Medical College of Wisconsin
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Methods for equivalence and noninferiority testing. Biol Blood Marrow Transplant 2009 Jan;15(1 Suppl):120-7 PMID: 19147090 PMCID: PMC2701110

Pubmed ID



Classical hypothesis testing focuses on testing whether treatments have differential effects on outcome. However, sometimes clinicians may be more interested in determining whether treatments are equivalent or whether one has noninferior outcomes. We review the hypotheses for these noninferiority and equivalence research questions, consider power and sample size issues, and discuss how to perform such a test for both binary and survival outcomes. The methods are illustrated on 2 recent studies in hematopoietic cell transplantation.

Author List

Tunes da Silva G, Logan BR, Klein JP


Brent R. Logan PhD Director, Professor in the Institute for Health and Equity department at Medical College of Wisconsin


2-s2.0-64749104971   50 Citations

MESH terms used to index this publication - Major topics in bold

Hematopoietic Stem Cell Transplantation
Odds Ratio
Research Design
Therapeutic Equivalency
Treatment Outcome
jenkins-FCD Prod-296 4db9d02597e0a2e889e230f853b641c12f1c3ee3