Membrane mechanisms in arterial hypertension. Hypertension 1983;5(4):404-8
Date
07/01/1983Pubmed ID
6345356DOI
10.1161/01.hyp.5.4.404Scopus ID
2-s2.0-0020538112 (requires institutional sign-in at Scopus site) 30 CitationsAbstract
The purpose of this review is to focus on alterations in vascular muscle membrane potentials (Em), ionic permeabilities, and ionic transport systems which may either contribute to or be a consequence of the hypertensive state. Three models of hypertension are discussed: 1) deoxycorticosterone-salt (DOCA-salt)-induced hypertension; 2) low-renin (presumably volume expanded) renal hypertension (LRRH); and 3) the spontaneously hypertensive rat (SHR) of the Okamoto-Aoki Kyoto-Wistar strain and its normotensive genetic control (WKY). The importance of studying all possible mechanisms of increased contraction in vascular smooth muscle is stressed.
Author List
Harder DR, Hermsmeyer KMESH terms used to index this publication - Major topics in bold
AnimalsBiological Transport
Desoxycorticosterone
Hypertension
Hypertension, Renal
In Vitro Techniques
Ions
Membrane Potentials
Muscle, Smooth, Vascular
Permeability
Rats
Rats, Inbred Strains
Sodium Chloride
Vasoconstriction
