Medical College of Wisconsin
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Chronic administration of naltrexone alters central catecholamine levels but not the development of hypertension in spontaneously hypertensive rats. Neuropharmacology 1982 Nov;21(11):1195-8

Date

11/01/1982

Pubmed ID

7177344

DOI

10.1016/0028-3908(82)90179-4

Abstract

The effect of chronic administration of the opiate antagonist naltrexone on the genesis and development of hypertension and correlated changes in central norepinephrine levels was evaluated in spontaneously hypertensive rats and Wistar-Kyoto controls. Capsules of poly-epsilon-caprolactone containing naltrexone in ethyl oleate or ethyl oleate alone were implanted in 4 week old SHR and WKY rats. Naltrexone failed to alter the genesis or magnitude of hypertension developed by the SHR and did not alter heart rates. Blood pressure and heart rate of WKY rats were also unaffected. A significant decrease in midbrain and hippocampal NE levels was observed in SHRs but not in WKYs following naltrexone.

Author List

Strahlendorf JC, Strahlendorf HK, McKown-Pulliam R, Hughes MJ, Lang IM

Author

Ivan M. Lang DVM, PhD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Blood Pressure
Brain Chemistry
Catecholamines
Heart Rate
Hypertension
Male
Naloxone
Naltrexone
Norepinephrine
Rats
Rats, Inbred Strains
Time Factors
jenkins-FCD Prod-411 e00897e83867fcfa48419861683711f8d99adb75