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Structural and functional changes associated with normal and abnormal fundus autofluorescence in patients with retinitis pigmentosa. Retina 2012 Feb;32(2):349-57

Date

09/13/2011

Pubmed ID

21909055

Pubmed Central ID

PMC3720996

DOI

10.1097/IAE.0b013e31821dfc17

Abstract

PURPOSE: To analyze the structure and visual function of regions bordering the hyperautofluorescent ring/arcs in retinitis pigmentosa.

METHODS: Twenty-one retinitis pigmentosa patients (21 eyes) with rings/arcs and 21 normal individuals (21 eyes) were studied. Visual sensitivity in the central 10° was measured with microperimetry. Retinal structure was evaluated with spectral-domain optical coherence tomography. The distance from the fovea to disruption/loss of the inner outer segment (IS/OS) junction and thicknesses of the total receptor plus retinal pigment epithelial complex and outer segment plus retinal pigment epithelial complex layers were measured. Results were compared with measurements of the distance from the fovea to the inner and outer borders of the ring/arc seen on fundus autofluorescence.

RESULTS: Disruption/loss of the inner outer segment junction occurred closer to the inner border of the ring/arc and it was closer to the fovea in eight eyes. For 19 eyes, outer segment plus and receptor plus RPE complex thicknesses were significantly decreased at locations closer to the fovea than the appearance of the inner border of hyperautofluorescence. Mean visual sensitivity was decreased inside, across, and outside the ring/arc by 3.5 ± 3.8, 8.9 ± 4.8, and 17.0 ± 2.4 dB, respectively.

CONCLUSION: Structural and functional changes can occur inside the hyperfluorescent ring/arc in retinitis pigmentosa.

Author List

Greenstein VC, Duncker T, Holopigian K, Carr RE, Greenberg JP, Tsang SH, Hood DC

Author

Jonathan P. Greenberg MD Instructor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Aged
Child
Cross-Sectional Studies
Female
Fluorescein Angiography
Fundus Oculi
Humans
Male
Middle Aged
Ophthalmoscopes
Retina
Retinitis Pigmentosa
Tomography, Optical Coherence
Visual Acuity
Visual Field Tests
Visual Fields
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