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C/EBPα deregulation as a paradigm for leukemogenesis. Leukemia 2017 Nov;31(11):2279-2285

Date

07/20/2017

Pubmed ID

28720765

Pubmed Central ID

PMC8197657

DOI

10.1038/leu.2017.229

Scopus ID

2-s2.0-85032623277 (requires institutional sign-in at Scopus site)   50 Citations

Abstract

Myeloid master regulator CCAAT enhancer-binding protein alpha (C/EBPα) is deregulated by multiple mechanisms in leukemia. Inhibition of C/EBPα function plays pivotal roles in leukemogenesis. While much is known about how C/EBPα orchestrates granulopoiesis, our understanding of molecular transformation events, the role(s) of cooperating mutations and clonal evolution during C/EBPα deregulation in leukemia remains elusive. In this review, we will summarize the latest research addressing these topics with special emphasis on CEBPA mutations. We conclude by describing emerging therapeutic strategies to restore C/EBPα function.

Author List

Pulikkan JA, Tenen DG, Behre G

Author

John A. Pulikkan PhD Assistant Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
CCAAT-Enhancer-Binding Protein-alpha
Hematopoietic Stem Cells
Humans
Leukemia, Myeloid, Acute
Mutation