Medical College of Wisconsin
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Yi-Wen Huang PhD

Yi-Wen Huang PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Obstetrics and Gynecology
Division: Administration
Program: Obstetrics and Gynecology

Member of the Cancer Center


  • Black raspberries suppress colonic adenoma development in ApcMin/+ mice: relation to metabolite profiles. (Pan P, Skaer CW, Wang HT, Stirdivant SM, Young MR, Oshima K, Stoner GD, Lechner JF, Huang YW, Wang LS) Carcinogenesis 2015 Oct;36(10):1245-53 PMID: 26246425 08/08/2015
  • Specific combinations of the chromatin-modifying enzyme modulators significantly attenuate glioblastoma cell proliferation and viability while exerting minimal effect on normal adult stem cells growth. (Alexanian AR, Huang YW) Tumour Biol 2015 Jun 19: PMID: 26084611 06/19/2015
  • Beneficial Regulation of Metabolic Profiles by Black Raspberries in Human Colorectal Cancer Patients. (Pan P, Skaer CW, Stirdivant SM, Young MR, Stoner GD, Lechner JF, Huang YW, Wang LS) Cancer Prev Res (Phila) 2015 Aug;8(8):743-50 PMID: 26054356 PMCID: PMC4527938 06/10/2015
  • Genome-wide DNA methylation analysis reveals estrogen-mediated epigenetic repression of metallothionein-1 gene cluster in breast cancer. (Jadhav RR, Ye Z, Huang RL, Liu J, Hsu PY, Huang YW, Rangel LB, Lai HC, Roa JC, Kirma NB, Huang TH, Jin VX) Clin Epigenetics 2015;7(1):13 PMID: 25763113 PMCID: PMC4355986 03/13/2015
  • Chemoprevention of esophageal cancer with black raspberries, their component anthocyanins, and a major anthocyanin metabolite, protocatechuic acid. (Peiffer DS, Zimmerman NP, Wang LS, Ransom BW, Carmella SG, Kuo CT, Siddiqui J, Chen JH, Oshima K, Huang YW, Hecht SS, Stoner GD) Cancer Prev Res (Phila) 2014 Jun;7(6):574-84 PMID: 24667581 03/29/2014
  • Detection of DNA methylation by MeDIP and MBDCap assays: an overview of techniques. (Hsu HK, Weng YI, Hsu PY, Huang TH, Huang YW) Methods Mol Biol 2014;1105:61-70 PMID: 24623219 03/14/2014
  • Hypermethylation of miR-203 in endometrial carcinomas. (Huang YW, Kuo CT, Chen JH, Goodfellow PJ, Huang TH, Rader JS, Uyar DS) Gynecol Oncol 2014 May;133(2):340-5 PMID: 24530564 PMCID: PMC4015135 02/18/2014
  • Black raspberries protectively regulate methylation of Wnt pathway genes in precancerous colon tissue. (Wang LS, Kuo CT, Huang TH, Yearsley M, Oshima K, Stoner GD, Yu J, Lechner JF, Huang YW) Cancer Prev Res (Phila) 2013 Dec;6(12):1317-27 PMID: 24129635 PMCID: PMC3902171 10/17/2013
  • Promoter hypomethylation of EpCAM-regulated bone morphogenetic protein gene family in recurrent endometrial cancer. (Hsu YT, Gu F, Huang YW, Liu J, Ruan J, Huang RL, Wang CM, Chen CL, Jadhav RR, Lai HC, Mutch DG, Goodfellow PJ, Thompson IM, Kirma NB, Huang TH) Clin Cancer Res 2013 Nov 15;19(22):6272-85 PMID: 24077349 PMCID: PMC4080631 10/01/2013
  • Dietary black raspberries modulate DNA methylation in dextran sodium sulfate (DSS)-induced ulcerative colitis. (Wang LS, Kuo CT, Stoner K, Yearsley M, Oshima K, Yu J, Huang TH, Rosenberg D, Peiffer D, Stoner G, Huang YW) Carcinogenesis 2013 Dec;34(12):2842-50 PMID: 24067901 PMCID: PMC3845896 09/27/2013
  • Black raspberry-derived anthocyanins demethylate tumor suppressor genes through the inhibition of DNMT1 and DNMT3B in colon cancer cells. (Wang LS, Kuo CT, Cho SJ, Seguin C, Siddiqui J, Stoner K, Weng YI, Huang TH, Tichelaar J, Yearsley M, Stoner GD, Huang YW) Nutr Cancer 2013;65(1):118-25 PMID: 23368921 PMCID: PMC3570951 02/02/2013
  • CpG island shore methylation regulates caveolin-1 expression in breast cancer. (Rao X, Evans J, Chae H, Pilrose J, Kim S, Yan P, Huang RL, Lai HC, Lin H, Liu Y, Miller D, Rhee JK, Huang YW, Gu F, Gray JW, Huang TM, Nephew KP) Oncogene 2013 Sep 19;32(38):4519-28 PMID: 23128390 PMCID: PMC3787796 11/07/2012
  • Canonical and atypical E2Fs regulate the mammalian endocycle. (Chen HZ, Ouseph MM, Li J, Pécot T, Chokshi V, Kent L, Bae S, Byrne M, Duran C, Comstock G, Trikha P, Mair M, Senapati S, Martin CK, Gandhi S, Wilson N, Liu B, Huang YW, Thompson JC, Raman S, Singh S, Leone M, Machiraju R, Huang K, Mo X, Fernandez S, Kalaszczynska I, Wolgemuth DJ, Sicinski P, Huang T, Jin V, Leone G) Nat Cell Biol 2012 Nov;14(11):1192-202 PMID: 23064266 PMCID: PMC3616487 10/16/2012
  • Downregulation of the tumor-suppressor miR-16 via progestin-mediated oncogenic signaling contributes to breast cancer development. (Rivas MA, Venturutti L, Huang YW, Schillaci R, Huang TH, Elizalde PV) Breast Cancer Res 2012;14(3):R77 PMID: 22583478 PMCID: PMC3446340 05/16/2012
  • Gene-Diet Interactions on Colorectal Cancer Risk. (Wang LS, Kuo CT, Huang YW, Stoner GD, Lechner JF) Curr Nutr Rep 2012;1:132-141 PMID: 24392268 PMCID: PMC3873016 01/01/2012
  • Aberrant TGFβ/SMAD4 signaling contributes to epigenetic silencing of a putative tumor suppressor, RunX1T1 in ovarian cancer. (Yeh KT, Chen TH, Yang HW, Chou JL, Chen LY, Yeh CM, Chen YH, Lin RI, Su HY, Chen GC, Deatherage DE, Huang YW, Yan PS, Lin HJ, Nephew KP, Huang TH, Lai HC, Chan MW) Epigenetics 2011 Jun;6(6):727-39 PMID: 21540640 PMCID: PMC3359493 05/05/2011
  • Comparing multiple ChIP-sequencing experiments. (Ozer HG, Huang YW, Wu J, Parvin JD, Huang TH, Huang K) J Bioinform Comput Biol 2011 Apr;9(2):269-82 PMID: 21523932 PMCID: PMC4289603 04/28/2011
  • Differential contributory roles of nucleotide excision and homologous recombination repair for enhancing cisplatin sensitivity in human ovarian cancer cells. (Wang QE, Milum K, Han C, Huang YW, Wani G, Thomale J, Wani AA) Mol Cancer 2011;10:24 PMID: 21385444 PMCID: PMC3064653 03/10/2011
  • Identifying hypermethylated CpG islands using a quantile regression model. (Sun S, Chen Z, Yan PS, Huang YW, Huang TH, Lin S) BMC Bioinformatics 2011;12:54 PMID: 21324121 PMCID: PMC3051900 02/18/2011
  • Epigenetic silencing mediated through activated PI3K/AKT signaling in breast cancer. (Zuo T, Liu TM, Lan X, Weng YI, Shen R, Gu F, Huang YW, Liyanarachchi S, Deatherage DE, Hsu PY, Taslim C, Ramaswamy B, Shapiro CL, Lin HJ, Cheng AS, Jin VX, Huang TH) Cancer Res 2011 Mar 1;71(5):1752-62 PMID: 21216892 PMCID: PMC3048165 01/11/2011
  • Modulation of genetic and epigenetic biomarkers of colorectal cancer in humans by black raspberries: a phase I pilot study. (Wang LS, Arnold M, Huang YW, Sardo C, Seguin C, Martin E, Huang TH, Riedl K, Schwartz S, Frankel W, Pearl D, Xu Y, Winston J 3rd, Yang GY, Stoner G) Clin Cancer Res 2011 Feb 1;17(3):598-610 PMID: 21123457 PMCID: PMC3076314 12/03/2010
  • RNA polymerase II binding patterns reveal genomic regions involved in microRNA gene regulation. (Wang G, Wang Y, Shen C, Huang YW, Huang K, Huang TH, Nephew KP, Li L, Liu Y) PLoS One 2010;5(11):e13798 PMID: 21072189 PMCID: PMC2970572 11/13/2010
  • An overview of epigenetics and chemoprevention. (Huang YW, Kuo CT, Stoner K, Huang TH, Wang LS) FEBS Lett 2011 Jul 7;585(13):2129-36 PMID: 21056563 PMCID: PMC3071863 11/09/2010
  • Epigenetic influences of low-dose bisphenol A in primary human breast epithelial cells. (Weng YI, Hsu PY, Liyanarachchi S, Liu J, Deatherage DE, Huang YW, Zuo T, Rodriguez B, Lin CH, Cheng AL, Huang TH) Toxicol Appl Pharmacol 2010 Oct 15;248(2):111-21 PMID: 20678512 PMCID: PMC2946518 08/04/2010
  • Function and regulatory mechanisms of the candidate tumor suppressor receptor protein tyrosine phosphatase gamma (PTPRG) in breast cancer cells. (Shu ST, Sugimoto Y, Liu S, Chang HL, Ye W, Wang LS, Huang YW, Yan P, Lin YC) Anticancer Res 2010 Jun;30(6):1937-46 PMID: 20651337 07/24/2010
  • Induction of apoptosis by (-)-gossypol-enriched cottonseed oil in human breast cancer cells. (Ye W, Chang HL, Wang LS, Huang YW, Shu S, Sugimoto Y, Dowd MK, Wan PJ, Lin YC) Int J Mol Med 2010 Jul;26(1):113-9 PMID: 20514430 06/02/2010
  • Profiling DNA methylomes from microarray to genome-scale sequencing. (Huang YW, Huang TH, Wang LS) Technol Cancer Res Treat 2010 Apr;9(2):139-47 PMID: 20218736 PMCID: PMC3011833 03/12/2010
  • Promoter hypermethylation of CIDEA, HAAO and RXFP3 associated with microsatellite instability in endometrial carcinomas. (Huang YW, Luo J, Weng YI, Mutch DG, Goodfellow PJ, Miller DS, Huang TH) Gynecol Oncol 2010 May;117(2):239-47 PMID: 20211485 PMCID: PMC2849881 03/10/2010
  • Promoter hypermethylation of FBXO32, a novel TGF-beta/SMAD4 target gene and tumor suppressor, is associated with poor prognosis in human ovarian cancer. (Chou JL, Su HY, Chen LY, Liao YP, Hartman-Frey C, Lai YH, Yang HW, Deatherage DE, Kuo CT, Huang YW, Yan PS, Hsiao SH, Tai CK, Lin HJ, Davuluri RV, Chao TK, Nephew KP, Huang TH, Lai HC, Chan MW) Lab Invest 2010 Mar;90(3):414-25 PMID: 20065949 PMCID: PMC2829100 01/13/2010
  • Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 oncogene in endometrial cancer. (Huang YW, Liu JC, Deatherage DE, Luo J, Mutch DG, Goodfellow PJ, Miller DS, Huang TH) Cancer Res 2009 Dec 1;69(23):9038-46 PMID: 19887623 PMCID: PMC2789184 11/06/2009
  • Identification of candidate epigenetic biomarkers for ovarian cancer detection. (Huang YW, Jansen RA, Fabbri E, Potter D, Liyanarachchi S, Chan MW, Liu JC, Crijns AP, Brown R, Nephew KP, van der Zee AG, Cohn DE, Yan PS, Huang TH, Lin HJ) Oncol Rep 2009 Oct;22(4):853-61 PMID: 19724865 PMCID: PMC2829240 09/03/2009
  • Keratinocyte growth factor (KGF) regulates estrogen receptor-alpha (ER-alpha) expression and cell apoptosis via phosphatidylinositol 3-kinase (PI3K)/Akt pathway in human breast cancer cells. (Chang HL, Sugimoto Y, Liu S, Wang LS, Huang YW, Ye W, Lin YC) Anticancer Res 2009 Aug;29(8):3195-205 PMID: 19661335 08/08/2009
  • (-)-Gossypol reduces invasiveness in metastatic prostate cancer cells. (Huang YW, Wang LS, Dowd MK, Wan PJ, Lin YC) Anticancer Res 2009 Jun;29(6):2179-88 PMID: 19528479 06/17/2009
  • Aberrant transforming growth factor beta1 signaling and SMAD4 nuclear translocation confer epigenetic repression of ADAM19 in ovarian cancer. (Chan MW, Huang YW, Hartman-Frey C, Kuo CT, Deatherage D, Qin H, Cheng AS, Yan PS, Davuluri RV, Huang TH, Nephew KP, Lin HJ) Neoplasia 2008 Sep;10(9):908-19 PMID: 18714391 PMCID: PMC2517635 08/21/2008
  • Conjugated linoleic acid induces apoptosis through estrogen receptor alpha in human breast tissue. (Wang LS, Huang YW, Liu S, Yan P, Lin YC) BMC Cancer 2008;8:208 PMID: 18652667 PMCID: PMC2517598 07/26/2008
  • Primary cultured human breast epithelial cells up-regulate protein disulfide isomerase in response to zeranol. (Updike MS, Sawdy JC, Wang LS, Liu S, Huang YW, Ye W, Farrar WB, Lin YC, Wick M) Anticancer Res 2007 Jan-Feb;27(1A):407-10 PMID: 17352260 03/14/2007
  • Modulation of multidrug resistance gene expression in human breast cancer cells by (-)-gossypol-enriched cottonseed oil. (Ye W, Chang HL, Wang LS, Huang YW, Shu S, Dowd MK, Wan PJ, Sugimoto Y, Lin YC) Anticancer Res 2007 Jan-Feb;27(1A):107-16 PMID: 17352222 03/14/2007
  • Effects of serum on (-)-gossypol-suppressed growth in human prostate cancer cells. (Huang YW, Wang LS, Chang HL, Ye W, Sugimoto Y, Dowd MK, Wan PJ, Lin YC) Anticancer Res 2006 Sep-Oct;26(5A):3613-20 PMID: 17094491 11/11/2006
  • Effect of keratinocyte growth factor on cell viability in primary cultured human prostate cancer stromal cells. (Huang YW, Wang LS, Chang HL, Ye W, Shu S, Sugimoto Y, Lin YC) J Steroid Biochem Mol Biol 2006 Jul;100(1-3):24-33 PMID: 16854582 07/21/2006
  • Molecular mechanisms of (-)-gossypol-induced apoptosis in human prostate cancer cells. (Huang YW, Wang LS, Chang HL, Ye W, Dowd MK, Wan PJ, Lin YC) Anticancer Res 2006 May-Jun;26(3A):1925-33 PMID: 16827126 07/11/2006
  • Keratinocyte growth factor (KGF) induces tamoxifen (Tam) resistance in human breast cancer MCF-7 cells. (Chang HL, Sugimoto Y, Liu S, Ye W, Wang LS, Huang YW, Lin YC) Anticancer Res 2006 May-Jun;26(3A):1773-84 PMID: 16827106 07/11/2006
  • Conjugated linoleic acid (CLA) modulates prostaglandin E2 (PGE2) signaling in canine mammary cells. (Wang LS, Huang YW, Liu S, Chang HL, Ye W, Shu S, Sugimoto Y, Funk JA, Smeaks DD, Hill LN, Lin YC) Anticancer Res 2006 Mar-Apr;26(2A):889-98 PMID: 16619484 04/20/2006
  • Conjugated linoleic acid (CLA) up-regulates the estrogen-regulated cancer suppressor gene, protein tyrosine phosphatase gamma (PTPgama), in human breast cells. (Wang LS, Huang YW, Sugimoto Y, Liu S, Chang HL, Ye W, Shu S, Lin YC) Anticancer Res 2006 Jan-Feb;26(1A):27-34 PMID: 16475675 02/16/2006
  • Effects of human breast stromal cells on conjugated linoleic acid (CLA) modulated vascular endothelial growth factor-A (VEGF-A) expression in MCF-7 cells. (Wang LS, Huang YW, Sugimoto Y, Liu S, Chang HL, Ye W, Shu S, Lin YC) Anticancer Res 2005 Nov-Dec;25(6B):4061-8 PMID: 16312046 11/30/2005
  • Decreased MCF-7 breast cancer cell proliferation by serum from a selected line of beef cattle. (Updike MS, Davis ME, Wang LS, Huang YW, Wick M, Lin YC) Anticancer Res 2005 Mar-Apr;25(2A):871-4 PMID: 15868921 05/05/2005
  • Last update: 09/30/2015