An immunodominant antigen of Brugia malayi is an asparaginyl-tRNA synthetase. FEBS Lett 1995 Oct 23;374(1):122-4
Date
10/23/1995Pubmed ID
7589498DOI
10.1016/0014-5793(95)01092-sScopus ID
2-s2.0-0028793421 (requires institutional sign-in at Scopus site) 32 CitationsAbstract
Lymphatic filariasis is caused by infection with the filarial nematodes Brugia malayi, Brugia timori, Wuchereria bancrofti and Onchocerca volvulus which collectively infect about 200 million persons throughout the world. Protein sequence homology analysis of a major nematode antigen suggested that it was a class II aminoacyl-tRNA synthetase. The overproduction, purification and verification that the major B. malayi antigen is an asparaginyl-tRNA synthetase is described.
Author List
Kron M, Marquard K, Härtlein M, Price S, Leberman RAuthor
Michael Kron MD Director, Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Amino Acid SequenceAmino Acyl-tRNA Synthetases
Animals
Antigens, Helminth
Aspartate-tRNA Ligase
Base Sequence
Brugia malayi
DNA Primers
Immunodominant Epitopes
Molecular Sequence Data
RNA, Transfer, Amino Acyl
RNA, Transfer, Asn
Recombinant Fusion Proteins