Tirandamycins from Streptomyces sp. 17944 inhibiting the parasite Brugia malayi asparagine tRNA synthetase. Org Lett 2011 Apr 15;13(8):2034-7
Date
03/17/2011Pubmed ID
21405052Pubmed Central ID
PMC3074013DOI
10.1021/ol200420uScopus ID
2-s2.0-79955388062 (requires institutional sign-in at Scopus site) 55 CitationsAbstract
Lymphatic filariasis is caused by the parasitic nematodes Brugia malayi and Wuchereria bancrofti, and asparaginyl-tRNA synthetase (AsnRS) is considered an excellent antifilarial target. The discovery of three new tirandamycins (TAMs), TAM E (1), F (2), and G (3), along with TAM A (4) and B (5), from Streptomyces sp. 17944 was reported. Remarkably, 5 selectively inhibits the B. malayi AsnRS and efficiently kills the adult B. malayi parasite, representing a new lead scaffold to discover and develop antifilarial drugs.
Author List
Yu Z, Vodanovic-Jankovic S, Ledeboer N, Huang SX, Rajski SR, Kron M, Shen BAuthors
Michael Kron MD Director, Professor in the Medicine department at Medical College of WisconsinNathan A. Ledeboer PhD Vice Chair, Professor in the Pathology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AminoglycosidesAnimals
Anti-Bacterial Agents
Aspartate-tRNA Ligase
Brugia malayi
Enzyme Inhibitors
Models, Molecular
Molecular Structure
RNA, Transfer, Amino Acyl
Streptomyces