Steroid-induced enhancement of functional recovery of postischemic, reperfused myocardium in conscious dogs. Am Heart J 1988 Oct;116(4):915-25
Date
10/01/1988Pubmed ID
3051986DOI
10.1016/0002-8703(88)90141-xScopus ID
2-s2.0-0023693367 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
The effects of methylprednisolone sodium succinate (20 mg/kg, intravenously administered) on the time course of functional recovery of myocardium following a 15-minute coronary artery occlusion period and subsequent 5 hour reperfusion period were studied in chronically instrumented, conscious dogs. In comparison to a control group, animals receiving methylprednisolone 90 minutes prior to coronary occlusion demonstrated less depression of regional segment shortening following 15 minutes of reperfusion (52 +/- 13% vs control levels of 23 +/- 7% of preocclusion values) and improved recovery at 5 hours postreperfusion (106 +/- 6% vs control levels of 54 +/- 4% of preocclusion values). In animals receiving methylprednisolone immediately prior to reperfusion, there was also similar recovery of segment shortening at 5 hours (97 +/- 3%). In contrast, dogs receiving methylprednisolone 15 minutes after the onset of reperfusion or sodium succinate (5.5 mg/kg, intravenously administered) 90 minutes prior to occlusion demonstrated no improvement in recovery of function. Experiments in dogs not subjected to coronary occlusion documented that methylprednisolone sodium succinate lacked inotropic and vasodilator properties. The results suggest that methylprednisolone administered prior to or during coronary artery occlusion but not after reperfusion enhances the functional recovery of hypokinetic, postischemic, reperfused myocardium. These effects are unrelated to any direct hemodynamic action of steroids or to the sodium succinate salt.
Author List
Wynsen JC, Preuss KC, Gross GJ, Brooks HL, Warltier DCMESH terms used to index this publication - Major topics in bold
AnimalsConsciousness
Coronary Disease
Dogs
Hemodynamics
Methylprednisolone
Methylprednisolone Hemisuccinate
Myocardial Contraction
Myocardial Reperfusion
Time Factors