Prospective clinical trial of a human tumor cloning system. Cancer Res 1983 Apr;43(4):1926-31
Date
04/01/1983Pubmed ID
6339044Scopus ID
2-s2.0-0020597149 (requires institutional sign-in at Scopus site) 326 CitationsAbstract
A prospective clinical trial was performed to evaluate the usefulness of a human tumor cloning system for selecting single-agent chemotherapy for patients with advanced cancers. Six hundred four single-agent trials were performed in the 470 patients whose tumors were submitted for drug sensitivity testing. Only 246 of these 604 trials (41%) could be directed by the cloning system results because of inadequate tumor growth and other difficulties. In these 246 prospective trials, there was a 60% true positive and an 85% true negative rate for predicting for response or lack of response of an individual patient's tumor to the single agent. There was also a relationship between the percentage of decrease in survival of tumor colony-forming units and the probability of a clinical response of the patient's tumor to the same drug used in vivo. Despite these encouraging findings, work to improve tumor growth and additional prospective clinical trials of the system are needed before the system can be recommended for routine clinical use.
Author List
Von Hoff DD, Clark GM, Stogdill BJ, Sarosdy MF, O'Brien MT, Casper JT, Mattox DE, Page CP, Cruz AB, Sandbach JFMESH terms used to index this publication - Major topics in bold
Breast NeoplasmsCells, Cultured
Clinical Trials as Topic
Clone Cells
Colonic Neoplasms
Colony-Forming Units Assay
Drug Evaluation, Preclinical
Female
Humans
Lung Neoplasms
Melanoma
Neoplasms
Ovarian Neoplasms
