer KA, Waalkes MP, Rogers JM) Environ Health Perspect 2012 Oct;120(10):1353-61 PMID: 22672778 PMCID: PMC3491941 06/08/2012       94 Citations
  • Maternal Hyperglycemia Disrupts Histone 3 Lysine 36 Trimethylation of the IGF-1 Gene. (Zinkhan EK, Fu Q, Wang Y, Yu X, Callaway CW, Segar JL, Scholz TD, McKnight RA, Joss-Moore L, Lane RH) J Nutr Metab 2012;2012:930364 PMID: 22548154 PMCID: PMC3324902 05/02/2012    
  • Developmental traumatic brain injury decreased brain derived neurotrophic factor expression late after injury. (Schober ME, Block B, Requena DF, Hale MA, Lane RH) Metab Brain Dis 2012 Jun;27(2):167-73 PMID: 22527999 PMCID: PMC3383795 04/25/2012       21 Citations
  • Altered expression and chromatin structure of the hippocampal IGF1r gene is associated with impaired hippocampal function in the adult IUGR male rat. (Caprau D, Schober ME, Bass K, O'Grady S, Ke X, Block B, Callaway CW, Hale M, Yu X, McKnight RA, Kesner RP, Lane RH) J Dev Orig Health Dis 2012 Apr;3(2):83-91 PMID: 25101918 04/01/2012    
  • Traumatic brain injury increased IGF-1B mRNA and altered IGF-1 exon 5 and promoter region epigenetic characteristics in the rat pup hippocampus. (Schober ME, Ke X, Xing B, Block BP, Requena DF, McKnight R, Lane RH) J Neurotrauma 2012 Jul 20;29(11):2075-85 PMID: 22413999 03/15/2012       17 Citations
  • Uteroplacental insufficiency alters rat hippocampal cellular phenotype in conjunction with ErbB receptor expression. (Fung C, Ke X, Brown AS, Yu X, McKnight RA, Lane RH) Pediatr Res 2012 Jul;72(1):2-9 PMID: 22367251 PMCID: PMC3612538 03/01/2012       21 Citations
  • Mechanical-tactile stimulation (MTS) intervention in a neonatal stress model improves long-term outcomes on bone. (Haley S, O'Grady S, Gulliver K, Bowman B, Baldassarre R, Miller S, Lane RH, Moyer-Mileur LJ) J Musculoskelet Neuronal Interact 2011 Sep;11(3):234-42 PMID: 21885898 PMCID: PMC3228307 09/03/2011       7 Citations
  • Epigenetics and the developmental origins of lung disease. (Joss-Moore LA, Albertine KH, Lane RH) Mol Genet Metab 2011 Sep-Oct;104(1-2):61-6 PMID: 21835665 PMCID: PMC3171512 08/13/2011       37 Citations
  • Intrauterine growth restriction affects hippocampal dual specificity phosphatase 5 gene expression and epigenetic characteristics. (Ke X, McKnight RA, Caprau D, O'Grady S, Fu Q, Yu X, Callaway CW, Albertine KH, Lane RH) Physiol Genomics 2011 Oct 20;43(20):1160-9 PMID: 21828247 PMCID: PMC3217330 08/11/2011       14 Citations
  • Mechanism of reduced lung injury by high-frequency nasal ventilation in a preterm lamb model of neonatal chronic lung disease. (Rehan VK, Fong J, Lee R, Sakurai R, Wang ZM, Dahl MJ, Lane RH, Albertine KH, Torday JS) Pediatr Res 2011 Nov;70(5):462-6 PMID: 21814155 PMCID: PMC3189277 08/05/2011       28 Citations
  • Intrauterine growth restriction alters T-lymphocyte cell number and dual specificity phosphatase 1 levels in the thymus of newborn and juvenile rats. (Contreras YM, Yu X, Hale MA, Callaway CW, Bareyan D, McKnight RA, Joss-Moore LA, Enioutina EY, Lane RH) Pediatr Res 2011 Aug;70(2):123-9 PMID: 21505375 04/21/2011    
  • IUGR differentially alters MeCP2 expression and H3K9Me3 of the PPARγ gene in male and female rat lungs during alveolarization. (Joss-Moore LA, Wang Y, Ogata EM, Sainz AJ, Yu X, Callaway CW, McKnight RA, Albertine KH, Lane RH) Birth Defects Res A Clin Mol Teratol 2011 Aug;91(8):672-81 PMID: 21425435 PMCID: PMC3152656 03/23/2011       29 Citations
  • IUGR decreases elastin mRNA expression in the developing rat lung and alters elastin content and lung compliance in the mature rat lung. (Joss-Moore LA, Wang Y, Yu X, Campbell MS, Callaway CW, McKnight RA, Wint A, Dahl MJ, Dull RO, Albertine KH, Lane RH) Physiol Genomics 2011 May 13;43(9):499-505 PMID: 21363967 PMCID: PMC3110897 03/03/2011       27 Citations
  • Early postnatal nutrition and programming of the preterm neonate. (Wiedmeier JE, Joss-Moore LA, Lane RH, Neu J) Nutr Rev 2011 Feb;69(2):76-82 PMID: 21294741 02/08/2011       49 Citations
  • Mechanical-tactile stimulation (MTS) during neonatal stress prevents hyperinsulinemia despite stress-induced adiposity in weanling rat pups. (Moyer-Mileur LJ, Haley S, Gulliver K, Thomson A, Slater H, Barrett B, Joss-Moore LA, Callaway C, McKnight RA, Moore B, Lane RH) Early Hum Dev 2011 Mar;87(3):159-63 PMID: 21211914 PMCID: PMC3228309 01/08/2011       10 Citations
  • Epigenomics: maternal high-fat diet exposure in utero disrupts peripheral circadian gene expression in nonhuman primates. (Suter M, Bocock P, Showalter L, Hu M, Shope C, McKnight R, Grove K, Lane R, Aagaard-Tillery K) FASEB J 2011 Feb;25(2):714-26 PMID: 21097519 PMCID: PMC3228348 11/26/2010       84 Citations
  • Early and Sustained Increase in the Expression of Hippocampal IGF-1, But Not EPO, in a Developmental Rodent Model of Traumatic Brain Injury. (Schober ME, Block B, Beachy JC, Statler KD, Giza CC, Lane RH) J Neurotrauma 2010 Oct 18: PMID: 20954842 10/20/2010    
  • IUGR decreases PPARγ and SETD8 Expression in neonatal rat lung and these effects are ameliorated by maternal DHA supplementation. (Joss-Moore LA, Wang Y, Baack ML, Yao J, Norris AW, Yu X, Callaway CW, McKnight RA, Albertine KH, Lane RH) Early Hum Dev 2010 Dec;86(12):785-91 PMID: 20869820 PMCID: PMC3138525 09/28/2010       48 Citations
  • Early and sustained increase in the expression of hippocampal IGF-1, but not EPO, in a developmental rodent model of traumatic brain injury. (Schober ME, Block B, Beachy JC, Statler KD, Giza CC, Lane RH) J Neurotrauma 2010 Nov;27(11):2011-20 PMID: 20822461 PMCID: PMC6468946 09/09/2010       26 Citations
  • Epigenetics of programmed obesity: alteration in IUGR rat hepatic IGF1 mRNA expression and histone structure in rapid vs. delayed postnatal catch-up growth. (Tosh DN, Fu Q, Callaway CW, McKnight RA, McMillen IC, Ross MG, Lane RH, Desai M) Am J Physiol Gastrointest Liver Physiol 2010 Nov;299(5):G1023-9 PMID: 20813916 PMCID: PMC2993166 09/04/2010       81 Citations
  • Intrauterine growth restriction alters hippocampal expression and chromatin structure of Cyp19a1 variants. (O'Grady SP, Caprau D, Ke XR, Contreras Y, Haley S, Ermini F, Penn A, Moyer-Mileur L, McKnight R, Lane R) Syst Biol Reprod Med 2010 Aug;56(4):292-302 PMID: 20662593 07/29/2010       8 Citations
  • Intrauterine growth restriction disturbs mediators of placental protein turnover. (McKnight RA, Joss-Moore LA, Lane RH) Epigenomics 2010 Jun;2(3):363-4 PMID: 22232787 06/01/2010    
  • Stem cell DNA methylation: a consequence of intrauterine growth restriction. (McKnight RA, Joss-Moore LA, Lane RH) Epigenomics 2010 Jun;2(3):359-60 PMID: 22121897 06/01/2010    
  • Intrauterine growth restriction, neural microRNA expression and hypertension in the mouse. (McKnight RA, Joss-Moore LA, Lane RH) Epigenomics 2010 Jun;2(3):360-1 PMID: 22232785 06/01/2010    
  • Placental variability in methylation reflects maternal and fetal pathogenesis. (McKnight RA, Joss-Moore LA, Lane RH) Epigenomics 2010 Jun;2(3):362-3 PMID: 22232786 06/01/2010    
  • Fetal growth restriction alters transcription factor binding and epigenetic mechanisms of renal 11beta-hydroxysteroid dehydrogenase type 2 in a sex-specific manner. (Baserga M, Kaur R, Hale MA, Bares A, Yu X, Callaway CW, McKnight RA, Lane RH) Am J Physiol Regul Integr Comp Physiol 2010 Jul;299(1):R334-42 PMID: 20427719 PMCID: PMC2904157 04/30/2010       59 Citations
  • Intrauterine growth retardation affects expression and epigenetic characteristics of the rat hippocampal glucocorticoid receptor gene. (Ke X, Schober ME, McKnight RA, O'Grady S, Caprau D, Yu X, Callaway CW, Lane RH) Physiol Genomics 2010 Jul 07;42(2):177-89 PMID: 20388836 04/15/2010       38 Citations
  • Uteroplacental insufficiency increases visceral adiposity and visceral adipose PPARgamma2 expression in male rat offspring prior to the onset of obesity. (Joss-Moore LA, Wang Y, Campbell MS, Moore B, Yu X, Callaway CW, McKnight RA, Desai M, Moyer-Mileur LJ, Lane RH) Early Hum Dev 2010 Mar;86(3):179-85 PMID: 20227202 PMCID: PMC2857740 03/17/2010       53 Citations
  • Epigenetics and fetal adaptation to perinatal events: diversity through fidelity. (Joss-Moore LA, Metcalfe DB, Albertine KH, McKnight RA, Lane RH) J Anim Sci 2010 Apr;88(13 Suppl):E216-22 PMID: 19854998 PMCID: PMC5701512 10/27/2009       29 Citations
  • A maternal high-fat diet is accompanied by alterations in the fetal primate metabolome. (Cox J, Williams S, Grove K, Lane RH, Aagaard-Tillery KM) Am J Obstet Gynecol 2009 Sep;201(3):281.e1-9 PMID: 19733280 PMCID: PMC2749563 09/08/2009       41 Citations
  • The developmental origins of adult disease. (Joss-Moore LA, Lane RH) Curr Opin Pediatr 2009 Apr;21(2):230-4 PMID: 19663040 PMCID: PMC2726974 08/11/2009       57 Citations
  • Epigenetics: intrauterine growth retardation (IUGR) modifies the histone code along the rat hepatic IGF-1 gene. (Fu Q, Yu X, Callaway CW, Lane RH, McKnight RA) FASEB J 2009 Aug;23(8):2438-49 PMID: 19364764 PMCID: PMC2717764 04/15/2009       131 Citations
  • Uteroplacental insufficiency affects kidney VEGF expression in a model of IUGR with compensatory glomerular hypertrophy and hypertension. (Baserga M, Bares AL, Hale MA, Callaway CW, McKnight RA, Lane PH, Lane RH) Early Hum Dev 2009 Jun;85(6):361-7 PMID: 19188030 PMCID: PMC4447306 02/04/2009       36 Citations
  • Intrauterine growth restriction due to uteroplacental insufficiency decreased white matter and altered NMDAR subunit composition in juvenile rat hippocampi. (Schober ME, McKnight RA, Yu X, Callaway CW, Ke X, Lane RH) Am J Physiol Regul Integr Comp Physiol 2009 Mar;296(3):R681-92 PMID: 19144756 01/16/2009       33 Citations
  • Programmed upregulation of adipogenic transcription factors in intrauterine growth-restricted offspring. (Desai M, Guang Han, Ferelli M, Kallichanda N, Lane RH) Reprod Sci 2008 Oct;15(8):785-96 PMID: 19017816 PMCID: PMC3444244 11/20/2008       51 Citations
  • Nasal ventilation alters mesenchymal cell turnover and improves alveolarization in preterm lambs. (Reyburn B, Li M, Metcalfe DB, Kroll NJ, Alvord J, Wint A, Dahl MJ, Sun J, Dong L, Wang ZM, Callaway C, McKnight RA, Moyer-Mileur L, Yoder BA, Null DM, Lane RH, Albertine KH) Am J Respir Crit Care Med 2008 Aug 15;178(4):407-18 PMID: 18556628 PMCID: PMC2542442 06/17/2008       46 Citations
  • Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome. (Aagaard-Tillery KM, Grove K, Bishop J, Ke X, Fu Q, McKnight R, Lane RH) J Mol Endocrinol 2008 Aug;41(2):91-102 PMID: 18515302 PMCID: PMC2959100 06/03/2008       257 Citations
  • In utero tobacco exposure is associated with modified effects of maternal factors on fetal growth. (Aagaard-Tillery KM, Porter TF, Lane RH, Varner MW, Lacoursiere DY) Am J Obstet Gynecol 2008 Jan;198(1):66.e1-6 PMID: 18166310 01/02/2008       50 Citations
  • Gestational programming of offspring obesity: a potential contributor to Alzheimer's disease. (Ross MG, Desai M, Khorram O, McKnight RA, Lane RH, Torday J) Curr Alzheimer Res 2007 Apr;4(2):213-7 PMID: 17430249 04/14/2007       33 Citations
  • Uteroplacental insufficiency decreases p53 serine-15 phosphorylation in term IUGR rat lungs. (O'Brien EA, Barnes V, Zhao L, McKnight RA, Yu X, Callaway CW, Wang L, Sun JC, Dahl MJ, Wint A, Wang Z, McIntyre TM, Albertine KH, Lane RH) Am J Physiol Regul Integr Comp Physiol 2007 Jul;293(1):R314-22 PMID: 17428897 04/13/2007       22 Citations
  • Uteroplacental insufficiency alters nephrogenesis and downregulates cyclooxygenase-2 expression in a model of IUGR with adult-onset hypertension. (Baserga M, Hale MA, Wang ZM, Yu X, Callaway CW, McKnight RA, Lane RH) Am J Physiol Regul Integr Comp Physiol 2007 May;292(5):R1943-55 PMID: 17272666 02/03/2007       36 Citations
  • Growth retardation alters the epigenetic characteristics of hepatic dual specificity phosphatase 5. (Fu Q, McKnight RA, Yu X, Callaway CW, Lane RH) FASEB J 2006 Oct;20(12):2127-9 PMID: 16940436 08/31/2006       62 Citations
  • Uteroplacental insufficiency increases p53 phosphorylation without triggering the p53-MDM2 functional circuit response in the IUGR rat kidney. (Baserga M, Hale MA, Ke X, Wang ZM, Yu X, Callaway CW, McKnight RA, Lane RH) Am J Physiol Regul Integr Comp Physiol 2006 Aug;291(2):R412-8 PMID: 16914427 08/18/2006       18 Citations
  • Basic and translational research in neonatal pharmacology. (Ward RM, Lane RH, Albertine KH) J Perinatol 2006 Jul;26 Suppl 2:S8-S12 PMID: 16801973 06/28/2006       6 Citations
  • Uteroplacental insufficiency affects epigenetic determinants of chromatin structure in brains of neonatal and juvenile IUGR rats. (Ke X, Lei Q, James SJ, Kelleher SL, Melnyk S, Jernigan S, Yu X, Wang L, Callaway CW, Gill G, Chan GM, Albertine KH, McKnight RA, Lane RH) Physiol Genomics 2006 Mar 13;25(1):16-28 PMID: 16380407 12/29/2005       117 Citations
  • Uteroplacental insufficiency alters hepatic expression, phosphorylation, and activity of the glucocorticoid receptor in fetal IUGR rats. (Baserga M, Hale MA, McKnight RA, Yu X, Callaway CW, Lane RH) Am J Physiol Regul Integr Comp Physiol 2005 Nov;289(5):R1348-53 PMID: 16002560 07/09/2005       33 Citations
  • Nonresponsiveness of cerebral p53-MDM2 functional circuit in newborn rat pups rendered IUGR via uteroplacental insufficiency. (Ke X, McKnight RA, Wang ZM, Yu X, Wang L, Callaway CW, Albertine KH, Lane RH) Am J Physiol Regul Integr Comp Physiol 2005 Apr;288(4):R1038-45 PMID: 15563574 11/26/2004       27 Citations
  • Epidermal growth factor reduces intestinal apoptosis in an experimental model of necrotizing enterocolitis. (Clark JA, Lane RH, Maclennan NK, Holubec H, Dvorakova K, Halpern MD, Williams CS, Payne CM, Dvorak B) Am J Physiol Gastrointest Liver Physiol 2005 Apr;288(4):G755-62 PMID: 15528252 11/06/2004       96 Citations
  • Uteroplacental insufficiency induces site-specific changes in histone H3 covalent modifications and affects DNA-histone H3 positioning in day 0 IUGR rat liver. (Fu Q, McKnight RA, Yu X, Wang L, Callaway CW, Lane RH) Physiol Genomics 2004 Dec 15;20(1):108-16 PMID: 15494474 10/21/2004       91 Citations
  • Uteroplacental insufficiency decreases small intestine growth and alters apoptotic homeostasis in term intrauterine growth retarded rats. (Baserga M, Bertolotto C, Maclennan NK, Hsu JL, Pham T, Laksana GS, Lane RH) Early Hum Dev 2004 Sep;79(2):93-105 PMID: 15324990 08/25/2004       52 Citations
  • Uteroplacental insufficiency alters DNA methylation, one-carbon metabolism, and histone acetylation in IUGR rats. (MacLennan NK, James SJ, Melnyk S, Piroozi A, Jernigan S, Hsu JL, Janke SM, Pham TD, Lane RH) Physiol Genomics 2004 Jun 17;18(1):43-50 PMID: 15084713 04/16/2004       161 Citations
  • Uteroplacental insufficiency increases apoptosis and alters p53 gene methylation in the full-term IUGR rat kidney. (Pham TD, MacLennan NK, Chiu CT, Laksana GS, Hsu JL, Lane RH) Am J Physiol Regul Integr Comp Physiol 2003 Nov;285(5):R962-70 PMID: 12869365 07/19/2003       226 Citations
  • IUGR alters postnatal rat skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1 gene expression in a fiber specific manner. (Lane RH, Maclennan NK, Daood MJ, Hsu JL, Janke SM, Pham TD, Puri AR, Watchko JF) Pediatr Res 2003 Jun;53(6):994-1000 PMID: 12646730 03/21/2003       36 Citations
  • IGF alters jejunal glucose transporter expression and serum glucose levels in immature rats. (Lane RH, Dvorak B, MacLennan NK, Dvorakova K, Halpern MD, Pham TD, Philipps AF) Am J Physiol Regul Integr Comp Physiol 2002 Dec;283(6):R1450-60 PMID: 12388463 10/22/2002       31 Citations
  • Increased hepatic peroxisome proliferator-activated receptor-gamma coactivator-1 gene expression in a rat model of intrauterine growth retardation and subsequent insulin resistance. (Lane RH, MacLennan NK, Hsu JL, Janke SM, Pham TD) Endocrinology 2002 Jul;143(7):2486-90 PMID: 12072378 06/20/2002       72 Citations
  • P-glycoprotein expression in mouse brain increases with maturation. (Tsai CE, Daood MJ, Lane RH, Hansen TW, Gruetzmacher EM, Watchko JF) Biol Neonate 2002 Jan;81(1):58-64 PMID: 11803178 01/23/2002       52 Citations
  • Uteroplacental insufficiency alters liver and skeletal muscle branched-chain amino acid metabolism in intrauterine growth-restricted fetal rats. (Kloesz JL, Serdikoff CM, Maclennan NK, Adibi SA, Lane RH) Pediatr Res 2001 Nov;50(5):604-10 PMID: 11641455 10/20/2001       18 Citations
  • Altered expression and function of mitochondrial beta-oxidation enzymes in juvenile intrauterine-growth-retarded rat skeletal muscle. (Lane RH, Kelley DE, Ritov VH, Tsirka AE, Gruetzmacher EM) Pediatr Res 2001 Jul;50(1):83-90 PMID: 11420423 06/23/2001       47 Citations
  • Myocardial gene expression of glucose transporter 1 and glucose transporter 4 in response to uteroplacental insufficiency in the rat. (Tsirka AE, Gruetzmacher EM, Kelley DE, Ritov VH, Devaskar SU, Lane RH) J Endocrinol 2001 May;169(2):373-80 PMID: 11312153 04/20/2001       40 Citations
  • Uteroplacental insufficiency lowers the threshold towards hypoxia-induced cerebral apoptosis in growth-retarded fetal rats. (Lane RH, Ramirez RJ, Tsirka AE, Kloesz JL, McLaughlin MK, Gruetzmacher EM, Devaskar SU) Brain Res 2001 Mar 23;895(1-2):186-93 PMID: 11259777 03/22/2001       54 Citations
  • Uteroplacental insufficiency alters hepatic fatty acid-metabolizing enzymes in juvenile and adult rats. (Lane RH, Kelley DE, Gruetzmacher EM, Devaskar SU) Am J Physiol Regul Integr Comp Physiol 2001 Jan;280(1):R183-90 PMID: 11124150 12/22/2000       87 Citations
  • Uteroplacental insufficiency alters cerebral mitochondrial gene expression and DNA in fetal and juvenile rats. (Lane RH, Tsirka AE, Gruetzmacher EM) Pediatr Res 2000 Jun;47(6):792-7 PMID: 10832740 06/01/2000       23 Citations
  • Placental expression of glucose transporter proteins 1 and 3 in growth-restricted fetal rats. (Reid GJ, Lane RH, Flozak AS, Simmons RA) Am J Obstet Gynecol 1999 Apr;180(4):1017-23 PMID: 10203672 04/16/1999       17 Citations
  • Localization and quantification of glucose transporters in liver of growth-retarded fetal and neonatal rats. (Lane RH, Crawford SE, Flozak AS, Simmons RA) Am J Physiol 1999 01;276(1):E135-42 PMID: 9886959 01/14/1999       45 Citations
  • Intrauterine growth retardation alters mitochondrial gene expression and function in fetal and juvenile rat skeletal muscle. (Lane RH, Chandorkar AK, Flozak AS, Simmons RA) Pediatr Res 1998 May;43(5):563-70 PMID: 9585000 05/19/1998       64 Citations
  • Measurement of GLUT mRNA in liver of fetal and neonatal rats using a novel method of quantitative polymerase chain reaction. (Lane RH, Flozak AS, Simmons RA) Biochem Mol Med 1996 Dec;59(2):192-9 PMID: 8986644 12/01/1996       23 Citations
  • Altered hepatic gene expression of enzymes involved in energy metabolism in the growth-retarded fetal rat. (Lane RH, Flozak AS, Ogata ES, Bell GI, Simmons RA) Pediatr Res 1996 Mar;39(3):390-4 PMID: 8929856 03/01/1996       67 Citations
  • Last update: 05/16/2019
    jenkins-FCD Prod-388 89e904233d719332173309c68ab82b0b2a78a3a7