Medical College of Wisconsin
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Yu-Chieh Wang PhD

Yu-Chieh Wang PhD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Dermatology
Program: General


I am willing to collaborate on research projects.


Research Experience

  • Antineoplastic Agents
  • Cell Survival
  • Cellular Reprogramming
  • Combined Modality Therapy
  • Congenital Disorders of Glycosylation
  • Developmental Biology
  • Endoplasmic Reticulum Stress
  • Gene Expression Regulation, Developmental
  • Glioblastoma
  • Glycosyltransferases
  • Human Embryonic Stem Cells
  • Induced Pluripotent Stem Cells
  • Lung Neoplasms
  • Melanocytes
  • Melanoma
  • Molecular Targeted Therapy
  • Neurogenesis
  • Organoids
  • Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase
  • Regenerative Medicine
  • Signal Transduction
  • Systems Biology
  • Therapies, Investigational
  • Transcriptome
  • Methodologies and Techniques

  • CRISPR-Cas Systems
  • Cell Line, Tumor
  • Cellular Reprogramming Techniques
  • Culture Techniques
  • Drug Screening Assays, Antitumor
  • Gene Expression Profiling
  • Glycomics
  • Microarray Analysis
  • Models, Animal
  • Pluripotent Stem Cells
  • Proteomics
  • Single-Cell Analysis
  • Publications (36)

  • Urine Sample-Derived Cerebral Organoids Suitable for Studying Neurodevelopment and Pharmacological Responses. (Lin VJT, Hu J, Zolekar A, Yan LJ, Wang YC) Front Cell Dev Biol 2020;8:304 PMID: 32528947 PMCID: PMC7247822 SCOPUS ID: 2-s2.0-85085497647 06/13/2020       1 Citation
  • On-chip multiplexed single-cell pattern and controllable intracellular delivery (Dong, Z., Jiao, Y., Hao, Y., Wang, P., Liu, Y., Shi, J., Chitrakar, C., Black, S., Wang, Y.-C., Lee, L.J., Li, M., Fan, Y., Chang, L.) Microsystems & Nanoengineering 02/24/2020    
  • Bioinspired Nanoparticles Engineered for Enhanced Delivery to the Bone (Gdowski AS, Lampe JB, Lin VJT, Joshi R, Wang YC, Mukerjee A, Vishwanatha JK, Ranjan AP) ACS Applied Nano Materials 25 October 2019;2(10):6249-6257 SCOPUS ID: 2-s2.0-85074676172 10/25/2019       2 Citations
  • Structural and functional insights into the bona fide catalytic state of Streptococcus pyogenes Cas9 HNH nuclease domain. (Zuo Z, Zolekar A, Babu K, Lin VJ, Hayatshahi HS, Rajan R, Wang YC, Liu J) Elife 2019 07 30;8 PMID: 31361218 PMCID: PMC6706240 SCOPUS ID: 2-s2.0-85071706842 07/31/2019       7 Citations
  • Wearable Devices for Single-Cell Sensing and Transfection. (Chang L, Wang YC, Ershad F, Yang R, Yu C, Fan Y) Trends Biotechnol 2019 11;37(11):1175-1188 PMID: 31072609 SCOPUS ID: 2-s2.0-85065091597 05/11/2019       9 Citations
  • Stress and interferon signalling-mediated apoptosis contributes to pleiotropic anticancer responses induced by targeting NGLY1. (Zolekar A, Lin VJT, Mishra NM, Ho YY, Hayatshahi HS, Parab A, Sampat R, Liao X, Hoffmann P, Liu J, Emmitte KA, Wang YC) Br J Cancer 2018 12;119(12):1538-1551 PMID: 30385822 PMCID: PMC6288164 SCOPUS ID: 2-s2.0-85055978337 11/06/2018       6 Citations
  • Potassium as a pluripotency-associated element identified through inorganic element profiling in human pluripotent stem cells. (Lin VJT, Zolekar A, Shi Y, Koneru B, Dimitrijevich S, Di Pasqua AJ, Wang YC) Sci Rep 2017 07 10;7(1):5005 PMID: 28694442 PMCID: PMC5504050 SCOPUS ID: 2-s2.0-85023172089 07/12/2017       7 Citations
  • New Monoclonal Antibodies to Defined Cell Surface Proteins on Human Pluripotent Stem Cells. (O'Brien CM, Chy HS, Zhou Q, Blumenfeld S, Lambshead JW, Liu X, Kie J, Capaldo BD, Chung TL, Adams TE, Phan T, Bentley JD, McKinstry WJ, Oliva K, McMurrick PJ, Wang YC, Rossello FJ, Lindeman GJ, Chen D, Jarde T, Clark AT, Abud HE, Visvader JE, Nefzger CM, Polo JM, Loring JF, Laslett AL) Stem Cells 2017 03;35(3):626-640 PMID: 28009074 PMCID: PMC5412944 SCOPUS ID: 2-s2.0-85016602811 12/23/2016       13 Citations
  • Understanding Melanocyte Stem Cells for Disease Modeling and Regenerative Medicine Applications. (Mull AN, Zolekar A, Wang YC) Int J Mol Sci 2015 Dec 21;16(12):30458-69 PMID: 26703580 PMCID: PMC4691150 SCOPUS ID: 2-s2.0-84951311009 12/26/2015       18 Citations
  • Tetracycline-Containing MCM-41 Mesoporous Silica Nanoparticles for the Treatment of Escherichia coli. (Koneru B, Shi Y, Wang YC, Chavala SH, Miller ML, Holbert B, Conson M, Ni A, Di Pasqua AJ) Molecules 2015 Oct 30;20(11):19690-8 PMID: 26528964 PMCID: PMC6332305 SCOPUS ID: 2-s2.0-84949948608 11/04/2015       26 Citations
  • Glycosyltransferase ST6GAL1 contributes to the regulation of pluripotency in human pluripotent stem cells. (Wang YC, Stein JW, Lynch CL, Tran HT, Lee CY, Coleman R, Hatch A, Antontsev VG, Chy HS, O'Brien CM, Murthy SK, Laslett AL, Peterson SE, Loring JF) Sci Rep 2015 Aug 25;5:13317 PMID: 26304831 PMCID: PMC4548446 SCOPUS ID: 2-s2.0-84940042013 08/26/2015       35 Citations
  • The 'sweet' spot of cellular pluripotency: protein glycosylation in human pluripotent stem cells and its applications in regenerative medicine. (Wang YC, Lin V, Loring JF, Peterson SE) Expert Opin Biol Ther 2015 May;15(5):679-87 PMID: 25736263 SCOPUS ID: 2-s2.0-84927617058 03/05/2015       4 Citations
  • Increased risk of genetic and epigenetic instability in human embryonic stem cells associated with specific culture conditions. (Garitaonandia I, Amir H, Boscolo FS, Wambua GK, Schultheisz HL, Sabatini K, Morey R, Waltz S, Wang YC, Tran H, Leonardo TR, Nazor K, Slavin I, Lynch C, Li Y, Coleman R, Gallego Romero I, Altun G, Reynolds D, Dalton S, Parast M, Loring JF, Laurent LC) PLoS One 2015;10(2):e0118307 PMID: 25714340 PMCID: PMC4340884 SCOPUS ID: 2-s2.0-84923869698 02/26/2015       73 Citations
  • Generation of hiPSCs (Tran HT, Lacambacal RE, Lynch CL, Loring JF, Ben-Nun IF, Wang YC) Genetic Engineering and Biotechnology News 15 November 2014;34(20):18-19 SCOPUS ID: 2-s2.0-84922190284 01/01/2014    
  • Protein post-translational modifications and regulation of pluripotency in human stem cells. (Wang YC, Peterson SE, Loring JF) Cell Res 2014 Feb;24(2):143-60 PMID: 24217768 PMCID: PMC3915910 SCOPUS ID: 2-s2.0-84893781709 11/13/2013       174 Citations
  • Matched miRNA and mRNA signatures from an hESC-based in vitro model of pancreatic differentiation reveal novel regulatory interactions. (Liao X, Xue H, Wang YC, Nazor KL, Guo S, Trivedi N, Peterson SE, Liu Y, Loring JF, Laurent LC) J Cell Sci 2013 Sep 01;126(Pt 17):3848-61 PMID: 23813959 PMCID: PMC3757328 SCOPUS ID: 2-s2.0-84883291103 07/03/2013       35 Citations
  • Melanocytes derived from transgene-free human induced pluripotent stem cells. (Jones JC, Sabatini K, Liao X, Tran HT, Lynch CL, Morey RE, Glenn-Pratola V, Boscolo FS, Yang Q, Parast MM, Liu Y, Peterson SE, Laurent LC, Loring JF, Wang YC) J Invest Dermatol 2013 Aug;133(8):2104-8 PMID: 23514962 PMCID: PMC3714355 SCOPUS ID: 2-s2.0-84880327584 03/22/2013       19 Citations
  • Full-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cells. (Ramsköld D, Luo S, Wang YC, Li R, Deng Q, Faridani OR, Daniels GA, Khrebtukova I, Loring JF, Laurent LC, Schroth GP, Sandberg R) Nat Biotechnol 2012 Aug;30(8):777-82 PMID: 22820318 PMCID: PMC3467340 SCOPUS ID: 2-s2.0-84864880991 07/24/2012       849 Citations
  • Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives. (Nazor KL, Altun G, Lynch C, Tran H, Harness JV, Slavin I, Garitaonandia I, Müller FJ, Wang YC, Boscolo FS, Fakunle E, Dumevska B, Lee S, Park HS, Olee T, D'Lima DD, Semechkin R, Parast MM, Galat V, Laslett AL, Schmidt U, Keirstead HS, Loring JF, Laurent LC) Cell Stem Cell 2012 May 04;10(5):620-34 PMID: 22560082 PMCID: PMC3348513 SCOPUS ID: 2-s2.0-84860643156 05/09/2012       256 Citations
  • Specific lectin biomarkers for isolation of human pluripotent stem cells identified through array-based glycomic analysis. (Wang YC, Nakagawa M, Garitaonandia I, Slavin I, Altun G, Lacharite RM, Nazor KL, Tran HT, Lynch CL, Leonardo TR, Liu Y, Peterson SE, Laurent LC, Yamanaka S, Loring JF) Cell Res 2011 Nov;21(11):1551-63 PMID: 21894191 PMCID: PMC3364725 SCOPUS ID: 2-s2.0-80555122989 09/07/2011       64 Citations
  • Induced pluripotent stem cells from highly endangered species. (Ben-Nun IF, Montague SC, Houck ML, Tran HT, Garitaonandia I, Leonardo TR, Wang YC, Charter SJ, Laurent LC, Ryder OA, Loring JF) Nat Methods 2011 Sep 04;8(10):829-31 PMID: 21892153 SCOPUS ID: 2-s2.0-80053375853 09/06/2011       101 Citations
  • Normal human pluripotent stem cell lines exhibit pervasive mosaic aneuploidy. (Peterson SE, Westra JW, Rehen SK, Young H, Bushman DM, Paczkowski CM, Yung YC, Lynch CL, Tran HT, Nickey KS, Wang YC, Laurent LC, Loring JF, Carpenter MK, Chun J) PLoS One 2011;6(8):e23018 PMID: 21857983 PMCID: PMC3156708 SCOPUS ID: 2-s2.0-80051674461 08/23/2011       49 Citations
  • OSU-HDAC42, a histone deacetylase inhibitor, blocks prostate tumor progression in the transgenic adenocarcinoma of the mouse prostate model. (Sargeant AM, Rengel RC, Kulp SK, Klein RD, Clinton SK, Wang YC, Chen CS) Cancer Res 2008 May 15;68(10):3999-4009 PMID: 18483287 SCOPUS ID: 2-s2.0-45549091261 05/17/2008       44 Citations
  • Targeting endoplasmic reticulum stress and Akt with OSU-03012 and gefitinib or erlotinib to overcome resistance to epidermal growth factor receptor inhibitors. (Wang YC, Kulp SK, Wang D, Yang CC, Sargeant AM, Hung JH, Kashida Y, Yamaguchi M, Chang GD, Chen CS) Cancer Res 2008 Apr 15;68(8):2820-30 PMID: 18413750 PMCID: PMC3904349 SCOPUS ID: 2-s2.0-42349106840 04/17/2008       43 Citations
  • Pharmacological exploitation of the peroxisome proliferator-activated receptor gamma agonist ciglitazone to develop a novel class of androgen receptor-ablative agents. (Yang J, Wei S, Wang DS, Wang YC, Kulp SK, Chen CS) J Med Chem 2008 Apr 10;51(7):2100-7 PMID: 18335975 PMCID: PMC3901315 SCOPUS ID: 2-s2.0-41849135388 03/14/2008       23 Citations
  • FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling. (Hung JH, Lu YS, Wang YC, Ma YH, Wang DS, Kulp SK, Muthusamy N, Byrd JC, Cheng AL, Chen CS) Cancer Res 2008 Feb 15;68(4):1204-12 PMID: 18281497 SCOPUS ID: 2-s2.0-39449103924 02/19/2008       89 Citations
  • Elevated p53 and p21waf1 mRNA expression in blood lymphocytes from lung cancer patients with chemoresistance. (Shih CM, Chen K, Wang YC, Lee PJ, Wang YC) Cancer Detect Prev 2007;31(5):366-70 PMID: 18035504 SCOPUS ID: 2-s2.0-36549020728 11/24/2007       7 Citations
  • 2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} acetamide (OSU-03012), a celecoxib derivative, directly targets p21-activated kinase. (Porchia LM, Guerra M, Wang YC, Zhang Y, Espinosa AV, Shinohara M, Kulp SK, Kirschner LS, Saji M, Chen CS, Ringel MD) Mol Pharmacol 2007 Nov;72(5):1124-31 PMID: 17673571 SCOPUS ID: 2-s2.0-35549012934 08/04/2007       65 Citations
  • Efficacy of a novel histone deacetylase inhibitor in murine models of hepatocellular carcinoma. (Lu YS, Kashida Y, Kulp SK, Wang YC, Wang D, Hung JH, Tang M, Lin ZZ, Chen TJ, Cheng AL, Chen CS) Hepatology 2007 Oct;46(4):1119-30 PMID: 17654699 SCOPUS ID: 2-s2.0-36348996655 07/27/2007       72 Citations
  • Thiazolidinediones modulate the expression of beta-catenin and other cell-cycle regulatory proteins by targeting the F-box proteins of Skp1-Cul1-F-box protein E3 ubiquitin ligase independently of peroxisome proliferator-activated receptor gamma. (Wei S, Lin LF, Yang CC, Wang YC, Chang GD, Chen H, Chen CS) Mol Pharmacol 2007 Sep;72(3):725-33 PMID: 17569795 SCOPUS ID: 2-s2.0-34548306411 06/16/2007       44 Citations
  • Histone deacetylase inhibitors sensitize prostate cancer cells to agents that produce DNA double-strand breaks by targeting Ku70 acetylation. (Chen CS, Wang YC, Yang HC, Huang PH, Kulp SK, Yang CC, Lu YS, Matsuyama S, Chen CY, Chen CS) Cancer Res 2007 Jun 01;67(11):5318-27 PMID: 17545612 SCOPUS ID: 2-s2.0-34347206854 06/05/2007       146 Citations
  • Peroxisome proliferator-activated receptor gamma-independent suppression of androgen receptor expression by troglitazone mechanism and pharmacologic exploitation. (Yang CC, Wang YC, Wei S, Lin LF, Chen CS, Lee CC, Lin CC, Chen CS) Cancer Res 2007 Apr 01;67(7):3229-38 PMID: 17409431 SCOPUS ID: 2-s2.0-34248174014 04/06/2007       43 Citations
  • Overcoming trastuzumab resistance in HER2-overexpressing breast cancer cells by using a novel celecoxib-derived phosphoinositide-dependent kinase-1 inhibitor. (Tseng PH, Wang YC, Weng SC, Weng JR, Chen CS, Brueggemeier RW, Shapiro CL, Chen CY, Dunn SE, Pollak M, Chen CS) Mol Pharmacol 2006 Nov;70(5):1534-41 PMID: 16887935 SCOPUS ID: 2-s2.0-33751168744 08/05/2006       64 Citations
  • Comparison of the cytotoxicity induced by different exposure to sodium arsenite in two fish cell lines. (Wang YC, Chaung RH, Tung LC) Aquat Toxicol 2004 Jul 30;69(1):67-79 PMID: 15210298 SCOPUS ID: 2-s2.0-2942726340 06/24/2004       80 Citations
  • Damage formation and repair efficiency in the p53 gene of cell lines and blood lymphocytes assayed by multiplex long quantitative polymerase chain reaction. (Wang YC, Lee PJ, Shih CM, Chen HY, Lee CC, Chang YY, Hsu YT, Liang YJ, Wang LY, Han WH, Wang YC) Anal Biochem 2003 Aug 15;319(2):206-15 PMID: 12871714 SCOPUS ID: 2-s2.0-12444250684 07/23/2003       36 Citations
  • Association of L-myc polymorphism with lung cancer susceptibility and prognosis in relation to age-selected controls and stratified cases. (Shih CM, Kuo YY, Wang YC, Jian SL, Hsu YT, Wu HY, Guo MW, Wang YC) Lung Cancer 2002 May;36(2):125-32 PMID: 11955646 SCOPUS ID: 2-s2.0-0036219891 04/17/2002       18 Citations
  • Last update: 05/06/2021