Cutting edge: IL-5 primes Th2 cytokine-producing capacity in eosinophils through a STAT5-dependent mechanism. J Immunol 2004 Sep 01;173(5):2918-22
Date
08/24/2004Pubmed ID
15322148DOI
10.4049/jimmunol.173.5.2918Scopus ID
2-s2.0-4344641107 (requires institutional sign-in at Scopus site) 32 CitationsAbstract
Both type-2 CD4(+) Th cells (CD4(+)Th2) and type-2 innate effector cells play critical roles in generating type-2 immunity that can either be protective against parasitic infection or cause tissue damage in allergy and asthma. How innate effector cells acquire the capacity to produce Th2 cytokines is not entirely known. We previously showed that IL-4 induced differentiation of Th2 cytokine-producing eosinophils. To determine whether other Th2 cytokines can also induce Th2 cytokine-producing capacity in innate effector cells, we cultured bone marrow progenitor cells in the presence of various Th2 cytokines. IL-5, but not IL-13 or IL-25, primed bone marrow progenitor cells to differentiate into robust IL-4-producing cells. The majority of IL-4-producing cells induced by IL-5 were eosinophils. Importantly, IL-5 completely depended on STAT5 to promote IL-4-producing capacity in eosinophils. Thus, our study demonstrates that IL-5 functions as a potent factor that drives bone marrow progenitor cells into IL-4-producing eosinophils.
Author List
Zhu Y, Chen L, Huang Z, Alkan S, Bunting KD, Wen R, Wang D, Huang HAuthor
Demin Wang PhD Professor in the Microbiology and Immunology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCell Differentiation
Cytokines
DNA-Binding Proteins
Eosinophils
Interleukin-4
Interleukin-5
Mice
Milk Proteins
STAT5 Transcription Factor
STAT6 Transcription Factor
Th2 Cells
Trans-Activators