Medical College of Wisconsin
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Weiguo Cui PhD

Weiguo Cui PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Microbiology and Immunology

Member of the Cancer Center


  • Single-cell RNA sequencing unveils an IL-10-producing helper subset that sustains humoral immunity during persistent infection. (Xin G, Zander R, Schauder DM, Chen Y, Weinstein JS, Drobyski WR, Tarakanova V, Craft J, Cui W) Nat Commun 2018 11 28;9(1):5037 PMID: 30487586 PMCID: PMC6261948 11/30/2018    
  • Frontline Science: PECAM-1 (CD31) expression in naïve and memory, but not acutely activated, CD8 T cells. (Newman DK, Fu G, McOlash L, Schauder D, Newman PJ, Cui W, Rao S, Johnson BD, Gershan JA, Riese MJ) J Leukoc Biol 2018 Nov;104(5):883-893 PMID: 30063264 PMCID: PMC6195461 08/01/2018       2 Citations
  • Diacylglycerol kinase ζ (DGKζ) and Casitas b-lineage proto-oncogene b-deficient mice have similar functional outcomes in T cells but DGKζ-deficient mice have increased T cell activation and tumor clearance. (Wesley EM, Xin G, McAllister D, Malarkannan S, Newman DK, Dwinell MB, Cui W, Johnson BD, Riese MJ) Immunohorizons 2018 Apr 01;2(4):107-118 PMID: 30027154 PMCID: PMC6048965 07/22/2018    
  • Two is better than one: advances in pathogen-boosted immunotherapy and adoptive T-cell therapy. (Xin G, Schauder DM, Zander R, Cui W) Immunotherapy 2017 09;9(10):837-849 PMID: 28877635 PMCID: PMC5941714 09/08/2017       1 Citations
  • The power of combining adoptive cell therapy (ACT) and pathogen-boosted vaccination to treat solid tumors. (Zander R, Cui W) Hum Vaccin Immunother 2017 10 03;13(10):2269-2271 PMID: 28708956 PMCID: PMC5647994 07/15/2017    
  • B Cell-Specific Expression of Ataxia-Telangiectasia Mutated Protein Kinase Promotes Chronic Gammaherpesvirus Infection. (Darrah EJ, Kulinski JM, Mboko WP, Xin G, Malherbe LP, Gauld SB, Cui W, Tarakanova VL) J Virol 2017 10 01;91(19) PMID: 28701397 PMCID: PMC5599758 07/14/2017    
  • Cardiotonic Steroids Stimulate Macrophage Inflammatory Responses Through a Pathway Involving CD36, TLR4, and Na/K-ATPase. (Chen Y, Huang W, Yang M, Xin G, Cui W, Xie Z, Silverstein RL) Arterioscler Thromb Vasc Biol 2017 08;37(8):1462-1469 PMID: 28619997 PMCID: PMC5532064 06/18/2017       4 Citations
  • Pathogen boosted adoptive cell transfer immunotherapy to treat solid tumors. (Xin G, Schauder DM, Jing W, Jiang A, Joshi NS, Johnson B, Cui W) Proc Natl Acad Sci U S A 2017 01 24;114(4):740-745 PMID: 28069963 PMCID: PMC5278465 01/11/2017       7 Citations
  • Dual Specificity Phosphatase 5 Is Essential for T Cell Survival. (Kutty RG, Xin G, Schauder DM, Cossette SM, Bordas M, Cui W, Ramchandran R) PLoS One 2016;11(12):e0167246 PMID: 27936095 PMCID: PMC5147890 12/10/2016       7 Citations
  • The adhesion molecule PECAM-1 enhances the TGF-β-mediated inhibition of T cell function. (Newman DK, Fu G, Adams T, Cui W, Arumugam V, Bluemn T, Riese MJ) Sci Signal 2016 Mar 08;9(418):ra27 PMID: 26956486 PMCID: PMC5087802 03/10/2016       6 Citations
  • Tumor Suppressor Interferon-Regulatory Factor 1 Counteracts the Germinal Center Reaction Driven by a Cancer-Associated Gammaherpesvirus. (Mboko WP, Olteanu H, Ray A, Xin G, Darrah EJ, Kumar SN, Kulinski JM, Cui W, Dittel BN, Gauld SB, Tarakanova VL) J Virol 2015 Dec 30;90(6):2818-29 PMID: 26719266 PMCID: PMC4810652 01/01/2016       6 Citations
  • A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control. (Xin G, Schauder DM, Lainez B, Weinstein JS, Dai Z, Chen Y, Esplugues E, Wen R, Wang D, Parish IA, Zajac AJ, Craft J, Cui W) Cell Rep 2015 Nov 10;13(6):1118-1124 PMID: 26527008 PMCID: PMC4859432 11/04/2015       20 Citations
  • Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells. (Laidlaw BJ, Cui W, Amezquita RA, Gray SM, Guan T, Lu Y, Kobayashi Y, Flavell RA, Kleinstein SH, Craft J, Kaech SM) Nat Immunol 2015 Aug;16(8):871-9 PMID: 26147684 PMCID: PMC4713030 07/07/2015       68 Citations
  • β-Catenin in dendritic cells exerts opposite functions in cross-priming and maintenance of CD8+ T cells through regulation of IL-10. (Fu C, Liang X, Cui W, Ober-Blöbaum JL, Vazzana J, Shrikant PA, Lee KP, Clausen BE, Mellman I, Jiang A) Proc Natl Acad Sci U S A 2015 Mar 03;112(9):2823-8 PMID: 25730849 PMCID: PMC4352820 03/03/2015       26 Citations
  • Kcnn4 is a regulator of macrophage multinucleation in bone homeostasis and inflammatory disease. (Kang H, Kerloc'h A, Rotival M, Xu X, Zhang Q, D'Souza Z, Kim M, Scholz JC, Ko JH, Srivastava PK, Genzen JR, Cui W, Aitman TJ, Game L, Melvin JE, Hanidu A, Dimock J, Zheng J, Souza D, Behera AK, Nabozny G, Cook HT, Bassett JH, Williams GR, Li J, Vignery A, Petretto E, Behmoaras J) Cell Rep 2014 Aug 21;8(4):1210-24 PMID: 25131209 PMCID: PMC4471813 08/19/2014       21 Citations
  • Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1. (Parish IA, Marshall HD, Staron MM, Lang PA, Brüstle A, Chen JH, Cui W, Tsui YC, Perry C, Laidlaw BJ, Ohashi PS, Weaver CT, Kaech SM) J Clin Invest 2014 Aug;124(8):3455-68 PMID: 25003188 PMCID: PMC4109559 07/09/2014       33 Citations
  • TLR4 ligands lipopolysaccharide and monophosphoryl lipid a differentially regulate effector and memory CD8+ T Cell differentiation. (Cui W, Joshi NS, Liu Y, Meng H, Kleinstein SH, Kaech SM) J Immunol 2014 May 01;192(9):4221-32 PMID: 24659688 PMCID: PMC4071140 03/25/2014       29 Citations
  • β-catenin mediates tumor-induced immunosuppression by inhibiting cross-priming of CD8⁺ T cells. (Liang X, Fu C, Cui W, Ober-Blöbaum JL, Zahner SP, Shrikant PA, Clausen BE, Flavell RA, Mellman I, Jiang A) J Leukoc Biol 2014 Jan;95(1):179-90 PMID: 24023259 09/12/2013       24 Citations
  • Transcriptional control of effector and memory CD8+ T cell differentiation. (Kaech SM, Cui W) Nat Rev Immunol 2012 Nov;12(11):749-61 PMID: 23080391 PMCID: PMC4137483 10/20/2012       496 Citations
  • Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype. (Demento SL, Cui W, Criscione JM, Stern E, Tulipan J, Kaech SM, Fahmy TM) Biomaterials 2012 Jun;33(19):4957-64 PMID: 22484047 PMCID: PMC5724530 04/10/2012       118 Citations
  • An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells. (Cui W, Liu Y, Weinstein JS, Craft J, Kaech SM) Immunity 2011 Nov 23;35(5):792-805 PMID: 22118527 PMCID: PMC3431922 11/29/2011       187 Citations
  • Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infection. (Marshall HD, Chandele A, Jung YW, Meng H, Poholek AC, Parish IA, Rutishauser R, Cui W, Kleinstein SH, Craft J, Kaech SM) Immunity 2011 Oct 28;35(4):633-46 PMID: 22018471 PMCID: PMC3444169 10/25/2011       136 Citations
  • Mechanisms of antigen presentation to T cells in murine graft-versus-host disease: cross-presentation and the appearance of cross-presentation. (Wang X, Li H, Matte-Martone C, Cui W, Li N, Tan HS, Roopenian D, Shlomchik WD) Blood 2011 Dec 08;118(24):6426-37 PMID: 21963602 PMCID: PMC3236124 10/04/2011       33 Citations
  • Increased numbers of preexisting memory CD8 T cells and decreased T-bet expression can restrain terminal differentiation of secondary effector and memory CD8 T cells. (Joshi NS, Cui W, Dominguez CX, Chen JH, Hand TW, Kaech SM) J Immunol 2011 Oct 15;187(8):4068-76 PMID: 21930973 PMCID: PMC3991478 09/21/2011       52 Citations
  • Memory T cells from minor histocompatibility antigen-vaccinated and virus-immune donors improve GVL and immune reconstitution. (Li N, Matte-Martone C, Zheng H, Cui W, Venkatesan S, Tan HS, McNiff J, Demetris AJ, Roopenian D, Kaech S, Shlomchik WD) Blood 2011 Nov 24;118(22):5965-76 PMID: 21917752 PMCID: PMC3228506 09/16/2011       27 Citations
  • Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival. (Hand TW, Cui W, Jung YW, Sefik E, Joshi NS, Chandele A, Liu Y, Kaech SM) Proc Natl Acad Sci U S A 2010 Sep 21;107(38):16601-6 PMID: 20823247 PMCID: PMC2944719 09/09/2010       111 Citations
  • TLR9-targeted biodegradable nanoparticles as immunization vectors protect against West Nile encephalitis. (Demento SL, Bonafé N, Cui W, Kaech SM, Caplan MJ, Fikrig E, Ledizet M, Fahmy TM) J Immunol 2010 Sep 01;185(5):2989-97 PMID: 20660705 PMCID: PMC3753007 07/28/2010       79 Citations
  • Generation of effector CD8+ T cells and their conversion to memory T cells. (Cui W, Kaech SM) Immunol Rev 2010 Jul;236:151-66 PMID: 20636815 PMCID: PMC4380273 07/20/2010       121 Citations
  • Role of MKP-1 in osteoclasts and bone homeostasis. (Carlson J, Cui W, Zhang Q, Xu X, Mercan F, Bennett AM, Vignery A) Am J Pathol 2009 Oct;175(4):1564-73 PMID: 19762714 PMCID: PMC2751553 09/19/2009       27 Citations
  • Effects of Signal 3 during CD8 T cell priming: Bystander production of IL-12 enhances effector T cell expansion but promotes terminal differentiation. (Cui W, Joshi NS, Jiang A, Kaech SM) Vaccine 2009 Mar 26;27(15):2177-87 PMID: 19201385 PMCID: PMC2803112 02/10/2009       78 Citations
  • MyD88 plays a critical T cell-intrinsic role in supporting CD8 T cell expansion during acute lymphocytic choriomeningitis virus infection. (Rahman AH, Cui W, Larosa DF, Taylor DK, Zhang J, Goldstein DR, Wherry EJ, Kaech SM, Turka LA) J Immunol 2008 Sep 15;181(6):3804-10 PMID: 18768833 PMCID: PMC2835404 09/05/2008       52 Citations
  • Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation. (Jiang A, Bloom O, Ono S, Cui W, Unternaehrer J, Jiang S, Whitney JA, Connolly J, Banchereau J, Mellman I) Immunity 2007 Oct;27(4):610-24 PMID: 17936032 PMCID: PMC2151979 10/16/2007       226 Citations
  • CD200 and its receptor, CD200R, modulate bone mass via the differentiation of osteoclasts. (Cui W, Cuartas E, Ke J, Zhang Q, Einarsson HB, Sedgwick JD, Li J, Vignery A) Proc Natl Acad Sci U S A 2007 Sep 04;104(36):14436-41 PMID: 17726108 PMCID: PMC1955461 08/30/2007       53 Citations
  • Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. (Joshi NS, Cui W, Chandele A, Lee HK, Urso DR, Hagman J, Gapin L, Kaech SM) Immunity 2007 Aug;27(2):281-95 PMID: 17723218 PMCID: PMC2034442 08/29/2007       884 Citations
  • The intracellular domain of CD44 promotes the fusion of macrophages. (Cui W, Ke JZ, Zhang Q, Ke HZ, Chalouni C, Vignery A) Blood 2006 Jan 15;107(2):796-805 PMID: 16195325 PMCID: PMC1473173 10/01/2005       74 Citations
  • IL-1 receptor-associated kinase M is a central regulator of osteoclast differentiation and activation. (Li H, Cuartas E, Cui W, Choi Y, Crawford TD, Ke HZ, Kobayashi KS, Flavell RA, Vignery A) J Exp Med 2005 Apr 04;201(7):1169-77 PMID: 15809356 PMCID: PMC2213136 04/06/2005       51 Citations
  • Last update: 12/31/2018
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