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William E. Antholine PhD

William E. Antholine PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Biophysics
Program: Research

Member of the Cancer Center


Publications

  • Better Resolution of High-Spin Cobalt Hyperfine at Low Frequency: Co-Doped Ba(ZnTa)O₃ as a Model Complex. (Antholine WE, Zhang S, Gonzales J, Newman N) Int J Mol Sci 2018 Nov 09;19(11) PMID: 30423944 PMCID: PMC6274703 11/15/2018    
  • Gallium Maltolate Disrupts Tumor Iron Metabolism and Retards the Growth of Glioblastoma by Inhibiting Mitochondrial Function and Ribonucleotide Reductase. (Chitambar CR, Al-Gizawiy MM, Alhajala HS, Pechman KR, Wereley JP, Wujek R, Clark PA, Kuo JS, Antholine WE, Schmainda KM) Mol Cancer Ther 2018 Jun;17(6):1240-1250 PMID: 29592883 PMCID: PMC5984712 03/30/2018    
  • A One-Hole CuS Cluster with NO Reductase Activity: A Structural and Functional Model for Cu. (Johnson BJ, Antholine WE, Lindeman SV, Graham MJ, Mankad NP) J Am Chem Soc 2016 Oct 03: PMID: 27685680 PMCID: PMC5378702 09/30/2016    
  • Di- and Trinuclear Mixed-Valence Copper Amidinate Complexes from Reduction of Iodine. (Lane AC, Barnes CL, Antholine WE, Wang D, Fiedler AT, Walensky JR) Inorg Chem 2015 Sep 08;54(17):8509-17 PMID: 26252561 PMCID: PMC4733884 08/08/2015       9 Citations
  • A Cu4S model for the nitrous oxide reductase active sites supported only by nitrogen ligands. (Johnson BJ, Antholine WE, Lindeman SV, Mankad NP) Chem Commun (Camb) 2015 Jul 28;51(59):11860-3 PMID: 26111160 PMCID: PMC4731228 06/26/2015       7 Citations
  • Synthesis, Spectroscopy, and Electrochemistry of (α-Diimine)M(CO)Br, M = Mn, Re, Complexes: Ligands Isoelectronic to Bipyridyl Show Differences in CO Reduction. (Vollmer MV, Machan CW, Clark ML, Antholine WE, Agarwal J, Schaefer HF 3rd, Kubiak CP, Walensky JR) Organometallics 2014 Sep 09;34(1):3-12 PMID: 25892841 PMCID: PMC4399245 04/22/2015    
  • The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death. (Xu J, Eriksson SE, Cebula M, Sandalova T, Hedström E, Pader I, Cheng Q, Myers CR, Antholine WE, Nagy P, Hellman U, Selivanova G, Lindqvist Y, Arnér ES) Cell Death Dis 2015 Jan 22;6:e1616 PMID: 25611390 PMCID: PMC4669772 01/23/2015       13 Citations
  • Nitric oxide modifies global histone methylation by inhibiting Jumonji C domain-containing demethylases. (Hickok JR, Vasudevan D, Antholine WE, Thomas DD) J Biol Chem 2013 May 31;288(22):16004-15 PMID: 23546878 PMCID: PMC3668755 04/03/2013       36 Citations
  • Redox activation of Fe(III)-thiosemicarbazones and Fe(III)-bleomycin by thioredoxin reductase: specificity of enzymatic redox centers and analysis of reactive species formation by ESR spin trapping. (Myers JM, Cheng Q, Antholine WE, Kalyanaraman B, Filipovska A, Arnér ES, Myers CR) Free Radic Biol Med 2013 Jul;60:183-94 PMID: 23485585 PMCID: PMC3654041 03/15/2013       9 Citations
  • Iron-targeting antitumor activity of gallium compounds and novel insights into triapine(®)-metal complexes. (Chitambar CR, Antholine WE) Antioxid Redox Signal 2013 Mar 10;18(8):956-72 PMID: 22900955 PMCID: PMC3557436 08/21/2012       29 Citations
  • Dual role of selected antioxidants found in dietary supplements: crossover between anti- and pro-oxidant activities in the presence of copper. (Yin JJ, Fu PP, Lutterodt H, Zhou YT, Antholine WE, Wamer W) J Agric Food Chem 2012 Mar 14;60(10):2554-61 PMID: 22339379 PMCID: PMC3971523 02/22/2012       33 Citations
  • Damage to mitochondrial complex I during cardiac ischemia reperfusion injury is reduced indirectly by anti-anginal drug ranolazine. (Gadicherla AK, Stowe DF, Antholine WE, Yang M, Camara AK) Biochim Biophys Acta 2012 Mar;1817(3):419-29 PMID: 22178605 PMCID: PMC3269517 12/20/2011       49 Citations
  • Cytotoxic Evaluation of 3-Aminopyridine-2-Carboxaldehyde Thiosemicarbazone, 3-AP, in Peripheral Blood Lymphocytes of Patients with Refractory Solid Tumors using Electron Paramagnetic Resonance. (Kolesar JM, Sachidanandam K, Schelman WR, Eickhoff J, Holen KD, Traynor AM, Alberti DB, Thomas JP, Chitambar CR, Wilding G, Antholine WE) Exp Ther Med 2011 Jan;2(1):119-123 PMID: 21373381 PMCID: PMC3046871 03/05/2011    
  • The intracellular redox stress caused by hexavalent chromium is selective for proteins that have key roles in cell survival and thiol redox control. (Myers JM, Antholine WE, Myers CR) Toxicology 2011 Mar 15;281(1-3):37-47 PMID: 21237240 PMCID: PMC3039098 01/18/2011       25 Citations
  • The iron-chelating drug triapine causes pronounced mitochondrial thiol redox stress. (Myers JM, Antholine WE, Zielonka J, Myers CR) Toxicol Lett 2011 Mar 05;201(2):130-6 PMID: 21195754 01/05/2011       13 Citations
  • Oxidation of histidine residues in copper-zinc superoxide dismutase by bicarbonate-stimulated peroxidase and thiol oxidase activities: pulse EPR and NMR studies. (Chandran K, McCracken J, Peterson FC, Antholine WE, Volkman BF, Kalyanaraman B) Biochemistry 2010 Dec 21;49(50):10616-22 PMID: 21038859 PMCID: PMC3501376 11/03/2010       11 Citations
  • Pulse Radiolysis Studies of Temperature Dependent Electron Transfers among Redox Centers in ba(3)-Cytochrome c Oxidase from Thermus thermophilus: Comparison of A- and B-Type Enzymes. (Farver O, Wherland S, Antholine WE, Gemmen GJ, Chen Y, Pecht I, Fee JA) Biochemistry 2010 Nov 08: PMID: 21028883 10/30/2010    
  • The pro-oxidant chromium(VI) inhibits mitochondrial complex I, complex II, and aconitase in the bronchial epithelium: EPR markers for Fe-S proteins. (Myers CR, Antholine WE, Myers JM) Free Radic Biol Med 2010 Dec 15;49(12):1903-15 PMID: 20883776 PMCID: PMC3005768 10/05/2010       25 Citations
  • Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model. (Ghosh A, Chandran K, Kalivendi SV, Joseph J, Antholine WE, Hillard CJ, Kanthasamy A, Kanthasamy A, Kalyanaraman B) Free Radic Biol Med 2010 Dec 01;49(11):1674-84 PMID: 20828611 PMCID: PMC4020411 09/11/2010       88 Citations
  • Spectral and thermodynamic properties of methanobactin from γ-proteobacterial methane oxidizing bacteria: a case for copper competition on a molecular level. (Choi DW, Bandow NL, McEllistrem MT, Semrau JD, Antholine WE, Hartsel SC, Gallagher W, Zea CJ, Pohl NL, Zahn JA, DiSpirito AA) J Inorg Biochem 2010 Dec;104(12):1240-7 PMID: 20817303 09/08/2010       32 Citations
  • The selenium-independent inherent pro-oxidant NADPH oxidase activity of mammalian thioredoxin reductase and its selenium-dependent direct peroxidase activities. (Cheng Q, Antholine WE, Myers JM, Kalyanaraman B, Arnér ES, Myers CR) J Biol Chem 2010 Jul 09;285(28):21708-23 PMID: 20457604 PMCID: PMC2898413 05/12/2010       33 Citations
  • Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells. (Eberhard Y, McDermott SP, Wang X, Gronda M, Venugopal A, Wood TE, Hurren R, Datti A, Batey RA, Wrana J, Antholine WE, Dick JE, Schimmer AD) Blood 2009 Oct 01;114(14):3064-73 PMID: 19589922 07/11/2009       92 Citations
  • Multifrequency EPR studies of [Cu(1.5)Cu(1.5)](+) for Cu2(mu-NR2)2 and Cu2(mu-PR2)2 diamond cores. (Mankad NP, Harkins SB, Antholine WE, Peters JC) Inorg Chem 2009 Aug 03;48(15):7026-32 PMID: 19572723 PMCID: PMC2744091 07/04/2009       8 Citations
  • EPR of Cu2+ prion protein constructs at 2 GHz using the g(perpendicular) region to characterize nitrogen ligation. (Hyde JS, Bennett B, Walter ED, Millhauser GL, Sidabras JW, Antholine WE) Biophys J 2009 Apr 22;96(8):3354-62 PMID: 19383478 PMCID: PMC2718275 04/23/2009       10 Citations
  • Evidence that phosphorylation of iron regulatory protein 1 at Serine 138 destabilizes the [4Fe-4S] cluster in cytosolic aconitase by enhancing 4Fe-3Fe cycling. (Deck KM, Vasanthakumar A, Anderson SA, Goforth JB, Kennedy MC, Antholine WE, Eisenstein RS) J Biol Chem 2009 May 08;284(19):12701-9 PMID: 19269970 PMCID: PMC2675999 03/10/2009       21 Citations
  • Three-coordinate copper(I) amido and aminyl radical complexes. (Mankad NP, Antholine WE, Szilagyi RK, Peters JC) J Am Chem Soc 2009 Mar 25;131(11):3878-80 PMID: 19253942 PMCID: PMC3110787 03/04/2009       63 Citations
  • Doxorubicin inactivates myocardial cytochrome c oxidase in rats: cardioprotection by Mito-Q. (Chandran K, Aggarwal D, Migrino RQ, Joseph J, McAllister D, Konorev EA, Antholine WE, Zielonka J, Srinivasan S, Avadhani NG, Kalyanaraman B) Biophys J 2009 Feb 18;96(4):1388-98 PMID: 19217856 PMCID: PMC2717244 02/17/2009       111 Citations
  • Addition of DNA to Cr(VI) and cytochrome b5 containing proteoliposomes leads to generation of DNA strand breaks and Cr(III) complexes. (Borthiry GR, Antholine WE, Myers JM, Myers CR) Chem Biodivers 2008 Aug;5(8):1545-57 PMID: 18729091 PMCID: PMC2715337 08/30/2008       5 Citations
  • Oxidase, superoxide dismutase, and hydrogen peroxide reductase activities of methanobactin from types I and II methanotrophs. (Choi DW, Semrau JD, Antholine WE, Hartsel SC, Anderson RC, Carey JN, Dreis AM, Kenseth EM, Renstrom JM, Scardino LL, Van Gorden GS, Volkert AA, Wingad AD, Yanzer PJ, McEllistrem MT, de la Mora AM, DiSpirito AA) J Inorg Biochem 2008 Aug;102(8):1571-80 PMID: 18372044 03/29/2008       39 Citations
  • Hexavalent chromium causes the oxidation of thioredoxin in human bronchial epithelial cells. (Myers JM, Antholine WE, Myers CR) Toxicology 2008 Apr 18;246(2-3):222-33 PMID: 18328613 PMCID: PMC2386998 03/11/2008       46 Citations
  • Reductive activation of hexavalent chromium by human lung epithelial cells: generation of Cr(V) and Cr(V)-thiol species. (Borthiry GR, Antholine WE, Myers JM, Myers CR) J Inorg Biochem 2008 Jul;102(7):1449-62 PMID: 18279960 PMCID: PMC2497427 02/19/2008       20 Citations
  • Electron paramagnetic resonance study of peripheral blood mononuclear cells from patients with refractory solid tumors treated with Triapine. (Kolesar JM, Schelman WR, Geiger PG, Holen KD, Traynor AM, Alberti DB, Thomas JP, Chitambar CR, Wilding G, Antholine WE) J Inorg Biochem 2008 Apr;102(4):693-8 PMID: 18061679 PMCID: PMC2390869 12/07/2007       19 Citations
  • Mössbauer studies of the membrane-associated methane monooxygenase from Methylococcus capsulatus bath: evidence for a Diiron center. (Martinho M, Choi DW, Dispirito AA, Antholine WE, Semrau JD, Münck E) J Am Chem Soc 2007 Dec 26;129(51):15783-5 PMID: 18052283 PMCID: PMC2533734 12/07/2007       63 Citations
  • Reduction of hexavalent chromium by human cytochrome b5: generation of hydroxyl radical and superoxide. (Borthiry GR, Antholine WE, Kalyanaraman B, Myers JM, Myers CR) Free Radic Biol Med 2007 Mar 15;42(6):738-55; discussion 735-7 PMID: 17320757 PMCID: PMC1993546 02/27/2007       43 Citations
  • Generation of novel copper sites by mutation of the axial ligand of amicyanin. Atomic resolution structures and spectroscopic properties. (Carrell CJ, Ma JK, Antholine WE, Hosler JP, Mathews FS, Davidson VL) Biochemistry 2007 Feb 20;46(7):1900-12 PMID: 17295442 02/14/2007       22 Citations
  • Spectral and thermodynamic properties of Ag(I), Au(III), Cd(II), Co(II), Fe(III), Hg(II), Mn(II), Ni(II), Pb(II), U(IV), and Zn(II) binding by methanobactin from Methylosinus trichosporium OB3b. (Choi DW, Do YS, Zea CJ, McEllistrem MT, Lee SW, Semrau JD, Pohl NL, Kisting CJ, Scardino LL, Hartsel SC, Boyd ES, Geesey GG, Riedel TP, Shafe PH, Kranski KA, Tritsch JR, Antholine WE, DiSpirito AA) J Inorg Biochem 2006 Dec;100(12):2150-61 PMID: 17070918 10/31/2006       64 Citations
  • Spectral, kinetic, and thermodynamic properties of Cu(I) and Cu(II) binding by methanobactin from Methylosinus trichosporium OB3b. (Choi DW, Zea CJ, Do YS, Semrau JD, Antholine WE, Hargrove MS, Pohl NL, Boyd ES, Geesey GG, Hartsel SC, Shafe PH, McEllistrem MT, Kisting CJ, Campbell D, Rao V, de la Mora AM, Dispirito AA) Biochemistry 2006 Feb 07;45(5):1442-53 PMID: 16445286 02/01/2006       79 Citations
  • Effect of methanobactin on the activity and electron paramagnetic resonance spectra of the membrane-associated methane monooxygenase in Methylococcus capsulatus Bath. (Choi DW, Antholine WE, Do YS, Semrau JD, Kisting CJ, Kunz RC, Campbell D, Rao V, Hartsel SC, DiSpirito AA) Microbiology 2005 Oct;151(Pt 10):3417-26 PMID: 16207923 10/07/2005       50 Citations
  • [Cu3(mu-S)2]3+ clusters supported by N-donor ligands: progress toward a synthetic model of the catalytic site of nitrous oxide reductase. (Brown EC, York JT, Antholine WE, Ruiz E, Alvarez S, Tolman WB) J Am Chem Soc 2005 Oct 12;127(40):13752-3 PMID: 16201771 10/06/2005       71 Citations
  • The octarepeat domain of the prion protein binds Cu(II) with three distinct coordination modes at pH 7.4. (Chattopadhyay M, Walter ED, Newell DJ, Jackson PJ, Aronoff-Spencer E, Peisach J, Gerfen GJ, Bennett B, Antholine WE, Millhauser GL) J Am Chem Soc 2005 Sep 14;127(36):12647-56 PMID: 16144413 PMCID: PMC2909831 09/08/2005       172 Citations
  • Thiol oxidase activity of copper, zinc superoxide dismutase stimulates bicarbonate-dependent peroxidase activity via formation of a carbonate radical. (Karunakaran C, Zhang H, Joseph J, Antholine WE, Kalyanaraman B) Chem Res Toxicol 2005 Mar;18(3):494-500 PMID: 15777089 03/22/2005       21 Citations
  • Assembly of cytochrome-c oxidase in the absence of assembly protein Surf1p leads to loss of the active site heme. (Smith D, Gray J, Mitchell L, Antholine WE, Hosler JP) J Biol Chem 2005 May 06;280(18):17652-6 PMID: 15764605 03/15/2005       61 Citations
  • Metal ion dependent antibiotics in chemotherapy. (Petering DH, Xia C, Antholine WE) Met Ions Biol Syst 2004;42:463-97 PMID: 15206111 06/23/2004       2 Citations
  • Direct probing of copper active site and free radical formed during bicarbonate-dependent peroxidase activity of bovine and human copper, zinc-superoxide dismutases. Low-temperature electron paramagnetic resonance and electron nuclear double resonance studies. (Karunakaran C, Zhang H, Crow JP, Antholine WE, Kalyanaraman B) J Biol Chem 2004 Jul 30;279(31):32534-40 PMID: 15123612 05/05/2004       27 Citations
  • Evidence that NiNi acetyl-CoA synthase is active and that the CuNi enzyme is not. (Seravalli J, Xiao Y, Gu W, Cramer SP, Antholine WE, Krymov V, Gerfen GJ, Ragsdale SW) Biochemistry 2004 Apr 06;43(13):3944-55 PMID: 15049702 03/31/2004       68 Citations
  • Vanadium(V) reduction by Shewanella oneidensis MR-1 requires menaquinone and cytochromes from the cytoplasmic and outer membranes. (Myers JM, Antholine WE, Myers CR) Appl Environ Microbiol 2004 Mar;70(3):1405-12 PMID: 15006760 PMCID: PMC368379 03/10/2004       43 Citations
  • Effect on ribonucleotide reductase of novel lipophilic iron chelators: the desferri-exochelins. (Hodges YK, Antholine WE, Horwitz LD) Biochem Biophys Res Commun 2004 Mar 12;315(3):595-8 PMID: 14975742 02/21/2004       23 Citations
  • The membrane-associated methane monooxygenase (pMMO) and pMMO-NADH:quinone oxidoreductase complex from Methylococcus capsulatus Bath. (Choi DW, Kunz RC, Boyd ES, Semrau JD, Antholine WE, Han JI, Zahn JA, Boyd JM, de la Mora AM, DiSpirito AA) J Bacteriol 2003 Oct;185(19):5755-64 PMID: 13129946 PMCID: PMC193963 09/18/2003       132 Citations
  • Properties of the reaction of chromate with metallothionein. (Krepkiy D, Antholine WE, Petering DH) Chem Res Toxicol 2003 Jun;16(6):750-6 PMID: 12807358 06/17/2003       15 Citations
  • Copper coordination in the full-length, recombinant prion protein. (Burns CS, Aronoff-Spencer E, Legname G, Prusiner SB, Antholine WE, Gerfen GJ, Peisach J, Millhauser GL) Biochemistry 2003 Jun 10;42(22):6794-803 PMID: 12779334 PMCID: PMC2905145 06/05/2003       241 Citations
  • Orientation of iron bleomycin and porphyrin complexes on DNA fibers. (Chikira M, Iiyama T, Sakamoto K, Antholine WE, Petering DH) Inorg Chem 2000 Apr 17;39(8):1779-86 PMID: 12526568 01/16/2003       21 Citations
  • Structurally distinct active sites in the copper(II)-substituted aminopeptidases from Aeromonas proteolytica and Escherichia coli. (Bennett B, Antholine WE, D'souza VM, Chen G, Ustinyuk L, Holz RC) J Am Chem Soc 2002 Nov 06;124(44):13025-34 PMID: 12405829 PMCID: PMC2669718 10/31/2002       29 Citations
  • Structures of HO(2)-Co(III)bleomycin A(2) bound to d(GAGCTC)(2) and d(GGAAGCTTCC)(2): structure-reactivity relationships of Co and Fe bleomycins. (Zhao C, Xia C, Mao Q, Försterling H, DeRose E, Antholine WE, Subczynski WK, Petering DH) J Inorg Biochem 2002 Jul 25;91(1):259-68 PMID: 12121784 07/18/2002       25 Citations
  • DNA-fiber EPR study of the orientation of Cu(II) complexes of 1,10-phenanthroline and its derivatives bound to DNA: mono(phenanthroline)-copper(II) and its ternary complexes with amino acids. (Chikira M, Tomizawa Y, Fukita D, Sugizaki T, Sugawara N, Yamazaki T, Sasano A, Shindo H, Palaniandavar M, Antholine WE) J Inorg Biochem 2002 Apr 28;89(3-4):163-73 PMID: 12062119 06/14/2002       133 Citations
  • Thiourea protects against copper-induced oxidative damage by formation of a redox-inactive thiourea-copper complex. (Zhu BZ, Antholine WE, Frei B) Free Radic Biol Med 2002 Jun 15;32(12):1333-8 PMID: 12057771 06/12/2002       41 Citations
  • Nature of the intermediate formed in the reduction of O(2) to H(2)O at the trinuclear copper cluster active site in native laccase. (Lee SK, George SD, Antholine WE, Hedman B, Hodgson KO, Solomon EI) J Am Chem Soc 2002 May 29;124(21):6180-93 PMID: 12022853 05/23/2002       229 Citations
  • Kinetics of reaction of DNA-bound Fe(III)bleomycin with ascorbate: interplay of specific and non-specific binding. (Li W, Antholine WE, Petering DH) J Inorg Biochem 2002 May 21;90(1-2):8-17 PMID: 12009250 05/16/2002       8 Citations
  • Role of the coordinating histidine in altering the mixed valency of Cu(A): an electron nuclear double resonance-electron paramagnetic resonance investigation. (Lukoyanov D, Berry SM, Lu Y, Antholine WE, Scholes CP) Biophys J 2002 May;82(5):2758-66 PMID: 11964261 PMCID: PMC1302063 04/20/2002       15 Citations
  • Molecular features of the copper binding sites in the octarepeat domain of the prion protein. (Burns CS, Aronoff-Spencer E, Dunham CM, Lario P, Avdievich NI, Antholine WE, Olmstead MM, Vrielink A, Gerfen GJ, Peisach J, Scott WG, Millhauser GL) Biochemistry 2002 Mar 26;41(12):3991-4001 PMID: 11900542 PMCID: PMC2905306 03/20/2002       339 Citations
  • Electronic structure description of the mu(4)-sulfide bridged tetranuclear Cu(Z) center in N(2)O reductase. (Chen P, DeBeer George S, Cabrito I, Antholine WE, Moura JJ, Moura I, Hedman B, Hodgson KO, Solomon EI) J Am Chem Soc 2002 Feb 06;124(5):744-5 PMID: 11817937 01/31/2002       60 Citations
  • Detection of a [3Fe-4S] cluster intermediate of cytosolic aconitase in yeast expressing iron regulatory protein 1. Insights into the mechanism of Fe-S cluster cycling. (Brown NM, Kennedy MC, Antholine WE, Eisenstein RS, Walden WE) J Biol Chem 2002 Mar 01;277(9):7246-54 PMID: 11744706 12/18/2001       51 Citations
  • Inhibition of malignant cell growth by 311, a novel iron chelator of the pyridoxal isonicotinoyl hydrazone class: effect on the R2 subunit of ribonucleotide reductase. (Green DA, Antholine WE, Wong SJ, Richardson DR, Chitambar CR) Clin Cancer Res 2001 Nov;7(11):3574-9 PMID: 11705879 11/14/2001       74 Citations
  • Model reactions of Cr (VI) with DNA mediated by thiol species. (Krepkiy D, Antholine WE, Myers C, Petering DH) Mol Cell Biochem 2001 Jun;222(1-2):213-9 PMID: 11678605 10/27/2001       11 Citations
  • Escherichia coli gamma-glutamylcysteine synthetase. Two active site metal ions affect substrate and inhibitor binding. (Kelly BS, Antholine WE, Griffith OW) J Biol Chem 2002 Jan 04;277(1):50-8 PMID: 11675389 10/25/2001       43 Citations
  • Interactions of iron bleomycin, phosphate or cyanide, and DNA: sequence-dependent conformations and reactions. (Li W, Xia C, Antholine WE, Petering DH) J Biol Inorg Chem 2001 Jun;6(5-6):618-27 PMID: 11472025 07/27/2001       6 Citations
  • Comparative binding properties of metallobleomycins with DNA 10-mers. (Li W, Zhao C, Xia C, Antholine WE, Petering DH) Biochemistry 2001 Jun 26;40(25):7559-68 PMID: 11412110 06/20/2001       14 Citations
  • Cytochrome b(5) plays a key role in human microsomal chromium(VI) reduction. (Jannetto PJ, Antholine WE, Myers CR) Toxicology 2001 Feb 28;159(3):119-33 PMID: 11223168 02/27/2001       15 Citations
  • Identification of the Cu2+ binding sites in the N-terminal domain of the prion protein by EPR and CD spectroscopy. (Aronoff-Spencer E, Burns CS, Avdievich NI, Gerfen GJ, Peisach J, Antholine WE, Ball HL, Cohen FE, Prusiner SB, Millhauser GL) Biochemistry 2000 Nov 14;39(45):13760-71 PMID: 11076515 PMCID: PMC2903970 11/15/2000       293 Citations
  • Identification of the structural subunits required for formation of the metal centers in subunit I of cytochrome c oxidase of Rhodobacter sphaeroides. (Bratton MR, Hiser L, Antholine WE, Hoganson C, Hosler JP) Biochemistry 2000 Oct 24;39(42):12989-95 PMID: 11041864 10/21/2000       29 Citations
  • Comparison of EPR-visible Cu(2+) sites in pMMO from Methylococcus capsulatus (Bath) and Methylomicrobium album BG8. (Lemos SS, Perille Collins ML, Eaton SS, Eaton GR, Antholine WE) Biophys J 2000 Aug;79(2):1085-94 PMID: 10920038 PMCID: PMC1301004 08/02/2000       30 Citations
  • How amino acids control the binding of Cu(II) ions to DNA. Part III. A novel interaction of a histidine complex with DNA. (Nagane R, Chikira M, Oumi M, Shindo H, Antholine WE) J Inorg Biochem 2000 Feb;78(3):243-9 PMID: 10805181 05/11/2000       36 Citations
  • Chromium(VI) reductase activity is associated with the cytoplasmic membrane of anaerobically grown Shewanella putrefaciens MR-1. (Myers CR, Carstens BP, Antholine WE, Myers JM) J Appl Microbiol 2000 Jan;88(1):98-106 PMID: 10735248 03/29/2000       191 Citations
  • Cellular adaptation to down-regulated iron transport into lymphoid leukaemic cells: effects on the expression of the gene for ribonucleotide reductase. (Chitambar CR, Wereley JP, Heiman T, Antholine WE, O'brien WJ) Biochem J 2000 Feb 01;345 Pt 3:681-5 PMID: 10642528 PMCID: PMC1220804 01/22/2000       10 Citations
  • Mechanism of superoxide dismutase/H(2)O(2)-mediated nitric oxide release from S-nitrosoglutathione--role of glutamate. (Singh RJ, Hogg N, Goss SP, Antholine WE, Kalyanaraman B) Arch Biochem Biophys 1999 Dec 01;372(1):8-15 PMID: 10562411 11/24/1999       27 Citations
  • Characterization of the adduct formed from the reaction between homocysteine thiolactone and low-density lipoprotein: antioxidant implications. (Ferguson E, Hogg N, Antholine WE, Joseph J, Singh RJ, Parthasarathy S, Kalyanaraman B) Free Radic Biol Med 1999 Apr;26(7-8):968-77 PMID: 10232841 05/08/1999       31 Citations
  • Type 2 Cu2+ in pMMO from Methylomicrobium album BG8. (Yuan H, Collins ML, Antholine WE) Biophys J 1999 Apr;76(4):2223-9 PMID: 10096917 PMCID: PMC1300195 03/30/1999       29 Citations
  • Concentration of Cu, EPR-detectable Cu, and formation of cupric-ferrocyanide in membranes with pMMO. (Yuan H, Collins ML, Antholine WE) J Inorg Biochem 1998 Dec;72(3-4):179-85 PMID: 10065536 03/05/1999       23 Citations
  • Complexation of type 2 copper by cytochrome c oxidase: probing of metal-specific binding sites by electron paramagnetic resonance. (Yuan H, Antholine WE, Kroneck PM) J Inorg Biochem 1998 Aug;71(1-2):99-107 PMID: 9755494 10/02/1998       9 Citations
  • An EPR investigation of the products of the reaction of cytosolic and mitochondrial aconitases with nitric oxide. (Kennedy MC, Antholine WE, Beinert H) J Biol Chem 1997 Aug 15;272(33):20340-7 PMID: 9252338 08/15/1997       198 Citations
  • Fe- and Co-bleomycins bound to site specific and nonspecific DNA decamers: comparative binding and reactivity of their metal centers. (Fulmer P, Zhao C, Li W, DeRose E, Antholine WE, Petering DH) Biochemistry 1997 Apr 08;36(14):4367-74 PMID: 9100034 04/08/1997       30 Citations
  • Interaction of nitrosyl Fe(II) complex of bleomycin with DNA. (Chikira M, Sakamoto K, Antholine WE) Nucleic Acids Symp Ser 1997(37):99-100 PMID: 9586018 01/01/1997    
  • Release of CuPTSM from human serum albumin after addition of fatty acids. (Yuan H, Antholine WE, Subczynski WK, Green MA) J Inorg Biochem 1996 Mar;61(4):251-9 PMID: 8867452 03/01/1996       21 Citations
  • Metal coordination environment and dynamics in 113cadmium bleomycin: relationship to zinc bleomycin. (Otvos JD, Antholine WE, Wehrli S, Petering DH) Biochemistry 1996 Feb 06;35(5):1458-65 PMID: 8634276 02/06/1996       23 Citations
  • Metallobleomycin-DNA interactions: structures and reactions related to bleomycin-induced DNA damage. (Petering DH, Mao Q, Li W, DeRose E, Antholine WE) Met Ions Biol Syst 1996;33:619-48 PMID: 8742858 01/01/1996       33 Citations
  • Electron spin-lattice relaxation of the [Cu(1.5) ... Cu(1.5)] dinuclear copper center in nitrous oxide reductase. (Pfenninger S, Antholine WE, Barr ME, Hyde JS, Kroneck PM, Zumft WG) Biophys J 1995 Dec;69(6):2761-9 PMID: 8599682 PMCID: PMC1236513 12/01/1995       22 Citations
  • An electron paramagnetic resonance method for quantification of copper isotopes in proteins: application to a mixed-isotope derivative of laccase. (Miller C, Fajardo J, Antholine WE, McMillin DR) Anal Biochem 1995 May 01;227(1):69-72 PMID: 7668393 05/01/1995    
  • Iron requirement for cellular DNA damage and growth inhibition by hydrogen peroxide and bleomycin. (Radtke K, Lornitzo FA, Byrnes RW, Antholine WE, Petering DH) Biochem J 1994 Sep 15;302 ( Pt 3):655-64 PMID: 7524474 PMCID: PMC1137281 09/15/1994       30 Citations
  • P. mevalonii 3-hydroxy-3-methylglutaryl-CoA lyase: electron paramagnetic resonance investigation of the copper binding site. (Narasimhan C, Antholine WE, Miziorko HM) Arch Biochem Biophys 1994 Aug 01;312(2):467-73 PMID: 7913596 08/01/1994       5 Citations
  • Metallothionein reacts with Fe2+ and NO to form products with A g = 2.039 ESR signal. (Kennedy MC, Gan T, Antholine WE, Petering DH) Biochem Biophys Res Commun 1993 Oct 29;196(2):632-5 PMID: 8240338 10/29/1993       50 Citations
  • Multiquantum EPR of the mixed valence copper site in nitrous oxide reductase. (Mchaourab HS, Pfenninger S, Antholine WE, Felix CC, Hyde JS, Kroneck PM) Biophys J 1993 May;64(5):1576-9 PMID: 8391869 PMCID: PMC1262484 05/01/1993       20 Citations
  • Low dietary iron prevents free radical formation and heart pathology of copper-deficient rats fed fructose. (Fields M, Lewis CG, Lure MD, Burns WA, Antholine WE) Proc Soc Exp Biol Med 1993 Feb;202(2):225-32 PMID: 8380928 02/01/1993       32 Citations
  • Low frequency EPR of Pseudomonas aeruginosa azurin. Analysis of ligand superhyperfine structure from a type 1 copper site. (Antholine WE, Hanna PM, McMillin DR) Biophys J 1993 Jan;64(1):267-72 PMID: 8381679 PMCID: PMC1262323 01/01/1993       18 Citations
  • Effect of gallium on the tyrosyl radical of the iron-dependent M2 subunit of ribonucleotide reductase. (Narasimhan J, Antholine WE, Chitambar CR) Biochem Pharmacol 1992 Dec 15;44(12):2403-8 PMID: 1335254 12/15/1992       79 Citations
  • Oxidation-reduction reactions in Ehrlich cells treated with copper-neocuproine. (Byrnes RW, Antholine WE, Petering DH) Free Radic Biol Med 1992 Nov;13(5):469-78 PMID: 1334027 11/01/1992       23 Citations
  • A comparative EPR investigation of the multicopper proteins nitrous-oxide reductase and cytochrome c oxidase. (Antholine WE, Kastrau DH, Steffens GC, Buse G, Zumft WG, Kroneck PM) Eur J Biochem 1992 Nov 01;209(3):875-81 PMID: 1330560 11/01/1992       167 Citations
  • The influence of gender on developing copper deficiency and on free radical generation of rats fed a fructose diet. (Fields M, Lewis CG, Lure M, Antholine WE) Metabolism 1992 Sep;41(9):989-94 PMID: 1325594 09/01/1992       39 Citations
  • Reaction of cyanide with cytochrome ba3 from Thermus thermophilus: spectroscopic characterization of the Fe(II)a3-CN.Cu(II)B-CN complex suggests four 14N atoms are coordinated to CuB. (Surerus KK, Oertling WA, Fan C, Gurbiel RJ, Einarsdóttir O, Antholine WE, Dyer RB, Hoffman BM, Woodruff WH, Fee JA) Proc Natl Acad Sci U S A 1992 Apr 15;89(8):3195-9 PMID: 1314380 PMCID: PMC48832 04/15/1992       47 Citations
  • Properties of redox-inactivated bleomycins. In vitro DNA damage and inhibition of Ehrlich cell proliferation. (Templin J, Berry L, Lyman S, Byrnes RW, Antholine WE, Petering DH) Biochem Pharmacol 1992 Feb 04;43(3):615-23 PMID: 1371685 02/04/1992       8 Citations
  • Reaction of DNA-bound Co(II)bleomycin with dioxygen. (Xu RX, Antholine WE, Petering DH) J Biol Chem 1992 Jan 15;267(2):950-5 PMID: 1370471 01/15/1992       25 Citations
  • Reaction of Co(II)bleomycin with dioxygen. (Xu RX, Antholine WE, Petering DH) J Biol Chem 1992 Jan 15;267(2):944-9 PMID: 1370470 01/15/1992       26 Citations
  • Interactions of 1,10-phenanthroline and its copper complex with Ehrlich cells. (Byrnes RW, Antholine WE, Petering DH) Free Radic Biol Med 1992;12(6):457-69 PMID: 1318248 01/01/1992       16 Citations
  • Inhibition of iron uptake in HL60 cells by 2-formylpyridine monothiosemicarbazonato Cu(II). (Narasimhan J, Antholine WE, Chitambar CR, Petering DH) Arch Biochem Biophys 1991 Sep;289(2):393-8 PMID: 1654860 09/01/1991       9 Citations
  • Orientation of non-blue cupric complexes on DNA fibers. (Chikira M, Sato T, Antholine WE, Petering DH) J Biol Chem 1991 Feb 15;266(5):2859-63 PMID: 1704368 02/15/1991       35 Citations
  • The severity of copper deficiency can be ameliorated by deferoxamine. (Fields M, Lewis CG, Lure MD, Burns WA, Antholine WE) Metabolism 1991 Jan;40(1):105-9 PMID: 1845818 01/01/1991       41 Citations
  • Spin-trapping studies of the oxidation-reduction reactions of iron bleomycin in the presence of thiols and buffer. (Antholine WE, Kalyanaraman B, Templin JA, Byrnes RW, Petering DH) Free Radic Biol Med 1991;10(2):119-23 PMID: 1707847 01/01/1991       21 Citations
  • Oxidation of low-density lipoprotein by Cu2+ and lipoxygenase: an electron spin resonance study. (Kalyanaraman B, Antholine WE, Parthasarathy S) Biochim Biophys Acta 1990 Sep 14;1035(3):286-92 PMID: 2169886 09/14/1990       41 Citations
  • Microimmiscibility and three-dimensional dynamic structures of phosphatidylcholine-cholesterol membranes: translational diffusion of a copper complex in the membrane. (Subczynski WK, Antholine WE, Hyde JS, Kusumi A) Biochemistry 1990 Aug 28;29(34):7936-45 PMID: 2261449 08/28/1990       63 Citations
  • Development of drug resistance to gallium nitrate through modulation of cellular iron uptake. (Chitambar CR, Zivkovic-Gilgenbach Z, Narasimhan J, Antholine WE) Cancer Res 1990 Aug 01;50(15):4468-72 PMID: 2164439 08/01/1990       26 Citations
  • Oxidative stress induced by a copper-thiosemicarbazone complex. (Byrnes RW, Mohan M, Antholine WE, Xu RX, Petering DH) Biochemistry 1990 Jul 31;29(30):7046-53 PMID: 2171640 07/31/1990       79 Citations
  • Multifrequency EPR evidence for a bimetallic center at the CuA site in cytochrome c oxidase. (Kroneck PM, Antholine WE, Kastrau DH, Buse G, Steffens GC, Zumft WG) FEBS Lett 1990 Jul 30;268(1):274-6 PMID: 2166686 07/30/1990       121 Citations
  • The copper site in nitrous oxide reductase. (Kroneck PM, Riester J, Zumft WG, Antholine WE) Biol Met 1990;3(2):103-9 PMID: 1965779 01/01/1990       26 Citations
  • The role of redox-active metals in the mechanism of action of bleomycin. (Petering DH, Byrnes RW, Antholine WE) Chem Biol Interact 1990;73(2-3):133-82 PMID: 1690086 01/01/1990       139 Citations
  • Orientation of dioxygen bound to cobalt(II) bleomycin-DNA fibers. (Chikira M, Antholine WE, Petering DH) J Biol Chem 1989 Dec 25;264(36):21478-80 PMID: 2480952 12/25/1989       20 Citations
  • Activity of bleomycin in iron- and copper-deficient cells. (Lyman S, Taylor P, Lornitzo F, Wier A, Stone D, Antholine WE, Petering DH) Biochem Pharmacol 1989 Dec 01;38(23):4273-82 PMID: 2480795 12/01/1989       12 Citations
  • ESR studies of the interaction of copper(II)GHK, histidine, and Ehrlich cells. (Antholine WE, Petering DH, Pickart L) J Inorg Biochem 1989 Mar;35(3):215-24 PMID: 2542448 03/01/1989       4 Citations
  • Inhibition of leukemic HL60 cell growth by transferrin-gallium: effects on ribonucleotide reductase and demonstration of drug synergy with hydroxyurea. (Chitambar CR, Matthaeus WG, Antholine WE, Graff K, O'Brien WJ) Blood 1988 Dec;72(6):1930-6 PMID: 3058232 12/01/1988       137 Citations
  • Type 2-depleted fungal laccase. (Hanna PM, McMillin DR, Pasenkiewicz-Gierula M, Antholine WE, Reinhammar B) Biochem J 1988 Jul 15;253(2):561-8 PMID: 2845923 PMCID: PMC1149334 07/15/1988       37 Citations
  • ESR studies of molecular interactions of copper(II) nirvanol and copper(II) diisopropylsalicylate with Ehrlich ascites tumor cells. (Pezeshk A, Antholine WE, Petering DH) J Inorg Biochem 1987 Dec;31(4):283-91 PMID: 2830367 12/01/1987       4 Citations
  • Adduct formation between the cupric site of phenylalanine hydroxylase from Chromobacterium violaceum and 6,7-dimethyltetrahydropterin. (Pember SO, Benkovic SJ, Villafranca JJ, Pasenkiewicz-Gierula M, Antholine WE) Biochemistry 1987 Jul 14;26(14):4477-83 PMID: 2822093 07/14/1987       26 Citations
  • Multi-frequency e.p.r. studies of a mercury-containing mixed-metal derivative of laccase. (Morie-Bebel MM, McMillin DR, Antholine WE) Biochem J 1986 Apr 15;235(2):415-20 PMID: 3017305 PMCID: PMC1146702 04/15/1986       26 Citations
  • ESR of copper and iron complexes with antitumor and cytotoxic properties. (Antholine WE, Kalyanaraman B, Petering DH) Environ Health Perspect 1985 Dec;64:19-35 PMID: 2420582 PMCID: PMC1568621 12/01/1985       44 Citations
  • Direct evidence of nitrogen coupling in the copper(II) complex of bovine serum albumin by S-band electron spin resonance technique. (Rakhit G, Antholine WE, Froncisz W, Hyde JS, Pilbrow JR, Sinclair GR, Sarkar B) J Inorg Biochem 1985 Nov;25(3):217-24 PMID: 2999331 11/01/1985       51 Citations
  • Interaction between bound cupric ion and spin-labeled cysteine beta-93 in human and horse hemoglobins. (Antholine WE, Taketa F, Wang JT, Manoharan PT, Rifkind JM) J Inorg Biochem 1985 Oct;25(2):95-108 PMID: 2997391 10/01/1985       13 Citations
  • Evidence that an iron-nickel-carbon complex is formed by reaction of CO with the CO dehydrogenase from Clostridium thermoaceticum. (Ragsdale SW, Wood HG, Antholine WE) Proc Natl Acad Sci U S A 1985 Oct;82(20):6811-4 PMID: 2995986 PMCID: PMC390777 10/01/1985       129 Citations
  • Free radicals from the photodecomposition of bleomycin. (Antholine WE, Sarna T, Sealy RC, Kalyanaraman B, Shields GD, Petering DH) Photochem Photobiol 1985 Apr;41(4):393-9 PMID: 2409563 04/01/1985       8 Citations
  • Structural, motional, and kinetic features of the Cu(II)-(L-His)2 complex in aqueous solution. (Valensin G, Basosi R, Antholine WE, Gaggelli E) J Inorg Biochem 1985 Feb;23(2):125-30 PMID: 3973584 02/01/1985       26 Citations
  • ESR parameters for cupric bleomycin in the mobilized state. (Antholine WE, Riedy G, Hyde JS, Basosi R, Petering DH) J Biomol Struct Dyn 1984 Oct;2(2):469-80 PMID: 6086067 10/01/1984       8 Citations
  • Interaction between low-affinity cupric ion and human methemoglobin. (Antholine WE, Basosi R, Hyde JS, Taketa F) J Inorg Biochem 1984 Jun;21(2):125-36 PMID: 6330294 06/01/1984       7 Citations
  • Structure of cupric bleomycin. Nitrogen and proton couplings from EPR and electron nuclear double resonance spectroscopy. (Antholine WE, Hyde JS, Sealy RC, Petering DH) J Biol Chem 1984 Apr 10;259(7):4437-40 PMID: 6200482 04/10/1984       21 Citations
  • Effects of 2-formylpyridine monothiosemicarbazonato copper II on red cell components. (Antholine WE, Taketa F) J Inorg Biochem 1984 Jan;20(1):69-78 PMID: 6229604 01/01/1984       27 Citations
  • The oxidation of cat, human, and the cat-human hybrid hemoglobins alpha 2 human beta 2 cat and alpha 2 cat beta 2 human by copper(II). (Taketa F, Antholine WE) J Inorg Biochem 1982 Oct;17(2):109-20 PMID: 7175522 10/01/1982       14 Citations
  • Studies on the chemical reactivity of copper bleomycin. (Antholine WE, Solaiman D, Saryan LA, Petering DH) J Inorg Biochem 1982 Oct;17(2):75-94 PMID: 6184448 10/01/1982       18 Citations
  • Interactions among iron(II) bleomycin, Lewis bases, and DNA. (Antholine WE, Petering DH, Saryan LA, Brown CE) Proc Natl Acad Sci U S A 1981 Dec;78(12):7517-20 PMID: 6174974 PMCID: PMC349299 12/01/1981       31 Citations
  • Combined modality of 2-formylpyridine monothiosemicarbazonato copper(II) and radiation. (Antholine WE, Gunn P, Hopwood LE) Int J Radiat Oncol Biol Phys 1981 Apr;7(4):491-5 PMID: 7251419 04/01/1981       25 Citations
  • Cytotoxic and antitumor properties of bleomycin and several of its metal complexes. (Rao EA, Saryan LA, Antholine WE, Petering DH) J Med Chem 1980 Dec;23(12):1310-8 PMID: 6161253 12/01/1980       59 Citations
  • Evidence that carnosine and anserine may participate in Wilson's disease. (Brown CE, Antholine WE) Biochem Biophys Res Commun 1980 Jan 29;92(2):470-7 PMID: 6243942 01/29/1980       13 Citations
  • Reaction of FeBlm with DNA: Fe(II)Blm-NO. (Antholine WE, Petering DH) Biochem Biophys Res Commun 1979 Nov 28;91(2):528-33 PMID: 92990 11/28/1979       22 Citations
  • On the reaction of iron bleomycin with thiols and oxygen. (Antholine WE, Petering DH) Biochem Biophys Res Commun 1979 Sep 12;90(1):384-9 PMID: 91373 09/12/1979       30 Citations
  • Chemical, biochemical, and cellular properties of copper and iron bleomycins. (Solaiman D, Rao EA, Petering DH, Sealy RC, Antholine WE) Int J Radiat Oncol Biol Phys 1979 Sep;5(9):1519-21 PMID: 94054 09/01/1979       18 Citations
  • Multiple forms of the cobalt(II)-carnosine complex. (Brown CE, Antholine WE) Biochem Biophys Res Commun 1979 May 28;88(2):529-36 PMID: 465053 05/28/1979       18 Citations
  • Paramagnetic changes during development of DMBA-induced mammary tumours in Sprague-Dawley rats. (Swartz HM, Antholine WE, Reichling BA) Phys Med Biol 1979 Mar;24(2):416-25 PMID: 221946 03/01/1979    
  • Chain nonequivalence in binding of nitric oxide to hemoglobin. (Taketa F, Antholine WE, Chen JY) J Biol Chem 1978 Aug 10;253(15):5448-51 PMID: 209042 08/10/1978       36 Citations
  • Inhibition of tumor cell transplantability by iron and copper complexes of 5-substituted 2-formylpyridine thiosemicarbazones. (Antholine WE, Knight JM, Petering DH) J Med Chem 1976 Feb;19(2):339-41 PMID: 1249818 02/01/1976       106 Citations
  • Nitrosylhemoglobin Wood: effects of inositol hexaphosphate on thiol reactivity and electron paramagnetic resonance spectrum. (Taketa F, Antholine WE, Mauk AG, Libnoch JA) Biochemistry 1975 Jul 15;14(14):3229-33 PMID: 238586 07/15/1975       25 Citations
  • Paramagnetic changes during development of a transplanted AKR-J leukemia in mice as measured by electron spin resonance. (Swartz HM, Mailer C, Ambegaonkar S, Antholine WE, McNellis DR, Schneller SJ) Cancer Res 1973 Nov;33(11):2588-95 PMID: 4355973 11/01/1973       13 Citations
  • Electron spin resonance spectra of feline NO-hemoglobins. (Antholine WE, Mauk AG, Swartz HM, Taketa F) FEBS Lett 1973 Oct 15;36(2):199-202 PMID: 4356789 10/15/1973       11 Citations
  • Last update: 11/19/2018
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