Medical College of Wisconsin
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Yan Lu PhD

Yan Lu PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Physiology
Program: Cancer Center


Publications

  • Concordant effects of aromatase inhibitors on gene expression in ER+ Rat and human mammary cancers and modulation of the proteins coded by these genes. (Lu Y, You M, Ghazoui Z, Liu P, Vedell PT, Wen W, Bode AM, Grubbs CJ, Lubet RA) Cancer Prev Res (Phila) 2013 Nov;6(11):1151-61 PMID 24067424
  • Effects on gene expression in rat liver after administration of RXR agonists: UAB30, 4-methyl-UAB30, and Targretin (Bexarotene). (Vedell PT, Lu Y, Grubbs CJ, Yin Y, Jiang H, Bland KI, Muccio DD, Cvetkovic D, You M, Lubet R) Mol Pharmacol 2013 Mar;83(3):698-708 PMID 23292798
  • Identification of somatic mutations in non-small cell lung carcinomas using whole-exome sequencing. (Liu P, Morrison C, Wang L, Xiong D, Vedell P, Cui P, Hua X, Ding F, Lu Y, James M, Ebben JD, Xu H, Adjei AA, Head K, Andrae JW, Tschannen MR, Jacob H, Pan J, Zhang Q, Van den Bergh F, Xiao H, Lo KC, Patel J, Richmond T, Watt MA, Albert T, Selzer R, Anderson M, Wang J, Wang Y, Starnes S, Yang P, You M) Carcinogenesis 2012 Jul;33(7):1270-6 PMID 22510280
  • MicroRNA profiling and prediction of recurrence/relapse-free survival in stage I lung cancer. (Lu Y, Govindan R, Wang L, Liu PY, Goodgame B, Wen W, Sezhiyan A, Pfeifer J, Li YF, Hua X, Wang Y, Yang P, You M) Carcinogenesis 2012 May;33(5):1046-54 PMID 22331473
  • Gene-expression signature predicts postoperative recurrence in stage I non-small cell lung cancer patients. (Lu Y, Wang L, Liu P, Yang P, You M) PLoS One 2012;7(1):e30880 PMID 22292069
  • Genome-wide association and fine mapping of genetic loci predisposing to colon carcinogenesis in mice. (Liu P, Lu Y, Liu H, Wen W, Jia D, Wang Y, You M) Mol Cancer Res 2012 Jan;10(1):66-74 PMID 22127497
  • Modulation of gene expression and cell-cycle signaling pathways by the EGFR inhibitor gefitinib (Iressa) in rat urinary bladder cancer. (Lu Y, Liu P, Van den Bergh F, Zellmer V, James M, Wen W, Grubbs CJ, Lubet RA, You M) Cancer Prev Res (Phila) 2012 Feb;5(2):248-59 PMID 21982874
  • A bootstrap-based regression method for comprehensive discovery of differential gene expressions: an application to the osteoporosis study. (Lu Y, Liu YZ, Liu PY, Dvornyk V, Deng HW) Eur J Med Genet 2011 Nov-Dec;54(6):e560-4 PMID 21843665
  • Chemoprevention of lung carcinogenesis by the combination of aerosolized budesonide and oral pioglitazone in A/J mice. (Fu H, Zhang J, Pan J, Zhang Q, Lu Y, Wen W, Lubet RA, Szabo E, Chen R, Wang Y, Chen DR, You M) Mol Carcinog 2011 Dec;50(12):913-21 PMID 21374736
  • Efficacy of the EGFr inhibitor Iressa on development of chemically-induced urinary bladder cancers: dose dependency and modulation of biomarkers. (Lubet RA, Lu Y, Bode AM, You M, Verney ZM, Steele VE, Townsend R, Juliana MM, Grubbs CJ) Oncol Rep 2011 May;25(5):1389-97 PMID 21369704
  • Cross-species comparison of orthologous gene expression in human bladder cancer and carcinogen-induced rodent models. (Lu Y, Liu P, Wen W, Grubbs CJ, Townsend RR, Malone JP, Lubet RA, You M) Am J Transl Res 2010;3(1):8-27 PMID 21139803
  • Chemopreventive effects of pioglitazone on chemically induced lung carcinogenesis in mice. (Wang Y, James M, Wen W, Lu Y, Szabo E, Lubet RA, You M) Mol Cancer Ther 2010 Nov;9(11):3074-82 PMID 21045137
  • TNFRSF11A and TNFSF11 are associated with age at menarche and natural menopause in white women. (Lu Y, Liu P, Recker RR, Deng HW, Dvornyk V) Menopause 2010 Sep-Oct;17(5):1048-54 PMID 20531232
  • A second genetic variant on chromosome 15q24-25.1 associates with lung cancer. (Liu P, Yang P, Wu X, Vikis HG, Lu Y, Wang Y, Schwartz AG, Pinney SM, de Andrade M, Gazdar A, Gaba C, Mandal D, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Spitz M, Amos CI, Anderson MW, You M) Cancer Res 2010 Apr 15;70(8):3128-35 PMID 20395203
  • Cumulative effect of multiple loci on genetic susceptibility to familial lung cancer. (Liu P, Vikis HG, Lu Y, Wang Y, Schwartz AG, Pinney SM, Yang P, de Andrade M, Gazdar A, Gaba C, Mandal D, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Amos CI, Anderson MW, You M) Cancer Epidemiol Biomarkers Prev 2010 Feb;19(2):517-24 PMID 20142248
  • ALOX12 gene is associated with the onset of natural menopause in white women. (Liu P, Lu Y, Recker RR, Deng HW, Dvornyk V) Menopause 2010 Jan-Feb;17(1):152-6 PMID 20061896
  • Identification of Las2, a major modifier gene affecting the Pas1 mouse lung tumor susceptibility locus. (Liu PY, Vikis H, James M, Lu Y, Wang DL, Liu HB, Wen WD, Wang Y, You M) Cancer Res 2009 Aug 1;69(15):6290-8 PMID 19622765
  • Association analyses suggest multiple interaction effects of the methylenetetrahydrofolate reductase polymorphisms on timing of menarche and natural menopause in white women. (Liu P, Lu Y, Recker RR, Deng HW, Dvornyk V) Menopause 2010 Jan-Feb;17(1):185-90 PMID 19593234
  • Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5. (Wang JC, Cruchaga C, Saccone NL, Bertelsen S, Liu P, Budde JP, Duan W, Fox L, Grucza RA, Kern J, Mayo K, Reyes O, Rice J, Saccone SF, Spiegel N, Steinbach JH, Stitzel JA, Anderson MW, You M, Stevens VL, Bierut LJ, Goate AM, COGEND collaborators and GELCC collaborators) Hum Mol Genet 2009 Aug 15;18(16):3125-35 PMID 19443489
  • Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene. (You M, Wang D, Liu P, Vikis H, James M, Lu Y, Wang Y, Wang M, Chen Q, Jia D, Liu Y, Wen W, Yang P, Sun Z, Pinney SM, Zheng W, Shu XO, Long J, Gao YT, Xiang YB, Chow WH, Rothman N, Petersen GM, de Andrade M, Wu Y, Cunningham JM, Wiest JS, Fain PR, Schwartz AG, Girard L, Gazdar A, Gaba C, Rothschild H, Mandal D, Coons T, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Amos CI, Anderson MW) Clin Cancer Res 2009 Apr 15;15(8):2666-74 PMID 19351763
  • RGS17, an overexpressed gene in human lung and prostate cancer, induces tumor cell proliferation through the cyclic AMP-PKA-CREB pathway. (James MA, Lu Y, Liu Y, Vikis HG, You M) Cancer Res 2009 Mar 1;69(5):2108-16 PMID 19244110
  • Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. (Liu P, Vikis HG, Wang D, Lu Y, Wang Y, Schwartz AG, Pinney SM, Yang P, de Andrade M, Petersen GM, Wiest JS, Fain PR, Gazdar A, Gaba C, Rothschild H, Mandal D, Coons T, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Wu X, Spitz MR, Eisen T, Houlston RS, Amos CI, Anderson MW, You M) J Natl Cancer Inst 2008 Sep 17;100(18):1326-30 PMID 18780872
  • Enhanced susceptibility to chemical induction of ovarian tumors in mice with a germ line p53 mutation. (Wang Y, Zhang Z, Lu Y, Yao R, Jia D, Wen W, LaRegina M, Crist K, Lubet R, You M) Mol Cancer Res 2008 Jan;6(1):99-109 PMID 18234966
  • Effect of menopause on gene expression profiles of circulating monocytes: a pilot in vivo microarray study. (Dvornyk V, Liu Y, Lu Y, Shen H, Lappe JM, Lei S, Recker RR, Deng H) J Genet Genomics 2007 Nov;34(11):974-83 PMID 18037134
  • Common human cancer genes discovered by integrated gene-expression analysis. (Lu Y, Yi Y, Liu P, Wen W, James M, Wang D, You M) PLoS One 2007;2(11):e1149 PMID 17989776
  • Large-scale in silico mapping of complex quantitative traits in inbred mice. (Liu P, Vikis H, Lu Y, Wang D, You M) PLoS One 2007;2(7):e651 PMID 17653278
  • A gene expression signature predicts survival of patients with stage I non-small cell lung cancer. (Lu Y, Lemon W, Liu PY, Yi Y, Morrison C, Yang P, Sun Z, Szoke J, Gerald WL, Watson M, Govindan R, You M) PLoS Med 2006 Dec;3(12):e467 PMID 17194181
  • Effect of an epidermal growth factor receptor inhibitor in mouse models of lung cancer. (Yan Y, Lu Y, Wang M, Vikis H, Yao R, Wang Y, Lubet RA, You M) Mol Cancer Res 2006 Dec;4(12):971-81 PMID 17189387
  • Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice. (Liu P, Wang Y, Vikis H, Maciag A, Wang D, Lu Y, Liu Y, You M) Nat Genet 2006 Aug;38(8):888-95 PMID 16862160
  • Accurate haplotype inference for multiple linked single-nucleotide polymorphisms using sibship data. (Liu PY, Lu Y, Deng HW) Genetics 2006 Sep;174(1):499-509 PMID 16783022
  • A gene expression signature that can predict green tea exposure and chemopreventive efficacy of lung cancer in mice. (Lu Y, Yao R, Yan Y, Wang Y, Hara Y, Lubet RA, You M) Cancer Res 2006 Feb 15;66(4):1956-63 PMID 16488994
  • Impacts of QTL x environment interactions on genetic response to marker-assisted selection. (Liu PY, Zhu J, Yan L) Yi Chuan Xue Bao 2006 Jan;33(1):63-71 PMID 16450589
  • Efficacy of the farnesyltransferase inhibitor R115777 in a rat mammary tumor model: role of Ha-ras mutations and use of microarray analysis in identifying potential targets. (Yao R, Wang Y, Lu Y, Lemon WJ, End DW, Grubbs CJ, Lubet RA, You M) Carcinogenesis 2006 Jul;27(7):1420-31 PMID 16403772
  • Tests of linkage and association of PTH/PTHrP receptor type 1 gene with bone mineral density and height in Caucasians. (Zhang YY, Liu PY, Lu Y, Xiao P, Liu YJ, Long JR, Shen H, Zhao LJ, Elze L, Recker RR, Deng HW) J Bone Miner Metab 2006;24(1):36-41 PMID 16369896
  • Race and sex differences and contribution of height: a study on bone size in healthy Caucasians and Chinese. (Zhang YY, Liu PY, Lu Y, Davies KM, Dvornyk V, Recker RR, Deng HW) Am J Hum Biol 2005 Sep-Oct;17(5):568-75 PMID 16136538
  • A novel pathophysiological mechanism for osteoporosis suggested by an in vivo gene expression study of circulating monocytes. (Liu YZ, Dvornyk V, Lu Y, Shen H, Lappe JM, Recker RR, Deng HW) J Biol Chem 2005 Aug 12;280(32):29011-6 PMID 15965235
  • Association tests of interleukin-6 (IL-6) and type II tumor necrosis factor receptor (TNFR2) genes with bone mineral density in Caucasians using a re-sampling approach. (Xiao P, Liu PY, Lu Y, Guo YF, Xiong DH, Li LH, Recker RR, Deng HW) Hum Genet 2005 Aug;117(4):340-8 PMID 15906094
  • Hotelling's T2 multivariate profiling for detecting differential expression in microarrays. (Lu Y, Liu PY, Xiao P, Deng HW) Bioinformatics 2005 Jul 15;21(14):3105-13 PMID 15905280
  • Linkage and association analyses of the UCP3 gene with obesity phenotypes in Caucasian families. (Liu YJ, Liu PY, Long J, Lu Y, Elze L, Recker RR, Deng HW) Physiol Genomics 2005 Jul 14;22(2):197-203 PMID 15870396
  • A two-step strategy for detecting differential gene expression in cDNA microarray data. (Lu Y, Zhu J, Liu P) Curr Genet 2005 Feb;47(2):121-31 PMID 15688252
  • APOE haplotypes influence bone mineral density in Caucasian males but not females. (Long JR, Liu PY, Liu YJ, Lu Y, Shen H, Zhao LJ, Xiong DH, Deng HW) Calcif Tissue Int 2004 Oct;75(4):299-304 PMID 15549644
  • Quantifying the relationship between gene expressions and trait values in general pedigrees. (Lu Y, Liu PY, Liu YJ, Xu FH, Deng HW) Genetics 2004 Dec;168(4):2395-405 PMID 15371358
  • Test of linkage and/or association between the estrogen receptor alpha gene with bone mineral density in Caucasian nuclear families. (Zhao LJ, Liu PY, Long JR, Lu Y, Xu FH, Zhang YY, Shen H, Xiao P, Elze L, Recker RR, Deng HW) Bone 2004 Aug;35(2):395-402 PMID 15268889
  • Tests of linkage and/or association of TGF-beta1 and COL1A1 genes with bone mass. (Long JR, Liu PY, Lu Y, Dvornyk V, Xiong DH, Zhao LJ, Deng HW) Osteoporos Int 2005 Jan;16(1):86-92 PMID 15164160
  • Patterns of linkage disequilibrium and haplotype distribution in disease candidate genes. (Long JR, Zhao LJ, Liu PY, Lu Y, Dvornyk V, Shen H, Liu YJ, Zhang YY, Xiong DH, Xiao P, Deng HW) BMC Genet 2004 May 24;5:11 PMID 15157284
  • Marker-assisted selection in segregating generations of self-fertilizing crops. (Liu P, Zhu J, Lu Y) Theor Appl Genet 2004 Jul;109(2):370-6 PMID 15069599
  • Tests of linkage and/or association of the LEPR gene polymorphisms with obesity phenotypes in Caucasian nuclear families. (Liu YJ, Rocha-Sanchez SM, Liu PY, Long JR, Lu Y, Elze L, Recker RR, Deng HW) Physiol Genomics 2004 Apr 13;17(2):101-6 PMID 14970363
  • Association between COL1A1 gene polymorphisms and bone size in Caucasians. (Long JR, Liu PY, Lu Y, Xiong DH, Zhao LJ, Zhang YY, Elze L, Recker RR, Deng HW) Eur J Hum Genet 2004 May;12(5):383-8 PMID 14722584
  • A method for marker-assisted selection based on QTLs with epistatic effects. (Liu P, Zhu J, Lou X, Lu Y) Genetica 2003 Sep;119(1):75-86 PMID 12903749
  • Grants and Awards

  • The Molecular Mechanisms of Dock9 Underlying Lung Carcinogenesis (#9207918 01/01/2013 - 12/31/2014) Sponsor: National Lung Cancer Partnership
  • The Role of Hypoxia-induced Micronas in Lung Tumor Metastasis (#9305945 01/01/2013 - 12/31/2013) Sponsor: Research Affairs Committee
  • Cancer Center Chemoprevention Program (#9520180 11/01/2010 - 10/31/2016) PI of AHW Chemoprevention Program Recruitment of Yan Lu, PhD. (#5520186)