Medical College of Wisconsin
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Yian Wang MD, PhD


Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Cancer Center

Member of the Cancer Center


  • Immunogenomic Landscape Contributes to Hyperprogressive Disease after Anti-PD-1 Immunotherapy for Cancer. (Xiong D, Wang Y, Singavi AK, Mackinnon AC, George B, You M) iScience 2018 Nov 30;9:258-277 PMID: 30439581 PMCID: PMC6234258 11/16/2018    
  • Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity. (Pan J, Lee Y, Cheng G, Zielonka J, Zhang Q, Bajzikova M, Xiong D, Tsaih SW, Hardy M, Flister M, Olsen CM, Wang Y, Vang O, Neuzil J, Myers CR, Kalyanaraman B, You M) iScience 2018 May 25;3:192-207 PMID: 30428319 PMCID: PMC6137433 11/15/2018    
  • Airway brushing as a new experimental methodology to detect airway gene expression signatures in mouse lung squamous cell carcinoma. (Pan J, Xiong D, Zhang Q, Szabo E, Miller MS, Lubet RA, Wang Y, You M) Sci Rep 2018 Jun 11;8(1):8895 PMID: 29891994 PMCID: PMC5995924 06/13/2018    
  • Novel mutational landscapes and expression signatures of lung squamous cell carcinoma. (Xiong D, Pan J, Yin Y, Jiang H, Szabo E, Lubet RA, Wang Y, You M) Oncotarget 2018 Jan 26;9(7):7424-7441 PMID: 29484121 PMCID: PMC5800913 02/28/2018    
  • Immunoprevention of KRAS-driven lung adenocarcinoma by a multipeptide vaccine. (Pan J, Zhang Q, Sei S, Shoemaker RH, Lubet RA, Wang Y, You M) Oncotarget 2017 Oct 10;8(47):82689-82699 PMID: 29137294 PMCID: PMC5669920 11/16/2017    
  • Effect of weekly or daily dosing regimen of Gefitinib in mouse models of lung cancer. (Zhang Q, Li R, Chen X, Lee SB, Pan J, Xiong D, Hu J, Miller MS, Szabo E, Lubet RA, Wang Y, You M) Oncotarget 2017 Sep 22;8(42):72447-72456 PMID: 29069801 PMCID: PMC5641144 10/27/2017    
  • Pioglitazone-mediated reversal of elevated glucose metabolism in the airway epithelium of mouse lung adenocarcinomas. (Xiong D, Pan J, Zhang Q, Szabo E, Miller MS, Lubet RA, Wang Y, You M) JCI Insight 2017 Jul 06;2(13) PMID: 28679956 PMCID: PMC5499364 07/07/2017    
  • Bronchial airway gene expression signatures in mouse lung squamous cell carcinoma and their modulation by cancer chemopreventive agents. (Xiong D, Pan J, Zhang Q, Szabo E, Miller MS, Lubet RA, You M, Wang Y) Oncotarget 2017 Mar 21;8(12):18885-18900 PMID: 27935865 PMCID: PMC5386655 12/10/2016    
  • Honokiol Decreases Lung Cancer Metastasis through Inhibition of the STAT3 Signaling Pathway. (Pan J, Lee Y, Zhang Q, Xiong D, Wan TC, Wang Y, You M) Cancer Prev Res (Phila) 2017 Feb;10(2):133-141 PMID: 27849557 PMCID: PMC6005650 11/17/2016       9 Citations
  • miR-375 induces docetaxel resistance in prostate cancer by targeting SEC23A and YAP1. (Wang Y, Lieberman R, Pan J, Zhang Q, Du M, Zhang P, Nevalainen M, Kohli M, Shenoy NK, Meng H, You M, Wang L) Mol Cancer 2016 11 10;15(1):70 PMID: 27832783 PMCID: PMC5105253 11/12/2016       20 Citations
  • CRISPR/Cas9 mediated knockout of the abdominal-A homeotic gene in the global pest, diamondback moth (Plutella xylostella). (Huang Y, Chen Y, Zeng B, Wang Y, James AA, Gurr GM, Yang G, Lin X, Huang Y, You M) Insect Biochem Mol Biol 2016 08;75:98-106 PMID: 27318252 06/19/2016       24 Citations
  • Honokiol targets mitochondria to halt cancer progression and metastasis. (Pan J, Lee Y, Wang Y, You M) Mol Nutr Food Res 2016 06;60(6):1383-95 PMID: 27276215 06/09/2016       16 Citations
  • Use of anaerobic hydrolysis pretreatment to enhance ultrasonic disintegration of excess sludge. (Li X, Zhu T, Shen Y, Chai T, Xie Y, You M, Wang Y) Water Sci Technol 2016;73(5):1190-6 PMID: 26942542 03/05/2016       1 Citations
  • PARK2 gene and familial lung cancer: what is the link? (Xiong D, Wang Y, You M) Future Oncol 2015;11(12):1707-10 PMID: 26075437 06/16/2015    
  • Inhibition of IGF1R signaling abrogates resistance to afatinib (BIBW2992) in EGFR T790M mutant lung cancer cells. (Lee Y, Wang Y, James M, Jeong JH, You M) Mol Carcinog 2016 May;55(5):991-1001 PMID: 26052929 PMCID: PMC6003619 06/09/2015       17 Citations
  • Enhanced antitumor activity of 3-bromopyruvate in combination with rapamycin in vivo and in vitro. (Zhang Q, Pan J, Lubet RA, Komas SM, Kalyanaraman B, Wang Y, You M) Cancer Prev Res (Phila) 2015 Apr;8(4):318-26 PMID: 25644152 PMCID: PMC6004825 02/04/2015       5 Citations
  • A recurrent mutation in PARK2 is associated with familial lung cancer. (Xiong D, Wang Y, Kupert E, Simpson C, Pinney SM, Gaba CR, Mandal D, Schwartz AG, Yang P, de Andrade M, Pikielny C, Byun J, Li Y, Stambolian D, Spitz MR, Liu Y, Amos CI, Bailey-Wilson JE, Anderson M, You M) Am J Hum Genet 2015 Feb 05;96(2):301-8 PMID: 25640678 PMCID: PMC4320264 02/03/2015       28 Citations
  • Dietary diindolylmethane suppresses inflammation-driven lung squamous cell carcinoma in mice. (Song JM, Qian X, Teferi F, Pan J, Wang Y, Kassie F) Cancer Prev Res (Phila) 2015 Jan;8(1):77-85 PMID: 25403850 PMCID: PMC4289649 11/19/2014       6 Citations
  • Honokiol inhibits lung tumorigenesis through inhibition of mitochondrial function. (Pan J, Zhang Q, Liu Q, Komas SM, Kalyanaraman B, Lubet RA, Wang Y, You M) Cancer Prev Res (Phila) 2014 Nov;7(11):1149-59 PMID: 25245764 PMCID: PMC6010030 09/24/2014       14 Citations
  • Targeting the insulin-like growth factor-1 receptor by picropodophyllin for lung cancer chemoprevention. (Zhang Q, Pan J, Lubet RA, Wang Y, You M) Mol Carcinog 2015 Jun;54 Suppl 1:E129-37 PMID: 25163779 08/29/2014       9 Citations
  • Transcriptomic analysis by RNA-seq reveals AP-1 pathway as key regulator that green tea may rely on to inhibit lung tumorigenesis. (Pan J, Zhang Q, Xiong D, Vedell P, Yan Y, Jiang H, Cui P, Ding F, Tichelaar JW, Wang Y, Lubet RA, You M) Mol Carcinog 2014 Jan;53(1):19-29 PMID: 24343902 12/18/2013    
  • Chemoprevention of lung squamous cell carcinoma by ginseng. (Pan J, Zhang Q, Li K, Liu Q, Wang Y, You M) Cancer Prev Res (Phila) 2013 Jun;6(6):530-9 PMID: 23550152 04/04/2013       8 Citations
  • Mouse models of lung squamous cell carcinomas. (You MS, Rouggly LC, You M, Wang Y) Cancer Metastasis Rev 2013 Jun;32(1-2):77-82 PMID: 23229817 12/12/2012       8 Citations
  • Lung cancer chemoprevention: difficulties, promise and potential agents? (Dragnev K, You M, Wang Y, Lubet R) Expert Opin Investig Drugs 2013 Jan;22(1):35-47 PMID: 23167766 11/22/2012       16 Citations
  • Exome sequencing identifies MXRA5 as a novel cancer gene frequently mutated in non-small cell lung carcinoma from Chinese patients. (Xiong D, Li G, Li K, Xu Q, Pan Z, Ding F, Vedell P, Liu P, Cui P, Hua X, Jiang H, Yin Y, Zhu Z, Li X, Zhang B, Ma D, Wang Y, You M) Carcinogenesis 2012 Sep;33(9):1797-805 PMID: 22696596 PMCID: PMC3514907 06/15/2012       27 Citations
  • Functional characterization of CLPTM1L as a lung cancer risk candidate gene in the 5p15.33 locus. (James MA, Wen W, Wang Y, Byers LA, Heymach JV, Coombes KR, Girard L, Minna J, You M) PLoS One 2012;7(6):e36116 PMID: 22675468 PMCID: PMC3366984 06/08/2012       63 Citations
  • Identification of somatic mutations in non-small cell lung carcinomas using whole-exome sequencing. (Liu P, Morrison C, Wang L, Xiong D, Vedell P, Cui P, Hua X, Ding F, Lu Y, James M, Ebben JD, Xu H, Adjei AA, Head K, Andrae JW, Tschannen MR, Jacob H, Pan J, Zhang Q, Van den Bergh F, Xiao H, Lo KC, Patel J, Richmond T, Watt MA, Albert T, Selzer R, Anderson M, Wang J, Wang Y, Starnes S, Yang P, You M) Carcinogenesis 2012 Jul;33(7):1270-6 PMID: 22510280 PMCID: PMC3499051 04/19/2012       112 Citations
  • Beetroot red (betanin) inhibits vinyl carbamate- and benzo(a)pyrene-induced lung tumorigenesis through apoptosis. (Zhang Q, Pan J, Wang Y, Lubet R, You M) Mol Carcinog 2013 Sep;52(9):686-91 PMID: 22456940 03/30/2012       12 Citations
  • Aerosolized 3-bromopyruvate inhibits lung tumorigenesis without causing liver toxicity. (Zhang Q, Pan J, North PE, Yang S, Lubet RA, Wang Y, You M) Cancer Prev Res (Phila) 2012 May;5(5):717-25 PMID: 22401980 03/10/2012       24 Citations
  • MicroRNA profiling and prediction of recurrence/relapse-free survival in stage I lung cancer. (Lu Y, Govindan R, Wang L, Liu PY, Goodgame B, Wen W, Sezhiyan A, Pfeifer J, Li YF, Hua X, Wang Y, Yang P, You M) Carcinogenesis 2012 May;33(5):1046-54 PMID: 22331473 PMCID: PMC3334512 02/15/2012       98 Citations
  • Animal models of lung cancer characterization and use for chemoprevention research. (Wang Y, Rouggly L, You M, Lubet R) Prog Mol Biol Transl Sci 2012;105:211-26 PMID: 22137433 12/06/2011       14 Citations
  • Genome-wide association and fine mapping of genetic loci predisposing to colon carcinogenesis in mice. (Liu P, Lu Y, Liu H, Wen W, Jia D, Wang Y, You M) Mol Cancer Res 2012 Jan;10(1):66-74 PMID: 22127497 12/01/2011       19 Citations
  • Chemopreventive effect of a mixture of Chinese Herbs (antitumor B) on chemically induced oral carcinogenesis. (Wang Y, Yao R, Gao S, Wen W, Du Y, Szabo E, Hu M, Lubet RA, You M) Mol Carcinog 2013 Jan;52(1):49-56 PMID: 22086836 11/17/2011       10 Citations
  • Chemoprevention of lung carcinogenesis by the combination of aerosolized budesonide and oral pioglitazone in A/J mice. (Fu H, Zhang J, Pan J, Zhang Q, Lu Y, Wen W, Lubet RA, Szabo E, Chen R, Wang Y, Chen DR, You M) Mol Carcinog 2011 Dec;50(12):913-21 PMID: 21374736 PMCID: PMC6015734 03/05/2011       26 Citations
  • Aerosolized bexarotene inhibits lung tumorigenesis without increasing plasma triglyceride and cholesterol levels in mice. (Zhang Q, Pan J, Zhang J, Liu P, Chen R, Chen DR, Lubet R, Wang Y, You M) Cancer Prev Res (Phila) 2011 Feb;4(2):270-6 PMID: 21163938 12/18/2010       15 Citations
  • Chemopreventive effects of pioglitazone on chemically induced lung carcinogenesis in mice. (Wang Y, James M, Wen W, Lu Y, Szabo E, Lubet RA, You M) Mol Cancer Ther 2010 Nov;9(11):3074-82 PMID: 21045137 11/04/2010       37 Citations
  • 26S proteasome activity is down-regulated in lung cancer stem-like cells propagated in vitro. (Pan J, Zhang Q, Wang Y, You M) PLoS One 2010 Oct 11;5(10):e13298 PMID: 20949018 PMCID: PMC2952619 10/16/2010       42 Citations
  • A dominant-negative c-jun mutant inhibits lung carcinogenesis in mice. (Tichelaar JW, Yan Y, Tan Q, Wang Y, Estensen RD, Young MR, Colburn NH, Yin H, Goodin C, Anderson MW, You M) Cancer Prev Res (Phila) 2010 Sep;3(9):1148-56 PMID: 20716630 PMCID: PMC2933283 08/19/2010       8 Citations
  • A second genetic variant on chromosome 15q24-25.1 associates with lung cancer. (Liu P, Yang P, Wu X, Vikis HG, Lu Y, Wang Y, Schwartz AG, Pinney SM, de Andrade M, Gazdar A, Gaba C, Mandal D, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Spitz M, Amos CI, Anderson MW, You M) Cancer Res 2010 Apr 15;70(8):3128-35 PMID: 20395203 PMCID: PMC3378320 04/17/2010       3 Citations
  • Cumulative effect of multiple loci on genetic susceptibility to familial lung cancer. (Liu P, Vikis HG, Lu Y, Wang Y, Schwartz AG, Pinney SM, Yang P, de Andrade M, Gazdar A, Gaba C, Mandal D, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Amos CI, Anderson MW, You M) Cancer Epidemiol Biomarkers Prev 2010 Feb;19(2):517-24 PMID: 20142248 PMCID: PMC2846747 02/10/2010       24 Citations
  • Effect of dietary Polyphenon E and EGCG on lung tumorigenesis in A/J Mice. (Zhang Q, Fu H, Pan J, He J, Ryota S, Hara Y, Wang Y, Lubet RA, You M) Pharm Res 2010 Jun;27(6):1066-71 PMID: 20112129 PMCID: PMC6007862 01/30/2010       25 Citations
  • Preventive effects of bexarotene and budesonide in a genetically engineered mouse model of small cell lung cancer. (Wang Y, Wen W, Yi Y, Zhang Z, Lubet RA, You M) Cancer Prev Res (Phila) 2009 Dec;2(12):1059-64 PMID: 19934342 PMCID: PMC6001362 11/26/2009       23 Citations
  • Haplotype and cell proliferation analyses of candidate lung cancer susceptibility genes on chromosome 15q24-25.1. (Liu Y, Liu P, Wen W, James MA, Wang Y, Bailey-Wilson JE, Amos CI, Pinney SM, Yang P, de Andrade M, Petersen GM, Wiest JS, Fain PR, Schwartz AG, Gazdar A, Gaba C, Rothschild H, Mandal D, Kupert E, Lee J, Seminara D, Minna J, Anderson MW, You M) Cancer Res 2009 Oct 01;69(19):7844-50 PMID: 19789337 PMCID: PMC2846106 10/01/2009       35 Citations
  • Last update: 02/12/2019
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