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Endocrine effects of ventilation, oxygenation and cord occlusion in near-term fetal sheep. J Dev Physiol 1991 Mar;15(3):133-8

Date

03/01/1991

Pubmed ID

1834728

Scopus ID

2-s2.0-0025900550   12 Citations

Abstract

The transition from fetal to newborn life is associated with significant endocrine changes. Some of these changes may be triggered by the effects of spontaneous respiration, increased oxygenation and removal of the placental circulation at birth. We, therefore, studied endocrine function during in utero ventilation, oxygenation and cord occlusion, in nine chronically-instrumented fetal sheep aged 137 to 140 days of gestation. During the sequential effects of in utero ventilation and oxygenation, plasma renin activity (PRA) and angiotensin II (AII) remained at control levels of 6.3 +/- 1.9 ng/ml per h and 66 +/- 15 pg/ml. After cord occlusion, PRA increased to 10.3 +/- 2.2 ng/ml per hr and AII increased to 86 +/- 24 pg/ml, the latter being non-significant. Plasma cortisol levels also increased from control levels of 3.5 +/- 1.0 to 6.7 +/- 0.8 g/dl during cord occlusion (P = 0.02). During the sequential effects of ventilation, oxygenation and cord occlusion, plasma epinephrine increased from control levels of 87 +/- 17 to 492 +/- 142 pg/ml (P = 0.04), and plasma norepinephrine levels increased slightly from 620 +/- 112 to 850 +/- 214 pg/ml. These data provide evidence that many of the changes in endocrine function seen at birth result from factors other than spontaneous respiration, oxygenation and umbilical cord occlusion.

Author List

Smith FG, Smith BA, Segar JL, Robillard JE

Author

Jeffrey L. Segar MD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Air
Angiotensin II
Animals
Arginine Vasopressin
Atrial Natriuretic Factor
Blood Gas Analysis
Blood Pressure
Carbon Dioxide
Dopamine
Endocrine Glands
Epinephrine
Female
Fetus
Heart Rate, Fetal
Hydrocortisone
Hydrogen-Ion Concentration
Norepinephrine
Oxygen
Pregnancy
Renin
Sheep
Umbilical Cord
jenkins-FCD Prod-398 336d56a365602aa89dcc112f077233607d6a5abc