Postprandial effects on electrolyte homeostasis in the kidney. Am J Physiol Renal Physiol 2019 Dec 01;317(6):F1405-F1408
Date
10/01/2019Pubmed ID
31566434Pubmed Central ID
PMC6960787DOI
10.1152/ajprenal.00350.2019Scopus ID
2-s2.0-85075958423 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
Insulin is known to be an important regulator of a number of different channels and transporters in the kidney, but its role in the kidney to prevent Na+ and volume loss during the osmotic load after a meal has only recently been validated. With increasing numbers of people suffering from diabetes and hypertension, furthering our understanding of insulin signaling and renal Na+ handling in both normal and diseased states is essential for improving patient treatments and outcomes. The present review is focused on postprandial effects on Na+ reabsorption in the kidney and the role of the epithelial Na+ channels as an important channel contributing to insulin-mediated Na+ reclamation.
Author List
Klemens CA, Brands MW, Staruschenko AMESH terms used to index this publication - Major topics in bold
AnimalsHomeostasis
Humans
Kidney
Postprandial Period
Water-Electrolyte Balance