Faculty Collaboration Database

Methoxyindoles and photoreceptor metabolism: activation of rod shedding. Science 1983 Mar 18;219(4590):1341-3

Date

03/18/1983

Pubmed ID

6828862

DOI

10.1126/science.6828862

Scopus ID

2-s2.0-0020568959 (requires institutional sign-in at Scopus site)   155 Citations

Abstract

Using an in vitro eye-cup preparation, we have evaluated a potential relationship between methoxyindole metabolism and photoreceptor disk shedding. Melatonin, 6-chloromelatonin, and 5-methoxytryptophol all activate rod disk shedding in culture. The effect is compound specific since serotonin and N-acetylserotonin are without effect, and it is similar to shedding in vivo because it is evoked by light and is quantitatively comparable to a normal intact animal response. The results suggest the involvement of 5-methoxyindoles in the control of rhythmic photoreceptor metabolism.

Author List

Besharse JC, Dunis DA

MESH terms used to index this publication - Major topics in bold

Animals
In Vitro Techniques
Indoles
Melatonin
Phagocytosis
Photoreceptor Cells
Xenopus laevis