Medical College of Wisconsin
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Subramaniam Malarkannan PhD

Subramaniam Malarkannan PhD


Institution: Medical College of Wisconsin
Department: Medicine
Division: Hematology and Oncology
Program: Bone Marrow Transplant

Member of the Cancer Center


  • Signaling in Effector Lymphocytes: Insights toward Safer Immunotherapy. (Rajasekaran K, Riese MJ, Rao S, Wang L, Thakar MS, Sentman CL, Malarkannan S) Front Immunol 2016;7:176 PMID: 27242783 PMCID: PMC4863891 06/01/2016
  • The Fyn-ADAP Axis: Cytotoxicity Versus Cytokine Production in Killer Cells. (Gerbec ZJ, Thakar MS, Malarkannan S) Front Immunol 2015;6:472 PMID: 26441977 PMCID: PMC4584950 10/07/2015
  • TCR signaling intensity controls CD8+ T cell responsiveness to TGF-β. (Arumugam V, Bluemn T, Wesley E, Schmidt AM, Kambayashi T, Malarkannan S, Riese MJ) J Leukoc Biol 2015 Nov;98(5):703-12 PMID: 26153417 PMCID: PMC4600064 07/15/2015
  • IQGAP1: insights into the function of a molecular puppeteer. (Abel AM, Schuldt KM, Rajasekaran K, Hwang D, Riese MJ, Rao S, Thakar MS, Malarkannan S) Mol Immunol 2015 Jun;65(2):336-49 PMID: 25733387 PMCID: PMC4480615 03/04/2015
  • Sall4 overexpression blocks murine hematopoiesis in a dose-dependent manner. (Milanovich S, Peterson J, Allred J, Stelloh C, Rajasekaran K, Fisher J, Duncan SA, Malarkannan S, Rao S) Exp Hematol 2015 Jan;43(1):53-64.e1-8 PMID: 25246269 PMCID: PMC4268405 09/24/2014
  • Effects of novel isoform-selective phosphoinositide 3-kinase inhibitors on natural killer cell function. (Yea SS, So L, Mallya S, Lee J, Rajasekaran K, Malarkannan S, Fruman DA) PLoS One 2014;9(6):e99486 PMID: 24915189 PMCID: PMC4051752 06/11/2014
  • Corrigendum: Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells. (Rajasekaran K, Kumar P, Schuldt KM, Peterson EJ, Vanhaesebroeck B, Dixit V, Thakar MS, Malarkannan S) Nat Immunol 2014 Jan 21;15(2):205 PMID: 24448581 01/23/2014
  • Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells. (Rajasekaran K, Kumar P, Schuldt KM, Peterson EJ, Vanhaesebroeck B, Dixit V, Thakar MS, Malarkannan S) Nat Immunol 2013 Nov;14(11):1127-36 PMID: 24036998 PMCID: PMC3855032 09/17/2013
  • Clinical relevance of natural killer cells following hematopoietic stem cell transplantation. (Palmer JM, Rajasekaran K, Thakar MS, Malarkannan S) J Cancer 2013;4(1):25-35 PMID: 23386902 PMCID: PMC3564244 02/07/2013
  • IL-22: An Evolutionary Missing-Link Authenticating the Role of the Immune System in Tissue Regeneration. (Kumar P, Rajasekaran K, Palmer JM, Thakar MS, Malarkannan S) J Cancer 2013;4(1):57-65 PMID: 23386905 PMCID: PMC3564247 02/07/2013
  • IL-22 from conventional NK cells is epithelial regenerative and inflammation protective during influenza infection. (Kumar P, Thakar MS, Ouyang W, Malarkannan S) Mucosal Immunol 2013 Jan;6(1):69-82 PMID: 22739232 PMCID: PMC3835350 06/29/2012
  • IQGAP1: a regulator of intracellular spacetime relativity. (Malarkannan S, Awasthi A, Rajasekaran K, Kumar P, Schuldt KM, Bartoszek A, Manoharan N, Goldner NK, Umhoefer CM, Thakar MS) J Immunol 2012 Mar 01;188(5):2057-63 PMID: 22345702 PMCID: PMC3286039 02/22/2012
  • High-throughput detection method for influenza virus. (Kumar P, Bartoszek AE, Moran TM, Gorski J, Bhattacharyya S, Navidad JF, Thakar MS, Malarkannan S) J Vis Exp 2012 Feb 04(60) PMID: 22331038 PMCID: PMC3369630 02/15/2012
  • Primary vascularization of the graft determines the immunodominance of murine minor H antigens during organ transplantation. (Kwun J, Malarkannan S, Burlingham WJ, Knechtle SJ) J Immunol 2011 Oct 15;187(8):3997-4006 PMID: 21900176 PMCID: PMC3357205 09/09/2011
  • Transforming growth factor-beta-activated kinase 1 regulates natural killer cell-mediated cytotoxicity and cytokine production. (Rajasekaran K, Chu H, Kumar P, Xiao Y, Tinguely M, Samarakoon A, Kim TW, Li X, Thakar MS, Zhang J, Malarkannan S) J Biol Chem 2011 Sep 09;286(36):31213-24 PMID: 21771792 PMCID: PMC3173069 07/21/2011
  • Functional dichotomy between NKG2D and CD28-mediated co-stimulation in human CD8+ T cells. (Rajasekaran K, Xiong V, Fong L, Gorski J, Malarkannan S) PLoS One 2010 Sep 09;5(9) PMID: 20844584 PMCID: PMC2936560 09/17/2010
  • Rap1b facilitates NK cell functions via IQGAP1-mediated signalosomes. (Awasthi A, Samarakoon A, Chu H, Kamalakannan R, Quilliam LA, Chrzanowska-Wodnicka M, White GC 2nd, Malarkannan S) J Exp Med 2010 Aug 30;207(9):1923-38 PMID: 20733035 PMCID: PMC2931159 08/25/2010
  • Evasion of natural killer cells by influenza virus. (Guo H, Kumar P, Malarkannan S) J Leukoc Biol 2011 Feb;89(2):189-94 PMID: 20682623 PMCID: PMC3024901 08/05/2010
  • The functional impairment of natural killer cells during influenza virus infection. (Guo H, Kumar P, Moran TM, Garcia-Sastre A, Zhou Y, Malarkannan S) Immunol Cell Biol 2009 Nov-Dec;87(8):579-89 PMID: 19721456 PMCID: PMC2882241 09/02/2009
  • Murine NKG2D ligands: "double, double toil and trouble". (Samarakoon A, Chu H, Malarkannan S) Mol Immunol 2009 Mar;46(6):1011-9 PMID: 19081632 PMCID: PMC2764959 12/17/2008
  • The p110 delta of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation. (Guo H, Samarakoon A, Vanhaesebroeck B, Malarkannan S) J Exp Med 2008 Sep 29;205(10):2419-35 PMID: 18809712 PMCID: PMC2556795 09/24/2008
  • Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5. (Schulteis RD, Chu H, Dai X, Chen Y, Edwards B, Haribhai D, Williams CB, Malarkannan S, Hessner MJ, Glisic-Milosavljevic S, Jana S, Kerschen EJ, Ghosh S, Wang D, Kwitek AE, Lernmark A, Gorski J, Weiler H) Blood 2008 Dec 15;112(13):4905-14 PMID: 18796632 PMCID: PMC2597598 09/18/2008
  • Rap1b regulates B cell development, homing, and T cell-dependent humoral immunity. (Chu H, Awasthi A, White GC 2nd, Chrzanowska-Wodnicka M, Malarkannan S) J Immunol 2008 Sep 01;181(5):3373-83 PMID: 18714009 PMCID: PMC4571460 08/21/2008
  • Deletion of PI3K-p85alpha gene impairs lineage commitment, terminal maturation, cytokine generation and cytotoxicity of NK cells. (Awasthi A, Samarakoon A, Dai X, Wen R, Wang D, Malarkannan S) Genes Immun 2008 Sep;9(6):522-35 PMID: 18548087 PMCID: PMC4623703 06/13/2008
  • Recognition of allo-peptide is governed by novel anchor imposition and limited variations in TCR contact residues. (Reinbold CJ, Malarkannan S) Mol Immunol 2008 Mar;45(5):1318-26 PMID: 17981332 PMCID: PMC3835348 11/06/2007
  • Bcl10 plays a divergent role in NK cell-mediated cytotoxicity and cytokine generation. (Malarkannan S, Regunathan J, Chu H, Kutlesa S, Chen Y, Zeng H, Wen R, Wang D) J Immunol 2007 Sep 15;179(6):3752-62 PMID: 17785812 09/06/2007
  • Differential and nonredundant roles of phospholipase Cgamma2 and phospholipase Cgamma1 in the terminal maturation of NK cells. (Regunathan J, Chen Y, Kutlesa S, Dai X, Bai L, Wen R, Wang D, Malarkannan S) J Immunol 2006 Oct 15;177(8):5365-76 PMID: 17015722 10/04/2006
  • The balancing act: inhibitory Ly49 regulate NKG2D-mediated NK cell functions. (Malarkannan S) Semin Immunol 2006 Jun;18(3):186-92 PMID: 16737823 PMCID: PMC2752866 06/02/2006
  • Unanticipated antigens: translation initiation at CUG with leucine. (Schwab SR, Shugart JA, Horng T, Malarkannan S, Shastri N) PLoS Biol 2004 Nov;2(11):e366 PMID: 15510226 PMCID: PMC524250 10/29/2004
  • NKG2D receptor-mediated NK cell function is regulated by inhibitory Ly49 receptors. (Regunathan J, Chen Y, Wang D, Malarkannan S) Blood 2005 Jan 01;105(1):233-40 PMID: 15328154 PMCID: PMC3889208 08/26/2004
  • A single nucleotide polymorphism in the Emp3 gene defines the H4 minor histocompatibility antigen. (Luedtke B, Pooler LM, Choi EY, Tranchita AM, Reinbold CJ, Brown AC, Shaffer DJ, Roopenian DC, Malarkannan S) Immunogenetics 2003 Aug;55(5):284-95 PMID: 12845499 07/08/2003
  • Real-time T-cell profiling identifies H60 as a major minor histocompatibility antigen in murine graft-versus-host disease. (Choi EY, Christianson GJ, Yoshimura Y, Jung N, Sproule TJ, Malarkannan S, Joyce S, Roopenian DC) Blood 2002 Dec 15;100(13):4259-65 PMID: 12393464 10/24/2002
  • Quantitative analysis of the immune response to mouse non-MHC transplantation antigens in vivo: the H60 histocompatibility antigen dominates over all others. (Choi EY, Yoshimura Y, Christianson GJ, Sproule TJ, Malarkannan S, Shastri N, Joyce S, Roopenian DC) J Immunol 2001 Apr 01;166(7):4370-9 PMID: 11254691 03/20/2001
  • Generation of antigen-specific, lacZ-inducible T-cell hybrids. (Malarkannan S, Mendoza LM, Shastri N) Methods Mol Biol 2001;156:265-72 PMID: 11068767 11/09/2000
  • Identification of CD8+ T-cell-stimulating antigen genes in cDNA libraries. (Mendoza LM, Malarkannan S, Shastri N) Methods Mol Biol 2001;156:255-63 PMID: 11068766 11/09/2000
  • Differences that matter: major cytotoxic T cell-stimulating minor histocompatibility antigens. (Malarkannan S, Horng T, Eden P, Gonzalez F, Shih P, Brouwenstijn N, Klinge H, Christianson G, Roopenian D, Shastri N) Immunity 2000 Sep;13(3):333-44 PMID: 11021531 10/06/2000
  • Presentation of out-of-frame peptide/MHC class I complexes by a novel translation initiation mechanism. (Malarkannan S, Horng T, Shih PP, Schwab S, Shastri N) Immunity 1999 Jun;10(6):681-90 PMID: 10403643 07/14/1999
  • The molecular and functional characterization of a dominant minor H antigen, H60. (Malarkannan S, Shih PP, Eden PA, Horng T, Zuberi AR, Christianson G, Roopenian D, Shastri N) J Immunol 1998 Oct 01;161(7):3501-9 PMID: 9759870 10/06/1998
  • The mouse mammary tumor virus env gene is the source of a CD8+ T-cell-stimulating peptide presented by a major histocompatibility complex class I molecule in a murine thymoma. (Malarkannan S, Serwold T, Nguyen V, Sherman LA, Shastri N) Proc Natl Acad Sci U S A 1996 Nov 26;93(24):13991-6 PMID: 8943048 PMCID: PMC19482 11/26/1996
  • Alloreactive CD8+ T cells can recognize unusual, rare, and unique processed peptide/MHC complexes. (Malarkannan S, Gonzalez F, Nguyen V, Adair G, Shastri N) J Immunol 1996 Nov 15;157(10):4464-73 PMID: 8906823 11/15/1996
  • A rare cryptic translation product is presented by Kb major histocompatibility complex class I molecule to alloreactive T cells. (Malarkannan S, Afkarian M, Shastri N) J Exp Med 1995 Dec 01;182(6):1739-50 PMID: 7500018 PMCID: PMC2192241 12/01/1995
  • The role of MHC class I molecules in the generation of endogenous peptide/MHC complexes. (Malarkannan S, Goth S, Buchholz DR, Shastri N) J Immunol 1995 Jan 15;154(2):585-98 PMID: 7814870 01/15/1995
  • Immunodetection of biotinylated lymphocyte-surface proteins by enhanced chemiluminescence: a nonradioactive method for cell-surface protein analysis. (Meier T, Arni S, Malarkannan S, Poincelet M, Hoessli D) Anal Biochem 1992 Jul;204(1):220-6 PMID: 1514691 07/01/1992
  • The classical and alternate pathways of T cell activation are impaired in leprosy. (Muthukkaruppan V, Chakkalath HR, Malarkannan S) Immunol Lett 1988 Sep;19(1):55-8 PMID: 2903849 09/01/1988
  • Last update: 06/01/2016
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