Faculty Collaboration Database

Fatal misonidazole-induced encephalopathy: an RTOG case report. Cancer 1982 Feb 01;49(3):423-6

Date

02/01/1982

Pubmed ID

7059905

DOI

10.1002/1097-0142(19820201)49:3<423::aid-cncr2820490305>3.0.co;2-l

Scopus ID

2-s2.0-0020070062 (requires institutional sign-in at Scopus site)   10 Citations

Abstract

A case of fatal encephalopathy following administration of misonidazole (MISO) is reported. Anorexia and dehydration preceded signs of encephalopathy after a cumulative dose of 18 g (11 g/m2) of MISO in five weekly doses. Serum MISO levels four hours after weekly administrations were markedly elevated. Postmortem examination revealed focal cortical neuronal necrosis and hemorrhage with focal demyelination. The possible relationship of dehydration or altered drug metabolism to the development of MISO central nervous system toxicity is noted.

Author List

Kun LE, Ho KC, Moulder JE

MESH terms used to index this publication - Major topics in bold

Brain Diseases
Carcinoma, Squamous Cell
Dose-Response Relationship, Drug
Female
Humans
Middle Aged
Misonidazole
Nitroimidazoles
Palatal Neoplasms
Tongue Neoplasms