Medical College of Wisconsin
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Risk factors for chronic graft-versus-host disease after HLA-identical sibling bone marrow transplantation. Blood 1990 Jun 15;75(12):2459-64 PMID: 2350582

Pubmed ID

2350582

Abstract

Chronic graft-versus-host disease (GVHD) is an important complication of bone marrow transplantation. We analyzed risk factors for chronic GVHD in 2,534 recipients of HLA-identical sibling transplants surviving at least 90 days after transplantation. The actuarial probability of developing chronic GVHD within three years posttransplant was 46% +/- 3% (95% confidence interval). The most important risk factor for chronic GVHD was acute GVHD. The 3-year probabilities of chronic GVHD were 28% +/- 3%, 49% +/- 5%, 59% +/- 6%, 80% +/- 9%, and 85% +/- 15% for persons with grades 0, I, II, III, and IV acute GVHD, respectively (P less than .0001). Among patients with no or grade I acute GVHD, recipient age greater than 20 years, use of non-T-cell depleted bone marrow, and alloimmune female donors for male recipients predicted a higher risk of chronic GVHD. When all three adverse risk factors were present, the probability of chronic GVHD was 62% among persons with no prior acute GVHD and 85% among those with grade I acute GVHD. Among patients with grade II through IV acute GVHD, no other risk factor predicted chronic GVHD. These data identify individuals who might benefit from treatment strategies aimed at changing the incidence of chronic GVHD.

Author List

Atkinson K, Horowitz MM, Gale RP, van Bekkum DW, Gluckman E, Good RA, Jacobsen N, Kolb HJ, Rimm AA, Ringdén O

Author

Mary M. Horowitz MD, MS Center Director, Professor in the Medicine department at Medical College of Wisconsin




Scopus

2-s2.0-0025292356   274 Citations

MESH terms used to index this publication - Major topics in bold

Acute Disease
Bone Marrow Transplantation
Chronic Disease
Female
Graft vs Host Disease
HLA Antigens
Histocompatibility
Humans
Leukemia
Male
Multivariate Analysis
Risk Factors
Sibling Relations
jenkins-FCD Prod-297 dff1a717c492f00bf6291286365f1f4fe95208f1