Medical College of Wisconsin
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Tengis S. Pavlov PhD

Tengis S. Pavlov PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Physiology


  • Cross-talk between insulin and IGF-1 receptors in the cortical collecting duct principal cells: implication for ENaC-mediated Na+ reabsorption. (Ilatovskaya DV, Levchenko V, Brands MW, Pavlov TS, Staruschenko A) Am J Physiol Renal Physiol 2015 Apr 1;308(7):F713-9 PMID 25651558
  • Impaired epithelial Na+ channel activity contributes to cystogenesis and development of autosomal recessive polycystic kidney disease in PCK rats. (Pavlov TS, Levchenko V, Ilatovskaya DV, Palygin O, Staruschenko A) Pediatr Res 2015 Jan;77(1-1):64-9 PMID 25279988
  • Role of Rho GDP dissociation inhibitor α in control of epithelial sodium channel (ENaC)-mediated sodium reabsorption. (Pavlov TS, Levchenko V, Staruschenko A) J Biol Chem 2014 Oct 10;289(41):28651-9 PMID 25164814
  • Impaired epithelial Na+ channels activity contributes to cystogenesis and development of autosomal recessive polycystic kidney disease in PCK rats (by Tengis Pavlov, Vladislav Levchenko, Daria Ilatovskaya, Oleg Palygin, and Alexander Staruschenko) Pediatrics Research
  • Epoxyeicosatrienoic acid analogue lowers blood pressure through vasodilation and sodium channel inhibition. (Hye Khan MA, Pavlov TS, Christain SV, Neckář J, Staruschenko A, Gauthier KM, Capdevila JH, Falck JR, Campbell WB, Imig JD) Clin Sci (Lond) 2014 Oct;127(7):463-74 PMID 24707975
  • Arp2/3 complex inhibitors adversely affect actin cytoskeleton remodeling in the cultured murine kidney collecting duct M-1 cells. (Ilatovskaya DV, Chubinskiy-Nadezhdin V, Pavlov TS, Shuyskiy LS, Tomilin V, Palygin O, Staruschenko A, Negulyaev YA) Cell Tissue Res 2013 Dec;354(3):783-92 PMID 24036843
  • Orally active epoxyeicosatrienoic acid analog attenuates kidney injury in hypertensive Dahl salt-sensitive rat. (Hye Khan MA, Neckár J, Manthati V, Errabelli R, Pavlov TS, Staruschenko A, Falck JR, Imig JD) Hypertension 2013 Nov;62(5):905-13 PMID 23980070
  • Epidermal growth factors in the kidney and relationship to hypertension. (Staruschenko A, Palygin O, Ilatovskaya DV, Pavlov TS) Am J Physiol Renal Physiol 2013 Jul 1;305(1):F12-20 PMID 23637204
  • Deficiency of renal cortical EGF increases ENaC activity and contributes to salt-sensitive hypertension. (Pavlov TS, Levchenko V, O'Connor PM, Ilatovskaya DV, Palygin O, Mori T, Mattson DL, Sorokin A, Lombard JH, Cowley AW Jr, Staruschenko A) J Am Soc Nephrol 2013 Jun;24(7):1053-62 PMID 23599382
  • Real-time electrochemical detection of ATP and H₂O₂ release in freshly isolated kidneys. (Palygin O, Levchenko V, Ilatovskaya DV, Pavlov TS, Ryan RP, Cowley AW Jr, Staruschenko A) Am J Physiol Renal Physiol 2013 Jul 1;305(1):F134-41 PMID 23594827
  • Regulation of ENaC in mice lacking renal insulin receptors in the collecting duct. (Pavlov TS, Ilatovskaya DV, Levchenko V, Li L, Ecelbarger CM, Staruschenko A) FASEB J 2013 Jul;27(7):2723-32 PMID 23558339
  • G-protein signaling modulator 1 deficiency accelerates cystic disease in an orthologous mouse model of autosomal dominant polycystic kidney disease. (Kwon M, Pavlov TS, Nozu K, Rasmussen SA, Ilatovskaya DV, Lerch-Gaggl A, North LM, Kim H, Qian F, Sweeney WE Jr, Avner ED, Blumer JB, Staruschenko A, Park F) Proc Natl Acad Sci U S A 2012 Dec 26;109(52):21462-7 PMID 23236168
  • ROS production as a common mechanism of ENaC regulation by EGF, insulin, and IGF-1. (Ilatovskaya DV, Pavlov TS, Levchenko V, Staruschenko A) Am J Physiol Cell Physiol 2013 Jan 1;304(1):C102-11 PMID 23135700
  • Regulation of TRPC6 channels by non-steroidal anti-inflammatory drugs (Ilatovskaya DV*, Pavlov TS*, Negulyaev YA, Staruschenko, A) Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology 2012 Jul; 6(3): 265-272
  • Regulation of TRPC6 Channels by Non-Steroidal Anti-Inflammatory Drugs. (Ilatovskaya DV, Pavlov TS, Negulyaev YA, Staruschenko A) Biochem (Mosc) Suppl Ser A Membr Cell Biol 2012 Jul;6(3):265-272 PMID 25279100
  • Mechanisms of epithelial sodium channel (ENaC) regulation by cortactin: Involvement of dynamin (Ilatovskaya DV, Pavlov TS, Negulyaev YA, Staruschenko A) Cell and Tissue Biology 2012 Feb; 6(1): 52-59
  • Effects of cytochrome P-450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC). (Pavlov TS, Ilatovskaya DV, Levchenko V, Mattson DL, Roman RJ, Staruschenko A) Am J Physiol Renal Physiol 2011 Sep;301(3):F672-81 PMID 21697242
  • Cortical actin binding protein cortactin mediates ENaC activity via Arp2/3 complex. (Ilatovskaya DV, Pavlov TS, Levchenko V, Negulyaev YA, Staruschenko A) FASEB J 2011 Aug;25(8):2688-99 PMID 21536685
  • Novel role of Rac1/WAVE signaling mechanism in regulation of the epithelial Na+ channel. (Karpushev AV, Levchenko V, Ilatovskaya DV, Pavlov TS, Staruschenko A) Hypertension 2011 May;57(5):996-1002 PMID 21464391
  • Regulation of ENaC-Mediated Sodium Reabsorption by Peroxisome Proliferator-Activated Receptors. (Pavlov TS, Imig JD, Staruschenko A) PPAR Res 2010;2010:703735 PMID 20613963
  • Endothelin-1 inhibits the epithelial Na+ channel through betaPix/14-3-3/Nedd4-2. (Pavlov TS, Chahdi A, Ilatovskaya DV, Levchenko V, Vandewalle A, Pochynyuk O, Sorokin A, Staruschenko A) J Am Soc Nephrol 2010 May;21(5):833-43 PMID 20338996
  • Intact cytoskeleton is required for small G protein dependent activation of the epithelial Na+ channel. (Karpushev AV, Ilatovskaya DV, Pavlov TS, Negulyaev YA, Staruschenko A) PLoS One 2010;5(1):e8827 PMID 20098689
  • EGF and its related growth factors mediate sodium transport in mpkCCDc14 cells via ErbB2 (neu/HER-2) receptor. (Levchenko V, Zheleznova NN, Pavlov TS, Vandewalle A, Wilson PD, Staruschenko A) J Cell Physiol 2010 Apr;223(1):252-9 PMID 20049896
  • Peroxisome proliferator-activated receptor gamma antagonists decrease Na+ transport via the epithelial Na+ channel. (Pavlov TS, Levchenko V, Karpushev AV, Vandewalle A, Staruschenko A) Mol Pharmacol 2009 Dec;76(6):1333-40 PMID 19752200
  • Regulation of the epithelial sodium channels (ENaC) by small G proteins and phosphatidylinositides (Karpushev AV, Pavlov TS, Staruschenko AV) Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology 2009; 3(3): 261-274
  • Regulation of ENaC expression at the cell surface by Rab11. (Karpushev AV, Levchenko V, Pavlov TS, Lam VY, Vinnakota KC, Vandewalle A, Wakatsuki T, Staruschenko A) Biochem Biophys Res Commun 2008 Dec 12;377(2):521-5 PMID 18926797
  • Selank and its metabolites maintain homeostasis in the gastric mucosa (Pavlov TS, Samonina GE, Bakaeva ZV, Zolotarev YuA, Guseva AA) Bulletin of Experimental Biology and Medicine 2007 Jan; 143(1): 51-53
  • Evenly tritium labeled peptides in study of peptide in vivo and in vitro biodegradation (Zolotarev, Y, Dadayan AK, Dolotov OV, Kozik VS, Kost NV, Sokolov OY, Dorokhova EM, Meshavkin VK, Inozemtseva LS, Gabaeva MV, Andreeva LA, Alfeeva LY, Pavlov TS, Badmaeva KE, Badmaeva SE, Bakaeva ZV, Kopylova GN, Samonina GE, Vaskovsky B, Grivennikov IA, Zozulya AA, Myasoedov NF) Russian Journal of Bioorganic Chemistry 2006 Mar; 32(2): 166-173
  • Effect of new synthetic anxiolytic selank on gastric wall blood flow and mesenteryc lymphatic vessels contractility in anesthetized rats (Pavlov TS, Sanzhieva LT, Samonina GE, Sergeev VI, Lelekova TV) I.M Sechenov Russian Physiological Journal Feb 2005; 91(2): 178-183
  • Grants and Awards

  • Regulation of ENaC in salt-sensitive hypertension via inflammation-induced ROS production (#9208218 08/15/2013 - 06/30/2015) Sponsor: NIH Heart Lung and Blood Institute
  • Regulation of ENaC in Servo-Controlled Dahl Salt-Sensitive Rats (#9306304 12/16/2013 - 12/15/2015) Sponsor: Research Affairs Committee
  • Last update: 04/20/2015