Medical College of Wisconsin
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Ronald Blake Hill PhD

Ronald Blake Hill PhD

Professor

Institution: Medical College of Wisconsin
Department: Biochemistry
Program: Protein Nucleic Acid Facility

Member of the Cancer Center


Research Experience

  • Biochemistry
  • Publications

  • Removal of a consensus proline is not sufficient to allow tetratricopeptide repeat oligomerization. (Bakkum AL, Hill RB) Protein Sci 2017 Oct;26(10):1974-1983 PMID: 28707340 PMCID: PMC5606541 07/15/2017
  • The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species. (Bordt EA, Clerc P, Roelofs BA, Saladino AJ, Tretter L, Adam-Vizi V, Cherok E, Khalil A, Yadava N, Ge SX, Francis TC, Kennedy NW, Picton LK, Kumar T, Uppuluri S, Miller AM, Itoh K, Karbowski M, Sesaki H, Hill RB, Polster BM) Dev Cell 2017 Mar 27;40(6):583-594.e6 PMID: 28350990 PMCID: PMC5398851 03/30/2017
  • Resistance of dynamin-related protein 1 oligomers to disassembly impairs mitophagy, resulting in myocardial inflammation and heart failure. (Cahill TJ, Leo V, Kelly M, Stockenhuber A, Kennedy NW, Bao L, Cereghetti GM, Harper AR, Czibik G, Liao C, Bellahcene M, Steeples V, Ghaffari S, Yavari A, Mayer A, Poulton J, Ferguson DJ, Scorrano L, Hettiarachchi NT, Peers C, Boyle J, Hill RB, Simmons A, Watkins H, Dear TN, Ashrafian H) J Biol Chem 2016 Dec 02;291(49):25762 PMID: 27913663 PMCID: PMC5207272 12/04/2016
  • A Targeted Mutation Identified through pKa Measurements Indicates a Postrecruitment Role for Fis1 in Yeast Mitochondrial Fission. (Koppenol-Raab M, Harwig MC, Posey AE, Egner JM, MacKenzie KR, Hill RB) J Biol Chem 2016 Sep 23;291(39):20329-44 PMID: 27496949 PMCID: PMC5034033 08/09/2016
  • A Designed "Nested" Dimer of Cyanovirin-N Increases Antiviral Activity. (Woodrum BW, Maxwell J, Allen DM, Wilson J, Krumpe LR, Bobkov AA, Hill RB, Kibler KV, O'Keefe BR, Ghirlanda G) Viruses 2016 Jun 06;8(6) PMID: 27275831 PMCID: PMC4926178 06/09/2016
  • Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure. (Cahill TJ, Leo V, Kelly M, Stockenhuber A, Kennedy NW, Bao L, Cereghetti G, Harper AR, Czibik G, Lao C, Bellahcene M, Steeples V, Ghaffari S, Yavari A, Mayer A, Poulton J, Ferguson DJ, Scorrano L, Hettiarachchi NT, Peers C, Boyle J, Hill RB, Simmons A, Watkins H, Dear TN, Ashrafian H) J Biol Chem 2015 Oct 23;290(43):25907-19 PMID: 26370078 PMCID: PMC4646246 09/16/2015
  • The Tail-End Is Only the Beginning: NMR Study Reveals a Membrane-Bound State of BCL-XL. (Hill RB, MacKenzie KR, Harwig MC) J Mol Biol 2015 Jul 03;427(13):2257-61 PMID: 25896456 04/22/2015
  • S-Nitrosation of monocarboxylate transporter 1: inhibition of pyruvate-fueled respiration and proliferation of breast cancer cells. (Diers AR, Broniowska KA, Chang CF, Hill RB, Hogg N) Free Radic Biol Med 2014 Apr;69:229-38 PMID: 24486553 PMCID: PMC3982622 02/04/2014
  • A designed point mutant in Fis1 disrupts dimerization and mitochondrial fission. (Lees JP, Manlandro CM, Picton LK, Tan AZ, Casares S, Flanagan JM, Fleming KG, Hill RB) J Mol Biol 2012 Oct 19;423(2):143-58 PMID: 22789569 PMCID: PMC3456991 07/14/2012
  • The 1.75 Å resolution structure of fission protein Fis1 from Saccharomyces cerevisiae reveals elusive interactions of the autoinhibitory domain. (Tooley JE, Khangulov V, Lees JP, Schlessman JL, Bewley MC, Heroux A, Bosch J, Hill RB) Acta Crystallogr Sect F Struct Biol Cryst Commun 2011 Nov 01;67(Pt 11):1310-5 PMID: 22102223 PMCID: PMC3212442 11/22/2011
  • The cytosolic domain of Fis1 binds and reversibly clusters lipid vesicles. (Wells RC, Hill RB) PLoS One 2011;6(6):e21384 PMID: 21738650 PMCID: PMC3125187 07/09/2011
  • Structural and mechanistic basis of Parl activity and regulation. (Jeyaraju DV, McBride HM, Hill RB, Pellegrini L) Cell Death Differ 2011 Sep;18(9):1531-9 PMID: 21415861 PMCID: PMC3134571 03/19/2011
  • The C. elegans B-cell lymphoma 2 (Bcl-2) homolog cell death abnormal 9 (CED-9) associates with and remodels LIPID membranes. (Tan FJ, Zuckerman JE, Wells RC, Hill RB) Protein Sci 2011 Jan;20(1):62-74 PMID: 21031486 PMCID: PMC3047062 10/30/2010
  • A lethal de novo mutation in the middle domain of the dynamin-related GTPase Drp1 impairs higher order assembly and mitochondrial division. (Chang CR, Manlandro CM, Arnoult D, Stadler J, Posey AE, Hill RB, Blackstone C) J Biol Chem 2010 Oct 15;285(42):32494-503 PMID: 20696759 PMCID: PMC2952251 08/11/2010
  • The PARL family of mitochondrial rhomboid proteases. (Hill RB, Pellegrini L) Semin Cell Dev Biol 2010 Aug;21(6):582-92 PMID: 20045481 PMCID: PMC2908206 01/05/2010
  • Evidence for conformational heterogeneity of fission protein Fis1 from Saccharomyces cerevisiae. (Picton LK, Casares S, Monahan AC, Majumdar A, Hill RB) Biochemistry 2009 Jul 21;48(28):6598-609 PMID: 19522466 PMCID: PMC2785846 06/16/2009
  • Role of conserved cysteines in the alphavirus E3 protein. (Parrott MM, Sitarski SA, Arnold RJ, Picton LK, Hill RB, Mukhopadhyay S) J Virol 2009 Mar;83(6):2584-91 PMID: 19109378 PMCID: PMC2648270 12/26/2008
  • CED-9 and mitochondrial homeostasis in C. elegans muscle. (Tan FJ, Husain M, Manlandro CM, Koppenol M, Fire AZ, Hill RB) J Cell Sci 2008 Oct 15;121(Pt 20):3373-82 PMID: 18827010 PMCID: PMC2785848 10/02/2008
  • Optimized expression and purification of myristoylated human neuronal calcium sensor 1 in E. coli. (De Cotiis DA, Woll MP, Fox TE, Hill RB, Levenson R, Flanagan JM) Protein Expr Purif 2008 Oct;61(2):103-12 PMID: 18634883 PMCID: PMC3770182 07/19/2008
  • Anti-apoptotic Bcl-2 Family Proteins Disassemble Ceramide Channels. (Siskind LJ, Feinstein L, Yu T, Davis JS, Jones D, Choi J, Zuckerman JE, Tan W, Hill RB, Hardwick JM, Colombini M) J Biol Chem 2008 Mar 14;283(11):6622-30 PMID: 18171672 PMCID: PMC2713582 01/04/2008
  • Direct binding of the dynamin-like GTPase, Dnm1, to mitochondrial dynamics protein Fis1 is negatively regulated by the Fis1 N-terminal arm. (Wells RC, Picton LK, Williams SC, Tan FJ, Hill RB) J Biol Chem 2007 Nov 16;282(46):33769-75 PMID: 17884824 PMCID: PMC3046406 09/22/2007
  • Regulation of apoptosis by C. elegans CED-9 in the absence of the C-terminal transmembrane domain. (Tan FJ, Fire AZ, Hill RB) Cell Death Differ 2007 Nov;14(11):1925-35 PMID: 17703231 PMCID: PMC3047747 08/19/2007
  • The N-terminal domain of Bcl-xL reversibly binds membranes in a pH-dependent manner. (Thuduppathy GR, Terrones O, Craig JW, Basañez G, Hill RB) Biochemistry 2006 Dec 05;45(48):14533-42 PMID: 17128992 PMCID: PMC1764622 11/30/2006
  • Evidence that membrane insertion of the cytosolic domain of Bcl-xL is governed by an electrostatic mechanism. (Thuduppathy GR, Craig JW, Kholodenko V, Schon A, Hill RB) J Mol Biol 2006 Jun 16;359(4):1045-58 PMID: 16650855 PMCID: PMC1785297 05/03/2006
  • Acid destabilization of the solution conformation of Bcl-xL does not drive its pH-dependent insertion into membranes. (Thuduppathy GR, Hill RB) Protein Sci 2006 Feb;15(2):248-57 PMID: 16385002 PMCID: PMC1752203 12/31/2005
  • Mitochondrial fission proteins regulate programmed cell death in yeast. (Fannjiang Y, Cheng WC, Lee SJ, Qi B, Pevsner J, McCaffery JM, Hill RB, Basañez G, Hardwick JM) Genes Dev 2004 Nov 15;18(22):2785-97 PMID: 15520274 PMCID: PMC528898 11/03/2004
  • Applications of NMR spin relaxation methods for measuring biological motions. (Thuduppathy GR, Hill RB) Methods Enzymol 2004;384:243-64 PMID: 15081691 PMCID: PMC3061832 04/15/2004
  • Cytosolic domain of the human mitochondrial fission protein fis1 adopts a TPR fold. (Dohm JA, Lee SJ, Hardwick JM, Hill RB, Gittis AG) Proteins 2004 Jan 01;54(1):153-6 PMID: 14705031 PMCID: PMC3047745 01/06/2004
  • Bcl-xL promotes the open configuration of the voltage-dependent anion channel and metabolite passage through the outer mitochondrial membrane. (Vander Heiden MG, Li XX, Gottleib E, Hill RB, Thompson CB, Colombini M) J Biol Chem 2001 Jun 01;276(22):19414-9 PMID: 11259441 03/22/2001
  • De novo design of helical bundles as models for understanding protein folding and function. (Hill RB, Raleigh DP, Lombardi A, DeGrado WF) Acc Chem Res 2000 Nov;33(11):745-54 PMID: 11087311 PMCID: PMC3050006 11/23/2000
  • pH-dependent tetramerization and amantadine binding of the transmembrane helix of M2 from the influenza A virus. (Salom D, Hill BR, Lear JD, DeGrado WF) Biochemistry 2000 Nov 21;39(46):14160-70 PMID: 11087364 PMCID: PMC3060174 11/23/2000
  • Molecular Motions and Protein Folding:  Characterization of the Backbone Dynamics and Folding Equilibrium of α2D Using 13C NMR Spin Relaxation (R. Blake Hill ,† Clay Bracken ,‡ William F. DeGrado ,*† and Arthur G. Palmer III*§) J Am Chem Soc 122 (47), pp 11610–11619 DOI: 10.1021/ja001129b 11/10/2000
  • A polar, solvent-exposed residue can be essential for native protein structure. (Hill RB, DeGrado WF) Structure 2000 May 15;8(5):471-9 PMID: 10801493 PMCID: PMC3050062 05/10/2000
  • Hydrogen Bonded Cluster Can Specify the Native State of a Protein (R.B. Hill, J-K Hong, and W.F. DeGrado) J Am Chem Soc 122 (4), pp 746–747 DOI: 10.1021/ja9919332 01/15/2000
  • The interaction between RTX toxins and target cells. (Lally ET, Hill RB, Kieba IR, Korostoff J) Trends Microbiol 1999 Sep;7(9):356-61 PMID: 10470043 09/02/1999
  • Solution structure of α2D, a nativelike de novo designed protein (R.B. Hill and W.F. DeGrado) J Am Chem Soci 120 (6), pp 1138–1145 DOI: 10.1021/ja9733649 02/03/1998
  • Overexpression, purification, and characterization of Escherichia coli acyl carrier protein and two mutant proteins. (Hill RB, MacKenzie KR, Flanagan JM, Cronan JE Jr, Prestegard JH) Protein Expr Purif 1995 Aug;6(4):394-400 PMID: 8527922 08/01/1995
  • Amide exchange rates in Escherichia coli acyl carrier protein: correlation with protein structure and dynamics. (Andrec M, Hill RB, Prestegard JH) Protein Sci 1995 May;4(5):983-93 PMID: 7663354 PMCID: PMC2143121 05/01/1995
  • 1H and 15N magnetic resonance assignments, secondary structure, and tertiary fold of Escherichia coli DnaJ(1-78). (Hill RB, Flanagan JM, Prestegard JH) Biochemistry 1995 Apr 25;34(16):5587-96 PMID: 7727420 04/25/1995
  • Effect of the antiglucocorticoid RU486 on adrenal steroidogenic enzyme activity and steroidogenesis. (Albertson BD, Hill RB, Sprague KA, Wood KE, Nieman LK, Loriaux DL) Eur J Endocrinol 1994 Feb;130(2):195-200 PMID: 8130896 02/01/1994
  • New NMR methods for the characterization of bound waters in macromolecules (R.W. Kriwacki, R.B. Hill, J.M. Flanagan, J.P. Caradonna, and J.H. Prestegard) J Am Chem Soc 115 (20), pp 8907–8911 DOI: 10.1021/ja00073a003 10/01/1993
  • Protein starvation and the small intestine. I. The growth and morphology of the small intestine in weanling rats. (Hill RB Jr, Prosper J, Hirschfield JS, Kern F Jr) Exp Mol Pathol 1968 Feb;8(1):66-74 PMID: 5637108 02/01/1968
  • Last update: 09/18/2017
    jenkins-FCD Prod-153 3ca6710ea990189ceb85f4312e7298b5922ce1a6