Regulators of G protein signaling in cardiovascular function during pregnancy. Physiol Genomics 2018 Aug 01;50(8):590-604
Date
04/28/2018Pubmed ID
29702036Pubmed Central ID
PMC6139632DOI
10.1152/physiolgenomics.00037.2018Scopus ID
2-s2.0-85056621405 (requires institutional sign-in at Scopus site) 26 CitationsAbstract
G protein-coupled receptor signaling mechanisms are implicated in many aspects of cardiovascular control, and dysfunction of such signaling mechanisms is commonly associated with disease states. Investigators have identified a large number of regulator of G protein signaling (RGS) proteins that variously contribute to the modulation of intracellular second-messenger signaling kinetics. These many RGS proteins each interact with a specific set of second-messenger cascades and receptor types and exhibit tissue-specific expression patterns. Increasing evidence supports the contribution of RGS proteins, or their loss, in the pathogenesis of cardiovascular dysfunctions. This review summarizes the current understanding of the functional contributions of RGS proteins, particularly within the B/R4 family, in cardiovascular disorders of pregnancy including gestational hypertension, uterine artery dysfunction, and preeclampsia.
Author List
Perschbacher KJ, Deng G, Fisher RA, Gibson-Corley KN, Santillan MK, Grobe JLAuthor
Justin L. Grobe PhD Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCardiovascular Physiological Phenomena
Female
Humans
Polymorphism, Single Nucleotide
Pregnancy
Protein Binding
RGS Proteins
Receptors, G-Protein-Coupled
Signal Transduction