Persistent reduction of conduction velocity and myelinated axon damage in vibrated rat tail nerves. Muscle Nerve 2009 Jun;39(6):770-5
Date
03/24/2009Pubmed ID
19306323DOI
10.1002/mus.21235Scopus ID
2-s2.0-67049136357 (requires institutional sign-in at Scopus site) 26 CitationsAbstract
Prolonged hand-transmitted vibration exposure in the workplace has been recognized for almost a century to cause neurodegenerative and vasospastic disease. Persistence of the diseased state for years after cessation of tool use is of grave concern. To understand persistence of vibration injury, the present study examined recovery of nerve conduction velocity and structural damage of myelinated axons in a rat tail vibration model. Both 7 and 14 days of vibration (4 h/day) decreased conduction velocity. The decrease correlated directly with the increased percentage of disrupted myelinated axons. The total number of myelinated axons was unchanged. During 2 months of recovery, conduction velocity returned to control level after 7-day vibration but remained decreased after 14-day vibration. The rat tail model provides insight into understanding the persistence of neural deficits in hand-arm vibration syndrome.
Author List
Loffredo MA, Yan JG, Kao D, Zhang LL, Matloub HS, Riley DAAuthor
Hani S. Matloub MD Professor in the Plastic Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsDisease Models, Animal
Electric Stimulation
Electrodiagnosis
Hand-Arm Vibration Syndrome
Male
Nerve Fibers, Myelinated
Neural Conduction
Peripheral Nerves
Rats
Rats, Sprague-Dawley
Reaction Time
Tail
Time Factors
Vibration
Wallerian Degeneration
