Medical College of Wisconsin
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Shawn Jobe MD, PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Hematology and Oncology - Pediatrics
Program: Hematology

Research Experience

  • Hemophilia A
  • Hemophilia B
  • Mitochondria
  • Necrosis
  • Platelet Activation
  • von Willebrand Diseases
  • Clinical Expertise

  • Blood Platelet Disorders
  • Hemophilia A
  • Hemophilia B
  • Thrombocytopenia
  • Leadership Positions

  • Medical Director, Comprehensive Center for Bleeding Disorders
  • Publications (29)

  • A dastardly, deadly duo in stroke. (Jobe S) Blood 2020 02 06;135(6):395-396 PMID: 32027749 02/07/2020    
  • Platelet α-granules contribute to organ-specific pathologies in a mouse model of severe malaria. (Darling TK, Schenk MP, Zhou CC, Maloba FM, Mimche PN, Gibbins JM, Jobe SM, Lamb TJ) Blood Adv 2020 01 14;4(1):1-8 PMID: 31891656 PMCID: PMC6960474 01/01/2020       3 Citations
  • Platelet respiration. (Kholmukhamedov A, Jobe S) Blood Adv 2019 02 26;3(4):599-602 PMID: 30792189 PMCID: PMC6391657 02/23/2019       1 Citation
  • Procoagulant Platelets Get Squeezed to Define the Boundaries of the Hemostatic Plug. (Kholmukhamedov A, Jobe S) Arterioscler Thromb Vasc Biol 2019 01;39(1):5-6 PMID: 30586335 12/27/2018       1 Citation
  • Platelet CD36 signaling through ERK5 promotes caspase-dependent procoagulant activity and fibrin deposition in vivo. (Yang M, Kholmukhamedov A, Schulte ML, Cooley BC, Scoggins NO, Wood JP, Cameron SJ, Morrell CN, Jobe SM, Silverstein RL) Blood Adv 2018 11 13;2(21):2848-2861 PMID: 30381401 PMCID: PMC6234364 SCOPUS ID: 2-s2.0-85062651330 11/02/2018       12 Citations
  • The mitochondrial calcium uniporter regulates procoagulant platelet formation. (Kholmukhamedov A, Janecke R, Choo HJ, Jobe SM) J Thromb Haemost 2018 11;16(11):2315-2321 PMID: 30179298 09/05/2018       7 Citations
  • rFIXFc for Immune Tolerance Induction in a Severe Hemophilia B Patient with an Inhibitor and Prior History of ITI Related Nephrotic Syndrome. (Malec L, Abshire T, Jobe S, White G) Haemophilia 2018 07;24(4):e294-e296 PMID: 30024646 SCOPUS ID: 2-s2.0-85050658407 07/20/2018       3 Citations
  • Congenital Disorders of Platelet Function and Number. (Sharma R, Perez Botero J, Jobe SM) Pediatr Clin North Am 2018 06;65(3):561-578 PMID: 29803283 05/29/2018       3 Citations
  • A microengineered vascularized bleeding model that integrates the principal components of hemostasis. (Sakurai Y, Hardy ET, Ahn B, Tran R, Fay ME, Ciciliano JC, Mannino RG, Myers DR, Qiu Y, Carden MA, Baldwin WH, Meeks SL, Gilbert GE, Jobe SM, Lam WA) Nat Commun 2018 02 06;9(1):509 PMID: 29410404 PMCID: PMC5802762 02/08/2018       18 Citations
  • Mitochondria and Platelet Cell Death. (Kholmukhamedov A, Jobe S) Thromb Haemost 2017 11;117(11):2207-2208 PMID: 29044296 10/19/2017       4 Citations
  • Inner Mitochondrial Membrane Disruption Links Apoptotic and Agonist-Initiated Phosphatidylserine Externalization in Platelets. (Choo HJ, Kholmukhamedov A, Zhou C, Jobe S) Arterioscler Thromb Vasc Biol 2017 08;37(8):1503-1512 PMID: 28663253 PMCID: PMC5560492 07/01/2017       24 Citations
  • Not dead yet. (Jobe SM) Blood 2015 Dec 24;126(26):2774-5 PMID: 26705341 12/26/2015       5 Citations
  • Mitochondrially mediated integrin αIIbβ3 protein inactivation limits thrombus growth. (Liu F, Gamez G, Myers DR, Clemmons W, Lam WA, Jobe SM) J Biol Chem 2013 Oct 18;288(42):30672-81 PMID: 24014035 PMCID: PMC3798537 09/10/2013       22 Citations
  • Dual mechanism of integrin αIIbβ3 closure in procoagulant platelets. (Mattheij NJ, Gilio K, van Kruchten R, Jobe SM, Wieschhaus AJ, Chishti AH, Collins P, Heemskerk JW, Cosemans JM) J Biol Chem 2013 May 10;288(19):13325-36 PMID: 23519467 PMCID: PMC3650371 03/23/2013       56 Citations
  • Mitochondrial calcium and reactive oxygen species regulate agonist-initiated platelet phosphatidylserine exposure. (Choo HJ, Saafir TB, Mkumba L, Wagner MB, Jobe SM) Arterioscler Thromb Vasc Biol 2012 Dec;32(12):2946-55 PMID: 23087357 PMCID: PMC3545632 10/23/2012       58 Citations
  • Platelet biogenesis and functions require correct protein O-glycosylation. (Wang Y, Jobe SM, Ding X, Choo H, Archer DR, Mi R, Ju T, Cummings RD) Proc Natl Acad Sci U S A 2012 Oct 02;109(40):16143-8 PMID: 22988088 PMCID: PMC3479543 09/19/2012       52 Citations
  • Mutations in NBEAL2, encoding a BEACH protein, cause gray platelet syndrome. (Kahr WH, Hinckley J, Li L, Schwertz H, Christensen H, Rowley JW, Pluthero FG, Urban D, Fabbro S, Nixon B, Gadzinski R, Storck M, Wang K, Ryu GY, Jobe SM, Schutte BC, Moseley J, Loughran NB, Parkinson J, Weyrich AS, Di Paola J) Nat Genet 2011 Jul 17;43(8):738-40 PMID: 21765413 PMCID: PMC6050511 07/19/2011    
  • Alcohol and maternal uterine vascular adaptations during pregnancy-part I: effects of chronic in vitro binge-like alcohol on uterine endothelial nitric oxide system and function. (Ramadoss J, Jobe SO, Magness RR) Alcohol Clin Exp Res 2011 Sep;35(9):1686-93 PMID: 21599719 PMCID: PMC4241777 05/24/2011       13 Citations
  • Leukocyte adhesion deficiency-III in an African-American patient. (Sabnis H, Kirpalani A, Horan J, McDowall A, Svensson L, Cooley A, Merck T, Jobe S, Hogg N, Briones M) Pediatr Blood Cancer 2010 Jul 15;55(1):180-2 PMID: 20213844 03/10/2010       16 Citations
  • Functional aspects of factor VIII expression after transplantation of genetically-modified hematopoietic stem cells for hemophilia A. (Ide LM, Iwakoshi NN, Gangadharan B, Jobe S, Moot R, McCarty D, Doering CB, Spencer HT) J Gene Med 2010 Apr;12(4):333-44 PMID: 20209485 03/09/2010       27 Citations
  • Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation and thrombosis. (Jobe SM, Wilson KM, Leo L, Raimondi A, Molkentin JD, Lentz SR, Di Paola J) Blood 2008 Feb 01;111(3):1257-65 PMID: 17989312 PMCID: PMC2214770 11/09/2007       139 Citations
  • Role of FcRgamma and factor XIIIA in coated platelet formation. (Jobe SM, Leo L, Eastvold JS, Dickneite G, Ratliff TL, Lentz SR, Di Paola J) Blood 2005 Dec 15;106(13):4146-51 PMID: 16105983 PMCID: PMC1895237 08/18/2005       39 Citations
  • Deep venous thrombosis and Turner syndrome. (Jobe S, Donohoue P, Di Paola J) J Pediatr Hematol Oncol 2004 Apr;26(4):272 PMID: 15087960 SCOPUS ID: 2-s2.0-16544383820 04/17/2004       11 Citations
  • The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression. (Lee Y, Shioi T, Kasahara H, Jobe SM, Wiese RJ, Markham BE, Izumo S) Mol Cell Biol 1998 Jun;18(6):3120-9 PMID: 9584153 PMCID: PMC108894 06/20/1998       237 Citations
  • cis-Acting sequences that mediate induction of beta-myosin heavy chain gene expression during left ventricular hypertrophy due to aortic constriction. (Hasegawa K, Lee SJ, Jobe SM, Markham BE, Kitsis RN) Circulation 1997 Dec 02;96(11):3943-53 PMID: 9403619 12/24/1997       146 Citations
  • Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload. (Herzig TC, Jobe SM, Aoki H, Molkentin JD, Cowley AW Jr, Izumo S, Markham BE) Proc Natl Acad Sci U S A 1997 Jul 08;94(14):7543-8 PMID: 9207128 PMCID: PMC23858 07/08/1997       172 Citations
  • Alpha-myosin heavy chain gene regulation: delineation and characterization of the cardiac muscle-specific enhancer and muscle-specific promoter. (Molkentin JD, Jobe SM, Markham BE) J Mol Cell Cardiol 1996 Jun;28(6):1211-25 PMID: 8782063 06/01/1996       52 Citations
  • Amino acid changes in the peptide binding site have structural consequences at the surface of class I glycoproteins. (Pease LR, Horton RM, Pullen JK, Hunt HD, Yun TJ, Rohren EM, Prescott JL, Jobe SM, Allen KS) J Immunol 1993 Apr 15;150(8 Pt 1):3375-81 PMID: 7682238 04/15/1993       19 Citations
  • Expression of the alpha-myosin heavy chain gene in the heart is regulated in part by an E-box-dependent mechanism. (Molkentin JD, Brogan RS, Jobe SM, Markham BE) J Biol Chem 1993 Feb 05;268(4):2602-9 PMID: 8428936 02/05/1993       31 Citations
  • Last update: 03/02/2020
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