Medical College of Wisconsin
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Robert R. Montgomery MD

Robert R. Montgomery MD

Professor

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Hematology/Oncology
Program: Oncology

Member of the Cancer Center


Community Partnerships

  • BloodCenter of Wisconsin
    Great Lakes Hemophilia Foundation
    Children's Hospital of Wisconsin
    Hemophilia and Thrombosis Research Society
    International Society of Thrombosis and Haemophilia
    National Hemophilia Foundation
  • Publications

  • The important role of von Willebrand factor in platelet-derived FVIII gene therapy for murine hemophilia A in the presence of inhibitory antibodies. (Shi Q, Schroeder JA, Kuether EL, Montgomery RR) J Thromb Haemost 2015 Jul;13(7):1301-9 PMID: 25955153 PMCID: PMC4496307
  • Crucial role for the VWF A1 domain in binding to type IV collagen. (Flood VH, Schlauderaff AC, Haberichter SL, Slobodianuk TL, Jacobi PM, Bellissimo DB, Christopherson PA, Friedman KD, Gill JC, Hoffmann RG, Montgomery RR, Zimmerman Program Investigators) Blood 2015 Apr 2;125(14):2297-304 PMID: 25662333 PMCID: PMC4383803
  • Normal range of bleeding scores for the ISTH-BAT: adult and pediatric data from the merging project. (Elbatarny M, Mollah S, Grabell J, Bae S, Deforest M, Tuttle A, Hopman W, Clark DS, Mauer AC, Bowman M, Riddel J, Christopherson PA, Montgomery RR, Zimmerman Program Investigators, Rand ML, Coller B, James PD) Haemophilia 2014 Nov;20(6):831-5 PMID: 25196510 PMCID: PMC4251588
  • Non-myeloablative conditioning with busulfan before hematopoietic stem cell transplantation leads to phenotypic correction of murine Bernard-Soulier syndrome. (Kanaji S, Fahs SA, Ware J, Montgomery RR, Shi Q) J Thromb Haemost 2014 Oct;12(10):1726-32 PMID: 25066812 PMCID: PMC4194147
  • A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII. (Fahs SA, Hille MT, Shi Q, Weiler H, Montgomery RR) Blood 2014 Jun 12;123(24):3706-13 PMID: 24705491 PMCID: PMC4055921
  • Evaluation of von Willebrand factor and von Willebrand factor propeptide in models of vascular endothelial cell activation, perturbation, and/or injury. (Brott DA, Katein A, Thomas H, Lawton M, Montgomery RR, Richardson RJ, Louden CS) Toxicol Pathol 2014 Jun;42(4):672-83 PMID: 24499802 PMCID: PMC4222990
  • Platelet gene therapy corrects the hemophilic phenotype in immunocompromised hemophilia A mice transplanted with genetically manipulated human cord blood stem cells. (Shi Q, Kuether EL, Chen Y, Schroeder JA, Fahs SA, Montgomery RR) Blood 2014 Jan 16;123(3):395-403 PMID: 24269957 PMCID: PMC3894495
  • Platelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of sitosterolemia. (Kanaji T, Kanaji S, Montgomery RR, Patel SB, Newman PJ) Blood 2013 Oct 10;122(15):2732-42 PMID: 23926302 PMCID: PMC3795464
  • Markers of vascular perturbation correlate with airway structural change in asthma. (Johansson MW, Kruger SJ, Schiebler ML, Evans MD, Sorkness RL, Denlinger LC, Busse WW, Jarjour NN, Montgomery RR, Mosher DF, Fain SB) Am J Respir Crit Care Med 2013 Jul 15;188(2):167-78 PMID: 23855693 PMCID: PMC3778758
  • The C-type lectin receptor CLEC4M binds, internalizes, and clears von Willebrand factor and contributes to the variation in plasma von Willebrand factor levels. (Rydz N, Swystun LL, Notley C, Paterson AD, Riches JJ, Sponagle K, Boonyawat B, Montgomery RR, James PD, Lillicrap D) Blood 2013 Jun 27;121(26):5228-37 PMID: 23529928 PMCID: PMC3722568
  • No increase in bleeding identified in type 1 VWD subjects with D1472H sequence variation. (Flood VH, Friedman KD, Gill JC, Haberichter SL, Christopherson PA, Branchford BR, Hoffmann RG, Abshire TC, Dunn AL, Di Paola JA, Hoots WK, Brown DL, Leissinger C, Lusher JM, Ragni MV, Shapiro AD, Montgomery RR) Blood 2013 May 2;121(18):3742-4 PMID: 23520336 PMCID: PMC3643771
  • Collagen binding provides a sensitive screen for variant von Willebrand disease. (Flood VH, Gill JC, Friedman KD, Christopherson PA, Jacobi PM, Hoffmann RG, Montgomery RR, Haberichter SL, Zimmerman Program Investigators) Clin Chem 2013 Apr;59(4):684-91 PMID: 23340442 PMCID: PMC3852672
  • Characterization of zebrafish von Willebrand factor reveals conservation of domain structure, multimerization, and intracellular storage. (Ghosh A, Vo A, Twiss BK, Kretz CA, Jozwiak MA, Montgomery RR, Shavit JA) Adv Hematol 2012;2012:214209 PMID: 23049555 PMCID: PMC3462383
  • Factor VIII inhibitors: von Willebrand factor makes a difference in vitro and in vivo. (Shi Q, Kuether EL, Schroeder JA, Perry CL, Fahs SA, Cox Gill J, Montgomery RR) J Thromb Haemost 2012 Nov;10(11):2328-37 PMID: 22908929 PMCID: PMC3670966
  • Standardization of von Willebrand factor propeptide: value assignment to the WHO 6th IS Factor VIII/von Willebrand factor, plasma (07/316). (Hubbard AR, Hamill M, Eikenboom HC, Montgomery RR, Mertens K, Haberichter S, SSC sub-committee on von Willebrand factor of ISTH) J Thromb Haemost 2012 May;10(5):959-60 PMID: 22696769 PMCID: PMC4196679
  • Contribution of platelet vs. endothelial VWF to platelet adhesion and hemostasis. (Kanaji S, Fahs SA, Shi Q, Haberichter SL, Montgomery RR) J Thromb Haemost 2012 Aug;10(8):1646-52 PMID: 22642380 PMCID: PMC3419786
  • Lentivirus-mediated platelet gene therapy of murine hemophilia A with pre-existing anti-factor VIII immunity. (Kuether EL, Schroeder JA, Fahs SA, Cooley BC, Chen Y, Montgomery RR, Wilcox DA, Shi Q) J Thromb Haemost 2012 Aug;10(8):1570-80 PMID: 22632092 PMCID: PMC3419807
  • Critical von Willebrand factor A1 domain residues influence type VI collagen binding. (Flood VH, Gill JC, Christopherson PA, Bellissimo DB, Friedman KD, Haberichter SL, Lentz SR, Montgomery RR) J Thromb Haemost 2012 Jul;10(7):1417-24 PMID: 22507569 PMCID: PMC3809952
  • Comparison of type I, type III and type VI collagen binding assays in diagnosis of von Willebrand disease. (Flood VH, Gill JC, Christopherson PA, Wren JS, Friedman KD, Haberichter SL, Hoffmann RG, Montgomery RR) J Thromb Haemost 2012 Jul;10(7):1425-32 PMID: 22507643 PMCID: PMC3809762
  • von Willebrand factor (VWF) propeptide binding to VWF D'D3 domain attenuates platelet activation and adhesion. (Madabhushi SR, Shang C, Dayananda KM, Rittenhouse-Olson K, Murphy M, Ryan TE, Montgomery RR, Neelamegham S) Blood 2012 May 17;119(20):4769-78 PMID: 22452980 PMCID: PMC3367877
  • Platelet and endothelial expression of clotting factors for the treatment of hemophilia. (Montgomery RR, Shi Q) Thromb Res 2012 May;129 Suppl 2:S46-8 PMID: 22421106 PMCID: PMC3581347
  • Intravascular recovery of VWF and FVIII following intraperitoneal injection and differences from intravenous and subcutaneous injection in mice. (Shi Q, Kuether EL, Schroeder JA, Fahs SA, Montgomery RR) Haemophilia 2012 Jul;18(4):639-46 PMID: 22221819 PMCID: PMC3323668
  • VWF mutations and new sequence variations identified in healthy controls are more frequent in the African-American population. (Bellissimo DB, Christopherson PA, Flood VH, Gill JC, Friedman KD, Haberichter SL, Shapiro AD, Abshire TC, Leissinger C, Hoots WK, Lusher JM, Ragni MV, Montgomery RR) Blood 2012 Mar 1;119(9):2135-40 PMID: 22197721 PMCID: PMC3311248
  • Von Willebrand disease in the United States: a perspective from Wisconsin. (Flood VH, Gill JC, Friedman KD, Bellissimo DB, Haberichter SL, Montgomery RR) Semin Thromb Hemost 2011 Jul;37(5):528-34 PMID: 22102196 PMCID: PMC3807766
  • Correction of murine Bernard-Soulier syndrome by lentivirus-mediated gene therapy. (Kanaji S, Kuether EL, Fahs SA, Schroeder JA, Ware J, Montgomery RR, Shi Q) Mol Ther 2012 Mar;20(3):625-32 PMID: 22044935 PMCID: PMC3293608
  • Alternative strategies for gene therapy of hemophilia. (Montgomery RR, Shi Q) Hematology Am Soc Hematol Educ Program 2010;2010:197-202 PMID: 21239794 PMCID: PMC3383974
  • Gain-of-function GPIb ELISA assay for VWF activity in the Zimmerman Program for the Molecular and Clinical Biology of VWD. (Flood VH, Gill JC, Morateck PA, Christopherson PA, Friedman KD, Haberichter SL, Hoffmann RG, Montgomery RR) Blood 2011 Feb 10;117(6):e67-74 PMID: 21148813 PMCID: PMC3056647
  • von Willebrand's disease diagnosis and laboratory issues. (Castaman G, Montgomery RR, Meschengieser SS, Haberichter SL, Woods AI, Lazzari MA) Haemophilia 2010 Jul;16 Suppl 5:67-73 PMID: 20590859 PMCID: PMC4313748
  • Unique strategies for therapeutic gene transfer in haemophilia A and haemophilia BWFH State-of-the-Art Session on Therapeutic Gene Transfer Buenos Aires, Argentina. (Montgomery RR, Monahan PE, Ozelo MC) Haemophilia 2010 Jul;16 Suppl 5:29-34 PMID: 20590853
  • Platelets as delivery systems for disease treatments. (Shi Q, Montgomery RR) Adv Drug Deliv Rev 2010 Sep 30;62(12):1196-203 PMID: 20619307 PMCID: PMC2991519
  • Targeting FVIII expression to endothelial cells regenerates a releasable pool of FVIII and restores hemostasis in a mouse model of hemophilia A. (Shi Q, Fahs SA, Kuether EL, Cooley BC, Weiler H, Montgomery RR) Blood 2010 Oct 21;116(16):3049-57 PMID: 20606161 PMCID: PMC2974610
  • Factor IX ectopically expressed in platelets can be stored in alpha-granules and corrects the phenotype of hemophilia B mice. (Zhang G, Shi Q, Fahs SA, Kuether EL, Walsh CE, Montgomery RR) Blood 2010 Aug 26;116(8):1235-43 PMID: 20445020 PMCID: PMC2938234
  • Absent collagen binding in a VWF A3 domain mutant: utility of the VWF:CB in diagnosis of VWD. (Flood VH, Lederman CA, Wren JS, Christopherson PA, Friedman KD, Hoffmann RG, Montgomery RR) J Thromb Haemost 2010 Jun;8(6):1431-3 PMID: 20345715 PMCID: PMC3892206
  • Common VWF exon 28 polymorphisms in African Americans affecting the VWF activity assay by ristocetin cofactor. (Flood VH, Gill JC, Morateck PA, Christopherson PA, Friedman KD, Haberichter SL, Branchford BR, Hoffmann RG, Abshire TC, Di Paola JA, Hoots WK, Leissinger C, Lusher JM, Ragni MV, Shapiro AD, Montgomery RR) Blood 2010 Jul 15;116(2):280-6 PMID: 20231421 PMCID: PMC2910611
  • Limitations of the ristocetin cofactor assay in measurement of von Willebrand factor function. (Flood VH, Friedman KD, Gill JC, Morateck PA, Wren JS, Scott JP, Montgomery RR) J Thromb Haemost 2009 Nov;7(11):1832-9 PMID: 19694940 PMCID: PMC3825106
  • Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site. (Raife TJ, Cao W, Atkinson BS, Bedell B, Montgomery RR, Lentz SR, Johnson GF, Zheng XL) Blood 2009 Aug 20;114(8):1666-74 PMID: 19541819 PMCID: PMC2731642
  • Clinical and laboratory diagnosis of von Willebrand disease: a synopsis of the 2008 NHLBI/NIH guidelines. (Nichols WL, Rick ME, Ortel TL, Montgomery RR, Sadler JE, Yawn BP, James AH, Hultin MB, Manco-Johnson MJ, Weinstein M) Am J Hematol 2009 Jun;84(6):366-70 PMID: 19415721
  • Genetic alteration of the D2 domain abolishes von Willebrand factor multimerization and trafficking into storage. (Haberichter SL, Allmann AM, Jozwiak MA, Montgomery RR, Gill JC) J Thromb Haemost 2009 Apr;7(4):641-50 PMID: 19192112 PMCID: PMC2745278
  • At least type VWD2B is a discrete variant of VWD, isn't it? (Montgomery RR) Blood 2009 Jan 15;113(3):501 PMID: 19147792 PMCID: PMC2628358
  • von Willebrand factor content in Alphanate(R) (Laurence J. Logan) - reply. (Nichols WL et al.) Haemophilia 2009 Jan 1;15(1):370-371 PMID: 18811592
  • Type 2B von Willebrand disease associated with the release of platelet agglutinates from megakaryocytes in the bone marrow. (Slayton WB, Patel M, Sola-Visner M, Harris N, Rivers A, Montgomery RR, Friedman KD) J Pediatr Hematol Oncol 2008 Sep;30(9):708-11 PMID: 18776767
  • Syngeneic transplantation of hematopoietic stem cells that are genetically modified to express factor VIII in platelets restores hemostasis to hemophilia A mice with preexisting FVIII immunity. (Shi Q, Fahs SA, Wilcox DA, Kuether EL, Morateck PA, Mareno N, Weiler H, Montgomery RR) Blood 2008 Oct 1;112(7):2713-21 PMID: 18495954 PMCID: PMC2556608
  • Identification of type 1 von Willebrand disease patients with reduced von Willebrand factor survival by assay of the VWF propeptide in the European study: molecular and clinical markers for the diagnosis and management of type 1 VWD (MCMDM-1VWD). (Haberichter SL, Castaman G, Budde U, Peake I, Goodeve A, Rodeghiero F, Federici AB, Batlle J, Meyer D, Mazurier C, Goudemand J, Eikenboom J, Schneppenheim R, Ingerslev J, Vorlova Z, Habart D, Holmberg L, Lethagen S, Pasi J, Hill FG, Montgomery RR) Blood 2008 May 15;111(10):4979-85 PMID: 18344424 PMCID: PMC2384129
  • von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA). (Nichols WL, Hultin MB, James AH, Manco-Johnson MJ, Montgomery RR, Ortel TL, Rick ME, Sadler JE, Weinstein M, Yawn BP) Haemophilia 2008 Mar;14(2):171-232 PMID: 18315614
  • Lentivirus-mediated platelet-derived factor VIII gene therapy in murine haemophilia A. (Shi Q, Wilcox DA, Fahs SA, Fang J, Johnson BD, DU LM, Desai D, Montgomery RR) J Thromb Haemost 2007 Feb;5(2):352-61 PMID: 17269937
  • When it comes to von Willebrand disease, does 1 + 1 = 3? (Montgomery RR) J Thromb Haemost 2006 Oct;4(10):2162-3 PMID: 16889558
  • Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor. (Sadler JE, Budde U, Eikenboom JC, Favaloro EJ, Hill FG, Holmberg L, Ingerslev J, Lee CA, Lillicrap D, Mannucci PM, Mazurier C, Meyer D, Nichols WL, Nishino M, Peake IR, Rodeghiero F, Schneppenheim R, Ruggeri ZM, Srivastava A, Montgomery RR, Federici AB, Working Party on von Willebrand Disease Classification) J Thromb Haemost 2006 Oct;4(10):2103-14 PMID: 16889557
  • Assay of the von Willebrand factor (VWF) propeptide to identify patients with type 1 von Willebrand disease with decreased VWF survival. (Haberichter SL, Balistreri M, Christopherson P, Morateck P, Gavazova S, Bellissimo DB, Manco-Johnson MJ, Gill JC, Montgomery RR) Blood 2006 Nov 15;108(10):3344-51 PMID: 16835381 PMCID: PMC1895439
  • Factor VIII ectopically targeted to platelets is therapeutic in hemophilia A with high-titer inhibitory antibodies. (Shi Q, Wilcox DA, Fahs SA, Weiler H, Wells CW, Cooley BC, Desai D, Morateck PA, Gorski J, Montgomery RR) J Clin Invest 2006 Jul;116(7):1974-82 PMID: 16823491 PMCID: PMC1483176
  • Regulated release of VWF and FVIII and the biologic implications. (Haberichter SL, Shi Q, Montgomery RR) Pediatr Blood Cancer 2006 May 1;46(5):547-53 PMID: 16470522
  • von Willebrand disease--the relevance of history. (Montgomery RR) J Thromb Haemost 2005 Dec;3(12):2617-8 PMID: 16359501
  • Genetic mutations in von Willebrand disease identified by DHPLC and DNA sequence analysis. (Kakela JK, Friedman KD, Haberichter SL, Buchholz NP, Christopherson PA, Kroner PA, Gill JC, Montgomery RR, Bellissimo DB) Mol Genet Metab 2006 Mar;87(3):262-71 PMID: 16321553
  • von Willebrand factor: the new treatment paradigm--introduction. (Lee CA, Montgomery RR) Blood Coagul Fibrinolysis 2005 Apr;16 Suppl 1:S1-2 PMID: 15849520
  • Intracellular interaction of von Willebrand factor and factor VIII depends on cellular context: lessons from platelet-expressed factor VIII. (Yarovoi H, Nurden AT, Montgomery RR, Nurden P, Poncz M) Blood 2005 Jun 15;105(12):4674-6 PMID: 15731176
  • Targeting platelet GPIbalpha transgene expression to human megakaryocytes and forming a complete complex with endogenous GPIbbeta and GPIX. (Shi Q, Wilcox DA, Morateck PA, Fahs SA, Kenny D, Montgomery RR) J Thromb Haemost 2004 Nov;2(11):1989-97 PMID: 15550031
  • Re-establishment of VWF-dependent Weibel-Palade bodies in VWD endothelial cells. (Haberichter SL, Merricks EP, Fahs SA, Christopherson PA, Nichols TC, Montgomery RR) Blood 2005 Jan 1;105(1):145-52 PMID: 15331450 PMCID: PMC3938105
  • Induction of megakaryocytes to synthesize and store a releasable pool of human factor VIII. (Wilcox DA, Shi Q, Nurden P, Haberichter SL, Rosenberg JB, Johnson BD, Nurden AT, White GC 2nd, Montgomery RR) J Thromb Haemost 2003 Dec;1(12):2477-89 PMID: 14675082
  • PECAM-1 negatively regulates GPIb/V/IX signaling in murine platelets. (Rathore V, Stapleton MA, Hillery CA, Montgomery RR, Nichols TC, Merricks EP, Newman DK, Newman PJ) Blood 2003 Nov 15;102(10):3658-64 PMID: 12893757
  • Factor VIII ectopically expressed in platelets: efficacy in hemophilia A treatment. (Yarovoi HV, Kufrin D, Eslin DE, Thornton MA, Haberichter SL, Shi Q, Zhu H, Camire R, Fakharzadeh SS, Kowalska MA, Wilcox DA, Sachais BS, Montgomery RR, Poncz M) Blood 2003 Dec 1;102(12):4006-13 PMID: 12881300
  • Expression of human factor VIII under control of the platelet-specific alphaIIb promoter in megakaryocytic cell line as well as storage together with VWF. (Shi Q, Wilcox DA, Fahs SA, Kroner PA, Montgomery RR) Mol Genet Metab 2003 May;79(1):25-33 PMID: 12765843
  • Comparative response of plasma VWF in dogs to up-regulation of VWF mRNA by interleukin-11 versus Weibel-Palade body release by desmopressin (DDAVP). (Olsen EH, McCain AS, Merricks EP, Fischer TH, Dillon IM, Raymer RA, Bellinger DA, Fahs SA, Montgomery RR, Keith JC Jr, Schaub RG, Nichols TC) Blood 2003 Jul 15;102(2):436-41 PMID: 12649145
  • Critical independent regions in the VWF propeptide and mature VWF that enable normal VWF storage. (Haberichter SL, Jacobi P, Montgomery RR) Blood 2003 Feb 15;101(4):1384-91 PMID: 12393513
  • The role of the D1 domain of the von Willebrand factor propeptide in multimerization of VWF. (Rosenberg JB, Haberichter SL, Jozwiak MA, Vokac EA, Kroner PA, Fahs SA, Kawai Y, Montgomery RR) Blood 2002 Sep 1;100(5):1699-706 PMID: 12176890
  • The von Willebrand factor propeptide (VWFpp) traffics an unrelated protein to storage. (Haberichter SL, Jozwiak MA, Rosenberg JB, Christopherson PA, Montgomery RR) Arterioscler Thromb Vasc Biol 2002 Jun 1;22(6):921-6 PMID: 12067899
  • The cysteine knot of platelet glycoprotein Ib beta (GPIb beta) is critical for the interaction of GPIb beta with GPIX. (Kenny D, Morateck PA, Montgomery RR) Blood 2002 Jun 15;99(12):4428-33 PMID: 12036872
  • von Willebrand disease: a common pediatric disorder. (Montgomery RR, Kroner PA) Pediatr Ann 2001 Sep;30(9):534-40 PMID: 11554262
  • Bleeding disorders: A common cause of menorrhagia in adolescents. (Bevan JA, Maloney KW, Hillery CA, Gill JC, Montgomery RR, Scott JP) J Pediatr 2001 Jun;138(6):856-61 PMID: 11391329
  • Genetic induction of a releasable pool of factor VIII in human endothelial cells. (Rosenberg JB, Greengard JS, Montgomery RR) Arterioscler Thromb Vasc Biol 2000 Dec;20(12):2689-95 PMID: 11116073
  • von Willebrand factor storage and multimerization: 2 independent intracellular processes. (Haberichter SL, Fahs SA, Montgomery RR) Blood 2000 Sep 1;96(5):1808-15 PMID: 10961880
  • von Willebrand factor and thrombotic thrombocytopenic purpura. (Raife TJ, Montgomery RR) Curr Opin Hematol 2000 Sep;7(5):278-83 PMID: 10961577
  • Surface expression of glycoprotein ib alpha is dependent on glycoprotein ib beta: evidence from a novel mutation causing Bernard-Soulier syndrome. (Moran N, Morateck PA, Deering A, Ryan M, Montgomery RR, Fitzgerald DJ, Kenny D) Blood 2000 Jul 15;96(2):532-9 PMID: 10887115
  • Interactions between von Willebrand factor and Factor VIII: where did they first meet. (Montgomery RR, Gill JC) J Pediatr Hematol Oncol 2000 May-Jun;22(3):269-75 PMID: 10864063
  • Low-molecular-weight heparin in thrombotic disease in children and adolescents. (Punzalan RC, Hillery CA, Montgomery RR, Scott CA, Gill JC) J Pediatr Hematol Oncol 2000 Mar-Apr;22(2):137-42 PMID: 10779027
  • Cloning and expression of canine glycoprotein Ibalpha. (Kenny D, Morateck PA, Fahs SA, Warltier DC, Montgomery RR) Thromb Haemost 1999 Oct;82(4):1327-33 PMID: 10544923
  • Contribution of the glycoprotein Ia 807TT, methylene tetrahydrofolate reductase 677TT and prothrombin 20210GA genotypes to prothrombotic risk among factor V 1691GA (Leiden) carriers. (Hessner MJ, Dinauer DM, Luhm RA, Endres JL, Montgomery RR, Friedman KD) Br J Haematol 1999 Jul;106(1):237-9 PMID: 10444193
  • Prevalence of prothrombin G20210A, factor V G1691A (Leiden), and methylenetetrahydrofolate reductase (MTHFR) C677T in seven different populations determined by multiplex allele-specific PCR. (Hessner MJ, Luhm RA, Pearson SL, Endean DJ, Friedman KD, Montgomery RR) Thromb Haemost 1999 May;81(5):733-8 PMID: 10365746
  • The critical interaction of glycoprotein (GP) IBbeta with GPIX-a genetic cause of Bernard-Soulier syndrome. (Kenny D, Morateck PA, Gill JC, Montgomery RR) Blood 1999 May 1;93(9):2968-75 PMID: 10216092
  • Naturally occurring mutations in glycoprotein Ibalpha that result in defective ligand binding and synthesis of a truncated protein. (Kenny D, Jónsson OG, Morateck PA, Montgomery RR) Blood 1998 Jul 1;92(1):175-83 PMID: 9639514
  • Type 2M von Willebrand disease: F606I and I662F mutations in the glycoprotein Ib binding domain selectively impair ristocetin- but not botrocetin-mediated binding of von Willebrand factor to platelets. (Hillery CA, Mancuso DJ, Evan Sadler J, Ponder JW, Jozwiak MA, Christopherson PA, Cox Gill J, Paul Scott J, Montgomery RR) Blood 1998 Mar 1;91(5):1572-81 PMID: 9473222
  • Intracellular trafficking of factor VIII to von Willebrand factor storage granules. (Rosenberg JB, Foster PA, Kaufman RJ, Vokac EA, Moussalli M, Kroner PA, Montgomery RR) J Clin Invest 1998 Feb 1;101(3):613-24 PMID: 9449695 PMCID: PMC508605
  • A dinucleotide deletion results in defective membrane anchoring and circulating soluble glycoprotein Ib alpha in a novel form of Bernard-Soulier syndrome. (Kenny D, Newman PJ, Morateck PA, Montgomery RR) Blood 1997 Oct 1;90(7):2626-33 PMID: 9326229
  • Interaction of von Willebrand factor with Staphylococcus aureus. (Herrmann M, Hartleib J, Kehrel B, Montgomery RR, Sixma JJ, Peters G) J Infect Dis 1997 Oct;176(4):984-91 PMID: 9333157
  • Type 2M:Milwaukee-1 von Willebrand disease: an in-frame deletion in the Cys509-Cys695 loop of the von Willebrand factor A1 domain causes deficient binding of von Willebrand factor to platelets. (Mancuso DJ, Kroner PA, Christopherson PA, Vokac EA, Gill JC, Montgomery RR) Blood 1996 Oct 1;88(7):2559-68 PMID: 8839848
  • Pharmacokinetics of von Willebrand factor and factor VIIIC in patients with severe von Willebrand disease (type 3 VWD): estimation of the rate of factor VIIIC synthesis. Cooperative Study Groups. (Menache D, Aronson DL, Darr F, Montgomery RR, Gill JC, Kessler CM, Lusher JM, Phatak PD, Shapiro AD, Thompson AR, White GC 2nd) Br J Haematol 1996 Sep;94(4):740-5 PMID: 8826903
  • Increased adhesion of erythrocytes to components of the extracellular matrix: isolation and characterization of a red blood cell lipid that binds thrombospondin and laminin. (Hillery CA, Du MC, Montgomery RR, Scott JP) Blood 1996 Jun 1;87(11):4879-86 PMID: 8639862
  • Inhibition of platelet adhesion to collagen by monoclonal anti-CD36 antibodies. (Matsuno K, Diaz-Ricart M, Montgomery RR, Aster RH, Jamieson GA, Tandon NN) Br J Haematol 1996 Mar;92(4):960-7 PMID: 8616094
  • The defective interaction between von Willebrand factor and factor VIII in a patient with type 1 von Willebrand disease is caused by substitution of Arg19 and His54 in mature von Willebrand factor. (Kroner PA, Foster PA, Fahs SA, Montgomery RR) Blood 1996 Feb 1;87(3):1013-21 PMID: 8562925
  • Direct demonstration of antigenic substitution of Borrelia burgdorferi ex vivo: exploration of the paradox of the early immune response to outer surface proteins A and C in Lyme disease. (Montgomery RR, Malawista SE, Feen KJ, Bockenstedt LK) J Exp Med 1996 Jan 1;183(1):261-9 PMID: 8551229 PMCID: PMC2192432
  • Comparison of six commercial plasma references for factor VIII, factor IX and von Willebrand factor. On behalf of the Subcommittee for Factor VIII and IX of the Scientific and Standardization Committee of the ISTH. (Kasper CK, Aronson DL, Davignon G, Foster P, Hillman-Wiseman C, Lusher JM, Manco-Johnson M, Meade JB, Montgomery RR, Rickles FR) Thromb Haemost 1995 Sep;74(3):987-9 PMID: 8571334
  • Fc- and non-Fc-mediated phagocytosis of Borrelia burgdorferi by macrophages. (Montgomery RR, Nathanson MH, Malawista SE) J Infect Dis 1994 Oct;170(4):890-3 PMID: 7930732
  • Cultured endothelial cells restore vasodilator responses to coronary arteries with impaired endothelial function and alter the response to a nitric oxide donor. (Kenny D, Coughlan MG, Kampine JP, Montgomery RR, Bosnjak ZJ, Warltier DC) Pharmacology 1994 Oct;49(4):249-56 PMID: 7831388
  • Relative antithrombotic effects of monoclonal antibodies targeting different platelet glycoprotein-adhesive molecule interactions in nonhuman primates. (Cadroy Y, Hanson SR, Kelly AB, Marzec UM, Evatt BL, Kunicki TJ, Montgomery RR, Harker LA) Blood 1994 Jun 1;83(11):3218-24 PMID: 8193356
  • Genetic mutations in ten unrelated American patients with symptomatic type 1 protein C deficiency. (Tsay W, Greengard JS, Montgomery RR, McPherson RA, Fucci JC, Koerper MA, Coughlin J, Griffin JH) Blood Coagul Fibrinolysis 1993 Oct;4(5):791-6 PMID: 8292730
  • Therapy of von Willebrand disease. (Scott JP, Montgomery RR) Semin Thromb Hemost 1993;19(1):37-47 PMID: 8456322
  • Multiple coagulation factor abnormalities in commercially available Passovoy-deficient plasma. (Foster PA, Montgomery RR, Endres-Brooks J) Blood 1992 Dec 15;80(12):3260-1 PMID: 1467533
  • Protein C survival during replacement therapy in homozygous protein C deficiency. (Marlar RA, Sills RH, Groncy PK, Montgomery RR, Madden RM) Am J Hematol 1992 Sep;41(1):24-31 PMID: 1503096
  • Expressed full-length von Willebrand factor containing missense mutations linked to type IIB von Willebrand disease shows enhanced binding to platelets. (Kroner PA, Kluessendorf ML, Scott JP, Montgomery RR) Blood 1992 Apr 15;79(8):2048-55 PMID: 1373334
  • Fine mapping of monoclonal antibody epitopes on human von Willebrand factor using a recombinant peptide library. (Ginsburg D, Bockenstedt PL, Allen EA, Fox DA, Foster PA, Ruggeri ZM, Zimmerman TS, Montgomery RR, Bahou WF, Johnson TA) Thromb Haemost 1992 Jan 23;67(1):166-71 PMID: 1377414
  • The rapid differentiation of type IIb von Willebrand's disease from platelet-type (pseudo-) von Willebrand's disease by the "neutral" monoclonal antibody binding assay. (Scott JP, Montgomery RR) Am J Clin Pathol 1991 Dec;96(6):723-8 PMID: 1746488
  • Accumulation of indigestible substances reduces fusion competence of macrophage lysosomes. (Montgomery RR, Webster P, Mellman I) J Immunol 1991 Nov 1;147(9):3087-95 PMID: 1919007
  • Abnormal binding of factor VIII is linked with the substitution of glutamine for arginine 91 in von Willebrand factor in a variant form of von Willebrand disease. (Kroner PA, Friedman KD, Fahs SA, Scott JP, Montgomery RR) J Biol Chem 1991 Oct 15;266(29):19146-9 PMID: 1918030
  • Dimeric ristocetin flocculates proteins, binds to platelets, and mediates von Willebrand factor-dependent agglutination of platelets. (Scott JP, Montgomery RR, Retzinger GS) J Biol Chem 1991 May 5;266(13):8149-55 PMID: 2022635
  • Evaluation of merocyanine 540-sensitized photoirradiation as a means to inactivate enveloped viruses in blood products. (O'Brien JM, Montgomery RR, Burns WH, Gaffney DK, Sieber F) J Lab Clin Med 1990 Oct;116(4):439-47 PMID: 2170551
  • Report on the diagnosis and treatment of homozygous protein C deficiency. Report of the Working Party on Homozygous Protein C Deficiency of the ICTH-Subcommittee on Protein C and Protein S. (Marlar RA, Montgomery RR, Broekmans AW) Thromb Haemost 1989 Jun 30;61(3):529-31 PMID: 2529664
  • Molecular basis of human von Willebrand disease: analysis of platelet von Willebrand factor mRNA. (Ginsburg D, Konkle BA, Gill JC, Montgomery RR, Bockenstedt PL, Johnson TA, Yang AY) Proc Natl Acad Sci U S A 1989 May;86(10):3723-7 PMID: 2786201 PMCID: PMC287212
  • Diagnosis and treatment of homozygous protein C deficiency. Report of the Working Party on Homozygous Protein C Deficiency of the Subcommittee on Protein C and Protein S, International Committee on Thrombosis and Haemostasis. (Marlar RA, Montgomery RR, Broekmans AW) J Pediatr 1989 Apr;114(4 Pt 1):528-34 PMID: 2647943
  • Endocytic and secretory repertoire of the lipid-loaded macrophage. (Montgomery RR, Cohn ZA) J Leukoc Biol 1989 Feb;45(2):129-38 PMID: 2492592
  • Enzymatic amplification of specific cDNA inserts from lambda gt11 libraries. (Friedman KD, Rosen NL, Newman PJ, Montgomery RR) Nucleic Acids Res 1988 Sep 12;16(17):8718 PMID: 2843825 PMCID: PMC338596
  • Homozygous protein C deficiency: observations on the nature of the molecular abnormality and the effectiveness of warfarin therapy. (Peters C, Casella JF, Marlar RA, Montgomery RR, Zinkham WH) Pediatrics 1988 Feb;81(2):272-6 PMID: 3340476
  • Effects of monoclonal antibodies against the platelet glycoprotein IIb/IIIa complex on thrombosis and hemostasis in the baboon. (Hanson SR, Pareti FI, Ruggeri ZM, Marzec UM, Kunicki TJ, Montgomery RR, Zimmerman TS, Harker LA) J Clin Invest 1988 Jan;81(1):149-58 PMID: 2961790 PMCID: PMC442486
  • Low-dose aspirin protects against lipid accumulation in primate vein bypass grafts. (Boerboom LE, Olinger GN, Kissebah AH, Montgomery RR) J Thorac Cardiovasc Surg 1987 Aug;94(2):251-5 PMID: 3613624
  • The effect of ABO blood group on the diagnosis of von Willebrand disease. (Gill JC, Endres-Brooks J, Bauer PJ, Marks WJ Jr, Montgomery RR) Blood 1987 Jun;69(6):1691-5 PMID: 3495304
  • Protein C deficiency. (Rappaport ES, Speights VO, Helbert B, Trowbridge A, Koops B, Montgomery RR, Marlar RA) South Med J 1987 Feb;80(2):240-2 PMID: 3810223
  • Endothelial cell processing of von Willebrand proteins. (Kawai Y, Montgomery RR) Ann N Y Acad Sci 1987;509:60-70 PMID: 3122620
  • Effects of reagent and cell-generated hydrogen peroxide on the properties of low density lipoprotein. (Montgomery RR, Nathan CF, Cohn ZA) Proc Natl Acad Sci U S A 1986 Sep;83(17):6631-5 PMID: 3018740 PMCID: PMC386558
  • Synthesis by cultured human umbilical vein endothelial cells of two proteins structurally and immunologically related to platelet membrane glycoproteins IIb and IIIa. (Newman PJ, Kawai Y, Montgomery RR, Kunicki TJ) J Cell Biol 1986 Jul;103(1):81-6 PMID: 2941443 PMCID: PMC2113805
  • HTLV-III serology in hemophilia: relationship with immunologic abnormalities. (Gill JC, Menitove JE, Anderson PR, Casper JT, Devare SG, Wood C, Adair S, Casey J, Scheffel C, Montgomery RR) J Pediatr 1986 Apr;108(4):511-6 PMID: 3083075
  • Loss of the largest von Willebrand factor multimers from the plasma of patients with congenital cardiac defects. (Gill JC, Wilson AD, Endres-Brooks J, Montgomery RR) Blood 1986 Mar;67(3):758-61 PMID: 3484979
  • Use of monoclonal antibody to increase the sensitivity and specificity of precipitating immunoassays and cell surface binding immunoassays. (Montgomery RR, Kunicki TJ, Glode LM) Methods Enzymol 1986;121:702-17 PMID: 3724493
  • Inherited absence of OKT4 lymphocyte antigen in a chronically transfused patient with homozygous sickle cell disease. (Gill JC, Maples J, Nikaein A, Kirchner P, Lockhart D, Snyder AJ, Montgomery RR, Casper JT) J Pediatr 1985 Aug;107(2):251-3 PMID: 3874945
  • Persistence and progression of immunologic abnormalities in haemophilia. (Gill JC, Wheeler D, Menitove JE, Aster RH, Casper JT, Kirchner P, Montgomery RR) Thromb Haemost 1985 Jun 24;53(3):328-31 PMID: 3931282
  • Newborn haemostasis. (Montgomery RR, Marlar RA, Gill JC) Clin Haematol 1985 Jun;14(2):443-60 PMID: 3899442
  • Endothelial cell synthesis of von Willebrand antigen II, von Willebrand factor, and von Willebrand factor/von Willebrand antigen II complex. (McCarroll DR, Levin EG, Montgomery RR) J Clin Invest 1985 Apr;75(4):1089-95 PMID: 3872883 PMCID: PMC425431
  • Cleavage of human von Willebrand factor by platelet calcium-activated protease. (Kunicki TJ, Montgomery RR, Schullek J) Blood 1985 Feb;65(2):352-6 PMID: 2981585
  • On the association of glycoprotein Ib and actin-binding protein in human platelets. (Okita JR, Pidard D, Newman PJ, Montgomery RR, Kunicki TJ) J Cell Biol 1985 Jan;100(1):317-21 PMID: 3155520 PMCID: PMC2113466
  • Comparison of the sensitivity of commercial APTT reagents in the detection of mild coagulopathies. (Marlar RA, Bauer PJ, Endres-Brooks JL, Montgomery RR, Miller CM, Schanen MM) Am J Clin Pathol 1984 Oct;82(4):436-9 PMID: 6475840
  • Severe homozygous protein C deficiency. (Sills RH, Marlar RA, Montgomery RR, Deshpande GN, Humbert JR) J Pediatr 1984 Sep;105(3):409-13 PMID: 6547978
  • Autoantibodies against platelet glycoprotein Ib in patients with chronic immune thrombocytopenic purpura. (Woods VL Jr, Kurata Y, Montgomery RR, Tani P, Mason D, Oh EH, McMillan R) Blood 1984 Jul;64(1):156-60 PMID: 6234034
  • Correlation between circulating levels of von Willebrand's antigen II and von Willebrand factor: discrimination between type I and type II von Willebrand's disease. (McCarroll DR, Ruggeri ZM, Montgomery RR) J Lab Clin Med 1984 May;103(5):704-11 PMID: 6609219
  • The effect of DDAVP on plasma levels of von Willebrand antigen II in normal individuals and patients with von Willebrand's disease. (McCarroll DR, Ruggeri ZM, Montgomery RR) Blood 1984 Mar;63(3):532-5 PMID: 6607754
  • Interaction of von Willebrand factor with human platelets in the plasma milieu. (Schullek J, Jordan J, Montgomery RR) J Clin Invest 1984 Feb;73(2):421-8 PMID: 6230372 PMCID: PMC425033
  • Interaction of AP-2, a monoclonal antibody specific for the human platelet glycoprotein IIb-IIIa complex, with intact platelets. (Pidard D, Montgomery RR, Bennett JS, Kunicki TJ) J Biol Chem 1983 Oct 25;258(20):12582-6 PMID: 6226659
  • Platelets have more than one binding site for von Willebrand factor. (Ruggeri ZM, De Marco L, Gatti L, Bader R, Montgomery RR) J Clin Invest 1983 Jul;72(1):1-12 PMID: 6223940 PMCID: PMC1129155
  • Generalized lymphadenopathy and T cell abnormalities in hemophilia A. (Gill JC, Menitove JE, Wheeler D, Aster RH, Montgomery RR) J Pediatr 1983 Jul;103(1):18-22 PMID: 6223133
  • Prepooled cryoprecipitate for treatment of hemophilia A. (Menitove JE, Spero JA, Richards WA, Lewis JH, Montgomery RR, Gill JC, Hasiba U, Wheeler DV, Sherwin JA, Russell-Vaskov S, Marlar RA, Maxwell NG, Aster RH) Transfusion 1983 May-Jun;23(3):265-7 PMID: 6407160
  • Diagnosis of Bernard-Soulier syndrome and Glanzmann's thrombasthenia with a monoclonal assay on whole blood. (Montgomery RR, Kunicki TJ, Taves C, Pidard D, Corcoran M) J Clin Invest 1983 Feb;71(2):385-9 PMID: 6822670 PMCID: PMC436878
  • T-lymphocyte subpopulations in patients with classic hemophilia treated with cryoprecipitate and lyophilized concentrates. (Menitove JE, Aster RH, Casper JT, Lauer SJ, Gottschall JL, Williams JE, Gill JC, Wheeler DV, Piaskowski V, Kirchner P, Montgomery RR) N Engl J Med 1983 Jan 13;308(2):83-6 PMID: 6401196
  • Specific factor VIII-related antigen fragmentation: an in vivo and in vitro phenomenon. (Montgomery RR, Johnson J) Blood 1982 Oct;60(4):930-9 PMID: 6180785
  • Influence of high molecular weight factor VIII on the measurement of low molecular weight factor VIII procoagulant in different assay systems. (Muntean W, Hathaway WE, Montgomery RR) Br J Haematol 1982 Aug;51(4):649-58 PMID: 6809034
  • A variant of von Willebrand's disease with abnormal expression of factor VIII procoagulant activity. (Montgomery RR, Hathaway WE, Johnson J, Jacobson L, Muntean W) Blood 1982 Jul;60(1):201-7 PMID: 6805535
  • Use of monoclonal antibody to increase sensitivity and specificity in quantitative immunodiffusion assays. (Glode LM, Montgomery RR, Smith CG, Link DB) J Immunol Methods 1982;48(1):13-22 PMID: 6799577
  • Platelet von Willebrand's antigen II: active release by aggregating agents and a marker of platelet release reaction in vivo. (Scott JP, Montgomery RR) Blood 1981 Dec;58(6):1075-80 PMID: 6975640
  • Acquired von Willebrand's disease in association with Wilm's tumor: regression following treatment. (Scott JP, Montgomery RR, Tubergen DG, Hays T) Blood 1981 Oct;58(4):665-9 PMID: 6268230
  • Newborn factor VIII complex: elevated activities in term infants and alterations in electrophoretic mobility related to illness and activated coagulation. (Johnson SS, Montgomery RR, Hathaway WE) Br J Haematol 1981 Apr;47(4):597-606 PMID: 6783064
  • Neutropenia in a patient with type IB glycogen storage disease: in vitro response to lithium chloride. (McCabe ER, Melvin TR, O'Brien D, Montgomery RR, Robinson WA, Bhasker C, Brown BI) J Pediatr 1980 Dec;97(6):944-6 PMID: 6255121
  • Regression on oxymetholone-induced hepatic tumors after bone marrow transplantation in aplastic anemia. (Montgomery RR, Ducore JM, Githens JH, August CS, Johnson ML) Transplantation 1980 Aug;30(2):90-6 PMID: 7010713
  • Acute bleeding emergencies. (Montgomery RR, Hathaway WE) Pediatr Clin North Am 1980 May;27(2):327-44 PMID: 6770325
  • Activated partial thromboplastin time and minor coagulopathies. (Hathaway WE, Assmus SL, Montgomery RR, Dubansky AS) Am J Clin Pathol 1979 Jan;71(1):22-5 PMID: 420168
  • von Willebrand's disease antigen II. A new plasma and platelet antigen deficient in severe von Willebrand's disease. (Montgomery RR, Zimmerman TS) J Clin Invest 1978 Jun;61(6):1498-507 PMID: 307007 PMCID: PMC372676
  • Hypoprothrombinemia: case report. (Montgomery RR, Otsuka A, Hathaway WE) Blood 1978 Feb;51(2):299-306 PMID: 620085
  • Clinical and physiologic studies of two siblings with prekallikrein (Fletcher factor) deficiency. (Hathaway WE, Wuepper KD, Weston WL, Humbert JR, Rivers RP, Genton E, August CS, Montgomery RR, Mass MF) Am J Med 1976 May 10;60(5):654-64 PMID: 1020754
  • Last update: 07/27/2015