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Tirandamycins from Streptomyces sp. 17944 inhibiting the parasite Brugia malayi asparagine tRNA synthetase. Org Lett 2011 Apr 15;13(8):2034-7

Date

03/17/2011

Pubmed ID

21405052

Pubmed Central ID

PMC3074013

DOI

10.1021/ol200420u

Scopus ID

2-s2.0-79955388062   37 Citations

Abstract

Lymphatic filariasis is caused by the parasitic nematodes Brugia malayi and Wuchereria bancrofti, and asparaginyl-tRNA synthetase (AsnRS) is considered an excellent antifilarial target. The discovery of three new tirandamycins (TAMs), TAM E (1), F (2), and G (3), along with TAM A (4) and B (5), from Streptomyces sp. 17944 was reported. Remarkably, 5 selectively inhibits the B. malayi AsnRS and efficiently kills the adult B. malayi parasite, representing a new lead scaffold to discover and develop antifilarial drugs.

Author List

Yu Z, Vodanovic-Jankovic S, Ledeboer N, Huang SX, Rajski SR, Kron M, Shen B

Author

Michael Kron MD Director, Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Aminoglycosides
Animals
Anti-Bacterial Agents
Aspartate-tRNA Ligase
Brugia malayi
Enzyme Inhibitors
Models, Molecular
Molecular Structure
RNA, Transfer, Amino Acyl
Streptomyces
jenkins-FCD Prod-388 89e904233d719332173309c68ab82b0b2a78a3a7